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Information on EC 3.1.13.1 - exoribonuclease II and Organism(s) Homo sapiens and UniProt Accession Q9H0D6
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3.1.13.1 exoribonuclease IISpecify your search results
Word Map
- 3.1.13.1
- dnase
- nucleic
- pancreatic
- strand
-
single-stranded
-
endoribonuclease
- viruses
- polynucleotide
- endonuclease
-
polyadenylation
- duplex
- polya
- ribonucleoproteins
- transcriptase
-
rna-binding
-
circrnas
-
exosome
- phosphorylase
- chemokine
- dsrnas
- tata
- virion
- rpa
- nucleases
-
stem-loops
- actinomycin
- helicase
-
endonucleolytic
- dicer
-
phosphodiester
-
rna-dependent
- pronase
- intermedius
- oligoadenylate
-
riboprobes
-
rna-protein
-
nucleolar
-
ribozyme
-
3'-terminal
-
angiogenin
-
argonaute
-
encapsidation
-
rna-induced
- pre-rrnas
- rna-dna
- antitoxin
-
mip-1alpha
-
snrnp
- medicine
- drosha
- degradation
- analysis
- norovirus
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
rnase, exoribonuclease, rnase r, rnase ii, rrp44, rnase 2, ribonuclease r, rnaser, ribonuclease 2, rc-rnase 2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ribonuclease II
ribonuclease Q
-
-
-
-
ribonuclease II
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates
acts in a processive manner
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
-
-
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CAS REGISTRY NUMBER
COMMENTARY
37288-24-7
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
interactions between NKRF, 5'->3' exoribonuclease 2 (XRN2) and the negative elongation factor (NELF)-E in HeLa cells
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
interactions between NKRF, 5'->3' exoribonuclease 2 (XRN2) and the negative elongation factor (NELF)-E in HeLa cells
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NaCl
-
a salt concentration of 0.05 M inhibits 50% of the activity, salt optimum: 0.01 M
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Specific secretory phase endometrial leukocytes of women with two and more consecutive idiopathic abortions are not significantly different from healthy controls.
Acidosis, Lactic
A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome, diabetes mellitus, hyperthyroidism and cardiomyopathy.
Acne Vulgaris
Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris.
Acute Kidney Injury
Erythropoietin production in rats with post-ischemic acute renal failure.
Acute Kidney Injury
Up-regulation of hepatocyte growth factor receptor: an amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure.
Acute Lung Injury
RNase attenuates acute lung injury induced by ischemia-reperfusion in mice.
Adenocarcinoma
Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.
Adenocarcinoma
Correlation between polymorphisms in microRNA-regulated genes and cervical cancer susceptibility in a Xinjiang Uygur population.
Adenocarcinoma
Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas.
Adenocarcinoma
Folate-Targeted mRNA Delivery Using Chitosan-Functionalized Selenium Nanoparticles: Potential in Cancer Immunotherapy.
Adenocarcinoma
Isolation and characterization of the human sucrase-isomaltase gene and demonstration of intestine-specific transcriptional elements.
Adenocarcinoma
Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line.
Adenocarcinoma
[Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells].
Adenocarcinoma of Lung
Elevated expression of interleukins in lung adenocarcinomas induced by N-Nitrosobis(2-hydroxypropyl)amine in rats.
Adenocarcinoma of Lung
Elevated expression of transforming growth factor betas and the tumor necrosis factor family in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Adenocarcinoma of Lung
RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.
Adenocarcinoma of Lung
[Combined action of binase and bleomycin toward human lung adenocarcinoma cells].
Adenoma
Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene.
Adenoma, Pleomorphic
Immunohistochemical demonstration of ribonuclease and amylase in normal and neoplastic parotid glands.
Adenosarcoma
DICER1 mutations are frequent in müllerian adenosarcomas and are independent of rhabdomyosarcomatous differentiation.
Adrenocortical Carcinoma
Novel splicing of an IGF2 polymorphic region in human adrenocortical carcinomas.
Alzheimer Disease
Age-related change in the proportion of amyloid precursor protein mRNAs in the gray matter of cerebral cortex.
Alzheimer Disease
Age-related changes in the proportion of amyloid precursor protein mRNAs in Alzheimer's disease and other neurological disorders.
Alzheimer Disease
Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7).
Amyloid Neuropathies
Identification of a new transthyretin variant (Ile49) in familial amyloidotic polyneuropathy using electrospray ionization mass spectrometry and nonisotopic RNase cleavage assay.
Amyotrophic Lateral Sclerosis
Intermediate filament steady-state mRNA levels in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase.
Amyotrophic Lateral Sclerosis
Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Anemia
[Activity of alkaline ribosome RNase in ribosomes from rabbit reticulocytes in the course of a phenylhydrazine anemia]
Anencephaly
Amniotic fluid alkaline ribonuclease activity: an indicator of foetal growth retardation and anencephaly.
Anencephaly
[Diagnostic value of amniotic fluid alkaline ribonuclease activity in anencephaly and IUGR]
Angina, Stable
Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects.
Angina, Unstable
Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects.
Arthritis
Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis.
Arthritis, Psoriatic
Influence of Extracellular RNAs, Released by Rheumatoid Arthritis Synovial Fibroblasts, on Their Adhesive and Invasive Properties.
Arthritis, Rheumatoid
The Increased RNase Activity of IRE1? in PBMCs from Patients with Rheumatoid Arthritis.
Asthma
A review of antisense therapeutic interventions for molecular biological targets in asthma.
Astrocytoma
Caspase-1 mediates Fas-induced apoptosis and is up-regulated by interferon-gamma in human astrocytoma cells.
Astrocytoma
Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma.
Astrocytoma
Interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-1 receptor type I, IL-1 receptor antagonist, and TGF-beta 1 mRNAs in pediatric astrocytomas, ependymomas, and primitive neuroectodermal tumors.
Atherosclerosis
Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4.
Atherosclerosis
Expression of alpha2-adrenergic receptors in normal and atherosclerotic rabbit aorta.
Atherosclerosis
Extracellular RNA, a Potential Drug Target for Alleviating Atherosclerosis, Ischemia/Reperfusion Injury and Organ Transplantation.
Atherosclerosis
Vascular expression of extracellular superoxide dismutase in atherosclerosis.
Autoimmune Diseases
The 40-kilodalton to autoantigen associates with nucleotides 21 to 64 of human mitochondrial RNA processing/7-2 RNA in vitro.
Avian Leukosis
Features of the chicken c-myc gene that influence the structure of c-myc RNA in normal cells and bursal lymphomas.
Blast Crisis
The TGF-beta type II receptor in chronic myeloid leukemia: analysis of microsatellite regions and gene expression.
Blister
No evidence for involvement of the growth hormone/insulin-like growth factor-1 axis in psoriasis.
Brain Diseases
A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome, diabetes mellitus, hyperthyroidism and cardiomyopathy.
Brain Edema
Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor.
Brain Edema
New directions in inflammation and immunity: the multi-functional role of the extracellular RNA/RNase system.
Brain Edema
RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute stroke.
Brain Injuries
Common patterns of bcl-2 family gene expression in two traumatic brain injury models.
Brain Neoplasms
Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors.
Breast Neoplasms
A Nuclear-Directed Ribonuclease Variant Targets Cancer Stem Cells and Inhibits Migration and Invasion of Breast Cancer Cells.
Breast Neoplasms
A variant estrogen receptor messenger ribonucleic acid is associated with reduced levels of estrogen binding in human mammary tumors.
Breast Neoplasms
Amplification of Genomic DNA for Decoy Receptor 3 Predicts Post-Resection Disease Recurrence in Breast Cancer Patients.
