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decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
2-butenoyl-CoA + H2O
CoA + 2-butenoate
-
-
-
?
3,4-dihydroxyphenylacetyl-CoA + H2O
CoA + 3,4-dihydroxyphenylacetate
-
-
-
?
3,5-dihydroxyphenylacetyl-CoA + H2O
CoA + 3,5-dihydroxyphenylacetate
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
-
?
3-hydroxybenzoyl-CoA + H2O
CoA + 3-hydroxybenzoate
-
-
-
?
3-hydroxyphenylacetyl-CoA + H2O
CoA + 3-hydroxyphenylacetate
-
-
-
?
4-chlorobenzoyl-CoA + H2O
CoA + 4-chlorobenzoate
-
-
-
?
4-hydroxyphenylacetyl-CoA + H2O
CoA + 4-hydroxyphenylacetate
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
acyl-CoA + H2O
CoA + a carboxylate
arachidonoyl-CoA + H2O
CoA + arachidonate
beta-hydroxybutyryl-CoA + H2O
CoA + beta-hydroxybutyrate
-
-
-
?
beta-methylcrotonyl-CoA + H2O
CoA + beta-methylcrotonate
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
eicosanoyl-CoA + H2O
CoA + eicosanoic acid
-
-
-
?
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
-
best substrate
-
-
?
glutaryl-CoA + H2O
CoA + glutarate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
hexanoyl-CoA + H2O
CoA + hexanoate
-
molecular dynamic simulations are carried out on the X-ray structure 3F5O with hexanoyl-CoA as the substrate
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linolate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
malonyl-CoA + H2O
CoA + malonate
-
-
-
?
methylmalonyl-CoA + H2O
CoA + methylmalonate
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
?
myristoyl-CoA + H2O
CoA + myristic acid
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butyrate
-
-
-
?
n-decanoyl-CoA + H2O
CoA + n-decanoate
-
-
-
?
n-hexanoyl-CoA + H2O
CoA + n-hexanoate
-
-
-
?
n-octanoyl-CoA + H2O
CoA + n-octanoate
-
-
-
?
n-propionyl-CoA + H2O
CoA + n-propionate
-
-
-
?
nafamostat + H2O
6-hydroxynaphthalene-2-carboximidamide + 4-carbamidamidobenzoic acid
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
palmitoleoyl-CoA + H2O
CoA + palmitoleate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
phenylacetyl-CoA + H2O
CoA + phenylacetate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
succinyl-CoA + H2O
CoA + succinate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tiglyl-CoA + H2O
CoA + (2E)-2-methylbut-2-enoate
-
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
-
-
?
additional information
?
-
acetyl-CoA + H2O
CoA + acetate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
preference for unsaturated acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
acyl-CoA of chain length C8-C18
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
involved in cholesterol metabolism
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
best substrate
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
no sufficient evidence that acyl-CoA is also the likely substrate in vivo
-
-
?
additional information
?
-
-
enzyme binds tightly and specifically to HIV-1 Nef protein, overview
-
-
?
additional information
?
-
ACOT4 protein is active on succinyl-CoA and medium to long chain acyl-CoAs. Human ACOT4 gene has acquired the functions of three mouse genes by a functional convergent evolution
-
-
?
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acyl-coa hydrolase deficiency
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
Adenocarcinoma of Lung
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Adenocarcinoma of Lung
Overexpression and proliferation dependence of acyl-CoA thioesterase 11 and 13 in lung adenocarcinoma.
Carcinoma
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Carcinoma, Squamous Cell
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Colonic Neoplasms
Exosomal miR-183-5p Shuttled by M2 Polarized Tumor-Associated Macrophage Promotes the Development of Colon Cancer via Targeting THEM4 Mediated PI3K/AKT and NF-?B Pathways.
Dyslexia
Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with Developmental Dyslexia.
Dyslexia
The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration.
Dyslipidemias
Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis.
Fatty Liver
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.
Fatty Liver
Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis.
Fatty Liver
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Infections
Weighted gene co-expression network analysis and drug-gene interaction bioinformatics uncover key genes associated with various presentations of malaria infection in African children and major drug candidates.
