Reference on EC 3.1.13.4 - poly(A)-specific ribonuclease
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schrder, H.C.; Zahn, R.K.; Dose, K.; Muller, W.E.G.
Purification and characterization of a poly(A)-specific exoribonuclease from calf thymus
J. Biol. Chem.
255
4535-4538
1980
Bos taurus
Schrder, H.C.; Bachmann, M.; Messer, R.; Muller, W.E.G.
Nucleotide-specific ribonucleases from eucaryotes. Their possible role during poly(A)(+)mRNA maturation and degradation
Prog. Mol. Subcell. Biol.
9
53-103
1985
Bos taurus, Mus musculus
-
Bachmann, M.; Schrder, H.C.; Messer, R.; Muller, W.E.
Base-specific ribonucleases potentially involved in heterogeneous nuclear RNA processing and poly(A) metabolism
FEBS Lett.
171
25-30
1984
Bos taurus, Mus musculus
Libonati, M.
Degradation of poly A and double-stranded RNA by aggregates of pancreatic ribonuclease
Biochim. Biophys. Acta
228
440-445
1971
Bos taurus
Sachs, A.B.; Deardorff, J.A.
Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast
Cell
70
961-973
1992
Saccharomyces cerevisiae
Boeck, R.; Tarun, S., Jr.; Rieger, M.; Deardorff, J.A.; Muller-Auer, S.; Sachs, A.B.
The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity
J. Biol. Chem.
271
432-438
1996
Saccharomyces cerevisiae
Brown, C.E.; Sachs, A.B.
Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation
Mol. Cell. Biol.
18
6548-6559
1998
Saccharomyces cerevisiae
Korner, C.G.; Wormington, M.; Muckenthaler, M.; Schneider, S.; Dehlin, E.; Wahle, E.
The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes
EMBO J.
17
5427-5437
1998
Bos taurus, Xenopus sp., Homo sapiens (O95453), Homo sapiens
Tock, M.R.; Walsh, A.P.; Carroll, G.; McDowall, K.J.
The CafA protein required for the 5'-maturation of 16S rRNA is a 5'-end-dependent ribonuclease that has context-dependent broad sequence specificity
J. Biol. Chem.
275
8726-8732
2000
Escherichia coli
Chen, J.; Chiang, Y.C.; Denis, C.L.
CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase
EMBO J.
21
1414-1426
2002
Saccharomyces cerevisiae
Martinez, J.; Ren, Y.G.; Thuresson, A.C.; Hellman, U.; Astrom, J.; Virtanen, A.
A 54-kDa fragment of the Poly(A)-specific ribonuclease is an oligomeric, processive, and cap-interacting Poly(A)-specific 3' exonuclease
J. Biol. Chem.
275
24222-24230
2000
Bos taurus
Ren, Y.G.; Martinez, J.; Virtanen, A.
Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavage
J. Biol. Chem.
277
5982-5987
2002
Homo sapiens
Uchida, N.; Hoshino, S.i.; Katada, T.
Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein
J. Biol. Chem.
279
1383-1391
2004
Homo sapiens (Q504Q3), Homo sapiens
Virtanen, A.; Martinez, J.; Ren, Y.G.
Purification of poly(A)-specific ribonuclease
Methods Enzymol.
342
303-309
2001
Bos taurus, Homo sapiens, Xenopus sp.
Gao, M.; Fritz, D.T.; Ford, L.P.; Wilusz, J.
Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro
Mol. Cell
5
479-488
2000
Homo sapiens
Lai, W.S.; Kennington, E.A.; Blackshear, P.J.
Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease
Mol. Cell. Biol.
23
3798-3812
2003
Homo sapiens (O95453)
Ren, Y.G.; Martinez, J.; Kirsebom, L.A.; Virtanen, A.
Inhibition of Klenow DNA polymerase and poly(A)-specific ribonuclease by aminoglycosides
RNA
8
1393-1400
2002
Bos taurus
Dunn, E.F.; Hammell, C.M.; Hodge, C.A.; Cole, C.N.
Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export
Genes Dev.
19
90-103
2005
Saccharomyces cerevisiae
Mangus, D.A.; Evans, M.C.; Agrin, N.S.; Smith, M.; Gongidi, P.; Jacobson, A.
Positive and negative regulation of poly(A) nuclease
Mol. Cell. Biol.
24
5521-5533
2004
Saccharomyces cerevisiae
Reverdatto, S.V.; Dutko, J.A.; Chekanova, J.A.; Hamilton, D.A.; Belostotsky, D.A.
mRNA deadenylation by PARN is essential for embryogenesis in higher plants
RNA
10
1200-1214
2004
Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe
Wu, M.; Reuter, M.; Lilie, H.; Liu, Y.; Wahle, E.; Song, H.