Breast Neoplasms
ATM heterozygosity and breast cancer: screening of 37 breast cancer patients for ATM mutations using a non-isotopic RNase cleavage-based assay.
Breast Neoplasms
Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth.
Breast Neoplasms
Chemotherapeutic drugs change actin skeleton organization and the expression of beta-thymosins in human breast cancer cells.
Breast Neoplasms
Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.
Breast Neoplasms
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17 beta-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells.
Breast Neoplasms
Epidermal growth factor gene expression in human breast cancer biopsy samples: relationship to estrogen and progesterone receptor gene expression.
Breast Neoplasms
ESR1 amplification in breast cancer by optimized RNase FISH: frequent but low-level and heterogeneous.
Breast Neoplasms
Expression of biliary glycoprotein (CD66a) in normal and malignant breast epithelial cells.
Breast Neoplasms
Expression of estrogen receptor beta messenger RNA variant in breast cancer.
Breast Neoplasms
Insulin-like growth factor receptor expression and function in human breast cancer.
Breast Neoplasms
Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.
Breast Neoplasms
Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins.
Breast Neoplasms
Mixed ductal-lobular carcinoma: an analysis of CDH1 DNA copy number variation and mutation.
Breast Neoplasms
Molecular docking and dynamics simulations of A.niger RNase from Aspergillus niger ATCC26550: for potential prevention of human cancer.
Breast Neoplasms
Purification and characterization of a ribonuclease with antiproliferative activity from the mystical wild mushroom Tuber indicum.
Breast Neoplasms
Relationship of clone 4 estrogen receptor variant messenger RNA expression to some known prognostic variables in human breast cancer.
Breast Neoplasms
RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells.
Breast Neoplasms
RNase MC2: a new Momordica charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of MAPKs and induction of caspase pathways.
Breast Neoplasms
[Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells].
Carcinogenesis
Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancers.
Carcinogenesis
DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing.
Carcinogenesis
Histochemical comparison of focal losses of RNase and ATPase activities in preneoplastic rat livers.
Carcinogenesis
Loss of DCC expression in neuroblastoma is associated with disease dissemination.
Carcinogenesis
Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.
Carcinogenesis
MicroRNAs in Cancer: The 22nd Hiroshima Cancer Seminar/The 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima.
Carcinogenesis
Predominant DICER1 Pathogenic Variants in Pediatric Follicular Thyroid Carcinomas.
Carcinogenesis
Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model.
Carcinoid Tumor
The interferon-alpha regulation of interferon regulatory factor 1 (IRF-1) and IRF-2 has therapeutic implications in carcinoid tumors.
Carcinoma
Anatomy of the RNA and gene products of MC29 and MH2, two defective avian tumor viruses causing acute leukemia and carcinoma: evidence for a new class of transforming genes.
Carcinoma
Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses.
Carcinoma
Combinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell death.
Carcinoma
Comparative base specificity, stability, and lectin activity of two lectins from eggs of Rana catesbeiana and R. japonica and liver ribonuclease from R. catesbeiana.
Carcinoma
Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung.
Carcinoma
Effects of diethylstilbestrol diphosphate on serum and tissue ribonuclease levels in prostatic carcinoma.
Carcinoma
Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas.
Carcinoma
Exon 3 of the alpha folate receptor gene contains a 5' splice site which confers enhanced ovarian carcinoma specific expression.
Carcinoma
Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas.
Carcinoma
Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma.
Carcinoma
Human tumor-cell growth modulatory effects of the aebs/hic-binding drugs used as single agents and in combination with a novel amphibian oocyte rnase.
Carcinoma
Immunohistochemical demonstration of ribonuclease and amylase in normal and neoplastic parotid glands.
Carcinoma
Immunological assay of pancreatic ribonuclease in serum as an indicator of pancreatic cancer.
Carcinoma
Involvement of RNase 7 in the malignant potential of oral squamous cell carcinoma cells.
Carcinoma
Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
Carcinoma
Novel human malignancy-associated gene (MAG) expressed in various tumors and in some tumor preexisting conditions.
Carcinoma
p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas.
Carcinoma
RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.
Carcinoma
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Carcinoma
[Molecular diversity of desmosomal cadherins and their potential as markers in the histodiagnosis of carcinomas]
Carcinoma
[The value of poly-C-specific serum ribonuclease and CEA in the diagnosis of pancreatic carcinoma (author's transl)]
Carcinoma, Acinar Cell
Immunohistochemical demonstration of ribonuclease and amylase in normal and neoplastic parotid glands.
Carcinoma, Acinar Cell
Serum ribonucleases in pancreatic cancer: relation to tumor histology.
Carcinoma, Ehrlich Tumor
Affinity labelling and characterization of the ppp(A2'p)nA-dependent endoribonuclease from different mammalian sources.
Carcinoma, Ehrlich Tumor
Independent regulation of ppp(A2'p)nA-dependent RNase in NIH 3T3, clone 1 cells by growth arrest and interferon treatment.
Carcinoma, Ehrlich Tumor
Interferon action. Covalent linkage of (2'-5')pppApApA(32P)pCp to (2'-5')(A)n-dependent ribonucleases in cell extracts by ultraviolet irradiation.
Carcinoma, Ehrlich Tumor
Isolation and properties of a single-strand 5'----3' exoribonuclease from Ehrlich ascites tumor cell nucleoli.
Carcinoma, Ehrlich Tumor
Purification and properties of a nuclear exoribonuclease from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Studies on the allosteric properties of nuclear exoribonuclease from Ehrlich ascites tumor.
Carcinoma, Embryonal
Identification and characterization of novel human endogenous retroviral sequences prefentially expressed in undifferentiated embryonal carcinoma cells.
Carcinoma, Embryonal
Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation.
Carcinoma, Embryonal
The mouse homologue of hst/k-FGF: sequence, genome organization and location relative to int-2.
Carcinoma, Hepatocellular
A solution hybridization/RNase protection assay with riboprobes to determine absolute levels of apoB, A-I, and E mRNA in human hepatoma cell lines.
Carcinoma, Hepatocellular
Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice.
Carcinoma, Hepatocellular
DNA binding by the heterodimeric Ah receptor. Relationship to dioxin-induced CYP1A1 transcription in vivo.
Carcinoma, Hepatocellular
Estimation of poly (C) avid serum ribonuclease in hepatoma patients.
Carcinoma, Hepatocellular
Expression of multidrug resistance (p-glycoprotein) mdr1 and mdr2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors.
Carcinoma, Hepatocellular
Expression patterns of cytokines and chemokines genes in human hepatoma cells.
Carcinoma, Hepatocellular
FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter.
Carcinoma, Hepatocellular
Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
HepG2 and SK-N-MC: two human models to study alpha-2 adrenergic receptors of the alpha-2C subtype.
Carcinoma, Hepatocellular
Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs.
Carcinoma, Hepatocellular
Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements.
Carcinoma, Hepatocellular
Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis.
Carcinoma, Hepatocellular
Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
Carcinoma, Hepatocellular
Lack of 2',5'-oligoadenylate-dependent RNase expression in the human hepatoma cell line HepG2.
Carcinoma, Hepatocellular
Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells.
Carcinoma, Hepatocellular
Oligonucleotide sequences of pancreatic and T1 ribonuclease digests of 5S ribosomal RNA from mouse cells.
Carcinoma, Hepatocellular
Purification and characterization of a ribonuclease with antiproliferative activity from the mystical wild mushroom Tuber indicum.
Carcinoma, Hepatocellular
Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP.
Carcinoma, Hepatocellular
Regulation of IRE1? by the small molecule inhibitor 4?8c in hepatoma cells.
Carcinoma, Hepatocellular
Requisite role of VEGF receptors in angiogenesis of hepatocellular carcinoma: a comparison with angiopoietin/Tie pathway.
