Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
3,5-dihydroxyphenylacetyl-CoA + H2O
3,5-dihydroxyphenylacetate + CoA
3-hydroxyphenylacetyl-CoA + H2O
3-hydroxyphenylacetate + CoA
4-hydroxyphenylacetyl-CoA + H2O
4-hydroxyphenylacetate + CoA
phenylacetyl-CoA + H2O
phenylacetate + CoA
additional information
?
-
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
-
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
the enzyme can liberate CoA from phenylacetyl-CoA and from hydroxyphenylacetyl-CoA substrates that form from the phenylacetate pathway
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
-
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
the enzyme can liberate CoA from phenylacetyl-CoA and from hydroxyphenylacetyl-CoA substrates that form from the phenylacetate pathway
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
-
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
the enzyme can liberate CoA from phenylacetyl-CoA and from hydroxyphenylacetyl-CoA substrates that are formed in the phenylacetate pathway
-
-
?
3,5-dihydroxyphenylacetyl-CoA + H2O
3,5-dihydroxyphenylacetate + CoA
-
-
-
?
3,5-dihydroxyphenylacetyl-CoA + H2O
3,5-dihydroxyphenylacetate + CoA
-
-
-
?
3,5-dihydroxyphenylacetyl-CoA + H2O
3,5-dihydroxyphenylacetate + CoA
-
-
-
?
3-hydroxyphenylacetyl-CoA + H2O
3-hydroxyphenylacetate + CoA
-
-
-
?
3-hydroxyphenylacetyl-CoA + H2O
3-hydroxyphenylacetate + CoA
-
-
-
?
4-hydroxyphenylacetyl-CoA + H2O
4-hydroxyphenylacetate + CoA
-
-
-
?
4-hydroxyphenylacetyl-CoA + H2O
4-hydroxyphenylacetate + CoA
-
-
-
?
phenylacetyl-CoA + H2O
phenylacetate + CoA
-
-
-
?
phenylacetyl-CoA + H2O
phenylacetate + CoA
-
-
-
?
phenylacetyl-CoA + H2O
phenylacetate + CoA
-
-
-
?
additional information
?
-
no activity with 4-hydroxybenzoyl-CoA, 3-hydroxybenzoyl-CoA, 4-hydroxybenzyl-CoA, 4-hydroxyphenacyl-CoA, 3-hydroxyphenacyl-CoA, 4-chlorobenzoyl-CoA, 4-methoxybenzoyl-CoA. Low activity with acetyl-CoA, n-hexanoyl-CoA, n-butyryl-CoA, isobutyryl-CoA, beta-hydroxybutyryl-CoA, methylmalonyl-CoA, crotonyl-CoA
-
-
?
additional information
?
-
no activity with 4-hydroxybenzoyl-CoA, 3-hydroxybenzoyl-CoA, 4-hydroxybenzyl-CoA, 4-hydroxyphenacyl-CoA, 3-hydroxyphenacyl-CoA, 4-chlorobenzoyl-CoA, 4-methoxybenzoyl-CoA. Low activity with acetyl-CoA, n-hexanoyl-CoA, n-butyryl-CoA, isobutyryl-CoA, beta-hydroxybutyryl-CoA, methylmalonyl-CoA, crotonyl-CoA
-
-
?
additional information
?
-
no activity with 4-hydroxybenzoyl-CoA, 4-hydroxybenzyl-CoA, 4-hydroxyphenacyl-CoA
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
the enzyme can liberate CoA from phenylacetyl-CoA and from hydroxyphenylacetyl-CoA substrates that form from the phenylacetate pathway
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
the enzyme can liberate CoA from phenylacetyl-CoA and from hydroxyphenylacetyl-CoA substrates that form from the phenylacetate pathway
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
3,4-dihydroxyphenylacetate + CoA
the enzyme can liberate CoA from phenylacetyl-CoA and from hydroxyphenylacetyl-CoA substrates that are formed in the phenylacetate pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0086 - 0.13
3,4-dihydroxyphenylacetyl-CoA
0.028 - 0.2
3,5-dihydroxyphenylacetyl-CoA
0.021 - 0.23
3-hydroxyphenylacetyl-CoA
0.018 - 0.28
4-hydroxyphenylacetyl-CoA
0.0096 - 0.39
phenylacetyl-CoA
0.0086
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N60A
0.016
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.024
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
0.033
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
0.045
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
0.047
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
0.048
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D75A
0.051
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.055
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N60D
0.13
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
0.028
3,5-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.2
3,5-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.021
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.032
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
0.034
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
0.08
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
0.08
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.09
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
0.23
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
0.018
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
0.028
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
0.035
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.055
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.09
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
0.25
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
0.28
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
0.0096
phenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.39
phenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0065 - 100
3,4-dihydroxyphenylacetyl-CoA
2.3 - 9
3,5-dihydroxyphenylacetyl-CoA
0.065 - 86
3-hydroxyphenylacetyl-CoA
0.17 - 79
4-hydroxyphenylacetyl-CoA
0.41 - 3.7
phenylacetyl-CoA
0.0065
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D75A
0.012
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N60A
0.076
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
0.11
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
0.18
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N60D
2.7
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
18
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
20
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
26
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
100
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
2.3
3,5-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
9
3,5-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.065
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
0.81
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
0.89
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
8.2
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
15
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
30
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
86
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.17
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
0.26
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
0.31
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
3.2
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
11
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
19
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
79
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.41
phenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
3.7
phenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.1 - 6250
3,4-dihydroxyphenylacetyl-CoA
45 - 80
3,5-dihydroxyphenylacetyl-CoA
0.7 - 4095
3-hydroxyphenylacetyl-CoA
0.7 - 2257
4-hydroxyphenylacetyl-CoA
0.1
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D75A
1
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N60A
3
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
3
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
3
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N60D
60
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
200
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
400
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
600
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
6250
3,4-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
45
3,5-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
80
3,5-dihydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.7
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
4
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
30
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
100
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
200
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
900
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
4095
3-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
0.7
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme D16A
1
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N46A
9
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme H52A
200
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme E14A
200
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, mutant enzyme N15A
200
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
2257
4-hydroxyphenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
10
phenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
43
phenylacetyl-CoA
pH 8.1, 25°C, wild-type enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Song, F.; Zhuang, Z.; Finci, L.; Dunaway-Mariano, D.; Kniewel, R.; Buglino, J.A.; Solorzano, V.; Wu, J.; Lima, C.D.
Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI
J. Biol. Chem.
281
11028-11038
2006
Escherichia coli (P76084), Aromatoleum evansii (Q9F9V0), Aromatoleum evansii DSM 6898 (Q9F9V0)
brenda