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Information on EC 3.1.2.3 - succinyl-CoA hydrolase

for references in articles please use BRENDA:EC3.1.2.3

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EC Tree

3 Hydrolases

3.1 Acting on ester bonds

3.1.2 Thioester hydrolases

3.1.2.3 succinyl-CoA hydrolase

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3.1.2.3
acyl-coas
thioesterases
acots
coa-sh
niger
dicarboxylic
cyp4a14

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Reaction Schemes

Synonyms

acot4, acetyl-coa thioesterase, show all synonyms

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

acetyl-CoA thioesterase

ACOT4

hydrolase, succinyl coenzyme A

succinyl coenzyme A deacylase

succinyl coenzyme A hydrolase

succinyl-CoA acylase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

succinyl-CoA + H2O = CoA + succinate

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

hydrolysis of thioester

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SYSTEMATIC NAME

IUBMB Comments

succinyl-CoA hydrolase

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CAS REGISTRY NUMBER

COMMENTARY

9025-86-9

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

glutaryl-CoA + H2O

CoA + glutarate

Mus musculus

665676

succinyl CoA + H2O

CoA + succinate

2 entries

succinyl-CoA + H2O

Sus scrofa

81013

additional information

Mus musculus

enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length

665676

succinyl CoA + H2O

CoA + succinate

Mus musculus

665676

succinyl CoA + H2O

CoA + succinate

Sus scrofa

81013

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

succinyl-CoA + H2O

Sus scrofa

81013

additional information

Mus musculus

enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length

665676

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

37.1

glutaryl-CoA

Mus musculus

665676

13.3

succinyl-CoA

Mus musculus

665676

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

1.14

Mus musculus

substrate glutaryl-CoA

665676

3.98

Mus musculus

substrate succinyl-CoA

665676

additional information

Sus scrofa

change of optical density per min

81013

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TEMPERATURE OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Sus scrofa

assay at

81013

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

brenda

brenda

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

brenda

brenda

brenda

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LOCALIZATION

ORGANISM

UNIPROT

COMMENTARY

GeneOntology No.

LITERATURE

SOURCE

brenda

Go to AA Sequence and Transmembrane Helices SearchGo to Localization Prediction

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q8N9L9 pBLAST

ACOT4_HUMAN

Homo sapiens

421

46327

Swiss-Prot

Show Sequence

other Location (Reliability: 3)

Q8BWN8 pBLAST

ACOT4_MOUSE

Mus musculus

421

46481

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

O14734 pBLAST

ACOT8_HUMAN

Homo sapiens

319

35914

Swiss-Prot

Show Sequence

other Location (Reliability: 2)

P58137 pBLAST

ACOT8_MOUSE

Mus musculus

320

35827

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

Q8VHK0 pBLAST

ACOT8_RAT

Rattus norvegicus

320

36003

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

100000

Sus scrofa

ultracentrifugation

81013

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Mus musculus

sequence contains a putative consensus type 1 peroxisome targeting signal

665676

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

frozen, stable for months

Sus scrofa

81013

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Go to Purification (commentary) Search

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

partial

Sus scrofa

81013

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

81013

Gergely, J.; Hele, P.; Ramakrishnan, C.V.

Succinyl and acetyl coenzyme A deacylases

J. Biol. Chem.

198

323-334

1952

Sus scrofa

brenda

665676

Westin, M.A.; Hunt, M.C.; Alexson, S.E.

The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes

J. Biol. Chem.

280

38125-38132

2005

Mus musculus

16141203

brenda

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EXTERNAL LINKS (specific for EC-Number 3.1.2.3)

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

IUBMB Enzyme Nomenclature

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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