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Adenocarcinoma
ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma.
Adenocarcinoma
Medium chain fatty acid synthesis in rodent mammary adenocarcinomas in vitro.
Alzheimer Disease
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Atherosclerosis
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (?C20)-acyl chains in macrophages.
Breast Neoplasms
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
Breast Neoplasms
An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.
Breast Neoplasms
Evaluation of thioesterase II as a serum marker for rat mammary cancer.
Carcinogenesis
The NIEHS Predictive-Toxicology Evaluation Project.
Carcinoma
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
Carcinoma
Thioesterase II, a new marker enzyme for human cells of breast epithelial origin.
Carcinoma, Hepatocellular
Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.
Cholera
Response of end bud cells from immature rat mammary gland to hormones when cultured in collagen gel.
Colonic Neoplasms
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.
Coma
Effect of inulin on efficient production and regulatory biosynthesis of bacillomycin D in Bacillus subtilis fmbJ.
Coma
Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.
Communicable Diseases
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
Deficiency Diseases
Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL.
Dehydration
Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis.
Dehydration
Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging.
Diabetes Mellitus, Type 2
Disallowance of Acot7 in ?-cells is required for normal glucose tolerance and insulin secretion.
Diabetes Mellitus, Type 2
The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver.
Fatty Liver
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.
Fatty Liver
Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice.
Fatty Liver
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Glucose Intolerance
Loss of ACOT7 potentiates seizures and metabolic dysfunction.
Hepatomegaly
The hypolipidemic peroxisome-proliferating drug, bis(carboxymethylthio)-1.10 decane, a dicarboxylic metabolite of tiadenol, is activated to an acylcoenzyme A thioester.
Huntington Disease
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Hypertriglyceridemia
Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats.
Infections
Identification of Low Molecular Weight Proteins and Peptides from Schistosoma mekongi Worm, Egg and Infected Mouse Sera.
Influenza, Human
Unravelling the thioesterases responsible for propionate formation in engineered Pseudomonas putida KT2440.
Influenza, Human
YesT: a new rhamnogalacturonan acetyl esterase from Bacillus subtilis.
Insulin Resistance
AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression.
Insulin Resistance
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Insulin Resistance
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
Intellectual Disability
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Leukemia, Myeloid, Acute
Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients.
Lipidoses
The long-chain acyl-CoA hydrolase activity in the heart of rat fed on rape-seed oil.
Liver Neoplasms, Experimental
Induction of peroxisomal beta-oxidation in 7800 C1 Morris hepatoma cells in steady state by fatty acids and fatty acid analogues.
Liver Neoplasms, Experimental
Synergistic actions of tetradecylthioacetic acid (TTA) and dexamethasone on induction of the peroxisomal beta-oxidation and on growth inhibition of Morris hepatoma cells. Both effects are counteracted by insulin.
Lung Neoplasms
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC?-p53-p21 signaling pathway.
Lysosomal Storage Diseases
Lysosomal storage diseases: Thioesterase mimetic reduces toxicity.
Malaria
Fatty Acid synthesis as a target for antimalarial drug discovery.
Malaria
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
Melanoma
Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells.
Melanoma
Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior.
Myoclonus
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.
Neoplasms
A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma.
Neoplasms
ACTH regulation of mitochondrial acyl-CoA thioesterase activity in Y1 adrenocortical tumour cells.
Neoplasms
Dose and Effect Thresholds for Early Key Events in a PPAR?-Mediated Mode of Action.
Neoplasms
Evaluation of thioesterase II as a serum marker for rat mammary cancer.
Neoplasms
Evidence for the involvement of polyunsaturated fatty acids in the regulation of long-chain acyl CoA thioesterases and peroxisome proliferation in rat carcinosarcoma.
Neoplasms
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.
Neoplasms
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain.
Neoplasms
Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
Neoplasms
Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy.
Neoplasms
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Neoplasms
Novel antagonists of the thioesterase domain of human fatty acid synthase.
