show all entries

Information on EC 3.1.2.3 - succinyl-CoA hydrolase

for references in articles please use BRENDA:EC3.1.2.3

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

EC Tree

3 Hydrolases

3.1 Acting on ester bonds

3.1.2 Thioester hydrolases

3.1.2.3 succinyl-CoA hydrolase

Specify your search results

Mark a special word or phrase in this record:

Search Reference ID:

Search UniProt Accession:

Select one or more organisms in this record:

To select more than one organism, hold the CTRL key and click the items in the list.

Word Map

hide

show

3.1.2.3
acyl-coas
thioesterases
acots
coa-sh
niger
dicarboxylic
cyp4a14

The enzyme appears in viruses and cellular organisms

Reaction Schemes

Synonyms

acot4, acetyl-coa thioesterase, show all synonyms

top print hide

show all columns Go to Synonym Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

acetyl-CoA thioesterase

ACOT4

hydrolase, succinyl coenzyme A

succinyl coenzyme A deacylase

succinyl coenzyme A hydrolase

succinyl-CoA acylase

top print hide

show all columns Go to Reaction Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

succinyl-CoA + H2O = CoA + succinate

top print hide

show all columns Go to Reaction Type Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

hydrolysis of thioester

top print hide

Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

succinyl-CoA hydrolase

top print hide

show all columns Go to CAS Registry Number Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

CAS REGISTRY NUMBER

COMMENTARY

9025-86-9

top print hide

show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

glutaryl-CoA + H2O

CoA + glutarate

Mus musculus

665676

succinyl CoA + H2O

CoA + succinate

2 entries

succinyl-CoA + H2O

Sus scrofa

81013

additional information

Mus musculus

enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length

665676

succinyl CoA + H2O

CoA + succinate

Mus musculus

665676

succinyl CoA + H2O

CoA + succinate

Sus scrofa

81013

top print hide

show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

succinyl-CoA + H2O

Sus scrofa

81013

additional information

Mus musculus

enzyme is responsible for the termination of beta-oxidation of dicarboxylic acids of medium chain length

665676

top print hide

show all columns Go to KM Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

37.1

glutaryl-CoA

Mus musculus

665676

13.3

succinyl-CoA

Mus musculus

665676

top print hide

show all columns Go to Specific Activity Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

1.14

Mus musculus

substrate glutaryl-CoA

665676

3.98

Mus musculus

substrate succinyl-CoA

665676

additional information

Sus scrofa

change of optical density per min

81013

top print hide

show all columns Go to Temperature Optimum Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

TEMPERATURE OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Sus scrofa

assay at

81013

top print hide

show all columns Go to Organism Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

brenda

brenda

show all columns Go to Source Tissue Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

brenda

brenda

brenda

show all columns Go to Localization Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

LOCALIZATION

ORGANISM

UNIPROT

COMMENTARY

GeneOntology No.

LITERATURE

SOURCE

brenda

Go to AA Sequence and Transmembrane Helices SearchGo to Localization Prediction

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q8N9L9 pBLAST

ACOT4_HUMAN

Homo sapiens

421

46327

Swiss-Prot

Show Sequence

other Location (Reliability: 3)

Q8BWN8 pBLAST

ACOT4_MOUSE

Mus musculus

421

46481

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

O14734 pBLAST

ACOT8_HUMAN

Homo sapiens

319

35914

Swiss-Prot

Show Sequence

other Location (Reliability: 2)

P58137 pBLAST

ACOT8_MOUSE

Mus musculus

320

35827

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

Q8VHK0 pBLAST

ACOT8_RAT

Rattus norvegicus

320

36003

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

top print hide

show all columns Go to Molecular Weight Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

100000

Sus scrofa

ultracentrifugation

81013

top print hide

show all columns Go to Posttranslational Modification Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Mus musculus

sequence contains a putative consensus type 1 peroxisome targeting signal

665676

top print hide

Go to Storage Stability Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

frozen, stable for months

Sus scrofa

81013

top print hide

Go to Purification (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

partial

Sus scrofa

81013

top print hide References Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

81013

Gergely, J.; Hele, P.; Ramakrishnan, C.V.

Succinyl and acetyl coenzyme A deacylases

J. Biol. Chem.

198

323-334

1952

Sus scrofa

brenda

665676

Westin, M.A.; Hunt, M.C.; Alexson, S.E.

The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes

J. Biol. Chem.

280

38125-38132

2005

Mus musculus

16141203

brenda

Entries 1 - 20 of 2

Show complete table

Select items on the left to see more content.

top print hide 11 entries

EXTERNAL LINKS (specific for EC-Number 3.1.2.3)

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

IUBMB Enzyme Nomenclature

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

html completed