Disease on EC 3.1.13.4 - poly(A)-specific ribonuclease
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Adenocarcinoma
Human Ccr4 and Caf1 Deadenylases Regulate Proliferation and Tumorigenicity of Human Gastric Cancer Cells via Modulating Cell Cycle Progression.
Alveolitis, Extrinsic Allergic
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Arthritis
The Acute-phase Response Is Not Predictive for the Development of Arthritis in Seropositive Arthralgia - A Prospective Cohort Study.
Bone Marrow Failure Disorders
Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN).
Breast Neoplasms
A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells.
Breast Neoplasms
IMP1 regulates UCA1-mediated cell invasion through facilitating UCA1 decay and decreasing the sponge effect of UCA1 for miR-122-5p.
Carcinoma
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors.
Carcinoma, Squamous Cell
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors.
Congenital Bone Marrow Failure Syndromes
Poly (A)-specific ribonuclease (PARN): More than just "mRNA stock clearing".
Cysts
twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis.
Dyskeratosis Congenita
CD8+ T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.
Dyskeratosis Congenita
Multiple bilateral hip fractures in a patient with dyskeratosis congenita caused by a novel mutation in the PARN gene.
Dyskeratosis Congenita
PARN modulates Y RNA stability, 3' end formation and its modification.
Dyskeratosis Congenita
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.
Dyskeratosis Congenita
Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.
Dyskeratosis Congenita
Poly(A)-specific ribonuclease is a nuclear ribosome biogenesis factor involved in human 18S rRNA maturation.
Dyskeratosis Congenita
Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita.
Dyskeratosis Congenita
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation.
Eye Neoplasms
The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models.
Fibrosarcoma
Comparison of ex vivo harvested and in vitro cultured materials from Echinococcus granulosus by measuring expression levels of five genes putatively involved in the development and maturation of adult worms.
Genetic Diseases, Inborn
Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways.
Genetic Diseases, Inborn
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation.
Heart Failure
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function.
Hypersensitivity
Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.
Idiopathic Interstitial Pneumonias
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Idiopathic Pulmonary Fibrosis
From incomplete penetrance with normal telomere length to severe disease and telomere shortening in a family with monoallelic and biallelic PARN pathogenic variants.
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways.
Idiopathic Pulmonary Fibrosis
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.
Idiopathic Pulmonary Fibrosis
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Idiopathic Pulmonary Fibrosis
[A rare familial form of idiopathic pulmonary fibrosis with Poly(A)-specific ribonuclease (PARN) mutation].
Infections
Alteration of nuclear (2'-5')oligoriboadenylate synthetase and nuclease activities preceding replication of human immunodeficiency virus in H9 cells.
Leukemia
Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker.
Liver Cirrhosis
Whole-Exome Sequencing in Adults With Chronic Kidney Disease: A Pilot Study.
Lung Diseases, Interstitial
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Lung Neoplasms
Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.
Lyme Disease
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.
Lymphoma, Non-Hodgkin
Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.
Malaria
CCR4-Associated Factor-1 Coordinates Expression of Plasmodium falciparum Egress and Invasion Proteins.
Melanoma
Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma.
Neoplasm Metastasis
CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARx03B3;, CEBP? and Inhibition of P-GSK3?/? and ?-Catenin.
Neoplasm Metastasis
Lack of effective translational regulation of PLD expression and exosome biogenesis in triple-negative breast cancer cells.
Neoplasm Metastasis
Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
Neoplasms
A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells.
Neoplasms
Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker.
Neoplasms
CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells.
Neoplasms
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
Neoplasms
Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression.
Neoplasms
Human Ccr4 and Caf1 Deadenylases Regulate Proliferation and Tumorigenicity of Human Gastric Cancer Cells via Modulating Cell Cycle Progression.
Neoplasms
Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.
Neoplasms
Increased sensitivity and accuracy of a single-stranded DNA splint-mediated ligation assay (sPAT) reveals poly(A) tail length dynamics of developmentally regulated mRNAs.
Neoplasms
Lack of effective translational regulation of PLD expression and exosome biogenesis in triple-negative breast cancer cells.
Neoplasms
Modulation of Poly(A)-specific Ribonuclease (PARN): current knowledge and perspectives.
Neoplasms
Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage.
Neoplasms
Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression.
Neoplasms
PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.
Neoplasms
Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.
Neoplasms
Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
Neoplasms
The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models.
Neoplasms
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.
Neoplasms
Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma.
Nervous System Diseases
Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression.
Neurologic Manifestations
Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN).
Obesity
Changes in poly(A) tail length dynamics from the loss of the circadian deadenylase Nocturnin.
Obesity
Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity.
poly(a)-specific ribonuclease deficiency
Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models.
poly(a)-specific ribonuclease deficiency
PARN modulates Y RNA stability, 3' end formation and its modification.
poly(a)-specific ribonuclease deficiency
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.
poly(a)-specific ribonuclease deficiency
Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.
poly(a)-specific ribonuclease deficiency
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
Pulmonary Fibrosis
Cell Type-Specific Quantification of Telomere Length and DNA Double-Strand Breaks in Individual Lung Cells by Fluorescence In Situ Hybridization and Fluorescent Immunohistochemistry.
Pulmonary Fibrosis
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.
Pulmonary Fibrosis
Poly(A)-specific ribonuclease is a nuclear ribosome biogenesis factor involved in human 18S rRNA maturation.
Pulmonary Fibrosis
Rare Genetic Variants in PARN are Associated with Pulmonary Fibrosis in Families.
Pulmonary Fibrosis
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Pulmonary Fibrosis
[A rare familial form of idiopathic pulmonary fibrosis with Poly(A)-specific ribonuclease (PARN) mutation].
rna-directed dna polymerase deficiency
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
rna-directed dna polymerase deficiency
Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease.
Sepsis
[Biological properties of opportunistic enterobacteria isolated from the blood of patients]
Starvation
Serum-deprivation stimulates cap-binding by PARN at the expense of eIF4E, consistent with the observed decrease in mRNA stability.
Starvation
The Recovery from Sulfur Starvation Is Independent from the mRNA Degradation Initiation Enzyme PARN in Arabidopsis.
Stomach Neoplasms
Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression.
Tauopathies
Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.
Tuberculosis
Structure and Function of RNase AS: A Novel Virulence Factor From Mycobacterium tuberculosis.
Virus Diseases
Resistance of vaccinia virus to interferons: modulation of the 2-5A system in interferon-treated, vaccinia virus infected cells.
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