Insulin Resistance
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
Insulin Resistance
Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis.
Insulin Resistance
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Liver Diseases
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Lung Neoplasms
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Neoplasms
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.
Neoplasms
Comprehensive genome methylation analysis in bladder cancer;identification and validation of novel methylated genes and application of these as urinary tumor markers.
Non-alcoholic Fatty Liver Disease
Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis.
Non-alcoholic Fatty Liver Disease
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Obesity
New players on the metabolic stage: How do you like Them Acots?
Obesity
Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue.
Obesity
Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis.
Obesity
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Overnutrition
Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress.
Tuberculosis
Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.
Tuberculosis
Insights into the Substrate Specificity of a Thioesterase Rv0098 of Mycobacterium Tuberculosis through X-ray Crystallographic and Molecular Dynamics Studies.
Tuberculosis
Structure based drug discovery for designing leads for the non-toxic metabolic targets in multi drug resistant Mycobacterium tuberculosis.
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0.22
2-butenoyl-CoA
wild-type protein, pH7.5, 25°C
0.01
3,4-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.025
3,5-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
2.9
3-hydroxy-3-methylglutaryl-CoA
wild-type protein, pH7.5, 25°C
0.032
3-hydroxybenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.026 - 0.9
3-hydroxyphenylacetyl-CoA
0.13
4-chlorobenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.049
4-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.29
acetyl-CoA
wild-type protein, pH7.5, 25°C
0.002 - 0.02
Arachidonoyl-CoA
0.11
beta-hydroxybutyryl-CoA
wild-type protein, pH7.5, 25°C
0.12
beta-methylcrotonyl-CoA
wild-type protein, pH7.5, 25°C
0.18
crotonyl-CoA
wild-type protein, pH7.5, 25°C
0.0076
dodecanoyl-CoA
pH 7.4, 30°C
0.67
glutaryl-CoA
wild-type protein, pH7.5, 25°C
0.0064
hexadecanoyl-CoA
pH 7.4, 30°C
0.0099
lauroyl-CoA
wild-type protein, pH7.5, 25°C
0.0154
linolenoyl-CoA
pH 7.5, 37°C, wild-type
0.0042 - 0.31
linoleoyl-CoA
0.28
malonyl-CoA
wild-type protein, pH7.5, 25°C
0.21
methylmalonyl-CoA
wild-type protein, pH7.5, 25°C
0.005 - 0.009
myristoyl-CoA
0.6
n-butyryl-CoA
wild-type protein, pH7.5, 25°C
0.0049
n-decanoyl-CoA
wild-type protein, pH7.5, 25°C
0.07
n-hexanoyl-CoA
wild-type protein, pH7.5, 25°C
0.026
n-octanoyl-CoA
wild-type protein, pH7.5, 25°C
0.19
n-propionyl-CoA
wild-type protein, pH7.5, 25°C
0.014
octanoyl-CoA
pH 7.4, 30°C
0.0088 - 0.009
oleoyl-CoA
0.009 - 0.026
palmitoleoyl-CoA
0.0024 - 0.016
palmitoyl-CoA
0.24
phenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.0042 - 0.02
stearoyl-CoA
0.25
tiglyl-CoA
wild-type protein, pH7.5, 25°C
0.0029
vaccenoyl-CoA
pH 7.5, 37°C, wild-type
0.026
3-hydroxyphenylacetyl-CoA
H56A mutant protein, pH7.5, 25°C
0.12
3-hydroxyphenylacetyl-CoA
K136A mutant protein, pH7.5, 25°C
0.16