Carcinoma, Hepatocellular
RNase and alkali sensitivity of closed circular mitochondrial DNA of rat ascites hepatoma cells.
Carcinoma, Hepatocellular
Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line.
Carcinoma, Hepatocellular
Sequence analysis of T1 ribonuclease fragments of 18S ribosomal RNA by 5'-terminal labeling, partial digestion, and homochromatography fingerprinting.
Carcinoma, Hepatocellular
The distribution of acid and alkaline ribonuclease activities in preneoplastic and neoplastic rat livers.
Carcinoma, Hepatocellular
Transcriptional regulation of human corticotropin releasing factor gene expression by cyclic adenosine 3',5'-monophosphate: differential effects at proximal and distal promoter elements.
Carcinoma, Hepatocellular
Transcriptional regulation of the gene for the second component of human complement: promoter analysis.
Carcinoma, Hepatocellular
Turnover of messenger RNA in transplantable hepatomas and host liver of rats.
Carcinoma, Hepatocellular
[Enzymes of anabolic and catabolic nucleic acid pathways in human hepatomas, in liver of healthy persons, and in liver of patients with cancer of gastrointestinal tract]
Carcinoma, Hepatocellular
[Nuclease activity of the cytoplasmic ribosomes of hepatocytes and several experimental hepatomas]
Carcinoma, Hepatocellular
[Various enzymes of isolated nuclear membranes and cell nuclei of the liver and hepatoma 27 of rats]
Carcinoma, Non-Small-Cell Lung
Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung.
Carcinoma, Non-Small-Cell Lung
Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas.
Carcinoma, Non-Small-Cell Lung
Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.
Carcinoma, Non-Small-Cell Lung
Validation of a polymerase chain reaction aided transcript titration assay (PATTY) for topoisomerase II in lung cancer samples.
Carcinoma, Ovarian Epithelial
Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer.
Carcinoma, Ovarian Epithelial
Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma.
Carcinoma, Renal Cell
Vascular endothelial growth factor-B and vascular endothelial growth factor-C expression in renal cell carcinomas: regulation by the von Hippel-Lindau gene and hypoxia.
Carcinoma, Squamous Cell
Effects of keratinocyte growth factor on the proliferation and radiation survival of human squamous cell carcinoma cell lines in vitro and in vivo.
Carcinoma, Squamous Cell
Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas.
Carcinoma, Squamous Cell
Epidermal growth factor receptor-dependent cytotoxic effect by an EGF-ribonuclease conjugate on human cancer cell lines--a trial for less immunogenic chimeric toxin.
Carcinoma, Squamous Cell
Epidermal growth factor receptor-dependent cytotoxicity for human squamous carcinoma cell lines of a conjugate composed of human EGF and RNase 1.
Carcinoma, Squamous Cell
Involvement of RNase 7 in the malignant potential of oral squamous cell carcinoma cells.
Carcinoma, Squamous Cell
Regulation of parathyroid hormone-related protein secretion and mRNA expression in normal human keratinocytes and a squamous carcinoma cell line.
Carcinoma, Squamous Cell
RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.
Carcinoma, Squamous Cell
[EGF regulation of specific endoribonuclease activity of 26S proteasomes from A431 cells: a potential role of proteasomes in control of mRNA stability]
Carcinoma, Squamous Cell
[Selective effect of epidermal growth factor on the endoribonuclease activity of different subpopulations of proteasomes from A431 cell line. Specificity of extracellular proteasome population]
Cardiomegaly
Decreased expression of the very low density lipoprotein receptor mRNA in the cardiac ventricle of spontaneously hypertensive rats.
Cardiomegaly
The pathways of protein synthesis and degradation in normal heart and during development and regression of cardiac hypertrophy.
Cardiomyopathies
A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome, diabetes mellitus, hyperthyroidism and cardiomyopathy.
Cardiomyopathies
A novel variant of transthyretin (Glu89Lys) associated with familial amyloidotic polyneuropathy.
Cardiomyopathies
Analysis of gene expression patterns in small amounts of human ventricular myocardium by a multiplex RNase protection assay.
Cardiomyopathies
Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure.
Cardiomyopathies
Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure.
Cardiomyopathies
NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia.
Cardiomyopathy, Dilated
Characterization of two human beta1-adrenergic receptor transcripts: cloning and alterations in the failing heart.
Cardiomyopathy, Dilated
Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure.
Cardiomyopathy, Dilated
NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia.
Cardiomyopathy, Hypertrophic
NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia.
Cardiovascular Diseases
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers.
Cardiovascular Diseases
Multifunctional RNase MCPIP1 and its Role in Cardiovascular Diseases.
Charcot-Marie-Tooth Disease
Mutations in the peripheral myelin protein zero and connexin32 genes detected by non-isotopic RNase cleavage assay and their phenotypes in Japanese patients with Charcot-Marie-Tooth disease.
Cholestasis
Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats.
Chondrosarcoma
Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes.
Choriocarcinoma
Translation of the placenta growth factor mRNA is severely affected by a small open reading frame localized in the 5' untranslated region.
Classical Swine Fever
A novel role of classical swine fever virus E(rns) glycoprotein in counteracting the newcastle disease virus (NDV)-mediated IFN-beta Induction.
Classical Swine Fever
Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs.
Classical Swine Fever
Characterization of the monoclonal antibody against classical swine fever virus glycoprotein E(rns) and its application to an indirect sandwich ELISA.
Classical Swine Fever
Comparison of the effects of RNase-negative and wild-type classical swine fever virus on peripheral blood cells of infected pigs.
Classical Swine Fever
Expression and functional characterization of classical swine fever virus E(rns) protein.
Classical Swine Fever
Inactivation of the RNase activity of glycoprotein E(rns) of classical swine fever virus results in a cytopathogenic virus.
Classical Swine Fever
Mutation of cysteine 171 of pestivirus E rns RNase prevents homodimer formation and leads to attenuation of classical swine fever virus.
Classical Swine Fever
Mutations abrogating the RNase activity in glycoprotein E(rns) of the pestivirus classical swine fever virus lead to virus attenuation.
Classical Swine Fever
RNase of classical swine fever virus: biochemical characterization and inhibition by virus-neutralizing monoclonal antibodies.
Classical Swine Fever
Secreted expression of the classical swine fever virus glycoprotein E(rns) in yeast and application to a sandwich blocking ELISA.
Coinfection
Adeno-associated virus RNAs appear in a temporal order and their splicing is stimulated during coinfection with adenovirus.
Coinfection
Satellite tobacco mosaic virus sequence variants with only five nucleotide differences can interfere with each other in a cross protection-like phenomenon in plants.
Colitis
Exploratory investigation of the anti-inflammatory effects of RNase A-treated Enterococcus faecalis strain EC-12.
Colitis, Ulcerative
IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease.
Colonic Neoplasms
Construction of ribonuclease-antibody conjugates for selective cytotoxicity.
Colonic Neoplasms
IRE1?-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells.
Colonic Neoplasms
Mutations spanning P53 exons 5-9 detected by non-isotopic RNAse cleavage assay and protein expression in human colon cancer.
Colonic Neoplasms
Production and characterization of scFvA33T1, an immunoRNase targeting colon cancer cells.
Colonic Neoplasms
Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers.
Colonic Neoplasms
Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line.
Colonic Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Colorectal Neoplasms
Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancers.
Colorectal Neoplasms
Detection of p53 gene mutations by nonisotopic RNase cleavage assay as a predictor of poor prognosis in colorectal cancers.
Colorectal Neoplasms
EGFR targeting enhances the efficiency of chemotherapy through inhibiting IRE1?-XBP1s pathway in colorectal cancer cells.
Colorectal Neoplasms
Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin ?-Sarcin- or RNase T1-Based Immunotoxins.
