Disease on EC 3.1.22.1 - deoxyribonuclease II
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Anemia
TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.
Arthritis
Apoptotic Cells Induced Signaling for Immune Homeostasis in Macrophages and Dendritic Cells.
Arthritis
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
Arthritis
Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands.
Arthritis
IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation.
Arthritis
Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model.
Arthritis, Rheumatoid
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
Arthritis, Rheumatoid
Genetic and expression analysis of SNPs in the human deoxyribonuclease II: SNPs in the promoter region reduce its in vivo activity through decreased promoter activity.
Arthritis, Rheumatoid
Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model.
Arthritis, Rheumatoid
Seven nonsynonymous SNPs in the gene encoding human deoxyribonuclease II may serve as a functional SNP potentially implicated in autoimmune dysfunction.
Ascorbic Acid Deficiency
[Development of acid deoxyribonuclease or DNase II activity during ascorbic acid deficiency in the guinea pig]
Autoimmune Diseases
Apoptotic Cells Induced Signaling for Immune Homeostasis in Macrophages and Dendritic Cells.
Avitaminosis
[Characteristics of the deoxyribonuclease II activity of the guinea pig liver during acute avitaminosis C]
Avitaminosis
[Comparison of effects of avitaminosis C on activity of acid DNase of testis in the young and adult guinea pig]
Bacterial Infections
Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation.
Carcinogenesis
Induction of the deficient acid DNAse activity in mouse interfollicular epidermis by croton oil as a possible tumor promoting mechanism.
Carcinogenesis
[Interaction between lysosomes and cell nucleus during diethylnitrosamine-induced carcinogenesis. I. Changes in subcellular distribution of the lysosomal enzymes acid deoxyribonuclease and beta-galactosidase during acute intoxication by diethylnitrosamine]
Carcinoma, Ehrlich Tumor
Association of DNA with the nuclear lamina in Ehrlich ascites tumor cells.
Carcinoma, Hepatocellular
Periodicity and fragment size of DNA from mouse TLT hepatoma chromatin and chromatin fractions using endogenous and exogenous nucleases.
Cardiomegaly
Novel Role for Caspase-Activated DNase in the Regulation of Pathological Cardiac Hypertrophy.
Cataract
Identification of Differential Gene Expression Pattern in Lens Epithelial Cells Derived from Cataractous and Noncataractous Lenses of Shumiya Cataract Rat.
Cataract
Involvement of DNase II-like acid DNase in the cataract formation of the UPL rat and the Shumiya cataract rat.
Choriocarcinoma
Expression of constitutively active c-MET receptor in human choriocarcinoma.
Choriocarcinoma
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Choriocarcinoma
Macrophage colony-stimulating factor induces the growth and differentiation of normal pregnancy human cytotrophoblast cells and hydatidiform moles but does not induce the growth and differentiation of choriocarcinoma cells.
Choriocarcinoma
[Studies on HLA-class I and class II antigen expression in cultured choriocarcinoma cell lines]
Choriocarcinoma, Non-gestational
[Studies on HLA-class I and class II antigen expression in cultured choriocarcinoma cell lines]
Cryptorchidism
[Influence of experimental cryptorchism on the ascorbic acid content and acid deoxyribonuclease activity of rat testis]
Cystic Fibrosis
Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging.
deoxyribonuclease ii deficiency
Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands.
deoxyribonuclease ii deficiency
DNase II deficiency impairs innate immune function in Drosophila.
deoxyribonuclease ii deficiency
Lupus manifestations in children with primary immunodeficiency diseases: Comprehensive phenotypic and genetic features and outcome.
deoxyribonuclease ii deficiency
Pulmonary arterial hypertension in interferonophaties: a case report and a review of the literature.
deoxyribonuclease ii deficiency
Reversibility of acid and alkaline deoxyribonuclease deficiency in malignant tumor cells.
deoxyribonuclease ii deficiency
Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
deoxyribonuclease ii deficiency
The Role of IFN?-Producing Th1 Cells in a Type I IFN-Independent Murine Model of Autoinflammation Resulting from DNase II-Deficiency.
deoxyribonuclease ii deficiency
Toward a better understanding of type I interferonopathies: a brief summary, update and beyond.
deoxyribonuclease ii deficiency
Type I interferon-mediated autoinflammation due to DNase II deficiency.
Endometrial Neoplasms
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Esophagitis, Peptic
The Activities of Acid DNase and 5'Nucleotidase in Erosive Reflux Esophagitis and Barrett's Epithelium.
Fatty Liver
DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-? signaling pathway.
Infections
Characterization of Two Trichinella spiralis Adult-Specific DNase II and Their Capacity to Induce Protective Immunity.
Infections
Fowlpox virus encodes nonessential homologs of cellular alpha-SNAP, PC-1, and an orphan human homolog of a secreted nematode protein.
Infections
Gene Expression of Putative Pathogenicity-Related Genes in Verticillium dahliae in Response to Elicitation with Potato Extracts and during Infection Using Quantitative Real-Time PCR.
Infections
Vaccination with a DNase II recombinant protein against Trichinella spiralis infection in pigs.
Leukemia
Intragenomic distribution of 5-methylcytosine in various forms of human and murine leukemic cells.
