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Anemia
TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.
Arthritis
Apoptotic Cells Induced Signaling for Immune Homeostasis in Macrophages and Dendritic Cells.
Arthritis
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
Arthritis
Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands.
Arthritis
IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation.
Arthritis
Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model.
Arthritis, Rheumatoid
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
Arthritis, Rheumatoid
Genetic and expression analysis of SNPs in the human deoxyribonuclease II: SNPs in the promoter region reduce its in vivo activity through decreased promoter activity.
Arthritis, Rheumatoid
Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model.
Arthritis, Rheumatoid
Seven nonsynonymous SNPs in the gene encoding human deoxyribonuclease II may serve as a functional SNP potentially implicated in autoimmune dysfunction.
Ascorbic Acid Deficiency
[Development of acid deoxyribonuclease or DNase II activity during ascorbic acid deficiency in the guinea pig]
Autoimmune Diseases
Apoptotic Cells Induced Signaling for Immune Homeostasis in Macrophages and Dendritic Cells.
Autoimmune Diseases
Molecular basis of DNA recognition in the immune system.
Avitaminosis
[Characteristics of the deoxyribonuclease II activity of the guinea pig liver during acute avitaminosis C]
Avitaminosis
[Comparison of effects of avitaminosis C on activity of acid DNase of testis in the young and adult guinea pig]
Avitaminosis
[Testicular degeneration and DNase II activity in various avitaminoses]
Bacterial Infections
Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation.
Carcinogenesis
Induction of the deficient acid DNAse activity in mouse interfollicular epidermis by croton oil as a possible tumor promoting mechanism.
Carcinogenesis
[Interaction between lysosomes and cell nucleus during diethylnitrosamine-induced carcinogenesis. I. Changes in subcellular distribution of the lysosomal enzymes acid deoxyribonuclease and beta-galactosidase during acute intoxication by diethylnitrosamine]
Carcinoma, Ehrlich Tumor
Association of DNA with the nuclear lamina in Ehrlich ascites tumor cells.
Carcinoma, Hepatocellular
Periodicity and fragment size of DNA from mouse TLT hepatoma chromatin and chromatin fractions using endogenous and exogenous nucleases.
Cardiomegaly
Novel Role for Caspase-Activated DNase in the Regulation of Pathological Cardiac Hypertrophy.
Cataract
Identification of Differential Gene Expression Pattern in Lens Epithelial Cells Derived from Cataractous and Noncataractous Lenses of Shumiya Cataract Rat.
Cataract
Involvement of DNase II-like acid DNase in the cataract formation of the UPL rat and the Shumiya cataract rat.
Choriocarcinoma
Expression of constitutively active c-MET receptor in human choriocarcinoma.
Choriocarcinoma
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Choriocarcinoma
Macrophage colony-stimulating factor induces the growth and differentiation of normal pregnancy human cytotrophoblast cells and hydatidiform moles but does not induce the growth and differentiation of choriocarcinoma cells.
Choriocarcinoma
[Studies on HLA-class I and class II antigen expression in cultured choriocarcinoma cell lines]
Choriocarcinoma, Non-gestational
[Studies on HLA-class I and class II antigen expression in cultured choriocarcinoma cell lines]
Cryptorchidism
[Influence of experimental cryptorchism on the ascorbic acid content and acid deoxyribonuclease activity of rat testis]
Cystic Fibrosis
Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging.
Cysts
[Deoxyribonuclease II activity in Sarcocystis fusiformis and S. gigantea cysts]
deoxyribonuclease ii deficiency
Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands.
deoxyribonuclease ii deficiency
DNase II deficiency impairs innate immune function in Drosophila.
deoxyribonuclease ii deficiency
Lupus manifestations in children with primary immunodeficiency diseases: Comprehensive phenotypic and genetic features and outcome.
deoxyribonuclease ii deficiency
Pulmonary arterial hypertension in interferonophaties: a case report and a review of the literature.
deoxyribonuclease ii deficiency
Reversibility of acid and alkaline deoxyribonuclease deficiency in malignant tumor cells.
deoxyribonuclease ii deficiency
Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
deoxyribonuclease ii deficiency
The Role of IFN?-Producing Th1 Cells in a Type I IFN-Independent Murine Model of Autoinflammation Resulting from DNase II-Deficiency.
deoxyribonuclease ii deficiency
Toward a better understanding of type I interferonopathies: a brief summary, update and beyond.
deoxyribonuclease ii deficiency
Type I interferon-mediated autoinflammation due to DNase II deficiency.