Colorectal Neoplasms
Increased mRNA expression of the receptor-like protein tyrosine phosphatase alpha in late stage colon carcinomas.
Colorectal Neoplasms
Potential role for peroxisome proliferator activated receptor (PPAR) in preventing colon cancer.
Colorectal Neoplasms
Tumor-derived suppressor factors (TDSFs) in normal and neoplastic colon and rectum.
Communicable Diseases
A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense.
Communicable Diseases
From housekeeper to microsurgeon: the diagnostic and therapeutic potential of ribonucleases.
Congenital Abnormalities
Implantation of perichondrium-derived chondrocytes in physeal defects of rabbit tibiae.
Connective Tissue Diseases
Effect of enzyme treatment of Chrithidia luciliae on the reactivity of its kinetoplast with anti-DNA sera.
COVID-19
Identification of the RNase-binding site of SARS-CoV-2 RNA for anchor primer-PCR detection of viral loading in 306 COVID-19 patients.
Cystadenoma
Immunohistochemical demonstration of ribonuclease and amylase in normal and neoplastic parotid glands.
Cystitis
Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis.
Cysts
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
Cysts
Development of species-specific rDNA probes for Giardia by multiple fluorescent in situ hybridization combined with immunocytochemical identification of cyst wall antigens.
Cysts
Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.
Cysts
Hotspot mutations in DICER1 causing GLOW Syndrome-associated macrocephaly via modulation of specific microRNA populations results in activation of PI3K/ATK/mTOR signaling.
Cytomegalovirus Infections
Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences.
Decompression Sickness
[Interaction of intracellular RNAase from Aspergillus clavatus with derivatives of its substrates]
Dehydration
Analysis by atomic force microscopy of morphological changes in barley chromosomes during FISH treatment.
Dehydration
Quantitative analysis of aquaporin mRNA expression in rat tissues by RNase protection assay.
Dengue
A novel method for the preparation of large cDNA fragments from dengue-3 RNA genome by long RT-PCR amplification.
Dermatitis, Atopic
RNase 7 downregulates TH2 cytokine production by activated human T-cells.
Dermatitis, Contact
Skin allograft rejection is suppressed in mice lacking the antiviral enzyme, 2',5'-oligoadenylate-dependent RNase L.
Diabetes Complications
Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation.
Diabetes Mellitus
A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome, diabetes mellitus, hyperthyroidism and cardiomyopathy.
Diabetes Mellitus
Cyclic nucleotide PDE-3. Quantitation of PDE-3A and -3B mRNAs in rat tissues by RNase protection assay.
Diabetes Mellitus
Possible impact of plasma RNase activity on immune dysfunction in juvenile diabetes mellitus.
Diabetes Mellitus, Type 1
Possible impact of plasma RNase activity on immune dysfunction in juvenile diabetes mellitus.
Diabetes Mellitus, Type 1
RNase L contributes to experimentally induced type 1 diabetes onset in mice.
Diabetes Mellitus, Type 1
Targeting ABL-IRE1? Signaling Spares ER-Stressed Pancreatic ? Cells to Reverse Autoimmune Diabetes.
Down Syndrome
Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease.
Dwarfism
The anti-viral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.
Dyskeratosis Congenita
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Ehlers-Danlos Syndrome
Characterization of 11 new mutations in COL3A1 of individuals with Ehlers-Danlos syndrome type IV: preliminary comparison of RNase cleavage, EMC and DHPLC assays.
Encephalitis
STUDIES ON INFECTIOUS RNA OF JAPANESE B ENCEPHALITIS VIRUS. II. CHANGE OF RNASE ACTIVITY IN MOUSE BRAINS DURING VIRUS AND RNA INFECTIONS.
Encephalitis, Japanese
STUDIES ON INFECTIOUS RNA OF JAPANESE B ENCEPHALITIS VIRUS. II. CHANGE OF RNASE ACTIVITY IN MOUSE BRAINS DURING VIRUS AND RNA INFECTIONS.
Encephalomyelitis, Venezuelan Equine
The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.
Endotoxemia
Simultaneous analysis of multiple cytokine receptor mRNAs by RNase protection assay in LPS-induced endotoxemia.
Enterocolitis
Insulinlike growth factor I and interleukin 1 beta messenger RNA in a rat model of granulomatous enterocolitis and hepatitis.
Eosinophilia
[Clinical significance of determination of serum RNase activities in patients with eosinophilia--II. Measurements using polyuridylic acid and polycytidylic acid as substrates]
Ependymoma
Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors.
Ependymoma
Interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-1 receptor type I, IL-1 receptor antagonist, and TGF-beta 1 mRNAs in pediatric astrocytomas, ependymomas, and primitive neuroectodermal tumors.
Epstein-Barr Virus Infections
Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection.
Esophageal Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
exoribonuclease ii deficiency
The Aicardi-Goutières syndrome. Molecular and clinical features of RNAse deficiency and microRNA overload.
Familial Mediterranean Fever
Non-isotopic RNase cleavage assay for mutation detection in MEFV, the gene responsible for familial Mediterranean fever, in a cohort of Greek patients.
Familial Mediterranean Fever
Sequence analysis in Familial Mediterranean Fever patients with no confirmatory genotype.
Fetal Growth Retardation
Expression of C-type natriuretic peptide in human placenta and myometrium in normal pregnancies and pregnancies complicated by intrauterine growth retardation. Preliminary results.
Fetal Growth Retardation
Expression of low density lipoprotein receptor messenger ribonucleic acid in placentas from pregnancies with intrauterine growth retardation.
Fetal Nutrition Disorders
Alkaline ribonuclease activity in maternal serum and in serum of newborns from birth up to thirty days of age. A study made with full-term appropriate-, full-term small- and preterm appropriate-for-gestational-age infants.
Flavivirus Infections
RNase L antiviral activity is not a critical component of the Oas1b-mediated flavivirus resistance phenotype.
Foot-and-Mouth Disease
Detection and localization of single-base sequence differences in foot-and-mouth disease virus genomes by the RNase mismatch cleavage method.
Foot-and-Mouth Disease
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations.
Foot-and-Mouth Disease
Recombination and oligonucleotide analysis of guanidine-resistant foot-and-mouth disease virus mutants.
Gastroesophageal Reflux
Volume 241, Number 1 (1997), in Article No. RC977772, "A Bidirectional Promoter Connects the p14.5 Gene to the Gene for RNase P and RNase MRP Protein Subunit hPOP1,rdquo; by Gerno Schmiedeknecht, Christa Büchler, and Gerd Schmitz, pages 59-67:
Glioblastoma
Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNA.
Glioblastoma
Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors.
Glioblastoma
Stable expression and characterization of the human brain potassium channel Kv2.1: blockade by antipsychotic agents.
Glioma
Agonist-mediated down-regulation of rat beta1-adrenergic receptor transcripts: role of potential post-transcriptional degradation factors.
Glioma
Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues.
Glioma
Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells.
Glioma
Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma.
Glioma
Induction of nerve growth factor responsiveness in C6-2B glioma cells by expression of trkA proto-oncogene.
Glioma
Lymphocyte adhesion molecule ligands and extracellular matrix proteins in gliomas and normal brain: expression of VCAM-1 in gliomas.
Glioma
Plectin transcript diversity: identification and tissue distribution of variants with distinct first coding exons and rodless isoforms.
Glioma
The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas.
Glomerulonephritis
Glomerular extracellular matrix accumulation in experimental anti-GBM Ab glomerulonephritis.
Glomerulonephritis
Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis.
Glucagonoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Graft vs Host Disease
A role for CD54 (intercellular adhesion molecule-1) in leukocyte recruitment to the lung during the development of experimental idiopathic pneumonia syndrome.
