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Information on EC 3.1.21.3 - type I site-specific deoxyribonuclease

for references in articles please use BRENDA:EC3.1.21.3

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IUBMB Comments

This is a large group of enzymes which, together with those now listed as EC 3.1.21.4 (type II site-specific deoxyribonuclease) and EC 3.1.21.5 (type III site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC 3.1.23 and EC 3.1.24. They have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. They are multifunctional proteins that also catalyse the reactions of EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] and EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase].

The enzyme appears in viruses and cellular organisms
Reaction Schemes
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endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolysed

Synonyms
restriction-modification system, ecoki, rease, ecor124i, type i restriction-modification system, atp-dependent dnase, exodeoxyribonuclease, type ii restriction-modification system, ecor124, ecoai, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolysed
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