Endometrial Neoplasms
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Esophagitis, Peptic
The Activities of Acid DNase and 5'Nucleotidase in Erosive Reflux Esophagitis and Barrett's Epithelium.
Fatty Liver
DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-? signaling pathway.
Fibroma
Fibroma virus-induced acid deoxyribonuclease in rabbit kidney cells.
Fowlpox
Cloning and expression of deoxyribonuclease II from chicken.
Infections
Characterization of Two Trichinella spiralis Adult-Specific DNase II and Their Capacity to Induce Protective Immunity.
Infections
DNase II deficiency impairs innate immune function in Drosophila.
Infections
Fowlpox virus encodes nonessential homologs of cellular alpha-SNAP, PC-1, and an orphan human homolog of a secreted nematode protein.
Infections
Gene Expression of Putative Pathogenicity-Related Genes in Verticillium dahliae in Response to Elicitation with Potato Extracts and during Infection Using Quantitative Real-Time PCR.
Infections
Vaccination with a DNase II recombinant protein against Trichinella spiralis infection in pigs.
Leukemia
Intragenomic distribution of 5-methylcytosine in various forms of human and murine leukemic cells.
Leukemia
[Cytochemical identification of acid deoxyribonuclease in blood cell cytoplasm. 3. Activity of acid deoxyribonuclease in leukocyte cytoplasm of children suffering from acute leukemia]
Leukemia, Erythroblastic, Acute
Localization of DNA methyltransferase in the chromatin of Friend erythroleukemia cells.
Liver Cirrhosis
DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-? signaling pathway.
Liver Neoplasms
Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort.
Lupus Erythematosus, Systemic
DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients.
Lupus Erythematosus, Systemic
Pulmonary arterial hypertension in interferonophaties: a case report and a review of the literature.
Lupus Erythematosus, Systemic
[DNAse II from phagocytes in the study of the pathogenesis of systemic lupus erythematosus]
Lymphoma, Non-Hodgkin
Selective effect of cortisol on deoxyribonuclease II activity of lymphosarcoma P1798.
Malnutrition
Differential effects of early undernutrition in white and grey matter regions of rat brain.
Movement Disorders
Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease.
Muscular Dystrophies
ENZYME STUDIES IN MUSCULAR DYSTROPHY. IV. ACID DEOXYRIBONUCLEASE IN NUTRITIONAL AND HEREDITARY MUSCULAR DYSTROPHY.
Muscular Dystrophies
ENZYME STUDIES IN MUSCULAR DYSTROPHY. VI. CATHEPSIN AND ACID DEOXYRIBONUCLEASE ACTIVITIES DURING THE PROGRESSION OF HEREDITARY MUSCULAR DYSTROPHY IN THE CHICKEN.
Neoplasms
Altered deoxyribonuclease activity in cancer cells and its role in non toxic adjuvant cancer therapy with mixed vitamins C and K3.
Neoplasms
Association of DNA with the nuclear lamina in Ehrlich ascites tumor cells.
Neoplasms
Bond-cleaving specificity of a deoxyribonuclease II from mouse mammary tumors.
Neoplasms
Changes in the template activity of chromatin isolated from sarcoma-180 ascites cells treated with mitomycin C and gamma irradiation in vivo.
Neoplasms
DNase II and the Chk2 DNA Damage Pathway Form a Genetic Barrier Blocking Replication of Horizontally Transferred DNA.
Neoplasms
Effect of deoxyribonuclease on adriamycin-polynucleotide complexes.
Neoplasms
Histochemical investigations on acid deoxyribonuclease in some tumours.
Neoplasms
Hyperplasia of epithelium adjacent to transitional cell carcinoma can be induced by growth factors through paracrine pathways.
Neoplasms
Induction of the deficient acid DNAse activity in mouse interfollicular epidermis by croton oil as a possible tumor promoting mechanism.
Neoplasms
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Neoplasms
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Neoplasms
Reversibility of acid and alkaline deoxyribonuclease deficiency in malignant tumor cells.
Neoplasms
The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy.
Neoplasms
The inhibition of tumor growth and deoxyribonuclease II by anionic polyelectrolytes.
