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acyl CoA hydrolase
-
-
-
-
acyl coenzyme A hydrolase
-
-
-
-
acyl coenzyme A thioesterase
-
-
-
-
acyl-CoA thioesterase 1
-
acyl-CoA thioesterase 2
-
acyl-CoA thioesterase-2
-
acyl-coenzyme A hydrolase
-
-
acyl-coenzyme A thioester hydrolase 2a
-
arachidonic acid-related esterase
-
-
EC 3.1.2.20
-
-
related
-
fatty acid synthase thioesterase
-
-
fatty acyl thioesterase I
-
-
-
-
HIV-Nef associated acyl coA thioesterase
-
-
-
-
hydrolase, acyl coenzyme A
-
-
-
-
hydrolase, palmitoyl coenzyme A
-
-
-
-
long chain acyl-CoA hydrolase
-
-
-
-
long chain acyl-CoA thioester hydrolase
-
-
long chain acyl-CoA thioesterase
long chain fatty-acyl-CoA hydrolase
-
-
-
-
long chain fatty-acyl-CoA thioesterase
-
-
-
-
long-chain acyl CoA thioesterase
-
-
long-chain acyl-CoA hydrolase
-
-
long-chain acyl-CoA thioesterase
long-chain acyl-CoA thioesterase 2
-
long-chain fatty acyl-CoA thioesterase
mitochondrial acyl-CoA thioesterase
-
-
-
-
mitochondrial thioesterase I
-
palmitoyl coenzyme A hydrolase
-
-
-
-
palmitoyl protein thioesterase-1
palmitoyl thioesterase
-
-
-
-
palmitoyl-CoA deacylase
-
-
-
-
palmitoyl-CoA hydrolase
-
-
-
-
palmityl coenzyme A deacylase
-
-
-
-
palmityl thioesterase
-
-
-
-
palmityl thioesterase I
-
-
-
-
palmityl thioesterase II
-
-
-
-
peroxisomal acyl-CoA thioesterase 2
thioesterase I/protease I/lysophospholipase L1
multifunctional enzyme with thioesterase, esterase, arylesterase, protease and lysophospholipase activities
type II fatty acid synthase
very long chain acyl-CoA thioesterase
-
-
-
-
ACH2

-
-
-
-
Acot1

-
ACOT2

-
Acot7

-
-
acyl-CoA hydrolase

-
acyl-CoA thioesterase

-
-
-
-
acyl-CoA thioesterase
-
-
acyl-CoA thioesterase
-
-
acyl-CoA thioesterase 7

-
-
acyl-CoA thioesterase 7
-
BACH

-
-
brain acyl-CoA hydrolase

-
-
-
-
brain acyl-CoA hydrolase
-
brain acyl-CoA hydrolase
-
-
brain acyl-CoA hydrolase
-
CTE-I

-
eFAS

-
-
FcoT

-
long chain acyl-CoA thioesterase

-
-
-
-
long chain acyl-CoA thioesterase
-
-
long-chain acyl-CoA thioesterase

-
-
long-chain acyl-CoA thioesterase
-
long-chain acyl-CoA thioesterase
-
long-chain fatty acyl-CoA thioesterase

-
long-chain fatty acyl-CoA thioesterase
-
-
MTE-I

-
-
Orf6 thioesterase

-
palmitoyl protein thioesterase-1

-
palmitoyl protein thioesterase-1
-
-
peroxisomal acyl-CoA thioesterase 2

-
peroxisomal acyl-CoA thioesterase 2
-
PPT1

-
PTE-2

-
PTE-Ia

-
-
PTE-Ib

-
-
TesA

-
-
thioesterase I

-
-
thioesterase I
multifunctional enzyme with thioesterase, esterase, arylesterase, protease and lysophospholipase activities
type II FAS