Structural insight into poly(A) binding and catalytic mechanism of human PARN
EMBO J.
24
4082-4093
2005
Homo sapiens (O95453), Homo sapiens
Nilsson, P.; Virtanen, A.
Expression and purification of recombinant poly(A)-specific ribonuclease (PARN)
Int. J. Biol. Macromol.
39
1-3
2006
Homo sapiens
Ren, Y.G.; Kirsebom, L.A.; Virtanen, A.
Coordination of divalent metal ions in the active site of poly(A)-specific ribonuclease
J. Biol. Chem.
279
48702-48706
2004
Escherichia coli, Escherichia coli BL21 (DE3)
Yamashita, A.; Chang, T.C.; Yamashita, Y.; Zhu, W.; Zhong, Z.; Chen, C.Y.; Shyu, A.B.
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover
Nat. Struct. Mol. Biol.
12
1054-1063
2005
Mus musculus
Seal, R.; Temperley, R.; Wilusz, J.; Lightowlers, R.N.; Chrzanowska-Lightowlers, Z.M.
Serum-deprivation stimulates cap-binding by PARN at the expense of eIF4E, consistent with the observed decrease in mRNA stability
Nucleic Acids Res.
33
376-387
2005
Homo sapiens
Nishimura, N.; Kitahata, N.; Seki, M.; Narusaka, Y.; Narusaka, M.; Kuromori, T.; Asami, T.; Shinozaki, K.; Hirayama, T.
Analysis of ABA hypersensitive germination2 revealed the pivotal functions of PARN in stress response in Arabidopsis
Plant J.
44
972-984
2005
Arabidopsis thaliana (Q9LG26)
Zhang, A.; Liu, W.F.; Yan, Y.B.
Role of the RRM domain in the activity, structure and stability of poly(A)-specific ribonuclease
Arch. Biochem. Biophys.
461
255-262
2007
Homo sapiens
Liu, W.; Zhang, A.; He, G.; Yan, Y.
The R3H domain stabilizes poly(A)-specific ribonuclease by stabilizing the RRM domain
Biochem. Biophys. Res. Commun.
360
846-851
2007
Homo sapiens
Chicoine, J.; Benoit, P.; Gamberi, C.; Paliouras, M.; Simonelig, M.; Lasko, P.
Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression
Dev. Cell
13
691-704
2007
Drosophila melanogaster
Liu, W.F.; Zhang, A.; Cheng, Y.; Zhou, H.M.; Yan, Y.B.
Effect of magnesium ions on the thermal stability of human poly(A)-specific ribonuclease
FEBS Lett.
581
1047-1052
2007
Homo sapiens
Nilsson, P.; Henriksson, N.; Niedzwiecka, A.; Balatsos, N.A.; Kokkoris, K.; Eriksson, J.; Virtanen, A.
A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties
J. Biol. Chem.
282
32902-32911
2007
Homo sapiens
Jonstrup, A.T.; Andersen, K.R.; Van, L.B.; Brodersen, D.E.
The 1.4-.ANG. crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme
Nucleic Acids Res.
35
3153-3164
2007
Schizosaccharomyces pombe (O74856), Schizosaccharomyces pombe
Hilgers, V.; Teixeira, D.; Parker, R.
Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae
RNA
12
1835-1845
2006
Saccharomyces cerevisiae
Rowlett, R.M.; Chrestensen, C.A.; Schroeder, M.J.; Harp, M.G.; Pelo, J.W.; Shabanowitz, J.; DeRose, R.; Hunt, D.F.; Sturgill, T.W.; Worthington, M.T.
Inhibition of tristetraprolin deadenylation by poly(A) binding protein
Am. J. Physiol. Gastrointest. Liver Physiol.
295
G421-G430
2008
Mus musculus
Liu, W.F.; Zhang, A.; Cheng, Y.; Zhou, H.M.; Yan, Y.B.
Allosteric regulation of human poly(A)-specific ribonuclease by cap and potassium ions
Biochem. Biophys. Res. Commun.
379
341-345
2009
Homo sapiens
Monecke, T.; Schell, S.; Dickmanns, A.; Ficner, R.
Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode
J. Mol. Biol.
382
827-834
2008
Homo sapiens (O95453)
Nagata, T.; Suzuki, S.; Endo, R.; Shirouzu, M.; Terada, T.; Inoue, M.; Kigawa, T.; Kobayashi, N.; Guentert, P.; Tanaka, A.; Hayashizaki, Y.; Muto, Y.; Yokoyama, S.
The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition
Nucleic Acids Res.
