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Acquired Immunodeficiency Syndrome
Target-Activated DNA Polymerase Activity for Sensitive RNase H Activity Assay.
Carcinogenesis
Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.
Carcinoma, Hepatocellular
Characterization of novel hepadnaviral RNA species accumulated in hepatoma cells treated with viral DNA polymerase inhibitors.
Decompression Sickness
Retroviral mutation rates and reverse transcriptase fidelity.
dna 5'-3' helicase deficiency
RTEL1 influences the abundance and localization of TERRA RNA.
dna topoisomerase deficiency
Topoisomerase I Essentiality, DnaA-Independent Chromosomal Replication, and Transcription-Replication Conflict in Escherichia coli.
exoribonuclease h deficiency
Functional complementation of an Escherichia coli ribonuclease H mutation by a cloned genomic fragment from the trypanosomatid Crithidia fasciculata.
exoribonuclease h deficiency
Identification of the genes encoding Mn2+-dependent RNase HII and Mg2+-dependent RNase HIII from Bacillus subtilis: classification of RNases H into three families.
exoribonuclease h deficiency
Isolation and characterization of a second RNase H (RNase HII) of Escherichia coli K-12 encoded by the rnhB gene.
exoribonuclease h deficiency
Replication of the Escherichia coli chromosome in RNase HI-deficient cells: multiple initiation regions and fork dynamics.
exoribonuclease h deficiency
RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA.
exoribonuclease h deficiency
The N-terminal hybrid binding domain of RNase HI from Thermotoga?maritima is important for substrate binding and Mg(2+) -dependent activity.
Fanconi Anemia
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage.
Foot-and-Mouth Disease
More precise location of the polycytidylic acid tract in foot and mouth disease virus RNA.
Foot-and-Mouth Disease
The nucleotide sequence at the 5' end of foot and mouth disease virus RNA.
Glioma
Increased 5-HT2A receptor expression and function following central glucocorticoid receptor knockdown in vivo.
Hepatitis
Detection of an RNase H activity associated with hepadnaviruses.
Hepatitis
The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.
Hepatitis B
A revised secondary structure model for the 3'-end of hepatitis B virus pregenomic RNA.
Hepatitis B
A ribonuclease H-oligo DNA conjugate that specifically cleaves hepatitis B viral messenger RNA.
Hepatitis B
A Tyr residue in the reverse transcriptase domain can mimic the protein-priming Tyr residue in the terminal protein domain of a hepadnavirus P protein.
Hepatitis B
Amino acids essential for RNase H activity of hepadnaviruses are also required for efficient elongation of minus-strand viral DNA.
Hepatitis B
Antibodies to the RNase H domain of hepatitis B virus P protein are associated with ongoing viral replication.
Hepatitis B
Detection of antibodies against DNA polymerase of hepatitis B virus in HBsAg-positive sera using ELISA.
Hepatitis B
Development and comparison of procedures for the selection of delta ribozyme cleavage sites within the hepatitis B virus.
Hepatitis B
Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase.
Hepatitis B
Evidence that the RNAseH activity of the duck hepatitis B virus is unable to act on exogenous substrates.
Hepatitis B
Expression of RNase H of human hepatitis B virus polymerase in Escherichia coli.
Hepatitis B
Expression, purification, and characterization of an active RNase H domain of the hepatitis B viral polymerase.
Hepatitis B
Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity.
Hepatitis B
Optimized expression from a synthetic gene of an untagged RNase H domain of human hepatitis B virus polymerase which is enzymatically active.
Hepatitis B
Progress in basic and clinical research on HIV resistance: report on the XVIII International HIV Drug Resistance Workshop.
Hepatitis B
Residues Arg703, Asp777, and Arg781 of the RNase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis.
Hepatitis B
Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus.
Hepatitis B
RNase H activity of human hepatitis B virus polymerase expressed in Escherichia coli.
Hepatitis B
Selected mutations of the duck hepatitis B virus P gene RNase H domain affect both RNA packaging and priming of minus-strand DNA synthesis.
Hepatitis B
Selective inhibition of the reverse transcription of duck hepatitis B virus by binding of 2',3'-dideoxyguanosine 5'-triphosphate to the viral polymerase.
Hepatitis B
Shedding light on RNaseH: a promising target for hepatitis B virus (HBV).
Hepatitis B
Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors.
Hepatitis B
The sequence of the RNA primer and the DNA template influence the initiation of plus-strand DNA synthesis in hepatitis B virus.
Hepatitis B
Ultradeep pyrosequencing and molecular modeling identify key structural features of hepatitis B virus RNase H, a putative target for antiviral intervention.
Hepatitis C
Fluorometric determination of RNase H via a DNAzyme conjugated to reduced graphene oxide, and its application to screening for inhibitors and activators.
