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Information on EC 3.1.2.29 - fluoroacetyl-CoA thioesterase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.2 Thioester hydrolases
                3.1.2.29 fluoroacetyl-CoA thioesterase
IUBMB Comments
Fluoroacetate is extremely toxic. It reacts with CoA to form fluoroacetyl-CoA, which substitutes for acetyl CoA and reacts with EC 2.3.3.1 (citrate synthase) to produce fluorocitrate, a metabolite of which binds very tightly to EC 4.2.1.3 (aconitase) and halts the TCA cycle. This enzyme hydrolyses fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance on the organisms that produce it. It has been described in the poisonous plant Dichapetalum cymosum and the bacterium Streptomyces cattleya, both of which are fluoroacetate producers.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
FlK, fluoroacetyl CoA thioesterase, fluoroacetyl-CoA thioesterase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
fluoroacetyl-CoA + H2O = fluoroacetate + CoA
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