-
-
type II fatty acid synthase

-
-
type II fatty acid synthase
-
-
-
ZAP128

-
-
-
-
additional information

-
cf. EC 3.1.2.19
additional information
-
immunologically not related with the thioesterase of fatty acid synthase or the acyl fatty acid synthase thioester hydrolase
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2-methylstearoyl-CoA + H2O
CoA + 2-methylstearate
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
synthetic substrate
-
-
?
2-trans-decenoyl-CoA + H2O
CoA + 2-trans-decenoate
-
-
?
3-hydroxy-3-methyl glutaryl-CoA + H2O
CoA + 3-hydroxy-3-methyl glutarate
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
?
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutanoate
-
reaction at 4.3% the rate of acetoacetyl-CoA hydrolysis
-
-
?
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutyrate
-
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
3-hydroxyhexadecanoyl-CoA + H2O
CoA + 3-hydroxyhexadecanoate
-
-
-
?
3-hydroxypalmitoyl-CoA + H2O
CoA + 3-hydroxypalmitate
-
-
?
3-oxodecanoyl-CoA + H2O
CoA + 3-oxodecanoate
-
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
acetyl-CoA + H2O
CoA + acetate
acyl-CoA + H2O
CoA + a carboxylate
arachidonoyl-CoA + H2O
arachidonic acid + CoA
arachidonoyl-CoA + H2O
CoA + arachidonate
arachidoyl-CoA + H2O
CoA + arachidate
benzoyl-CoA + H2O
CoA + benzoate
butyryl-CoA + H2O
butanoate + CoA
-
-
?
butyryl-[acyl-carrier protein] + H2O
butanoate + acyl-carrier protein
-
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholate
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
choloyl-CoA + H2O
CoA + cholate
best substrate
-
?
choloyl-CoA + H2O
CoA + choloate
cis-methylene-9,10-hexadecanoyl-CoA + H2O
CoA + cis-methylene-9,10-hexadecanoate
-
-
-
?
cis-palmitoleoyl-CoA + H2O
CoA + palmitoleate
-
-
-
?
cis-vaccenoyl-CoA + H2O
CoA + cis-vaccenate
-
-
-
?
clofibroyl-CoA + H2O
CoA + clofibrate
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
decanoyl-CoA + H2O
CoA + decanoate
dipalmitoylglycero-3-phosphocholine + H2O
?
-
-
-
-
?
DL-palmitoyl carnitine + H2O
palmitate + DL-carnitine
-
-
-
-
?
docosahexaenoyl-CoA + H2O
CoA + docosahexaenoate
-
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
eicosanoyl-CoA + H2O
CoA + eicosanoate
-
-
-
-
?
eicosanoyl-CoA + H2O
CoA + eicosanoic acid
-
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
hexanoyl-CoA + H2O
CoA + hexanoate
hexanoyl-CoA + H2O
CoA + n-hexanoate
-
-
?
lauroyl-CoA + H2O
CoA + laurate
linolenoyl-CoA + H2O
CoA + linolenoate
linoleoyl-CoA + H2O
CoA + linoleate
linoleoyl-CoA + H2O
CoA + linoleoate
-
-
?
malonyl-CoA + H2O
CoA + malonate
malonyl-CoA + H2O
malonate + CoA
-
-
-
?
monolauroyl sucrose + H2O
lauroate + sucrose
-
-
-
-
?
monoolein + H2O
oleate + glycerol
-
-
-
-
?
monopalmitoyl sucrose + H2O
palmitate + sucrose
-
-
-
-
?
myristoleoyl-CoA + H2O
myristoleoate + CoA
myristoyl-CoA + H2O
CoA + myristate
n-butyryl-CoA + H2O
CoA + n-butanoate
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester + H2O
N-carbobenzoxy-L-tyrosine + p-nitrophenol
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
octanoyl-CoA + H2O
CoA + octanoate
oleoyl pantetheine + H2O
oleate + pantetheine
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
oleoyl-CoA + H2O
CoA + oleic acid
-
-
-
?
oleyl-[acyl-carrier protein] + H2O
oleate + acyl-carrier protein
-
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoate
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butyrate
-
-
-
?
palmitoleoyl-CoA
CoA + CoA + palmitoleoate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
palmitoleoyl-CoA + H2O
CoA + palmitoleic acid
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
palmitoyl-CoA + H2O
CoA + palmitate
palmitoyl-CoA + H2O
palmitate + CoA
-
-
-
?
polyoxyethylene sorbitan monooleate + H2O
?
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
propionyl-[acyl-carrier protein] + H2O
propionate + acyl-carrier protein
-
-
-
?
prostaglandin F2alpha + H2O
?
-
-
?
prostaglandin F2alpha-CoA + H2O
prostaglandin F2alpha + CoA
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
succinyl-CoA + H2O
CoA + succinate
-
reaction at 33% the rate of acetoacetyl-CoA hydrolysis
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
tetradecylthioacetyl-CoA + H2O
CoA + tetradecylthioacetate
-
best substrate
-
-
?
tetradecylthiopropionyl-CoA + H2O
CoA + tetradecylthiopropionate
-
-
-
-
?
trihydroxycoprostanoyl-CoA + H2O
CoA + trihydroxycoprostanoate
-
-
?
tripalmitoylglycerol + H2O
?
-
-
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
additional information
?
-
3-hydroxydecanoyl-CoA + H2O