Hepatitis C
Progress in basic and clinical research on HIV resistance: report on the XVIII International HIV Drug Resistance Workshop.
Hepatitis C
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.
Herpes Simplex
Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3'-to-5' Direction and Is Dependent on the 3'-to-5' Exonuclease Active Site.
HIV Infections
Alpha-oligonucleotides: a unique class of modified chimeric nucleic acids.
Huntington Disease
Differential effects on allele selective silencing of mutant huntingtin by two stereoisomers of ?,?-constrained nucleic acid.
Hypersensitivity
Sea urchin egg mitochondrial DNA contains a short displacement loop (D-loop) in the replication origin region.
Infections
A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection.
Infections
An end-point method based on graphene oxide for RNase H analysis and inhibitors screening.
Infections
Antibodies to the RNase H domain of hepatitis B virus P protein are associated with ongoing viral replication.
Infections
Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: potential application in hemochromatosis.
Infections
Bacteriophage T4 encodes an RNase H which removes RNA primers made by the T4 DNA replication system in vitro.
Infections
Conformational Changes in the 5' End of the HIV-1 Genome Dependent on the Debranching Enzyme DBR1 During Early Stages of Infection.
Infections
Discordant expression of the immediate-early 1 and 2 gene regions of human cytomegalovirus at early times after infection involves posttranscriptional processing events.
Infections
Either bacteriophage T4 RNase H or Escherichia coli DNA polymerase I is essential for phage replication.
Infections
In Vitro Enzymatic and Cell Culture-Based Assays for Measuring Activity of HBV RNaseH Inhibitors.
Infections
Nonradioactive detection of retroviral-associated RNase H activity in a microplate-based, high-throughput format.
Infections
Oligonucleotide-based strategies to inhibit human hepatitis C virus.
Infections
Ribonuclease H levels in herpes simplex virus-infected cells.
Infections
Role of gene 6 exonuclease in the replication and packaging of bacteriophage T7 DNA.
Infections
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.
Infections
The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.
Influenza, Human
A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection.
Influenza, Human
Catalytic metal ions and enzymatic processing of DNA and RNA.
Influenza, Human
Characterization of influenza virus NS1 protein by using a novel helper-virus-free reverse genetic system.
Leishmaniasis
Increased efficacy of antileishmanial antisense phosphorothioate oligonucleotides in Leishmania amazonensis overexpressing ribonuclease H.
Leprosy
Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase.
Leukemia
A large deletion in the connection subdomain of murine leukemia virus reverse transcriptase or replacement of the RNase H domain with Escherichia coli RNase H results in altered polymerase and RNase H activities.
Leukemia
Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function.
Leukemia
Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation.
Leukemia
Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases.
Leukemia
Characterization of reverse transcriptase and RNase H from friend-murine leukemia virus.
Leukemia
Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase.
Leukemia
Cleavage specificities of Moloney murine leukemia virus RNase H implicated in the second strand transfer during reverse transcription.
Leukemia
Crystal structure of the moloney murine leukemia virus RNase H domain.
Leukemia
Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus.
Leukemia
Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H.
Leukemia
Defects in primer-template binding, processive DNA synthesis, and RNase H activity associated with chimeric reverse transcriptases having the murine leukemia virus polymerase domain joined to Escherichia coli RNase H.
Leukemia
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
Leukemia
Detection of enteroviruses in cell cultures by using in situ transcription.
Leukemia
Differential effects of Moloney murine leukemia virus reverse transcriptase mutations on RNase H activity in Mg2+ and Mn2+.
Leukemia
Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.
Leukemia
Dynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.
Leukemia
Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937.
Leukemia
Effects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase.
Leukemia
Expression of a murine leukemia virus Gag-Escherichia coli RNase HI fusion polyprotein significantly inhibits virus spread.
Leukemia
Expression of an enzymatically active murine retroviral reverse transcriptase in human cells.
Leukemia
Expression of Moloney murine leukemia virus RNase H rescues the growth defect of an Escherichia coli mutant.
Leukemia
Ferrate oxidation of murine leukemia virus reverse transcriptase: identification of the template-primer binding domain.
Leukemia
Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N-terminal extension.
Leukemia
Functional organization of the murine leukemia virus reverse transcriptase: characterization of a bacterially expressed AKR DNA polymerase deficient in RNase H activity.
Leukemia
Inhibition by RNA of RNase H activity associated with reverse transcriptase in Rauscher murine leukemia virus cores.
Leukemia
Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptase.
Leukemia
Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone.
Leukemia
Mammalian retrovirus-associated RNase H is virus coded.
Leukemia
Mechanism of action of Moloney murine leukemia virus RNA-directed DNA polymerase associated RNase H (RNase H I).
Leukemia
Mechanism of action of Moloney murine leukemia virus RNase H III.
Leukemia
Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides.
Leukemia
Metal binding and activation of the ribonuclease H domain from moloney murine leukemia virus.
