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Information on EC 3.1.2.1 - acetyl-CoA hydrolase and Organism(s) Homo sapiens and UniProt Accession Q8WYK0

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.2 Thioester hydrolases
                3.1.2.1 acetyl-CoA hydrolase
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: Q8WYK0 not found.
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
Synonyms
acetyl-coa hydrolase, acot12, ach1p, human arylamine n-acetyltransferase type 1, acetyl coa hydrolase, (mouse)nat2, acetyl-coa decarbonylase synthase enzyme complex, mouse arylamine n-acetyltransferase type 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(HUMN)NAT1
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Acetate utilization protein
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acetyl coenzyme A acylase
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acetyl coenzyme A deacylase
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acetyl coenzyme A hydrolase
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acetyl-CoA acylase
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acetyl-CoA deacylase
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acetyl-CoA hydrolase
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human arylamine N-acetyltransferase Type 1
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hydrolase, acetyl coenzyme A
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rACH
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + H2O = CoA + acetate
show the reaction diagram
as shown by proton nuclear magnetic resonance spectroscopy the disappearance of acetyl CH3 from acetyl Coenzyme A occurrs concomitantly with the appearance of a CH3 peak corresponding to that of free acetate and suggesting that folate is not acetylated during the reaction
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of thioester
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA hydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
9027-54-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + H2O
?
show the reaction diagram
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?
acetyl-CoA + H2O
CoA + acetate
show the reaction diagram
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-
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?
butyryl-CoA + H2O
butanoate + CoA
show the reaction diagram
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-
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?
lauroyl-CoA
lauroate + CoA
show the reaction diagram
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-
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?
oleoyl-CoA
oleate + CoA
show the reaction diagram
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-
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?
palmitoyl-CoA
palmitate + CoA
show the reaction diagram
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-
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + H2O
?
show the reaction diagram
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
folate
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folate binds at the enzyme's active site, and facilitate acetyl coenzyme A hydrolysis
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
naphthoquinone
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
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assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ACO12_HUMAN
555
0
62034
Swiss-Prot
other Location (Reliability: 2)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
functionally expressed in Sf9 insect cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bronfman, M.; Leighton, F.
Carnitine acyltransferase and acyl-coenzyme A hydrolase activities in human liver. Quantitative analysis of their subcellular localization
Biochem. J.
224
721-730
1984
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Suematsu, N.; Isohashi, F.
Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase
Acta Biochim. Pol.
53
553-561
2006
Homo sapiens (Q8WYK0), Homo sapiens
Manually annotated by BRENDA team
Laurieri, N.; Dairou, J.; Egleton, J.E.; Stanley, L.A.; Russell, A.J.; Dupret, J.M.; Sim, E.; Rodrigues-Lima, F.
From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2
PLoS ONE
9
e96370
2014
Homo sapiens, Mus musculus
Manually annotated by BRENDA team