CoA + 3-hydroxydecanoate
-
-
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
-
reaction at 1.4% the rate of acetoacetyl-CoA hydrolysis
-
-
?
4,8-dimethylnonanoyl-CoA + H2O

CoA + 4,8-dimethylnonanoate
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
involved in pristanic acid beta-oxidation, scheme of the pathway
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
hydrolysis allows transport of 4,8-dimethylnonanoate from peroxisomes to mitochondria for full oxidation
-
?
acetoacetyl-CoA + H2O

CoA + acetoacetate
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
8% activity compared to palmitoyl-CoA
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
best substrate
-
-
?
acetyl-CoA + H2O

CoA + acetate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
no activity
-
-
?
acetyl-CoA + H2O
CoA + acetate
poor substrate
-
?
acetyl-CoA + H2O
CoA + acetate
-
reaction at 33% the rate of acetoacetyl-CoA hydrolysis
-
-
?
acyl-CoA + H2O

CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
prefers unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
enzyme is not linked to fatty acid oxidation
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
preference for unsaturated acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
acyl-CoA of chain length C8-C18
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
saturated and unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
involved in fatty acid metabolism
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain to very-long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
saturated and unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
specific for very-long acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
long-chain fatty-acyl-CoA
-
-
ir
acyl-CoA + H2O
CoA + a carboxylate
-
specific for acyl-CoA, S-palmitoyl-glutathione and S-palmitoyl-cysteine are no substrates
-
?
acyl-CoA + H2O
CoA + a carboxylate
involved in fatty acid metabolism
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
arachidonoyl-CoA + H2O

arachidonic acid + CoA
-
-
-
?
arachidonoyl-CoA + H2O
arachidonic acid + CoA
-
enzyme is involved in steroidogenesis, overview
-
?
arachidonoyl-CoA + H2O

CoA + arachidonate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
most effective substrate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
involved in cholesterol metabolism
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
i.e. all-cis-5,8,11,14-eicosatetranoate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme provides arachidonic acid for prostaglandin synthesis in microsomes of kidney medulla
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
i.e. all-cis-5,8,11,14-eicosatetranoate
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
regulation, e.g. in the heart, of the enzyme is performed via beta-adrenergic receptors and their antagonists, e.g. actinomycin D
-
?
arachidoyl-CoA + H2O

CoA + arachidate
-
-
-
?
arachidoyl-CoA + H2O
CoA + arachidate
-
-
?
benzoyl-CoA + H2O

CoA + benzoate
-
-
-
?
benzoyl-CoA + H2O
CoA + benzoate
-
-
-
?
benzoyl-CoA + H2O
CoA + benzoate
-
-
-
?
chenodeoxycholoyl-CoA + H2O

CoA + chenodeoxycholoate
activity is PPARalpha-inducible
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
bile acid derivative substrate
-
-
?
choloyl-CoA + H2O

CoA + choloate
activity is PPARalpha-inducible
-
-
?
choloyl-CoA + H2O
CoA + choloate
bile acid derivative substrate
-
-
?
crotonyl-CoA + H2O

CoA + crotonate
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
-
-
?
crotonyl-CoA + H2O
CoA + crotonate
-
i.e. [trans]-2-butenoyl-CoA, reaction at 9.4% the rate of acetoacetyl-CoA hydrolysis
-
-
?
decanoyl-CoA + H2O

CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
reaction at 89% the rate of acetoacetyl-CoA hydrolysis
-
-
?
dodecanoyl-CoA + H2O

CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
best substrate
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
i.e. lauroyl-CoA
-
-
?
eicosapentaenoyl-CoA + H2O

CoA + eicosapentaenoate
-
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
-
-
-
?
eicosapentaenoyl-CoA + H2O
CoA + eicosapentaenoate
-
-
-
-
?
gamma-linolenoyl-CoA + H2O

CoA + gamma-linolenoate
-
best substrate
-
-
?
gamma-linolenoyl-CoA + H2O
CoA + gamma-linolenoate
-
-
-
-
?
hexadecanoyl-CoA + H2O

CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
best substrate
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
preferred substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
best substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
ir
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
reaction at 60% the rate of acetoacetyl-CoA hydrolysis
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexanoyl-CoA + H2O

CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
poor substrate
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
poor substrate
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
lauroyl-CoA + H2O

CoA + laurate
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
lauroyl-CoA + H2O
CoA + laurate
-
-
-
?
linolenoyl-CoA + H2O

CoA + linolenoate
-
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
-
?
linoleoyl-CoA + H2O

CoA + linoleate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
malonyl-CoA + H2O

CoA + malonate
-
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
?
myristoleoyl-CoA + H2O

myristoleoate + CoA
-
-
-
-
?
myristoleoyl-CoA + H2O
myristoleoate + CoA
-
-
?
myristoyl-CoA + H2O

CoA + myristate
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
highly preferred substrate
-
?
myristoyl-CoA + H2O
CoA + myristate
-
highly preferred substrate, temperature regulated activity, mechanism
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
?
n-butyryl-CoA + H2O

CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
poor substrate
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
no activity
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
reaction at 81% the rate of acetoacetyl-CoA hydrolysis
-
-
?
octadecanoyl-CoA + H2O

CoA + octadecanoate
-
i.e. stearoyl-CoA
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
preferred substrate
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
preferred substrate
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
i.e. stearoyl-CoA
-
-
?
octanoyl-CoA + H2O

CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
oleoyl-CoA + H2O

CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
just slowly hydrolyzed
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
i.e. [cis]-9-octadecenoyl-CoA, reaction at 40% the rate of acetoacetyl-CoA hydrolysis
-
-
?
palmitoleoyl-CoA + H2O

CoA + palmitoleate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
activity of ACH2 is not linked to fatty acid oxidation
-
-
?
palmitoleoyl-CoA + H2O

CoA + palmitoleoate
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
best substrate
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
?
palmitoyl-CoA + H2O

CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
ligand-binding pocket of the thioesterase domain encompasses the catalytic triad of Ser2308, His2481, Asp2338. The hydrophobic interactions are the major decisive factor for the optimal binding of the alphatic chain of palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
broad substrate specificity for long-chain acyl-CoA substrates
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
the enzyme affects specifically cellular systems and functions, but not all acyl-CoA-utilizing processes, overexpression leads to reduction of growth rate but not to phospholipid synthesis
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
80783, 80785, 80791, 94478, 171023, 646115, 646125, 646128, 646129, 646131, 646134, 646140, 646141, 646144, 646162, 646164, 646167, 646169, 646171, 646173 -
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
propionyl-CoA + H2O

CoA + propionate
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
?
stearoyl-CoA + H2O

CoA + stearate
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
tetradecanoyl-CoA + H2O

CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
specific for
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
best substrate
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
i.e. myristoyl-CoA
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
i.e. myristoyl-CoA
-
-
?
vaccenoyl-CoA + H2O

CoA + vaccenoate
-
cis-isomer
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
-
-
-
?
vaccenoyl-CoA + H2O
CoA + vaccenoate
-
i.e. [trans]-11-octadecenoyl-CoA, preferred substrate of unsaturated acyl-CoA
-
-
?
additional information