Neoplasms
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity.
Neoplasms
RAS Subcellular Localization Inversely Regulates Thyroid Tumor Growth and Dissemination.
Neoplasms
Regulation of conidiation and antagonistic properties of the soil-borne plant beneficial fungus Trichoderma virens by a novel proline-, glycine-, tyrosine-rich protein and a GPI-anchored cell wall protein.
Neoplasms
The mammalian START domain protein family in lipid transport in health and disease.
Neoplasms
The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture.
Neoplasms
Thioesterase II, a new marker enzyme for human cells of breast epithelial origin.
Neuroblastoma
Novel Interactive Partners of Neuroligin 3: New Aspects for Pathogenesis of Autism.
Neuroinflammatory Diseases
In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation.
Neuronal Ceroid-Lipofuscinoses
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.
Neuronal Ceroid-Lipofuscinoses
Atypical late infantile and juvenile forms of neuronal ceroid lipofuscinosis and their diagnostic difficulties.
Neuronal Ceroid-Lipofuscinoses
Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features.
Neuronal Ceroid-Lipofuscinoses
Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease.
Neuronal Ceroid-Lipofuscinoses
pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.
Neuronal Ceroid-Lipofuscinoses
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases.
Obesity
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.
Obesity
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart.
Obesity
Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.
Obesity
Metabolic and Tissue-Specific Regulation of Acyl-CoA Metabolism.
Obesity
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Obesity
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
palmitoyl-coa hydrolase deficiency
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (?C20)-acyl chains in macrophages.
palmitoyl-coa hydrolase deficiency
Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL.
palmitoyl-coa hydrolase deficiency
[Effect of short-chain thioesterase deficiency on P(3HB-co-LA) biosynthesis in Escherichia coli].
Pancreatic Neoplasms
A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk.
Peripheral Arterial Disease
Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
Scabies
YesT: a new rhamnogalacturonan acetyl esterase from Bacillus subtilis.
Seizures
Loss of ACOT7 potentiates seizures and metabolic dysfunction.
Sepsis
Cardiomyocyte specific expression of Acyl-coA thioesterase 1 attenuates sepsis induced cardiac dysfunction and mortality.
Starvation
Inhibition of fatty acid synthesis in Escherichia coli in the absence of phospholipid synthesis and release of inhibition by thioesterase action.
Stomach Neoplasms
ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma.
Stomach Neoplasms
Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
Stroke
Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.
Tuberculosis
Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
Tuberculosis
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Tuberculosis
Insights into the Substrate Specificity of a Thioesterase Rv0098 of Mycobacterium Tuberculosis through X-ray Crystallographic and Molecular Dynamics Studies.
Tuberculosis
Lipid biosynthesis as a target for antibacterial agents.
Tularemia
Functional expression of Francisella tularensis FabH and FabI, potential antibacterial targets.
Vision Disorders
A girl with infantile neuronal ceroid lipofuscinosis caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1.
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Bronfman, M.; Leighton, F.
Carnitine acyltransferase and acyl-coenzyme A hydrolase activities in human liver. Quantitative analysis of their subcellular localization
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224
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1984
Homo sapiens, Rattus norvegicus
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Berge, R.K.; Hagen, L.E.; Farstad, M.
Isolation of palmitoyl-CoA hydrolases from human blood platelets
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1981
Homo sapiens
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Poupon, V.; Begue, B.; Gagnon, J.; Dautry-Varsat, A.; Cerf-Bensussan, N.; Benmerah, A.
Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase
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274
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1999
Arabidopsis thaliana, Bacillus subtilis, Caenorhabditis elegans, Drosophila melanogaster, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Homo sapiens, Mus musculus (Q9R0X4), Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
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Broustas, C.G.; Larkins, L.K.; Uhler, M.D.; Hajra, A.K.