Granuloma
Effects of purified macrophage RNase on granuloma fibroblasts with reference to silicosis.
Head and Neck Neoplasms
A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody-ribonuclease fusion protein targeting the EGF receptor.
Heart Arrest
RNase alleviates neurological dysfunction in mice undergoing cardiac arrest and cardiopulmonary resuscitation.
Heart Failure
Analysis of gene expression patterns in small amounts of human ventricular myocardium by a multiplex RNase protection assay.
Heart Failure
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure.
Hemangiosarcoma
Development of synthetic microRNA-214 showing enhanced cytotoxicity and RNase resistance for treatment of canine hemangiosarcoma.
Hepatitis
Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity.
Hepatitis
Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology.
Hepatitis
High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants.
Hepatitis
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.
Hepatitis
Insulinlike growth factor I and interleukin 1 beta messenger RNA in a rat model of granulomatous enterocolitis and hepatitis.
Hepatitis
Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity.
Hepatitis
RNase footprinting demonstrates antigenomic hepatitis delta virus ribozyme structural rearrangement as a result of self-cleavage reaction.
Hepatitis
The spectrum of complement-fixing antinuclear antibodies in patients with hepatocellular carcinoma.
Hepatitis A
Discrimination of infectious hepatitis A viruses by propidium monoazide real-time RT-PCR.
Hepatitis A
Enzymatic and viability RT-qPCR assays for evaluation of Enterovirus, Hepatitis A virus and Norovirus inactivation. Implications for public health risk assessment.
Hepatitis B
Characterization and selectivity of catalytic antibodies from human serum with RNase activity.
Hepatitis B
Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro.
Hepatitis C
Detailed mapping of RNA secondary structures in core and NS5B-encoding region sequences of hepatitis C virus by RNase cleavage and novel bioinformatic prediction methods.
Hepatitis C
Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2.
Hepatitis C
Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.
Hepatitis C
Strategic approach to produce low-cost, efficient, and stable competitive internal controls for detection of RNA viruses by use of reverse transcription-PCR.
Hepatoblastoma
Expression of genes involved with cell cycle control, cell growth and chromatin modification are altered in hepatoblastomas.
Herpes Simplex
Activation of the ppp(A2'p)nA system in interferon-treated, herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2'p)nA-dependent RNase.
Herpes Simplex
Different patterns of induction of fibroblast growth factor-2 and brain-derived neurotrophic factor messenger RNAs during kindling epileptogenesis, and development of a herpes simplex vector for fibroblast growth factor-2 gene transfer in vivo.
Herpes Simplex
Herpes Simplex Virus 1 UL41 Protein Suppresses the IRE1/XBP1 Signal Pathway of the Unfolded Protein Response via Its RNase Activity.
Herpes Simplex
HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses.
Herpes Simplex
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells.
Herpes Simplex
Inhibition of herpes simplex virus 1 gene expression and replication by RNase P-associated external guide sequences.
Herpes Simplex
Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA.
Herpes Simplex
Interferon-beta suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway.
Herpes Simplex
Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase.
Herpes Simplex
RNA degradation induced by the herpes simplex virus vhs protein proceeds 5' to 3' in vitro.
Herpes Simplex
RNase 7 Promotes Sensing of Self-DNA by Human Keratinocytes and Activates an Antiviral Immune Response.
Herpes Simplex
Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.
Herpes Simplex
Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice.
Herpes Simplex
The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNA.
Herpes Simplex
The Herpes Simplex Virus Host Shutoff RNase Degrades Cellular and Viral mRNAs Made before Infection but Not Viral mRNA Made after Infection.
Herpes Simplex
The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation.
Herpes Simplex
The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs.
Herpes Simplex
The upstream regulatory region of the human papilloma virus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones.
Herpes Simplex
The Virion Host Shutoff RNase Plays a Key Role in Blocking the Activation of Protein Kinase R in Cells Infected with Herpes Simplex Virus 1.
Herpes Simplex
Transcriptional analysis of the herpes simplex virus type 1 region containing the TRL/UL junction.
Herpes Simplex
Tristetraprolin recruits the herpes simplex virion host shutoff RNase to the AU-rich elements in the stress response mRNAs to enable their cleavage.
Herpes Simplex
Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells.
Herpes Zoster
Inhibition of zona pellucida gene expression by antisense oligonucleotides injected into mouse oocytes.
Histiocytoma, Malignant Fibrous
Homozygous microdeletion of the ERI1 and MFHAS1 genes in a patient with intellectual disability, limb abnormalities, and cardiac malformation.
Hyperalgesia
Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines.
Hypertension
Decreased expression of the very low density lipoprotein receptor mRNA in the cardiac ventricle of spontaneously hypertensive rats.
Hypertension, Renovascular
Atrophy or hypertrophy in chronic renal ischemia: role of the IGF-I system.
Hyperthyroidism
A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome, diabetes mellitus, hyperthyroidism and cardiomyopathy.
Hyperthyroidism
Thyroid hormone regulates postnatal expression of transient K+ channel isoforms in rat ventricle.
Hypoglycemia
Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line.
Hyponatremia
Ectopic production and processing of atrial natriuretic peptide in a small cell lung carcinoma cell line and tumor from a patient with hyponatremia.
Hypothyroidism
Variation in rat serum alkaline RNase after experimentally induced hypothyroidism.
Immune System Diseases
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.
Infections
A glutaredoxin, encoded by the G4L gene of vaccinia virus, is essential for virion morphogenesis.
Infections
A novel RNase 3/ECP peptide for Pseudomonas aeruginosa biofilm eradication. Combining antimicrobial, lipopolysaccharide binding and cell agglutinating activities.
Infections
A type II secreted RNase of Legionella pneumophila facilitates optimal intracellular infection of Hartmannella vermiformis.
Infections
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
Infections
Alteration of cellular ribonucleases associated with murine oncogenic virus infection.
Infections
Alterations in cellular RNA decapping dynamics affect tomato spotted wilt virus cap snatching and infection in Arabidopsis.
Infections
Alterations in cytokine but not chemokine mRNA expression during three distinct Theiler's virus infections.
Infections
Amino acid substitutions in the CA protein of Moloney murine leukemia virus that block early events in infection.
Infections
Analysis of genetic variation in Theiler's virus during persistent infection in the mouse central nervous system.
Infections
Analysis of the interrelationship between IL-12, TNF-alpha, and IFN-gamma production during murine listeriosis.
Infections
Bacteriophage T4 encodes an RNase H which removes RNA primers made by the T4 DNA replication system in vitro.
Infections
Baculovirus vectors repress phenobarbital-mediated gene induction and stimulate cytokine expression in primary cultures of rat hepatocytes.
Infections
Bovine viral diarrhea virus: prevention of persistent fetal infection by a combination of two mutations affecting Erns RNase and Npro protease.
Infections
Cell type-dependent RNA recombination frequency in the Japanese encephalitis virus.
Infections
Characterization of a nerve growth factor-inducible cellular activity that enhances herpes simplex virus type 1 gene expression and replication of an ICP0 null mutant in cells of neural lineage.
Infections
Chemokine induction and leukocyte trafficking to the lungs during murine gammaherpesvirus 68 (MHV-68) infection.
Infections
Comparison of Rous sarcoma virus RNA processing in chicken and mouse fibroblasts: evidence for double-spliced RNA in nonpermissive mouse cells.
Infections
Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin.
Infections
Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences.
Infections
Cytokine profile induced by a primary infection with Ostertagia ostertagi in cattle.
Infections
Development and validation of flow cytometric measurement for parasitaemia using autofluorescence and YOYO-1 in rodent malaria.
Infections
Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection.
Infections
Different patterns of the L-histidine decarboxylase (HDC) gene expression in mice resistant and susceptible to experimental cutaneous leishmaniasis.