Neoplasms
[Cytochemical determination of acid deoxyribonuclease activity in the nuclei of lymphocytes of BALB/c mice with methylcholanthrene-induced tumors]
Neoplasms
[Deoxyribonucleases in spontaneous and experimental tumors of the nervous system]
Neoplasms
[Histone specific proteinase and DNase activity of spleen lymphocyte nuclei during oncogenesis and under the effect of hydrobromide-5-(5',6' benzocoumaroyl-3')-methylaminouracil]
Neuroblastoma
Embryonic chicken brain and mouse neuroblastoma cells N1E-115 and N-18 contain an inhibitor of acid deoxyribonuclease.
Ovarian Neoplasms
Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.
Pancreatic Diseases
Clinical investigation of serum deoxyribonuclease: II. Clinical studies of serum deoxyribonuclease activity in pancreatic disease.
Pancreatitis
Relationship between pancreatic enzymes and pathological changes in the pancreas in acute pancreatitis. The significance of determination of serum deoxyribonuclease.
Psoriasis
[Change in the activity of acid proteinase and deoxyribonuclease II of blood serum in psoriasis]
purine-nucleoside phosphorylase deficiency
Lupus manifestations in children with primary immunodeficiency diseases: Comprehensive phenotypic and genetic features and outcome.
Retinal Degeneration
The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.
Retinal Degeneration
The LEI/L-DNase II pathway is activated in light-induced retinal degeneration in rats.
Sarcoma
Immunological studies on Yoshida sarcoma cells. I. The effect of heterologous anti-Yoshida sarcoma cell antibodies on the lysosomal acid DNase of sarcoma cells.
Sarcoma
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Sarcoma
Susceptibility of Rous sarcoma virus-specific sequences integrated into SR-C3H/He mouse ascites sarcoma cell chromatin to DNase I and DNase II.
Sarcoma, Avian
Susceptibility of Rous sarcoma virus-specific sequences integrated into SR-C3H/He mouse ascites sarcoma cell chromatin to DNase I and DNase II.
Sarcoma, Yoshida
Immunological studies on Yoshida sarcoma cells. I. The effect of heterologous anti-Yoshida sarcoma cell antibodies on the lysosomal acid DNase of sarcoma cells.
Seizures
Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures.
Seizures
Picrotoxin-induced convulsions and lysosomal function in the rat brain.
Starvation
Genetic regulation of phosphate transport system II in Neurospora.
Trichinellosis
Proteomic Analysis of Trichinella spiralis Adult Worm Excretory-Secretory Proteins Recognized by Sera of Patients with Early Trichinellosis.
Trichinellosis
Screening and characterization of early diagnostic antigens in excretory-secretory proteins from Trichinella spiralis intestinal infective larvae by immunoproteomics.
Vaccinia
5'OH DNA breaks in apoptosis and their labeling by topoisomerase-based approach.
Virus Diseases
Cytochemical studies of polyoma virus infection. 3. Deoxyribonuclease II.
Virus Diseases
Nucleases and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in murine sarcoma virus (Moloney)-infected mice.
Vitamin A Deficiency
[Acid deoxyribonuclease activity and testicular degeneration in rats with vitamin A deficiency]
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A335Term
does not eliminate DNase II activity
A58del
in Japanese, African, Korean and Caucasian subjects, homozygous for the G292 allele. Shows almost no DNase II activity
H188A
shows similar levels of activity to that of the wild-type
H188K
shows similar levels of activity to that of the wild-type
H188R
in Japanese, African, Korean and Caucasian subjects, homozygous for the A683 allele. DNase II activity is similar to that of the wild-type
Q329Term
eliminates DNase II activity
R23A
exerts no effect on the DNase II activity
R23H
exerts no effect on the DNase II activity
R23I
in Japanese, African, Korean and Caucasian subjects, homozygous for the G188 allele. DNase II activity is similar to that of the wild-type
R298A
drastically abrogates DNase II activity
R298H
drastically abrogates DNase II activity
R298K
drastically abrogates DNase II activity
R298L
in Japanese, African, Korean and Caucasian subjects, homozygous for the G1013 allele. Reduces the DNase II activity greatly to less than 10% of that of the wild-type