3-hydroxyphenylacetyl-CoA
T69A mutant protein, pH7.5, 25°C
0.23
3-hydroxyphenylacetyl-CoA
D65E mutant protein, pH7.5, 25°C
0.3
3-hydroxyphenylacetyl-CoA
N50A mutant protein, pH7.5, 25°C
0.31
3-hydroxyphenylacetyl-CoA
S83A mutant protein, pH7.5, 25°C
0.36
3-hydroxyphenylacetyl-CoA
D65N mutant protein, pH7.5, 25°C
0.41
3-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.62
3-hydroxyphenylacetyl-CoA
H134A mutant protein, pH7.5, 25°C
0.9
3-hydroxyphenylacetyl-CoA
H137A mutant protein, pH7.5, 25°C
0.002
Arachidonoyl-CoA
-
isozyme MTE-I, pH 7.4, 37°C
0.0041
Arachidonoyl-CoA
-
isozyme CTE-I, pH 7.4, 37°C
0.0092
Arachidonoyl-CoA
pH 7.4, 30°C
0.019
Arachidonoyl-CoA
pH 7.5, 37°C, wild-type
0.02
Arachidonoyl-CoA
wild-type protein, pH7.5, 25°C
0.0042
linoleoyl-CoA
pH 7.5, 37°C, wild-type
0.31
linoleoyl-CoA
wild-type protein, pH7.5, 25°C
0.005
myristoyl-CoA
wild-type protein, pH7.5, 25°C
0.0086
myristoyl-CoA
pH 7.5, 37°C, wild-type
0.009
myristoyl-CoA
wild-type protein, pH7.5, 37°C
0.0088
oleoyl-CoA
pH 7.4, 30°C
0.009
oleoyl-CoA
wild-type protein, pH7.5, 25°C
0.009
palmitoleoyl-CoA
wild-type protein, pH7.5, 25°C
0.026
palmitoleoyl-CoA
pH 7.5, 37°C, wild-type
0.0024
palmitoyl-CoA
pH 7.5, 37°C, wild-type
0.016
palmitoyl-CoA
wild-type protein, pH7.5, 25°C
0.0042
stearoyl-CoA
pH 7.5, 37°C, wild-type
0.02
stearoyl-CoA
wild-type protein, pH7.5, 25°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.014
2-butenoyl-CoA
wild-type protein, pH7.5, 25°C
0.19
3,4-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.19
3,5-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.079
3-hydroxy-3-methylglutaryl-CoA
wild-type protein, pH7.5, 25°C
0.011
3-hydroxybenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.007 - 1.4
3-hydroxyphenylacetyl-CoA
0.0032
4-chlorobenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.14
4-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.054
acetyl-CoA
wild-type protein, pH7.5, 25°C
0.022 - 1.4
Arachidonoyl-CoA
0.18
beta-hydroxybutyryl-CoA
wild-type protein, pH7.5, 25°C
0.023
beta-methylcrotonyl-CoA
wild-type protein, pH7.5, 25°C
0.0076
crotonyl-CoA
wild-type protein, pH7.5, 25°C
0.05
glutaryl-CoA
wild-type protein, pH7.5, 25°C
0.019
lauroyl-CoA
wild-type protein, pH7.5, 25°C
13.3
linolenoyl-CoA
pH 7.5, 37°C, wild-type
0.017 - 12.2
linoleoyl-CoA
0.066
malonyl-CoA
wild-type protein, pH7.5, 25°C
0.083
methylmalonyl-CoA
wild-type protein, pH7.5, 25°C
0.02 - 19.7
myristoyl-CoA
0.047
n-butyryl-CoA
wild-type protein, pH7.5, 25°C
0.016
n-decanoyl-CoA
wild-type protein, pH7.5, 25°C
0.022
n-hexanoyl-CoA
wild-type protein, pH7.5, 25°C
0.0047
n-octanoyl-CoA
wild-type protein, pH7.5, 25°C
0.036
n-propionyl-CoA
wild-type protein, pH7.5, 25°C
0.011
oleoyl-CoA
wild-type protein, pH7.5, 25°C
0.017 - 11.5
palmitoleoyl-CoA
0.0044 - 16.6
palmitoyl-CoA
0.084
phenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.02
tiglyl-CoA
wild-type protein, pH7.5, 25°C
1.8
vaccenoyl-CoA
pH 7.5, 37°C, wild-type
additional information
additional information
-
0.007
3-hydroxyphenylacetyl-CoA
N50A mutant protein, pH7.5, 25°C
0.15
3-hydroxyphenylacetyl-CoA
S83A mutant protein, pH7.5, 25°C
0.16
3-hydroxyphenylacetyl-CoA
D65E mutant protein, pH7.5, 25°C
0.16
3-hydroxyphenylacetyl-CoA
H134A mutant protein, pH7.5, 25°C
0.32
3-hydroxyphenylacetyl-CoA
K136A mutant protein, pH7.5, 25°C
0.36
3-hydroxyphenylacetyl-CoA