Leukemia
Multiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.
Leukemia
Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptase.
Leukemia
Mutations in the RNase H primer grip domain of murine leukemia virus reverse transcriptase decrease efficiency and accuracy of plus-strand DNA transfer.
Leukemia
Mutations of the RNase H C helix of the Moloney murine leukemia virus reverse transcriptase reveal defects in polypurine tract recognition.
Leukemia
Plus-strand priming by Moloney murine leukemia virus. The sequence features important for cleavage by RNase H.
Leukemia
Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled.
Leukemia
Preliminary physical mapping of RNA-RNA linkages in the genomic RNA of Moloney murine leukemia virus.
Leukemia
Preparation and characterization of the RNase H domain of Moloney murine leukemia virus reverse transcriptase.
Leukemia
Purification of M-MLVH- RT on a 9-aminoethyladenine-(1,6-diamine-hexane)-triazine selected from a combinatorial library of dNTP-mimetic ligands.
Leukemia
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.
Leukemia
Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase.
Leukemia
Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteins.
Leukemia
Reverse transcriptase-associated ribonuclease H does not require zinc for catalysis.
Leukemia
Reverse transcriptase-associated RNase H activity. II. Inhibition by natural and synthetic RNA.
Leukemia
Reverse transcriptase. The use of cloned Moloney murine leukemia virus reverse transcriptase to synthesize DNA from RNA.
Leukemia
Reverse transcription of a naturally occurring nonretroviral RNA produces a precise deletion in the majority of its cDNA products.
Leukemia
Reversion of a Moloney murine leukemia virus RNase H mutant at a second site restores enzyme function and infectivity.
Leukemia
RNA degradation and primer selection by Moloney murine leukemia virus reverse transcriptase contribute to the accuracy of plus strand initiation.
Leukemia
RNase H activity is required for high-frequency repeat deletion during Moloney murine leukemia virus replication.
Leukemia
RNase H activity of reverse transcriptases on substrates derived from the 5' end of retroviral genome.
Leukemia
RNase H activity: structure, specificity, and function in reverse transcription.
Leukemia
RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template.
Leukemia
RNase H domain of Moloney murine leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificity.
Leukemia
RNase H of human leukemic cells: a new biological parameter in the study of human leukemias (review).
Leukemia
Selective inactivation of M-MuLV RT RNase H activity by site-directed PEGylation: an improved ability to synthesize long cDNA molecules.
Leukemia
Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and Moloney murine leukemia virus reverse transcriptase.
Leukemia
Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus.
Leukemia
Specific inhibition of DNA polymerase-associated RNase H by DNA.
Leukemia
Specificities involved in the initiation of retroviral plus-strand DNA.
Leukemia
Specificity of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H in removal of the minus-strand primer, tRNA(Lys3).
Leukemia
Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase.
Leukemia
Structural models of ribonuclease H domains in reverse transcriptases from retroviruses.
Leukemia
Studies on reverse transcriptase of RNA tumor viruses III. Properties of purified Moloney murine leukemia virus DNA polymerase and associated RNase H.
Leukemia
Study of MMLV RT- binding with DNA using surface plasmon resonance biosensor.
Leukemia
The basic loop of the RNase H domain of MLV RT is important both for RNase H and for polymerase activity.
Leukemia
The interaction of illimaquinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses.
Leukemia
The isolated RNase H domain of murine leukemia virus reverse transcriptase. Retention of activity with concomitant loss of specificity.
Leukemia
The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase.
Leukemia
The role of Moloney murine leukemia virus RNase H activity in the formation of plus-strand primers.
Leukemia
The role of template-primer in protection of reverse transcriptase from thermal inactivation.
Leukemia
Two defective forms of reverse transcriptase can complement to restore retroviral infectivity.
Leukemia
Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.
Leukemia, Feline
Multiple RNase H activities in mammalian type C retravirus lysates.
Leukemia, Myeloid, Acute
RNase H of human leukemic cells: a new biological parameter in the study of human leukemias (review).
Liver Diseases
Expression of RNase H of human hepatitis B virus polymerase in Escherichia coli.
Melanoma
Peptide-oligonucleotide conjugates exhibiting pyrimidine-X cleavage specificity efficiently silence miRNA target acting synergistically with RNase H.
Mitochondrial Diseases
Clinicopathologic and molecular spectrum of RNASEH1-related mitochondrial disease.
Mouth Diseases
More precise location of the polycytidylic acid tract in foot and mouth disease virus RNA.
Mouth Diseases
The nucleotide sequence at the 5' end of foot and mouth disease virus RNA.
Neoplasms
An end-point method based on graphene oxide for RNase H analysis and inhibitors screening.