Infections
Dimerisation of glycoprotein E(rns) of classical swine fever virus is not essential for viral replication and infection.
Infections
Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication.
Infections
Early cytokine and chemokine gene expression during Pseudomonas aeruginosa corneal infection in mice.
Infections
Ebola virus infection of human PBMCs causes massive death of macrophages, CD4 and CD8 T cell sub-populations in vitro.
Infections
Effect of RNase III on efficiency of translation of bacteriophage T7 lysozyme mRNA.
Infections
Expression of antimicrobial peptides and toll-like receptors is increased in tinea and pityriasis versicolor.
Infections
Genetic variation of foot-and-mouth disease virus isolates recovered from persistently infected water buffalo (Bubalus bubalis).
Infections
Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41.
Infections
Herpes simplex virus 2 virion host shutoff protein interferes with type I interferon production and responsiveness.
Infections
Host Defense Peptide RNase 7 Is Down-regulated in the Skin of Diabetic Patients with or without Chronic Ulcers, and its Expression is Altered with Metformin.
Infections
Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome.
Infections
In vitro and in vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions.
Infections
In vitro transcription by cytoplasmic extracts from cells infected with African swine fever virus.
Infections
Inability to detect RNase V in Escherichia coli and comparison of other ribonucleases before and after infection with coliphage T7.
Infections
Increased severity of HSV-1 keratitis and mortality in mice lacking the 2-5A-dependent RNase L gene.
Infections
Infection of keratinocytes with Trichophytum rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression.
Infections
Inflammatory responses to pneumovirus infection in IFN-alpha beta R gene-deleted mice.
Infections
Inhibition of L-deleted foot-and-mouth disease virus replication by alpha/beta interferon involves double-stranded RNA-dependent protein kinase.
Infections
Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract.
Infections
JC virus induces nonapoptotic cell death of human central nervous system progenitor cell-derived astrocytes.
Infections
Kinetics of murine gammaherpesvirus 68 gene expression following infection of murine cells in culture and in mice.
Infections
MCPIP1/regnase-I inhibits simian immunodeficiency virus and is not counteracted by Vpx.
Infections
Modulation of ppp(A2'p)nA-dependent RNase by a temperature-sensitive mutant of vaccinia virus.
Infections
Molecular analysis of an occlusion body protein from Culex nigripalpus nucleopolyhedrovirus (CuniNPV).
Infections
Molecular cloning of cDNAs encoding ribonuclease-related proteins in Nicotiana glutinosa leaves, as induced in response to wounding or to TMV-infection.
Infections
Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR-Cas immunity.
Infections
Opposite Roles of RNase and Kinase Activities of Inositol-Requiring Enzyme 1 (IRE1) on HSV-1 Replication.
Infections
Orf virus encodes a homolog of the vaccinia virus interferon-resistance gene E3L.
Infections
Polynucleotide phosphorylase independently controls virulence factor expression levels and export in Yersinia spp.
Infections
Processing of unstable bacteriophage T4 gene 32 mRNAs into a stable species requires Escherichia coli ribonuclease E.
Infections
Regulation of macrophage gene expression by Mycobacterium tuberculosis: down-regulation of mitochondrial cytochrome c oxidase.
Infections
Regulation of the herpesvirus saimiri (HVS) delayed-early 110-kilodalton promoter by HVS immediate-early gene products and a homolog of the Epstein-Barr virus R trans activator.
Infections
Replication, stability, and gene expression of tobacco mosaic virus mutants with a second 30K ORF.
Infections
Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand.
Infections
Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection.
Infections
Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract.
Infections
Ribonuclease activity of buckwheat plant (Fagopyrum esculentum) cultivars with different sensitivities to buckwheat burn virus.
Infections
Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.
Infections
Ribonucleases in HIV Type 1 Inhibition: Effect of Recombinant RNases on Infection of Primary T Cells and Immune Activation-Induced RNase Gene and Protein Expression.
Infections
RNase 7 but not psoriasin nor sPLA2-IIA associates with Mycobacterium tuberculosis during airway epithelial cell infection.
Infections
RNase 7 Promotes Sensing of Self-DNA by Human Keratinocytes and Activates an Antiviral Immune Response.
Infections
RNase 7 Strongly Promotes TLR9-Mediated DNA Sensing by Human Plasmacytoid Dendritic Cells.
Infections
RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.
Infections
RNase of classical swine fever virus: biochemical characterization and inhibition by virus-neutralizing monoclonal antibodies.
Infections
RNase P-Associated External Guide Sequence Effectively Reduces the Expression of Human CC-Chemokine Receptor 5 and Inhibits the Infection of Human Immunodeficiency Virus 1.
Infections
Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.
Infections
Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells.
Infections
Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
Infections
Selective killing of human immunodeficiency virus-infected cells by targeted gene transfer and inducible gene expression using a recombinant human immunodeficiency virus vector.
Infections
Sequence-specific backbone resonance assignments and microsecond timescale molecular dynamics simulation of human eosinophil-derived neurotoxin.
Infections
Severity of Staphylococcus aureus Infection of the Skin is Associated with Inducibility of Human {beta}-Defensin 3, but not Human {beta}-Defensin 2.
Infections
STUDIES ON INFECTIOUS RNA OF JAPANESE B ENCEPHALITIS VIRUS. II. CHANGE OF RNASE ACTIVITY IN MOUSE BRAINS DURING VIRUS AND RNA INFECTIONS.
Infections
The Coxiella burnetii effector protein CaeB modulates endoplasmatic reticulum (ER) stress signalling and is required for efficient replication in Galleria mellonella.
Infections
The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence.
Infections
The Herpes Simplex Virus Host Shutoff RNase Degrades Cellular and Viral mRNAs Made before Infection but Not Viral mRNA Made after Infection.
Infections
The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation.
Infections
The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna.
Infections
The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs.
Infections
The ribonuclease-III-processing site near the 5' end of an RNA precursor of bacteriophage T4 and its effect on termination.
Infections
The RNase R from Campylobacter jejuni has unique features and is involved in the first steps of infection.
Infections
The two transcription units of the autonomous parvovirus minute virus of mice are transcribed in a temporal order.
Infections
The UCUAAAC promoter motif is not required for high-frequency leader recombination in bovine coronavirus defective interfering RNA.
Infections
The Virion Host Shutoff RNase Plays a Key Role in Blocking the Activation of Protein Kinase R in Cells Infected with Herpes Simplex Virus 1.
Infections
Time course of serum nuclease activity in mice infected with plasmodium malariae.
Infections
TNF-alpha gene-modified dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity in mice.
Infections
Toxoplasma gondii induces the secretion of monocyte chemotactic protein-1 in human fibroblasts, in vitro.
Infections
[Serum nucleases as nonspecific antiviral factors and their role in artificial anti-influenza immunity]
Infertility
Expression of Engineered Nuclear Male Sterility in Brassica napus (Genetics, Morphology, Cytology, and Sensitivity to Temperature).
Infertility
Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease.
Infertility
Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.
Infertility
Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract.
Infertility
Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.
Infertility
Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway.
Infertility, Male
Development of biosafe genetically modified Solanum tuberosum (potato) cultivars for growth within a centre of origin of the crop.
Infertility, Male
RNase Z(S1) processes UbL40 mRNAs and controls thermosensitive genic male sterility in rice.
Influenza, Human
A multi-functional enzyme with RNA polymerase and RNase activities: molecular anatomy of influenza virus RNA polymerase.
Influenza, Human
Cellular 5'-3' mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication.
Influenza, Human
Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice.
Influenza, Human
Delivery of a thermo-enzymatically treated influenza vaccine using pulmonary surfactant in pigs.