Leukemia
[Cytochemical identification of acid deoxyribonuclease in blood cell cytoplasm. 3. Activity of acid deoxyribonuclease in leukocyte cytoplasm of children suffering from acute leukemia]
Leukemia, Erythroblastic, Acute
Localization of DNA methyltransferase in the chromatin of Friend erythroleukemia cells.
Liver Cirrhosis
DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-? signaling pathway.
Liver Neoplasms
Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort.
Lupus Erythematosus, Systemic
DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients.
Lupus Erythematosus, Systemic
Pulmonary arterial hypertension in interferonophaties: a case report and a review of the literature.
Lupus Erythematosus, Systemic
[DNAse II from phagocytes in the study of the pathogenesis of systemic lupus erythematosus]
Lymphoma, Non-Hodgkin
Selective effect of cortisol on deoxyribonuclease II activity of lymphosarcoma P1798.
Malnutrition
Differential effects of early undernutrition in white and grey matter regions of rat brain.
Movement Disorders
Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease.
Muscular Dystrophies
ENZYME STUDIES IN MUSCULAR DYSTROPHY. IV. ACID DEOXYRIBONUCLEASE IN NUTRITIONAL AND HEREDITARY MUSCULAR DYSTROPHY.
Muscular Dystrophies
ENZYME STUDIES IN MUSCULAR DYSTROPHY. VI. CATHEPSIN AND ACID DEOXYRIBONUCLEASE ACTIVITIES DURING THE PROGRESSION OF HEREDITARY MUSCULAR DYSTROPHY IN THE CHICKEN.
Neoplasms
Altered deoxyribonuclease activity in cancer cells and its role in non toxic adjuvant cancer therapy with mixed vitamins C and K3.
Neoplasms
Changes in the template activity of chromatin isolated from sarcoma-180 ascites cells treated with mitomycin C and gamma irradiation in vivo.
Neoplasms
DNase II and the Chk2 DNA Damage Pathway Form a Genetic Barrier Blocking Replication of Horizontally Transferred DNA.
Neoplasms
Hyperplasia of epithelium adjacent to transitional cell carcinoma can be induced by growth factors through paracrine pathways.
Neoplasms
Induction of the deficient acid DNAse activity in mouse interfollicular epidermis by croton oil as a possible tumor promoting mechanism.
Neoplasms
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Neoplasms
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Neoplasms
Reversibility of acid and alkaline deoxyribonuclease deficiency in malignant tumor cells.
Neoplasms
The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy.
Neoplasms
The inhibition of tumor growth and deoxyribonuclease II by anionic polyelectrolytes.
Neoplasms
[Cytochemical determination of acid deoxyribonuclease activity in the nuclei of lymphocytes of BALB/c mice with methylcholanthrene-induced tumors]
Neoplasms
[Histone specific proteinase and DNase activity of spleen lymphocyte nuclei during oncogenesis and under the effect of hydrobromide-5-(5',6' benzocoumaroyl-3')-methylaminouracil]
Neuroblastoma
Embryonic chicken brain and mouse neuroblastoma cells N1E-115 and N-18 contain an inhibitor of acid deoxyribonuclease.
Ovarian Neoplasms
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Pancreatic Diseases
Clinical investigation of serum deoxyribonuclease: II. Clinical studies of serum deoxyribonuclease activity in pancreatic disease.
Pancreatitis
Relationship between pancreatic enzymes and pathological changes in the pancreas in acute pancreatitis. The significance of determination of serum deoxyribonuclease.
Psoriasis
[Change in the activity of acid proteinase and deoxyribonuclease II of blood serum in psoriasis]
purine-nucleoside phosphorylase deficiency
Lupus manifestations in children with primary immunodeficiency diseases: Comprehensive phenotypic and genetic features and outcome.
Retinal Degeneration
The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.
Retinal Degeneration
The LEI/L-DNase II pathway is activated in light-induced retinal degeneration in rats.
Sarcoma
Immunological studies on Yoshida sarcoma cells. I. The effect of heterologous anti-Yoshida sarcoma cell antibodies on the lysosomal acid DNase of sarcoma cells.
Sarcoma
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Sarcoma
Susceptibility of Rous sarcoma virus-specific sequences integrated into SR-C3H/He mouse ascites sarcoma cell chromatin to DNase I and DNase II.
Sarcoma, Avian
Susceptibility of Rous sarcoma virus-specific sequences integrated into SR-C3H/He mouse ascites sarcoma cell chromatin to DNase I and DNase II.
Sarcoma, Yoshida
Immunological studies on Yoshida sarcoma cells. I. The effect of heterologous anti-Yoshida sarcoma cell antibodies on the lysosomal acid DNase of sarcoma cells.
Seizures
Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures.
Trichinellosis
Proteomic Analysis of Trichinella spiralis Adult Worm Excretory-Secretory Proteins Recognized by Sera of Patients with Early Trichinellosis.
Trichinellosis
Screening and characterization of early diagnostic antigens in excretory-secretory proteins from Trichinella spiralis intestinal infective larvae by immunoproteomics.
Virus Diseases
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Vitamin A Deficiency
[Acid deoxyribonuclease activity and testicular degeneration in rats with vitamin A deficiency]
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