BRENDA Home
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
acot4, acetyl-coa thioesterase,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-CoA thioesterase
-
-
hydrolase, succinyl coenzyme A
-
-
-
-
succinyl coenzyme A deacylase
-
-
-
-
succinyl coenzyme A hydrolase
-
-
-
-
succinyl-CoA acylase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
succinyl-CoA + H2O = CoA + succinate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
hydrolysis of thioester
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
glutaryl-CoA + H2O
CoA + glutarate
-
-
-
-
?
succinyl CoA + H2O
CoA + succinate
succinyl-CoA + H2O
?
-
-
-
-
?
additional information
?
-
-
enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length
-
-
?
succinyl CoA + H2O

CoA + succinate
-
-
-
-
?
succinyl CoA + H2O
CoA + succinate
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
succinyl-CoA + H2O
?
-
-
-
-
?
additional information
?
-
-
enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Brain Diseases
In silico prioritization based on coexpression can aid epileptic encephalopathy gene discovery.
Carcinogenesis
ACOT4 accumulation via AKT-mediated phosphorylation promotes pancreatic tumourigenesis.
Carcinoma
The combined expressions of B7H4 and ACOT4 in cancer-associated fibroblasts are related to poor prognosis in patients with gastric carcinoma.
Fatty Liver
The direction of cross affects [corrected] obesity after puberty in male but not female offspring.
Ischemic Stroke
Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.
Neoplasms
ACOT4 accumulation via AKT-mediated phosphorylation promotes pancreatic tumourigenesis.
Neoplasms
The combined expressions of B7H4 and ACOT4 in cancer-associated fibroblasts are related to poor prognosis in patients with gastric carcinoma.
Stroke
Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.14
-
substrate glutaryl-CoA
3.98
-
substrate succinyl-CoA
additional information
-
change of optical density per min
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACOT4_HUMAN
421
0
46327
Swiss-Prot
other Location (Reliability: 3)
ACOT4_MOUSE
421
0
46481
Swiss-Prot
other Location (Reliability: 1)
ACOT8_HUMAN
319
0
35914
Swiss-Prot
other Location (Reliability: 2)
ACOT8_MOUSE
320
0
35827
Swiss-Prot
other Location (Reliability: 1)
ACOT8_RAT
320
0
36003
Swiss-Prot
other Location (Reliability: 1)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
100000
-
ultracentrifugation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
sequence contains a putative consensus type 1 peroxisome targeting signal
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
frozen, stable for months
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Gergely, J.; Hele, P.; Ramakrishnan, C.V.
Succinyl and acetyl coenzyme A deacylases
J. Biol. Chem.
198
323-334
1952
Sus scrofa
-
brenda
Westin, M.A.; Hunt, M.C.; Alexson, S.E.
The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes
J. Biol. Chem.
280
38125-38132
2005
Mus musculus
brenda
Select items on the left to see more content.
html completed