Influenza, Human
IgG-neutralized influenza virus undergoes primary, but not secondary uncoating in vivo.
Influenza, Human
Molecular mapping of influenza virus RNA polymerase by site-specific antibodies.
Influenza, Human
RNase L limits host and viral protein synthesis via inhibition of mRNA export.
Influenza, Human
Use of chimeric influenza viruses as a novel internal control for diagnostic rRT-PCR assays.
Influenza, Human
[Inhibitor participation in the regulation of serum RNAse activity in the formation of immunity against influenza]
Influenza, Human
[Serum nucleases as nonspecific antiviral factors and their role in artificial anti-influenza immunity]
Insulin Resistance
RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation.
Insulinoma
Glucose induces glucose 6-phosphatase hydrolytic subunit gene transcription in an insulinoma cell line (INS-1).
Insulinoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Insulinoma
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
Intellectual Disability
Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice.
Keratitis
Recombinant IL-22 promotes protection in a murine model of Aspergillus flavus keratitis and mediates host immune responses in human corneal epithelial cells.
Keratitis, Herpetic
Increased severity of HSV-1 keratitis and mortality in mice lacking the 2-5A-dependent RNase L gene.
Kidney Diseases
Immunological assay of pancreatic ribonuclease in serum as an indicator of pancreatic cancer.
Kidney Failure, Chronic
Influence of renal insufficiency on levels of serum ribonuclease in patients with multiple myeloma.
Kidney Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Latent Infection
Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41.
Leiomyoma
Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium.
Leiomyoma
Relative overexpression of the parathyroid hormone-related protein gene in human leiomyomas.
Leishmaniasis, Visceral
Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi.
Leukemia
A novel ribonuclease with antiproliferative activity toward leukemia and lymphoma cells and HIV-1 reverse transcriptase inhibitory activity from the mushroom, Hohenbuehelia serotina.
Leukemia
A one-tube method of reverse transcription-PCR to efficiently amplify a 3-kilobase region from the RNA polymerase gene to the poly(A) tail of small round-structured viruses (Norwalk-like viruses).
Leukemia
Alteration of cellular ribonucleases associated with murine oncogenic virus infection.
Leukemia
Analysis of two strains of Friend murine leukemia viruses differing in ability to induce early splenomegaly: lack of relationship with generation of recombinant mink cell focus-forming viruses.
Leukemia
Anatomy of the RNA and gene products of MC29 and MH2, two defective avian tumor viruses causing acute leukemia and carcinoma: evidence for a new class of transforming genes.
Leukemia
Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias.
Leukemia
cDNA heterogeneity suggests structural variants related to the high-affinity IgE receptor.
Leukemia
Characterization and mapping of RNase T1-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses.
Leukemia
Characterization of RNA strand displacement synthesis by Moloney murine leukemia virus reverse transcriptase.
Leukemia
Characterization of the double stranded RNA dependent RNase activity associated with recombinant reverse transcriptases.
Leukemia
Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines.
Leukemia
Enhanced amplification of hepatitis C virus (HCV) cDNA by PCR: detection of HCV RNA in archival sera.
Leukemia
Expression of c-myc is not critical for cell proliferation in established human leukemia lines.
Leukemia
Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine.
Leukemia
Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias.
Leukemia
Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias.
Leukemia
Generation of mink cell focus-forming viruses by Friend murine leukemia virus: recombination with specific endogenous proviral sequences.
Leukemia
Mapping host range-specific oligonucleotides within genomes of the ecotropic and mink cell focus-inducing strains of Moloney murine leukemia virus.
Leukemia
Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides.
Leukemia
Plus-strand priming by Moloney murine leukemia virus. The sequence features important for cleavage by RNase H.
Leukemia
Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding specificity and fail to associate productively with rat CD3 zeta.
Leukemia
Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase.
Leukemia
Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template.
Leukemia
Reverse transcriptase-associated RNase H activity. II. Inhibition by natural and synthetic RNA.
Leukemia
Reverse transcription of a naturally occurring nonretroviral RNA produces a precise deletion in the majority of its cDNA products.
Leukemia
Reversion of a Moloney murine leukemia virus RNase H mutant at a second site restores enzyme function and infectivity.
Leukemia
RNase T1-resistant oligonucleotides of an N- and a B-tropic murine leukemia virus of BALB/c: evidence for recombination between these viruses.
Leukemia
RNase T1-resistant oligonucleotides of B-tropic murine leukemia virus from BALB/c and five of its NB-tropic derivatives.
Leukemia
Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and ?ML1-ETO oncogenes.
Leukemia
Structural models of ribonuclease H domains in reverse transcriptases from retroviruses.
Leukemia
Studies on reverse transcriptase of RNA tumor viruses III. Properties of purified Moloney murine leukemia virus DNA polymerase and associated RNase H.
Leukemia
T1 oligonucleotides that segregate with tropism and with properties of gp70 in recombinants between N- and B-tropic murine leukemia viruses.
Leukemia
[Consideration on the classification and therapy of acute leukemia of infants. II. Hydrolysis of leukemia erythrocytes by DNase and RNase. With special reference to normal or leukemic bone marrow cells]
Leukemia L1210
A novel ribonuclease with antiproliferative activity from fresh fruiting bodies of the edible mushroom Hypsizigus marmoreus.
Leukemia L1210
A novel ribonuclease with potent HIV-1 reverse transcriptase inhibitory activity from cultured mushroom Schizophyllum commune.
Leukemia, Erythroblastic, Acute
Cytotoxic potential of ribonuclease and ribonuclease hybrid proteins.
Leukemia, Erythroblastic, Acute
Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette.
Leukemia, Erythroblastic, Acute
Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene.
Leukemia, Erythroblastic, Acute
Isolation of the human aquaporin-1 promoter and functional characterization in human erythroleukemia cell lines.
Leukemia, Erythroblastic, Acute
Rational immunotherapy with ribonuclease chimeras. An approach toward humanizing immunotoxins.
Leukemia, Erythroblastic, Acute
Regulation of Endoribonuclease Activity of Alpha-Type Proteasome Subunits in Proerythroleukemia K562 Upon Hemin-Induced Differentiation.
Leukemia, Erythroblastic, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukemia, Large Granular Lymphocytic
Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Determining of actual activities of acid and alkaline ribonuclease in human serum and urine.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Changes in serum RNase activities in chronic phase and acute crisis of chronic myelocytic leukemia]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Clinical significance of determination of serum RNase activities in patients with eosinophilia--II. Measurements using polyuridylic acid and polycytidylic acid as substrates]
Leukemia, Myeloid, Acute
Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemia.
Leukemia, Myeloid, Acute
Expression of the Kit and KitA receptor isoforms in human acute myelogenous leukemia.
Leukemia, Myeloid, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukemia, Promyelocytic, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukemia, T-Cell
Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines.
Leukemia-Lymphoma, Adult T-Cell
Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma.
Liver Cirrhosis
DNA microarray analysis identified molecular pathways mediating the effects of supplementation of branched-chain amino acids on CCl4-induced cirrhosis in rats.
Liver Cirrhosis
Peroxisome proliferator-activated receptors and hepatic stellate cell activation.
Liver Diseases
Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice.
Liver Failure, Acute
Hepatic expression of hepatocyte growth factor gene mRNA in acute liver failure.
Liver Neoplasms
In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells.
Liver Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Liver Neoplasms, Experimental
Comparison of large fragments obtained by T1 RNase digestion of ribosomal and nucleolar preribosomal RNA of Novikoff hepatoma ascites cells: the 5'-terminal eicosanucleotide.
Liver Neoplasms, Experimental
Isolation and characterization of a 125-kilodalton rapidly labeled nucleolar phosphoprotein.
Liver Neoplasms, Experimental
Modified nucleotides in T1 RNase oligonucleotides of 18S ribosomal RNA of the Novikoff hepatoma.