D65N mutant protein, pH7.5, 25°C
0.62
3-hydroxyphenylacetyl-CoA
H56A mutant protein, pH7.5, 25°C
0.66
3-hydroxyphenylacetyl-CoA
T69A mutant protein, pH7.5, 25°C
0.83
3-hydroxyphenylacetyl-CoA
H137A mutant protein, pH7.5, 25°C
1.4
3-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.022
Arachidonoyl-CoA
wild-type protein, pH7.5, 25°C
1.4
Arachidonoyl-CoA
pH 7.5, 37°C, wild-type
0.017
linoleoyl-CoA
wild-type protein, pH7.5, 25°C
0.8
linoleoyl-CoA
pH 7.5, 37°C, mutant D167A
12.2
linoleoyl-CoA
pH 7.5, 37°C, wild-type
0.02
myristoyl-CoA
wild-type protein, pH7.5, 25°C
0.07
myristoyl-CoA
wild-type protein, pH7.5, 37°C
19.7
myristoyl-CoA
pH 7.5, 37°C, wild-type
0.017
palmitoleoyl-CoA
wild-type protein, pH7.5, 25°C
11.5
palmitoleoyl-CoA
pH 7.5, 37°C, wild-type
0.0044
palmitoyl-CoA
wild-type protein, pH7.5, 25°C
0.5
palmitoyl-CoA
pH 7.5, 37°C, mutant D167A
16.6
palmitoyl-CoA
pH 7.5, 37°C, wild-type
0.011
stearoyl-CoA
wild-type protein, pH7.5, 25°C
0.2
stearoyl-CoA
pH 7.5, 37°C, mutant D167A
1.2
stearoyl-CoA
pH 7.5, 37°C, wild-type
additional information
additional information
no activity observed with 4-hydroxybenzoyl-CoA, lauroyl-acyl carrier protein, myristoyl-acyl carrier protein, palmitoyl-acyl carrier protein, octanoyl-acyl carrier protein, oleoyl-acyl carrier protein and acylated peptide N-acetyl-Gly-Ala-Cys-S-palmitoyl, turnover number of mutant protein D65A below 0.00001 s-1 for 3-hydroxyphenylacetyl-CoA
-
additional information
additional information
-
no activity observed with 4-hydroxybenzoyl-CoA, lauroyl-acyl carrier protein, myristoyl-acyl carrier protein, palmitoyl-acyl carrier protein, octanoyl-acyl carrier protein, oleoyl-acyl carrier protein and acylated peptide N-acetyl-Gly-Ala-Cys-S-palmitoyl, turnover number of mutant protein D65A below 0.00001 s-1 for 3-hydroxyphenylacetyl-CoA
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.064
2-butenoyl-CoA
wild-type protein, pH7.5, 25°C
18
3,4-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
7.9
3,5-dihydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.027
3-hydroxy-3-methylglutaryl-CoA
wild-type protein, pH7.5, 25°C
0.35
3-hydroxybenzoyl-CoA
wild-type protein, pH7.5, 25°C
0.023 - 35
3-hydroxyphenylacetyl-CoA
0.025
4-chlorobenzoyl-CoA
wild-type protein, pH7.5, 25°C
2.9
4-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.18
acetyl-CoA
wild-type protein, pH7.5, 25°C
1.1 - 73
Arachidonoyl-CoA
1.6
beta-hydroxybutyryl-CoA
wild-type protein, pH7.5, 25°C
0.19
beta-methylcrotonyl-CoA
wild-type protein, pH7.5, 25°C
0.47
crotonyl-CoA
wild-type protein, pH7.5, 25°C
0.75
glutaryl-CoA
wild-type protein, pH7.5, 25°C
1.9
lauroyl-CoA
wild-type protein, pH7.5, 25°C
860
linolenoyl-CoA
pH 7.5, 37°C, wild-type
0.054 - 2900
linoleoyl-CoA
0.24
malonyl-CoA
wild-type protein, pH7.5, 25°C
0.39
methylmalonyl-CoA
wild-type protein, pH7.5, 25°C
0.078
n-butyryl-CoA
wild-type protein, pH7.5, 25°C
3.3
n-decanoyl-CoA
wild-type protein, pH7.5, 25°C
0.31
n-hexanoyl-CoA
wild-type protein, pH7.5, 25°C
0.18
n-octanoyl-CoA
wild-type protein, pH7.5, 25°C
0.19
n-propionyl-CoA
wild-type protein, pH7.5, 25°C
1.3
oleoyl-CoA
wild-type protein, pH7.5, 25°C
1.9 - 430
palmitoleoyl-CoA
0.28 - 6900
palmitoyl-CoA
0.35
phenylacetyl-CoA
wild-type protein, pH7.5, 25°C
0.082
tiglyl-CoA
wild-type protein, pH7.5, 25°C
540
vaccenoyl-CoA
pH 7.5, 37°C, wild-type
0.023
3-hydroxyphenylacetyl-CoA