Molecular cloning and expression of cDNA encoding rat brain cytosolic acyl-coenzyme A thioester hydrolase
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271
10470-10476
1996
Homo sapiens, Rattus norvegicus (Q64559)
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Yamada, J.; Kurata, A.; Hirata, M.; Taniguchi, T.; Takama, H.; Furihata, T.; Shiratori, K.; Iida, N.; Takagi-Sakuma, M.; Watanabe, T.; Kurosaki, K.; Endo, T.; Suga, T.
Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase
J. Biochem.
126
1013-1019
1999
Homo sapiens (O00154), Homo sapiens
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Yamada, J.; Furihata, T.; Tamura, H.; Watanabe, T.; Suga, T.
Long-chain acyl-CoA hydrolase from rat brain cytosol: purification, characterization, and immunohistochemical localization
Arch. Biochem. Biophys.
326
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1996
Bos taurus, Canis lupus familiaris, Cavia porcellus, Homo sapiens, Mesocricetus auratus, Oryctolagus cuniculus, Platyrrhini, Rattus norvegicus, Sus scrofa
brenda
Maloberti, P.; Lozano, R.C.; Mele, P.G.; Cano, F.; Colonna, C.; Mendez, C.F.; Paz, C.; Podesta, E.J.
Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells
Eur. J. Biochem.
269
5599-5607
2002
Homo sapiens
brenda
Jones, J.M.; Nau, K.; Geraghty, M.T.; Erdmann, R.; Gould, S.J.
Identification of peroxisomal acyl-CoA thioesterases in yeast and humans
J. Biol. Chem.
274
9216-9223
1999
Homo sapiens (O14734), Homo sapiens, Saccharomyces cerevisiae (P41903), Saccharomyces cerevisiae
brenda
Duttaroy, A.K.; Crozet, D.; Taylor, J.; Gordon, M.J.
Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids
Prostaglandins
68
43-48
2003
Homo sapiens
brenda
Cohen, G.B.; Rangan, V.S.; Chen, B.K.; Smith, S.; Baltimore, D.
The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation
J. Biol. Chem.
275
23097-23105
2000
Homo sapiens
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Hunt, M.C.; Solaas, K.; Kase, B.F.; Alexson, S.E.
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism
J. Biol. Chem.
277
1128-1138
2002
Homo sapiens (O14734), Mus musculus (P58137), Mus musculus
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Yamada, J.; Kuramochi, Y.; Takagi, M.; Watanabe, T.; Suga, T.
Human brain acyl-CoA hydrolase isoforms encoded by a single gene
Biochem. Biophys. Res. Commun.
299
49-56
2002
Homo sapiens (O00154), Homo sapiens
brenda
Yang, J.W.; Czech, T.; Yamada, J.; Csaszar, E.; Baumgartner, C.; Slavc, I.; Lubec, G.
Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy
Amino Acids
27
269-275
2004
Homo sapiens
brenda
Takagi, M.; Suto, F.; Suga, T.; Yamada, J.
Sterol regulatory element-binding protein-2 modulates human brain acyl-CoA hydrolase gene transcription
Mol. Cell. Biochem.
275
199-206
2005
Homo sapiens
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Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.
Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs
FASEB J.
20
1855-1864
2006
Homo sapiens (P49753), Homo sapiens (Q86TX2), Homo sapiens
brenda
Kim, S.J.; Zhang, Z.; Sarkar, C.; Tsai, P.C.; Lee, Y.C.; Dye, L.; Mukherjee, A.B.
Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice
J. Clin. Invest.
118
3075-3086
2008
Mus musculus, Homo sapiens (P50897)
brenda
Cheng, F.; Wang, Q.; Chen, M.; Quiocho, F.A.; Ma, J.
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands
Proteins
70
1228-1234
2008
Homo sapiens
brenda
Cheng, F.; Wang, Q.; Chen, M.; Quiocho, F.A.; Ma, J.
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands
Proteins Struct. Funct. Bioinform.
70
1228-1234
2008
Homo sapiens
brenda