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EC Tree
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
acot4, acetyl-coa thioesterase,
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acetyl-CoA thioesterase
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hydrolase, succinyl coenzyme A
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succinyl coenzyme A deacylase
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succinyl coenzyme A hydrolase
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succinyl-CoA acylase
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succinyl-CoA + H2O = CoA + succinate
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hydrolysis of thioester
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glutaryl-CoA + H2O
CoA + glutarate
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succinyl CoA + H2O
CoA + succinate
succinyl-CoA + H2O
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additional information
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enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length
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succinyl CoA + H2O
CoA + succinate
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succinyl CoA + H2O
CoA + succinate
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succinyl-CoA + H2O
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additional information
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enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length
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Brain Diseases
In silico prioritization based on coexpression can aid epileptic encephalopathy gene discovery.
Carcinogenesis
ACOT4 accumulation via AKT-mediated phosphorylation promotes pancreatic tumourigenesis.
Carcinoma
The combined expressions of B7H4 and ACOT4 in cancer-associated fibroblasts are related to poor prognosis in patients with gastric carcinoma.
Fatty Liver
The direction of cross affects [corrected] obesity after puberty in male but not female offspring.
Ischemic Stroke
Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.
Neoplasms
ACOT4 accumulation via AKT-mediated phosphorylation promotes pancreatic tumourigenesis.
Neoplasms
The combined expressions of B7H4 and ACOT4 in cancer-associated fibroblasts are related to poor prognosis in patients with gastric carcinoma.
Stroke
Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.
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1.14
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substrate glutaryl-CoA
3.98
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substrate succinyl-CoA
additional information
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change of optical density per min
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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ACOT4_HUMAN
421
0
46327
Swiss-Prot
other Location (Reliability: 3)
ACOT4_MOUSE
421
0
46481
Swiss-Prot
other Location (Reliability: 1)
ACOT8_HUMAN
319
0
35914
Swiss-Prot
other Location (Reliability: 2)
ACOT8_MOUSE
320
0
35827
Swiss-Prot
other Location (Reliability: 1)
ACOT8_RAT
320
0
36003
Swiss-Prot
other Location (Reliability: 1)
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100000
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ultracentrifugation
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additional information
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sequence contains a putative consensus type 1 peroxisome targeting signal
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frozen, stable for months
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Gergely, J.; Hele, P.; Ramakrishnan, C.V.
Succinyl and acetyl coenzyme A deacylases
J. Biol. Chem.
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323-334
1952
Sus scrofa
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brenda
Westin, M.A.; Hunt, M.C.; Alexson, S.E.
The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes
J. Biol. Chem.
280
38125-38132
2005
Mus musculus
brenda
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3.1.2.3 succinyl-CoA hydrolase
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