?
-
-
substrate specificity alters with pH
-
-
?
additional information
?
-
-
broad substrate specificity, preference for long-chain unsaturated fatty acids
-
?
additional information
?
-
broad substrate specificity, preference for long-chain unsaturated fatty acids
-
?
additional information
?
-
-
no activity with short-chain acyl-CoA substrates
-
?
additional information
?
-
-
extreme accumulation, 28fold increased compared to 0ưC, of myristoyl-CoA in cells at nonpermissive temperature close to 20ưC, causing growth arrest
-
-
?
additional information
?
-
decanoyl pantetheine is no substrate
-
-
?
additional information
?
-
-
decanoyl pantetheine is no substrate
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
no sufficient evidence that acyl-CoA is also the likely substrate in vivo
-
-
?
additional information
?
-
-
enzyme binds tightly and specifically to HIV-1 Nef protein, overview
-
-
?
additional information
?
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
sterol regulatory element-binding protein-2 modulates human brain acyl-CoA hydrolase gene transcription
-
-
?
additional information
?
-
-
the ligand binding pocket of the thioesterase domain is a decisive factor in chain length specificity
-
-
?
additional information
?
-
-
docking studies to the pocket of the catalytic triad Ser 2308, His 2481, and Asp 2338, using palmitate, and fatty acids with chain lengths of 12 to 20 carbon atoms. The ligand binding pocket of the thioesterase domain is a decisive factor in chain length specificity. Binding of palmitate results in the most favorable binding free enrgy among the fatty acids tested. The experimentally amino acids of the catalytic triad Ser2308, His2481, and Asp2338 are located very close to the carboxyl group of palmitate. The close location of Arg2482 to the carboxyl group of palmitate and the catalytic triad implies an important role of this residue in catalysis
-
-
?
additional information
?
-
broad chain length specificity
-
?
additional information
?
-
-
broad chain length specificity
-
?
additional information
?
-
-
enzyme regulation
-
?
additional information
?
-
-
enzyme regulation by dietary manipulation
-
-
?
additional information
?
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
isozyme CTE-I: diurnal regulation and regulation by fat content of the diet
-
?
additional information
?
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
role in eicosanoid synthesis and inflammation
-
-
?
additional information
?
-
-
role in eicosanoid synthesis and inflammation
-
-
?
additional information
?
-
-
PPT1-knockout mice, PPT1 deficiency causes persistent membrane anchorage of the palmitoylated synaptic vesicle proteins, which hinder the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during synaptic vesicle exocytosis
-
-
?
additional information
?
-
no activity with octanoyl-CoA
-
-
?
additional information
?
-
-
no activity with octanoyl-CoA
-
-
?
additional information
?
-
enzyme assays reveal that Orf6 has a higher specific activity toward long-chain fatty acyl-CoA substrates (palmitoyl-CoA and eicosapentaenoyl-CoA) than toward short-chain or aromatic acyl-CoA substrates
-
-
?
additional information
?
-
-
enzyme assays reveal that Orf6 has a higher specific activity toward long-chain fatty acyl-CoA substrates (palmitoyl-CoA and eicosapentaenoyl-CoA) than toward short-chain or aromatic acyl-CoA substrates
-
-
?
additional information
?
-
enzyme assays reveal that Orf6 has a higher specific activity toward long-chain fatty acyl-CoA substrates (palmitoyl-CoA and eicosapentaenoyl-CoA) than toward short-chain or aromatic acyl-CoA substrates
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
no activity with malonyl-CoA, ligneceroyl-CoA, and nervonoyl-CoA
-
-
?
additional information
?
-
-
differential regulation of distinct ACSl isoforms at the transcriptional level
-
-
?
additional information
?
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
additional information
?
-
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
additional information
?
-
-
no substrates are malonyl-CoA, acetoacetyl glutathione, acetoacetyl N-acetylcysteamine or acetoacetyl pantetheine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
acyl-CoA + H2O
CoA + a carboxylate
arachidonoyl-CoA + H2O
arachidonic acid + CoA
-
enzyme is involved in steroidogenesis, overview
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
myristoyl-CoA + H2O
CoA + myristate
-
highly preferred substrate, temperature regulated activity, mechanism
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleate
activity of ACH2 is not linked to fatty acid oxidation
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
stearoyl-CoA + H2O
CoA + stearate
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
additional information
?
-
4,8-dimethylnonanoyl-CoA + H2O

CoA + 4,8-dimethylnonanoate
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
involved in pristanic acid beta-oxidation, scheme of the pathway
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
hydrolysis allows transport of 4,8-dimethylnonanoate from peroxisomes to mitochondria for full oxidation
-
?
acyl-CoA + H2O

CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
enzyme is not linked to fatty acid oxidation
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
involved in fatty acid metabolism
-
?
acyl-CoA + H2O
CoA + a carboxylate
involved in fatty acid metabolism
-
?
arachidonoyl-CoA + H2O

CoA + arachidonate
-
involved in cholesterol metabolism
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme provides arachidonic acid for prostaglandin synthesis in microsomes of kidney medulla
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
enzyme is responsible for the mobilization of stored arachidonic acid in cells
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
regulation, e.g. in the heart, of the enzyme is performed via beta-adrenergic receptors and their antagonists, e.g. actinomycin D
-
?
hexadecanoyl-CoA + H2O

CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
preferred substrate
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
i.e. palmitoyl-CoA
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
reaction at 60% the rate of acetoacetyl-CoA hydrolysis
-
-
?
palmitoyl-CoA + H2O

CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
the enzyme affects specifically cellular systems and functions, but not all acyl-CoA-utilizing processes, overexpression leads to reduction of growth rate but not to phospholipid synthesis
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
80783, 80785, 80791, 94478, 171023, 646115, 646125, 646128, 646129, 646131, 646134, 646140, 646141, 646144, 646162, 646164, 646167, 646169, 646171, 646173 -
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
stearoyl-CoA + H2O

CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
?
additional information

?
-
-
extreme accumulation, 28fold increased compared to 0ưC, of myristoyl-CoA in cells at nonpermissive temperature close to 20ưC, causing growth arrest
-
-
?
additional information
?
-
-
no sufficient evidence that acyl-CoA is also the likely substrate in vivo
-
-
?
additional information
?
-
-
enzyme binds tightly and specifically to HIV-1 Nef protein, overview
-
-
?
additional information
?
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
sterol regulatory element-binding protein-2 modulates human brain acyl-CoA hydrolase gene transcription
-
-
?
additional information
?
-
-
enzyme regulation
-
?
additional information
?
-
-
enzyme regulation by dietary manipulation
-
-
?
additional information
?
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
enzyme might play an important role in prevention of CoA sequestration and in facilitating excretion of chain-shortened carboxylic acids, enzyme has a key regulatory function in peroxisomal lipid metabolism
-
?
additional information
?
-
-
isozyme CTE-I: diurnal regulation and regulation by fat content of the diet
-
?
additional information
?
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
role in eicosanoid synthesis and inflammation
-
-
?
additional information
?
-
-
role in eicosanoid synthesis and inflammation
-
-
?
additional information
?
-
-
PPT1-knockout mice, PPT1 deficiency causes persistent membrane anchorage of the palmitoylated synaptic vesicle proteins, which hinder the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during synaptic vesicle exocytosis
-
-
?
additional information
?
-
-
differential regulation of distinct ACSl isoforms at the transcriptional level
-
-
?
additional information
?
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
additional information
?
-
-
involved in the biosynthesis of the polyketide pikromycin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-acyl-sn-glycerol-3-phosphocholine
-
competitive inhibition at low concentration of palmitoyl-CoA
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
23% inhibition at 10 mM
13-hydroperoxyoctadecadienoic acid
-
only the mitochondrial enzyme form is inhibited, not the cytosolic one
2,2'-(decane-1,10-diyldisulfanediyl)diacetic acid
-
palmitoyl-CoA hydrolase activity, L-fraction and peroxisomes, especially of 3-thia fatty acids treated rats
2,4-dichlorophenoxyacetate
-
reduced activity in microsomes and mitochondria
3-O-methylmannose polysaccharide
-
-
-
4-Pentenoate
-
reduced activity in microsomes
5,5'-dithiobis(2-nitrobenzoate)
-
-
6-O-methylglucose polysaccharide
-
-
-
Acetyl salicylate
-
reduced activity in microsomes
AMP
-
acetyl-CoA as substrate
beta-hydroxybutyrate
-
moderately inhibits the microsomal enzyme activity
bis-(4-nitrophenyl) phosphate
-
-
Co2+
-
slightly inhibits the mitochondrial enzyme
CoA
intraperoxisomal regulatory role
CoA-S-S-CoA
-
competitive to acetyl-CoA; i.e. oxidized CoA, additive with NADH, kinetics
D-carnitine
-
inhibits at concentrations over 6 mM
diisopropylfluorophosphate
dodecanoyl-CoA
-
substrate inhibition
DTNB
above 0.3 mM; above 0.3 mM
EDTA
-
inhibits the activity of the mitochondrial enzyme at concentrations of 0.5 mM
FAD
-
slightly inhibits the microsomal enzyme
FMN
-
inhibits the mitochondrial-matrix enzyme activity
fumarate
-
inhibits the mitochondrial-matrix enzyme activity
GTP
-
acetyl-CoA as substrate
hexadecanoyl-CoA
-
substrate inhibition
Ibuprofen
-
reduced activity in microsomes and mitochondria
L-carnitine
-
inhibits at concentrations over 6 mM
lysophosphatidic acid
-
-
lysophosphatidylethanolamine
-
weakly inhibitory
lysophosphatidylserine
-
weakly inhibitory
methyl methanethiosulfonate
-
slight inhibition
methylene blue
-
photooxidation
myristoyl-CoA
-
substrate inhibition, in vivo 28fold increased substrate concentration at 20ưC leads to reduced enzyme activity
NAD+
-
inhibits the mitochondrial-matrix enzyme
NGDA
-
isozymes CTE-I and MTE-I
nicotinic acid
-
inhibits the mitochondrial-matrix enzyme activity
nordihydroguaiaretic acid
-
inhibition of acyl-CoA thioesterase and mitochondrial arachidonic acid-related thioesterase
O,O-Diethyl-O-(2,4,5-trichlorophenyl)-phosphate
-
-
O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphate
-
-
O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphorothionate
-
i.e. Chloropyrifos
O,O-Dimethyl-O-(2,4,5-trichloro-1-phenyl)-phosphate
-
-
O,O-Dimethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphate
-
i.e. Fospirate
octylglucoside
-
50% inhibition at 0.3%
p-chloromercuribenzoic acid
palmitic acid
-
1 mM inhibits by 30%
Pb2+
-
slightly inhibits the mitochondrial enzyme
tetradecanoyl-CoA
-
substrate inhibition
unsaturated fatty acids
-
-
-
Valproate
-
reduced activity in microsomes and mitochondria
2,4-dinitrofluorobenzene

