This is the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, phenylacetyl-CoA dehydrogenase.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
More, PaaI, PaaI thioesterase, phenylacetyl coenzyme A hydrolase, more
an enzyme preparation of phenylacetyl-CoA:acceptor oxidoreductase, EC 1.17.5.1, catalyzes the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1
an enzyme preparation of phenylacetyl-CoA:acceptor oxidoreductase, EC 1.17.5.1, catalyzes the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, may be an additional membrane-bound enzyme or more likely one of the subunits of phenylacetyl-CoA:acceptor oxidoreductase is responsible for the hydrolysis of phenylglyoxylyl-CoA
phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA
first step
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phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA
This is the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, phenylacetyl-CoA dehydrogenase
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SYSTEMATIC NAME
IUBMB Comments
phenylglyoxylyl-CoA hydrolase
This is the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, phenylacetyl-CoA dehydrogenase.
hydrolyzes phenylacetyl-CoA at the same rate as p-nitrophenyl acetate or phenoxyacetylglycine, approximately 5fold lower activity as with phenoxyacetyl-CoA
involved in anaerobic metabolism of phenylalanine, catalyzes the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1
involved in anaerobic metabolism of phenylalanine, catalyzes the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion method. Crystals of wild type enzyme and mutants N37A, D52A, and T68A are obtained in conditions composed of 200 mM ammonium tartrate dibasic, 20% (w/v) PEG 3350, 100 mM Tris, pH 7.5; 200 mM lithium sulfate, 100 mM Tris-HCl, 30% (w/v) PEG 4000, 200 mM magnesium chloride, PEG 400, 100 mM HEPES, pH 7.5; 200 mM magnesium chloride, 14% (w/v) PEG 3350, 100 mM Tris, pH 6.0, respectively
Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum-iron-sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica
Phenylacetyl-CoA:acceptor oxidoreductase, a new a-oxidizing enzyme that produces phenylglyoxylate. Assay, membrane localization, and differential production in Thauera aromatica
Structural and functional characterization of the PaaI thioesterase from Streptococcus pneumoniae reveals a dual specificity for phenylacetyl-CoA and medium-chain fatty Acyl-CoAs and a novel CoA-induced fit mechanism
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3.1.2.25 phenylacetyl-CoA hydrolase
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