N50A mutant protein, pH7.5, 25°C
0.17
3-hydroxyphenylacetyl-CoA
H134A mutant protein, pH7.5, 25°C
0.58
3-hydroxyphenylacetyl-CoA
S83A mutant protein, pH7.5, 25°C
0.67
3-hydroxyphenylacetyl-CoA
D65E mutant protein, pH7.5, 25°C
0.92
3-hydroxyphenylacetyl-CoA
H137A mutant protein, pH7.5, 25°C
1
3-hydroxyphenylacetyl-CoA
D65N mutant protein, pH7.5, 25°C
2.6
3-hydroxyphenylacetyl-CoA
K136A mutant protein, pH7.5, 25°C
4.1
3-hydroxyphenylacetyl-CoA
T69A mutant protein, pH7.5, 25°C
24
3-hydroxyphenylacetyl-CoA
H56A mutant protein, pH7.5, 25°C
35
3-hydroxyphenylacetyl-CoA
wild-type protein, pH7.5, 25°C
1.1
Arachidonoyl-CoA
wild-type protein, pH7.5, 25°C
73
Arachidonoyl-CoA
pH 7.5, 37°C, wild-type
0.054
linoleoyl-CoA
wild-type protein, pH7.5, 25°C
2900
linoleoyl-CoA
pH 7.5, 37°C, wild-type
4
myristoyl-CoA
wild-type protein, pH7.5, 25°C
7.7
myristoyl-CoA
wild-type protein, pH7.5, 37°C
2300
myristoyl-CoA
pH 7.5, 37°C, wild-type
1.9
palmitoleoyl-CoA
wild-type protein, pH7.5, 25°C
430
palmitoleoyl-CoA
pH 7.5, 37°C, wild-type
0.28
palmitoyl-CoA
wild-type protein, pH7.5, 25°C
6900
palmitoyl-CoA
pH 7.5, 37°C, wild-type
5.5
stearoyl-CoA
wild-type protein, pH7.5, 25°C
290
stearoyl-CoA
pH 7.5, 37°C, wild-type
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Homo sapiens (O14734), Saccharomyces cerevisiae (P41903)
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Duttaroy, A.K.; Crozet, D.; Taylor, J.; Gordon, M.J.
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids
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Homo sapiens
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The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation
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Identification of fatty acid oxidation disorder patients with lowered acyl-CoA thioesterase activity in human skin fibroblasts
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35
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Homo sapiens
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Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.
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Homo sapiens (Q3I5F7)
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Nafamostat is hydrolysed by human liver cytosolic long-chain acyl-CoA hydrolase
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37
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2007
Homo sapiens
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Mandel, C.R.; Tweel, B.; Tong, L.
Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)
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385
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Homo sapiens
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Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.
The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis
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48
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Homo sapiens (Q9NPJ3), Homo sapiens
brenda
Cantu, D.C.; Ardevol, A.; Rovira, C.; Reilly, P.J.
Molecular mechanism of a hotdog-fold acyl-CoA thioesterase
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20
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Homo sapiens
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Mus musculus, Homo sapiens (Q5T1C6)
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