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IUBMB Comments The enzyme has been characterized from mammals and from the bacterium Streptantibioticus cattleyicolor . In mammals it hydrolyses excess 4′-phosphopantetheine to prevent cell damage. In S. cattleyicolor it participates in the biosynthesis of the β-lactam antibiotic thienamycin.
Synonyms PanK4 , pantothenate kinase 4, thnH ,
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pantothenate kinase 4
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PanK4
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thnH
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4'-phosphopantetheine + H2O = pantetheine + phosphate
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4'-phosphopantetheine phosphohydrolase
The enzyme has been characterized from mammals and from the bacterium Streptantibioticus cattleyicolor. In mammals it hydrolyses excess 4'-phosphopantetheine to prevent cell damage. In S. cattleyicolor it participates in the biosynthesis of the beta-lactam antibiotic thienamycin.
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2',5'-ADP + H2O
2',5'-AMP + phosphate
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Substrates: -
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4'-phosphopantetheine + H2O
pantetheine + phosphate
4-nitrophenyl diphosphate + H2O
4-nitrophenyl phosphate + phosphate
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Substrates: highest activity
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D-galactose 1'-phosphate + H2O
D-galactose + phosphate
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Substrates: lowest activity
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D-glucose 6'-phosphate + H2O
D-glucose + phosphate
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Substrates: -
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glycine phosphate + H2O
glycine + phosphate
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Substrates: -
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additional information
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Substrates: the enzyme has a markedly reduced cleavage rate for prederivatized 4-phosphopantetheine
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4'-phosphopantetheine + H2O
pantetheine + phosphate
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Substrates: -
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4'-phosphopantetheine + H2O
pantetheine + phosphate
Substrates: -
?
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4'-phosphopantetheine + H2O
pantetheine + phosphate
4'-phosphopantetheine + H2O
pantetheine + phosphate
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Substrates: -
?
4'-phosphopantetheine + H2O
pantetheine + phosphate
Substrates: -
?
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Co2+
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0.5 mM used in assay conditions
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UniProt
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Highest Expressing Human Cell Lines
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Gene Links
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Q83XP6_STRCT
224
0
23956
TrEMBL
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Ni-NTA column chromatography
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expressed in Escherichia coli
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expressed in Escherichia coli BL21(DE3) pLysS cells
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Huang, L.; Khusnutdinova, A.; Nocek, B.; Brown, G.; Xu, X.; Cui, H.; Petit, P.; Flick, R.; Zallot, R.; Balmant, K.; Ziemak, M.; Shanklin, J.; De Crecy-Lagard, V.; Fiehn, O.; Gregory, J.; Joachimiak, A.; Savchenko, A.; Yakunin, A.; Hanson, A.
A family of metal-dependent phosphatases implicated in metabolite damage-control
Nat. Chem. Biol.
12
621-627
2016
Homo sapiens
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Freeman, M.; Moshos, K.; Bodner, M.; Li, R.; Townsend, C.
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis
Proc. Natl. Acad. Sci. USA
105
11128-11133
2008
Streptantibioticus cattleyicolor (Q83XP6)
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