Neoplasms
Noncovalent Stabilization of Vesicular Polyion Complexes with Chemically Modified/Single-Stranded Oligonucleotides and PEG-b-guanidinylated Polypeptides for Intracavity Encapsulation of Effector Enzymes Aimed at Cooperative Gene Knockdown.
Neoplasms
Promoter region of the human platelet-derived growth factor A-chain gene.
Neoplasms
Reverse transcriptase of RNA tumor viruses. V. In vitro proteolysis of reverse transcriptase from avian myeloblastosis virus and isolation of a polypeptide manifesting only RNase H activity.
Neoplasms
RNase H and RNA-directed DNA polymerase: associated enzymatic activities of murine mammary tumor virus.
Neoplasms
Studies on reverse transcriptase of RNA tumor viruses III. Properties of purified Moloney murine leukemia virus DNA polymerase and associated RNase H.
Neoplasms
Studies on reverse transcriptase of RNA tumor viruses. I. Localization of thermolabile DNA polymerase and RNase H activities on one polypeptide.
Neoplasms, Muscle Tissue
The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase.
Neurodegenerative Diseases
Out of balance: R-loops in human disease.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6-deoxythioguanosine incorporation into DNA.
Prostatic Neoplasms
A M-MLV reverse transcriptase with reduced RNaseH activity allows greater sensitivity of gene expression detection in formalin fixed and paraffin embedded prostate cancer samples.
Prostatic Neoplasms
The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides.
Retinoblastoma
Endogenous CRX expression and IRBP promoter activity in retinoblastoma cells.
Sarcoma
In vitro transcription of 70S RNA by the RNA-directed DNA polymerase of Rouse sarcoma virus: lack of influence of RNase H.
Sarcoma
Multiple RNase H activities in mammalian type C retravirus lysates.
Sarcoma
[Presence of RNase H activity not associated with reverse transcriptase activity in Moloney murine sarcoma virions]
Sarcoma, Avian
Alternate polypurine tracts (PPTs) affect the rous sarcoma virus RNase H cleavage specificity and reveal a preferential cleavage following a GA dinucleotide sequence at the PPT-U3 junction.
Sarcoma, Avian
Asymmetric subunit organization of heterodimeric Rous sarcoma virus reverse transcriptase alphabeta: localization of the polymerase and RNase H active sites in the alpha subunit.
Sarcoma, Avian
Effect of viral RNase H on the avian sarcoma viral genome during early transcription in vitro.
Sarcoma, Avian
Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent activation of the associated RNase H.
Sarcoma, Avian
Homodimeric reverse transcriptases from rous sarcoma virus mutated within the polymerase or RNase H active site of one subunit are active.
Sarcoma, Avian
In vitro transcription of 70S RNA by the RNA-directed DNA polymerase of Rouse sarcoma virus: lack of influence of RNase H.
Sarcoma, Avian
Mutations in the U5 sequences adjacent to the primer binding site do not affect tRNA cleavage by rous sarcoma virus RNase H but do cause aberrant integrations in vivo.
Sarcoma, Avian
Mutations of the RNase H C helix of the Moloney murine leukemia virus reverse transcriptase reveal defects in polypurine tract recognition.
Sarcoma, Avian
New procedure for the direct analysis of in vitro reverse transcription of Rous sarcoma virus RNA.
Sarcoma, Avian
RNase H hydrolysis of the 5' terminus of the avian sarcoma virus genome during reverse transcription.
Sarcoma, Avian
Sequence and comparative structural analysis of the murine leukaemia virus amphotropic strain 4070A RNase H domain.
Sarcoma, Avian
Soluble Rous sarcoma virus reverse transcriptases alpha, alphabeta, and beta purified from insect cells are processive DNA polymerases that lack an RNase H 3' --> 5' directed processing activity.
Sarcoma, Avian
Specificities involved in the initiation of retroviral plus-strand DNA.
Sarcoma, Avian
The effects of alternate polypurine tracts (PPTs) and mutations of sequences adjacent to the PPT on viral replication and cleavage specificity of the Rous sarcoma virus reverse transcriptase.
Sarcoma, Avian
Two avian sarcoma virus mutants with defects in the DNA polymerase-RNase H complex.
Tuberculosis
Cloning, expression, purification and preliminary crystallographic analysis of the RNase HI domain of the Mycobacterium tuberculosis protein Rv2228c as a maltose-binding protein fusion.
Tuberculosis
Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase.
Tuberculosis
Structural and functional characterisation of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis.
Virus Diseases
Antibodies to the RNase H domain of hepatitis B virus P protein are associated with ongoing viral replication.
Virus Diseases
Delivery of double-stranded DNA thioaptamers into HIV-1 infected cells for antiviral activity.
Virus Diseases
Fluorometric determination of RNase H via a DNAzyme conjugated to reduced graphene oxide, and its application to screening for inhibitors and activators.
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3.1.13.2 exoribonuclease H
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
