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Enzyme Nomenclature
Information on EC 3.1.2.25 - phenylacetyl-CoA hydrolase
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
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EC NUMBER 
COMMENTARY 
3.1.2.25
-
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RECOMMENDED NAME
GeneOntology No.
phenylacetyl-CoA hydrolase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA
first step
-
-
-
phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA
This is the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, phenylacetyl-CoA dehydrogenase
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
phenylglyoxylyl-CoA hydrolase
This is the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, phenylacetyl-CoA dehydrogenase.
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CAS REGISTRY NUMBER
COMMENTARY
210756-43-7
cf. 1.17.5.1
57219-72-4
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
hydrolyzes p-nitrophenyl acetate at the same rate as phenylacetyl-CoA or phenoxyacetylglycine
-
?
phenoxyacetyl-CoA + H2O
phenoxyacetate + CoA
-
approximately 5fold higher activity than with phenylacetyl-CoA
-
?
phenoxyacetylglycine + H2O
?
-
hydrolyzes phenoxyacetylglycine at the same rate as phenylacetyl-CoA or p-nitrophenyl acetate
-
?
phenylacetyl-CoA + H2O
phenylacetate + CoA
-
hydrolyzes phenylacetyl-CoA at the same rate as p-nitrophenyl acetate or phenoxyacetylglycine, approximately 5fold lower activity as with phenoxyacetyl-CoA
-
?
phenylglyoxylyl-CoA + H2O
phenylglyoxylate + CoA
-
hydrolytic release of coenzyme A from phenylglyoxylyl-CoA
-
?
phenylglyoxylyl-CoA + H2O
phenylglyoxylate + CoA
-
involved in anaerobic metabolism of phenylalanine, catalyzes the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1
-
?
additional information
?
-
-
catalyzes the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
phenylglyoxylyl-CoA + H2O
phenylglyoxylate + CoA
-
involved in anaerobic metabolism of phenylalanine, catalyzes the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1
-
?
additional information
?
-
-
catalyzes the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1
-
?
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 3.1.2.25)
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