V190I
in Korean subjects,heterozygous for the G688 and A688 alleles. In Japanese, homozygous for the G688 allele. DNase II activity is similar to that of the wild-type
V284A
activity remains low
V284L
activity remains low
V284M
in Japanese, African, Korean and Caucasian subjects, homozygous for the G970 allele. Reduces the DNase II activity greatly to less than 10% of that of the wild-type
C11A
-
the mutation decreases the activity
C159A
-
complete loss of activity
C19A
-
complete loss of activity
C267A
-
complete loss of activity
C299A
-
the mutation increases the activity
C308A
-
complete loss of activity
C327A
-
complete loss of activity
C347A
-
complete loss of activity
D107N
-
although the mutant is capable of even greater glycosylation, this mutant results in some loss of activity
N212Q
-
mutation decreases activity, tunicamycin treatment results in complete loss of activity
N266Q
-
mutation decreases activity, tunicamycin treatment results in complete loss of activity
N290Q
-
mutation decreases activity, tunicamycin treatment results in complete loss of activity
N69Q
-
mutation decreases activity, tunicamycin treatment results in complete loss of activity
N86Q
-
mutation decreases activity, tunicamycin treatment results in complete loss of activity
additional information
-
mutation of the histidine moiety of His 368 completely abolishes endonuclease activity of L-DNase II
Q322Term
eliminates DNase II activity
Q322Term
in Japanese, African, Korean and Caucasian subjects, homozygous for the C1084 allele. Shows almost no DNase II activity
H295A
-
mutant can effectively bind DNA, but has a direct role in the catalysis
H295A
the mutant is inactive
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Baker, K.P.; Baron, W.F.; Henzel, W.J.; Spencer, S.A.
Molecular cloning and characterization of human and murine DNase II
Gene
215
281-289
1998
Homo sapiens, Mus musculus, Sus scrofa
brenda
Krieser, R.J.; Eastman, A.
The cloning and expression of human deoxyribonuclease II. A possible role in apoptosis
J. Biol. Chem.
273
30909-30914
1998
Homo sapiens (O00115), Homo sapiens
brenda
Takeshita, H.; Yasuda, T.; Iida, R.; Nakajima, T.; Hosomi, O.; Nakashima, Y.; Mori, S.; Nomoto, H.; Kishi, K.
Identification of the three non-identical subunits cnstituting human deoxyribonuclease II
FEBS Lett.
440
239-242
1998
Homo sapiens
brenda
Yasuda, T.; Nadano, D.; Awazu, S.; Kishi, K.
Human urine deoxyribonuclease II (DNase II) isoenzymes: a novel immunoaffinity purification, biochemical multiplicity, genetic heterogeneity and broad distribution among tissues and body fluids
Biochim. Biophys. Acta
1119
185-193
1992
Homo sapiens
brenda
Harosh, I.; Binninger, D.M.; Harris, P.V.; Mezzina, M.; Boyd, J.B.
Mechanism of action of deoxyribonuclease II from human lymphoblasts
Eur. J. Biochem.
202
479-484
1991
Homo sapiens
brenda
Murai, K.; Yamanaka, M.; Akagi, K.; Anai, M.
Purification and properties of deoxyribonuclease II from human urine
J. Biochem.
87
1097-1103
1980
Homo sapiens
brenda
Slor, H.
Purification of 14C-labelled deoxyribonuclease II from HeLa S3 lysosomes and its use as a marker for the study of nuclear deoxyribonuclease II
Biochem. J.
136
83-87
1973
Homo sapiens
brenda
Schroeder, W.A.; Shelton, R.J.; Shelton, J.B.; Robberson, B.; Apell, G.
DNase II inhibitor in tissues and urine - pH and salt artifacts
Arch. Biochem. Biophys.
131
652-658
1969
Homo sapiens
brenda
MacLea, K.S.; Krieser, R.J.; Eastman, A.
Revised structure of the active form of human deoxyribonuclease IIalpha
Biochem. Biophys. Res. Commun.
292
415-421
2002
Homo sapiens (Q8WZ79), Homo sapiens
brenda
MacLea, K.S.; Krieser, R.J.; Eastman, A.
Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging
Biochem. J.
371
867-876
2003
Homo sapiens
brenda
Chou, S.F.; Chen, H.L.; Lu, S.C.
Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells
Eur. J. Biochem.
270
1855-1862
2003
Homo sapiens
brenda
Krieser, R.J.; MacLea, K.S.; Park, J.P.; Eastman, A.
The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta
Gene
269
205-216
2001
Homo sapiens (Q8WZ79), Homo sapiens, Mus musculus
brenda
MacLea, K.S.; Krieser, R.J.; Eastman, A.