-
inhibits very slowly
2,4-dinitrofluorobenzene
-
-
acetyl-CoA

-
-
acyl-CoA

e.g. lauroyl-CoA, at 0.005 mM, can be overcome by addition of bovine serum albumin or alpha-casein
acyl-CoA
substrate inhibition at concentrations higher than 0.005-0.01 mM of acyl-CoA longer than C10, BSA protects
ADP

-
inhibits the mitochondrial-matrix enzyme
ATP

-
inhibits ACH1 but not ACH2
ATP
-
inhibits the mitochondrial-matrix enzyme
ATP
-
competitive to acetyl-CoA
bovine serum albumin

-
-
-
bovine serum albumin
-
octadecanoyl-CoA as substrate, stimulates with C-6 to C-12 CoA as substrates
-
bovine serum albumin
-
-
-
bovine serum albumin
-
-
-
bovine serum albumin
-
a high amount inhibits the hydrolase
-
bovine serum albumin
-
a high amount inhibits the hydrolase
-
C75

-
binds the thioesterase domain in a similar orientation to that of palmitate, with its hydrophobic group buried inside the distal pocket and hydrophilic group interacting with the catalytic triad
C75
-
docking studies. C75 binds the thioestrase domain in a similar orientation to that of palmitate, with its hydrophobic group buried inside the distal pocket and hydrophilic group interacting with the catalytic triad
Ca2+

-
weakly inhibitory
Ca2+
-
inhibits ACH1, but ACH 2 just at higher concentrations
Ca2+
-
50% inhibition at 1.6 mM
Ca2+
-
inhibits the microsomal enzyme
Ca2+
-
10 mM inhibits the enzyme by 30-35%
Clofibrate

-
-
Clofibrate
-
reduced activity of the mitochondrial enzyme
CoASH

feedback inhibition of recombinant enzyme at concentrations above 0.1 mM
CoASH
-
product inhibition, acetyl-CoA as substrate, kinetics
Cu2+

