Information on EC 3.1.2.3 - succinyl-CoA hydrolase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.2.3
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RECOMMENDED NAME
GeneOntology No.
succinyl-CoA hydrolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
succinyl-CoA + H2O = CoA + succinate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of thioester
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SYSTEMATIC NAME
IUBMB Comments
succinyl-CoA hydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
9025-86-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glutaryl-CoA + H2O
CoA + glutarate
show the reaction diagram
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?
succinyl CoA + H2O
CoA + succinate
show the reaction diagram
succinyl-CoA + H2O
?
show the reaction diagram
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-
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additional information
?
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enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + H2O
?
show the reaction diagram
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-
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additional information
?
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enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
37.1
glutaryl-CoA
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13.3
succinyl-CoA
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.14
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substrate glutaryl-CoA
3.98
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substrate succinyl-CoA
additional information
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change of optical density per min
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
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Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
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ultracentrifugation
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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sequence contains a putative consensus type 1 peroxisome targeting signal
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
frozen, stable for months
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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