36
4754-4767
2008
Mus musculus (Q8VDG3), Mus musculus
Balatsos, N.A.; Vlachakis, D.; Maragozidis, P.; Manta, S.; Anastasakis, D.; Kyritsis, A.; Vlassi, M.; Komiotis, D.; Stathopoulos, C.
Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides
Biochemistry
48
6044-6051
2009
Homo sapiens (O95453), Homo sapiens
Balatsos, N.A.; Anastasakis, D.; Stathopoulos, C.
Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis
J. Enzyme Inhib. Med. Chem.
24
516-523
2009
Homo sapiens
Niedzwiecka, A.; Lekka, M.; Nilsson, P.; Virtanen, A.
Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering
Biophys. Chem.
158
141-149
2011
Homo sapiens (Q96LI5), Homo sapiens
Wang, H.; Morita, M.; Yang, X.; Suzuki, T.; Yang, W.; Wang, J.; Ito, K.; Wang, Q.; Zhao, C.; Bartlam, M.; Yamamoto, T.; Rao, Z.
Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity
EMBO J.
29
2566-2576
2010
Homo sapiens
Utter, C.J.; Garcia, S.A.; Milone, J.; Bellofatto, V.
Poly(A)-specific ribonuclease (PARN-1) function in stage-specific mRNA turnover in Trypanosoma brucei
Eukaryot. Cell
10
1230-1240
2011
Trypanosoma brucei, Trypanosoma brucei Lister 427
He, G.J.; Liu, W.F.; Yan, Y.B.
Dissimilar roles of the four conserved acidic residues in the thermal stability of poly(a)-specific ribonuclease
Int. J. Mol. Sci.
12
2901-2916
2011
Homo sapiens (O95453)
Henriksson, N.; Nilsson, P.; Wu, M.; Song, H.; Virtanen, A.
Recognition of adenosine residues by the active site of poly(A)-specific ribonuclease
J. Biol. Chem.
285
163-170
2010
Homo sapiens
Maragozidis, P.; Karangeli, M.; Labrou, M.; Dimoulou, G.; Papaspyrou, K.; Salataj, E.; Pournaras, S.; Matsouka, P.; Gourgoulianis, K.I.; Balatsos, N.A.
Alterations of deadenylase expression in acute leukemias: evidence for poly(A)-specific ribonuclease as a potential biomarker
Acta Haematol.
128
39-46
2012
Homo sapiens
He, G.J.; Zhang, A.; Liu, W.F.; Yan, Y.B.
Distinct roles of the R3H and RRM domains in poly(A)-specific ribonuclease structural integrity and catalysis
Biochim. Biophys. Acta
1834
1089-1098
2013
Homo sapiens (O95453)
He, G.J.; Yan, Y.B.
Self-association of poly(A)-specific ribonuclease (PARN) triggered by the R3H domain
Biochim. Biophys. Acta
1844
2077-2085
2014
Homo sapiens (O95453)
Yoda, M.; Cifuentes, D.; Izumi, N.; Sakaguchi, Y.; Suzuki, T.; Giraldez, A.J.; Tomari, Y.
Poly(A)-specific ribonuclease mediates 3-end trimming of Argonaute2-cleaved precursor microRNAs
Cell Rep.
5
715-726
2013
Homo sapiens
Hirayama, T.; Matsuura, T.; Ushiyama, S.; Narusaka, M.; Kurihara, Y.; Yasuda, M.; Ohtani, M.; Seki, M.; Demura, T.; Nakashita, H.; Narusaka, Y.; Hayashi, S.
A poly(A)-specific ribonuclease directly regulates the poly(A) status of mitochondrial mRNA in Arabidopsis
Nat. Commun.
4
2247
2013
Arabidopsis thaliana (Q9LG26)
Vlachakis, D.; Pavlopoulou, A.; Tsiliki, G.; Komiotis, D.; Stathopoulos, C.; Balatsos, N.; Kossida, S.
An integrated in silico approach to design specific inhibitors targeting human poly(A)-specific ribonuclease
PLoS ONE
7
e51113
2012
Homo sapiens (O95453), Homo sapiens
Romano, M.; Van De Weerd, R.; Brouwer, F.; Roviello, G.; Lacroix, R.; Sparrius, M.; Van Den Brink-Van Stempvoort, G.; Maaskant, J.; Van Der Sar, A.; Appelmelk, B.; Geurtsen, J.; Berisio, R.
Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo
Structure
22
719-730
2014
Mycobacterium marinum (B2HGU6)
Kim, J.; Sambalkhundev, G.O.; Kim, S.; Son, J.; Han, A.R.; Ko, S.M.; Hwang, K.Y.; Lee, W.C.