-
-
diethyldicarbonate

-
95% inhibition at 2 mM
diethyldicarbonate
hydroxylamine reverses
diethyldicarbonate
-
hydroxylamine reverses
diethyldicarbonate
-
inactivation
diisopropylfluorophosphate

-
94% inhibition at 5 mM, maximal inhibition
diisopropylfluorophosphate
-
complete inhibition
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
at 0.01 mM inhibition of 95% after 40 min.
diisopropylfluorophosphate
-
1 mM DFP at 40 min at 25ưC produces a 95% inhibition at palmityl thioesterase I
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
0.01 mM inhibits
diisopropylfluorophosphate
-
no inhibition
diisopropylfluorophosphate
-
1 mM inhibits activity completely
diisopropylfluorophosphate
-
-
iodoacetamide

-
-
KCl

-
-
KCl
-
inhibits at high concentrations
KCl
-
inhibits the mitochondrial enzyme above 125 mM
L-palmitoyl carnitine

-
competitively inhibits at 0.02-04 mM
L-palmitoyl carnitine
-
competitive to acyl-CoA
lysophosphatidylcholine

-
strongly inhibitory
lysophosphatidylcholine
-
-
lysophosphatidylcholine
-
-
lysophosphatidylinositol

-
strong inhibition
lysophosphatidylinositol
-
-
Mg2+

-
weak inhibition
Mg2+
-
0.5 mM gives 40% inhibition
Mg2+
-
inhibits ACH1, but ACH2 just at higher concentrations
Mg2+
-
50% inhibition at 1.6 mM
Mg2+
-
inhibits the microsomal enzyme, at higher concentrations also the mitochondrial enzyme
Mg2+
-
10 mM inhibits the enzyme by 30-35%
Mn2+

-
weakly inhibitory
Mn2+
-
0.2 mM gives 60% inhibition
Mn2+
-
inhibits ACH1, but ACH2 just at higher concentrations
N-ethylmaleimide

-
0.001 mM gives 50% inhibition
NaCl

-
-
NaCl
-
inhibits at high concentrations
NADH

-
no inhibition
NADH
-
additive with oxidized CoA, noncompetitive
oleic acid

-
-
oleic acid
-
1 mM inhibits by 90%
orlistat

-
in the lowest-energy conformation, its central formylamino group is very close to the catalytic triad of the thioesterase domain. Its shorter chain is placed into the distal pocket where palmitate acyl chain binds and its longer chain extends into pocket 2
orlistat
-
docking studies, high binding affinity for the thioesterase domain
p-chloromercuribenzoic acid

-
-
p-chloromercuribenzoic acid
-
p-chloromercuribenzoic acid
-
-
p-hydroxymercuribenzoate

-
99% inhibition at 0.1 mM
p-hydroxymercuribenzoate
-
weak inhibition
p-hydroxymercuribenzoate
-
0.005 mM gives 50% inhibition
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
p-hydroxymercuribenzoate
-
-
PMSF

-
96% inhibition at 1 mM
PMSF
-
less effective than DFP, produces a 27% loss of activity under similar conditions
SDS

-
-
SDS
-
50% inhibition at 0.035%
sodium deoxycholate

-
-
sodium deoxycholate
-
50% inhibition at 0.04%
Triton X-100

-
-
Triton X-100
-
0.05-.0025% inhibits the activity
Triton X-100
-
50% inhibition at 0.01%
Zn2+

-
-
additional information

-
reversible substrate inhibition by long-chain acyl-CoAs at concentration 0.005 mM, reversibel by bovine serum albumin and alpha-casein
-
additional information
reversible substrate inhibition by long-chain acyl-CoAs at concentration 0.005 mM, reversibel by bovine serum albumin and alpha-casein
-
additional information
no inhibition by iodoacetate
-
additional information
-
no inhibition by iodoacetate
-
additional information
-
no inhibition by NEM
-
additional information
-
-
-
additional information
-
no inhibition by NEM, iodoacetamide, L-carnitine
-
additional information
-
no inhibition by EDTA, Mg2+, Fe2+, NAD+, NADP+, NADPH, glutamate, 2-oxoglutarate, pyruvate, alanine, asparagine, succinate; no inhibition by NEM
-
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