A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei
Gene
305
1-12
2003
Bos taurus (P56541), Caenorhabditis elegans (P34387), Caenorhabditis elegans (P34508), Caenorhabditis elegans (Q17778), Caenorhabditis elegans, Caenorhabditis elegans F09G8.2 (P34387), Caenorhabditis elegans K04H4.6 (P34508), Caenorhabditis elegans NUC-1 (Q17778), Drosophila melanogaster (Q7JYM9), Homo sapiens (O00115), Homo sapiens (Q8WZ79), Homo sapiens, Mus musculus (P56542), Mus musculus (Q9QY48), Rattus norvegicus (Q9QZK8), Rattus norvegicus (Q9QZK9), Sus scrofa (O62855)
brenda
Evans, C.J.; Aguilera, R.J.
DNase II: genes, enzymes and function
Gene
322
1-15
2003
Caenorhabditis elegans, Caenorhabditis elegans NUC-1, Drosophila melanogaster, Homo sapiens, Mus musculus
brenda
Cymerman, I.A.; Meiss, G.; Bujnicki, J.M.
DNase II is a member of the phospholipase D superfamily
Bioinformatics
21
3959-3962
2005
Homo sapiens
brenda
Shin, H.D.; Park, B.L.; Cheong, H.S.; Lee, H.S.; Jun, J.B.; Bae, S.C.
DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients
J. Hum. Genet.
50
107-111
2005
Homo sapiens
brenda
Brossas, J.Y.; Tanguy, R.; Brignole-Baudouin, F.; Courtois, Y.; Torriglia, A.; Treton, J.
L-DNase II associated with active process during ethanol induced cell death in ARPE-19
Mol. Vis.
10
65-73
2004
Homo sapiens
brenda
Cherepanova, A.; Tamkovich, S.; Pyshnyi, D.; Kharkova, M.; Vlassov, V.; Laktionov, P.
Immunochemical assay for deoxyribonuclease activity in body fluids
J. Immunol. Methods
325
96-103
2007
Homo sapiens
brenda
Schaefer, P.; Cymerman, I.A.; Bujnicki, J.M.; Meiss, G.
Human lysosomal DNase IIalpha contains two requisite PLD-signature (HxK) motifs: evidence for a pseudodimeric structure of the active enzyme species
Protein Sci.
16
82-91
2007
Homo sapiens
brenda
Torriglia, A.; Lepretre, C.; Padron-Barthe, L.; Chahory, S.; Martin, E.
Molecular mechanism of L-DNase II activation and function as a molecular switch in apoptosis
Biochem. Pharmacol.
76
1490-1502
2008
Gallus gallus, Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Lepretre, C.; Fleurier, Y.; Martin, E.; Torriglia, A.
Nuclear export of LEI/L-DNase II by Crm1 is essential for cell survival
Biochim. Biophys. Acta
1783
1068-1075
2008
Cricetulus griseus, Homo sapiens, Sus scrofa
brenda
Liu, M.F.; Wu, X.P.; Wang, X.L.; Yu, Y.L.; Wang, W.F.; Chen, Q.J.; Boireau, P.; Liu, M.Y.
The functions of Deoxyribonuclease II in immunity and development
DNA Cell Biol.
27
223-228
2008
Acanthaster planci, Drosophila sp. (in: flies), Haemonchus contortus, Homo sapiens, Mus musculus, Sus scrofa, Trichinella spiralis
brenda
Ueki, M.; Takeshita, H.; Fujihara, J.; Kimura-Kataoka, K.; Iida, R.; Yuasa, I.; Nakajima, T.; Kominato, Y.; Yasuda, T.
Genetic and expression analysis of all 7 non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease II gene, with potential relevance to autoimmunity
Clin. Chim. Acta
411
92-98
2010
Homo sapiens (O00115), Homo sapiens
brenda
Fischer, H.; Scherz, J.; Szabo, S.; Mildner, M.; Benarafa, C.; Torriglia, A.; Tschachler, E.; Eckhart, L.
DNase 2 is the main DNA-degrading enzyme of the stratum corneum
PLoS ONE
6
e17581
2011
Homo sapiens, Mus musculus
brenda
Jaadane, I.; Nagbou, A.; Behar-Cohen, F.; Torriglia, A.
Interaction of leukocyte elastase inhibitor/L-DNase II with BCL-2 and BAX
Biochim. Biophys. Acta
1843
2807-2815
2014
Homo sapiens
brenda