Processing of A-form ssDNA by cryptic RNase H fold exonuclease PF2046.
Arch. Biochem. Biophys.
606
143-150
2016
Pyrococcus furiosus (Q8TZE9), Pyrococcus furiosus ATCC 43587 (Q8TZE9), Pyrococcus furiosus Vc1 (Q8TZE9), Pyrococcus furiosus JCM 8422 (Q8TZE9)
He, G.; Yan, Y.
Contributions of the C-terminal domain to poly(A)-specific ribonuclease (PARN) stability and self-association
Biochem. Biophys. Rep.
18
100626
2019
Homo sapiens (O95453)
-
Zhang, L.; Yan, Y.
Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression
Biochim. Biophys. Acta
1853
522-534
2015
Homo sapiens (O95453), Homo sapiens
Niedzwiecka, A.; Nilsson, P.; Worch, R.; Stepinski, J.; Darzynkiewicz, E.; Virtanen, A.
Molecular recognition of mRNA 5' cap by 3' poly(A)-specific ribonuclease (PARN) differs from interactions known for other cap-binding proteins
Biochim. Biophys. Acta
1864
331-345
2016
Homo sapiens (O95453)
Jadhav, G.; Kaur, I.; Maryati, M.; Airhihen, B.; Fischer, P.; Winkler, G.
Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1
Bioorg. Med. Chem. Lett.
25
4219-4224
2015
Homo sapiens (O95453), Homo sapiens (Q9UIV1), Homo sapiens
Dhanraj, S.; Gunja, S.M.; Deveau, A.P.; Nissbeck, M.; Boonyawat, B.; Coombs, A.J.; Renieri, A.; Mucciolo, M.; Marozza, A.; Buoni, S.; Turner, L.; Li, H.; Jarrar, A.; Sabanayagam, M.; Kirby, M.; Shago, M.; Pinto, D.; Berman, J.N.; Scherer, S.W.; Virtanen, A.; Dror, Y.
Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN)
J. Med. Genet.
52
738-748
2015
Homo sapiens (O95453), Homo sapiens
Maragozidis, P.; Papanastasi, E.; Scutelnic, D.; Totomi, A.; Kokkori, I.; Zarogiannis, S.G.; Kerenidi, T.; Gourgoulianis, K.I.; Balatsos, N.A.
Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer prognostic value and impact on gene expression
Mol. Cancer
14
187
2015
Homo sapiens (O95453), Homo sapiens
Moon, D.H.; Segal, M.; Boyraz, B.; Guinan, E.; Hofmann, I.; Cahan, P.; Tai, A.K.; Agarwal, S.
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component
Nat. Genet.
47
1482-1488
2015
Homo sapiens (O95453), Homo sapiens
Anastasakis, D.; Skeparnias, I.; Shaukat, A.N.; Grafanaki, K.; Kanellou, A.; Taraviras, S.; Papachristou, D.J.; Papakyriakou, A.; Stathopoulos, C.
Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development
Nucleic Acids Res.
44
8908-8920
2016
Homo sapiens (Q8NA58), Homo sapiens, Mus musculus (B2RXZ1), Mus musculus
Ishikawa, H.; Yoshikawa, H.; Izumikawa, K.; Miura, Y.; Taoka, M.; Nobe, Y.; Yamauchi, Y.; Nakayama, H.; Simpson, R.J.; Isobe, T.; Takahashi, N.
Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells
Nucleic Acids Res.
45
3437-3447
2017
Homo sapiens (O95453), Homo sapiens
Montellese, C.; Montel-Lehry, N.; Henras, A.K.; Kutay, U.; Gleizes, P.E.; ODonohue, M.F.
Poly(A)-specific ribonuclease is a nuclear ribosome biogenesis factor involved in human 18S rRNA maturation
Nucleic Acids Res.
45
6822-6836
2017
Homo sapiens (O95453), Homo sapiens
Lee, D.; Park, D.; Park, J.; Kim, J.; Shin, C.
Poly(A)-specific ribonuclease sculpts the 3' ends of microRNAs
RNA
25
388-405
2019
Homo sapiens (O95453)
-
Godwin, A.; Kojima, S.; Green, C.; Wilusz, J.
Kiss your tail goodbye The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology
Biochim. Biophys. Acta
1829
571-579
2013
Mus musculus (O35710), Mus musculus (Q8VDG3), Homo sapiens (O95453)
Baggs, J.E.; Green, C.B.
Nocturnin, a deadenylase in Xenopus laevis retina a mechanism for posttranscriptional control of circadian-related mRNA
Curr. Biol.
13
189-198
2003
Xenopus laevis (P79942), Xenopus laevis (Q90ZA1), Xenopus laevis
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