Liver Neoplasms, Experimental
Sensitivity to RNase treatment of ribosomes and rRNA from normal rat liver and Novikoff hepatoma.
Lung Injury
A role for CD54 (intercellular adhesion molecule-1) in leukocyte recruitment to the lung during the development of experimental idiopathic pneumonia syndrome.
Lung Injury
Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury.
Lung Neoplasms
Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines.
Lung Neoplasms
Antitumor efficacy of the cytotoxic RNase, ranpirnase, on A549 human lung cancer xenografts of nude mice.
Lung Neoplasms
Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung.
Lung Neoplasms
Human ribonuclease with a pendant poly(ethylene glycol) inhibits tumor growth in mice.
Lung Neoplasms
Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.
Lung Neoplasms
IFN-? restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Lung Neoplasms
Influence of nutritional status on circulatory ribonuclease C levels in patients with cancer.
Lung Neoplasms
Mechanisms of enhanced tumoricidal efficacy of multiple small dosages of ranpirnase, the novel cytotoxic ribonuclease, on lung cancer.
Lung Neoplasms
MRP is frequently expressed in human lung-cancer cell lines, in non-small-cell lung cancer and in normal lungs.
Lung Neoplasms
Possible mechanisms of improved radiation response by cytotoxic RNase, Onconase, on A549 human lung cancer xenografts of nude mice.
Lung Neoplasms
Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.
Lung Neoplasms
Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors.
Lung Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Lung Neoplasms
Small cell lung carcinoma cell lines express mRNA for calcitonin and alpha- and beta-calcitonin gene related peptides.
Lung Neoplasms
Validation of a polymerase chain reaction aided transcript titration assay (PATTY) for topoisomerase II in lung cancer samples.
Lupus Erythematosus, Systemic
Catalytic diversity of polyclonal RNA-hydrolyzing IgG antibodies from the sera of patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Characterization and selectivity of catalytic antibodies from human serum with RNase activity.
Lupus Erythematosus, Systemic
Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice.
Lymphatic Metastasis
Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis.
Lymphoma
A novel ribonuclease with antiproliferative activity toward leukemia and lymphoma cells and HIV-1 reverse transcriptase inhibitory activity from the mushroom, Hohenbuehelia serotina.
Lymphoma
A novel ribonuclease with potent HIV-1 reverse transcriptase inhibitory activity from cultured mushroom Schizophyllum commune.
Lymphoma
Antibody targeted therapeutics for lymphoma: new focus on the CD22 antigen and RNA.
Lymphoma
Common and idiosyncratic patterns of cytokine gene expression by Epstein-Barr virus transformed human B cell lines.
Lymphoma
Complementarity determining region-III is a useful molecular marker for the evaluation of minimal residual disease in mantle cell lymphoma.
Lymphoma
Detection of minimal residual disease B cell lymphoma by a PCR-mediated RNase protection assay.
Lymphoma
Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P.
Lymphoma
Features of the chicken c-myc gene that influence the structure of c-myc RNA in normal cells and bursal lymphomas.
Lymphoma
META-controlled env-initiated transcripts encoding superantigens of murine Mtv29 and Mtv7 and their possible role in B cell lymphomagenesis.
Lymphoma
Phase I/II trial of cure-oriented high-dose chemoradiotherapy with transplantation of CD34+ peripheral blood stem cells purified by the immunomagnetic bead method for refractory hematological malignancies. Nagoya CD34+ PBSCT Study Group.
Lymphoma
Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents.
Lymphoma
Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents: a new generation of therapeutics.
Lymphoma, B-Cell
Detection of minimal residual disease B cell lymphoma by a PCR-mediated RNase protection assay.
Lymphoma, Mantle-Cell
Complementarity determining region-III is a useful molecular marker for the evaluation of minimal residual disease in mantle cell lymphoma.
Lymphoma, Mantle-Cell
Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.
Lymphoma, Non-Hodgkin
Antitumour Activity of the Ribonuclease Binase from Bacillus pumilus in the RLS40 Tumour Model Is Associated with the Reorganisation of the miRNA Network and Reversion of Cancer-Related Cascades to Normal Functioning.
Lymphoma, Non-Hodgkin
CD74: a new candidate target for the immunotherapy of B-cell neoplasms.
Lymphoma, T-Cell
Molecular evaluation of bone marrow involvement in peripheral T-cell lymphoma with a PCR-mediated RNase protection assay.
Lymphoma, T-Cell, Cutaneous
Dysregulated Expression of Antimicrobial Peptides in Skin Lesions of Patients with Cutaneous T-cell Lymphoma.
Lymphoma, T-Cell, Peripheral
Molecular evaluation of bone marrow involvement in peripheral T-cell lymphoma with a PCR-mediated RNase protection assay.
Malabsorption Syndromes
Comparison of ochratoxin, aflatoxin, and T-2 toxin for their effects on selected parameters related to digestion and evidence for specific metabolism of carotenoids in chickens.
Malnutrition
Effects of early undernutrition and subsequent refeeding on alkaline ribonuclease activity of rat cerebrum and liver.
Malnutrition
Suboptimal energy balance selectively up-regulates muscle GLUT gene expression but reduces insulin-dependent glucose uptake during postnatal development.
Measles
RNA interference with measles virus N, P, and L mRNAs efficiently prevents and with matrix protein mRNA enhances viral transcription.
Megalencephaly
Hotspot mutations in DICER1 causing GLOW Syndrome-associated macrocephaly via modulation of specific microRNA populations results in activation of PI3K/ATK/mTOR signaling.
Melanoma
Antitumor action of bovine seminal ribonuclease. Cytostatic effect on human melanoma and mouse seminoma.
Melanoma
Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivo.
Melanoma
Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells.
Melanoma
Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival.
Melanoma
Mutation Scanning of D1705 and D1709 in the RNAse IIIb Domain of MicroRNA Processing Enzyme Dicer in Cutaneous Melanoma.
Melanoma
Phenotypic profiling of engineered mouse melanomas with manipulated histamine production identifies histamine H2 receptor and rho-C as histamine-regulated melanoma progression markers.
Melanoma
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.
Mesothelioma, Malignant
A novel combination: ranpirnase and rosiglitazone induce a synergistic apoptotic effect by down-regulating Fra-1 and Survivin in cancer cells.
Mesothelioma, Malignant
Secretory expression of glycosylated and aglycosylated mutein of onconase from Pichia pastoris using different secretion signals and their purification and characterization.
Metabolic Diseases
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers.
Metrorrhagia
[Sample pre-processing for mass spectrometric analysis of glycoprotein structure]
Mitochondrial Myopathies
A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome, diabetes mellitus, hyperthyroidism and cardiomyopathy.
Mouth Neoplasms
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
Multiple Myeloma
Influence of renal insufficiency on levels of serum ribonuclease in patients with multiple myeloma.
Multiple Myeloma
Targeting Adaptive IRE1? Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib.
Multiple Sclerosis
Hydrolysis of myelin basic protein by polyclonal catalytic IgGs from the sera of patients with multiple sclerosis.
Multiple Sclerosis
Simultaneous measurement of 2':3' cyclic-nucleotide 3' phosphodiesterase and RNase activities in sera and spinal fluids of multiple sclerosis patients.
Muscle Spasticity
5-HT1Dbeta receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina.
Muscle Spasticity
Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines.
Mycoplasma Infections
Elevation of endothelin biosynthesis in human endothelial cells with mycoplasma infection.
Mycoses
Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 against Candida albicans.
Myocardial Infarction
Determining of actual activities of acid and alkaline ribonuclease in human serum and urine.
Myocardial Infarction
Extracellular RNA, a Potential Drug Target for Alleviating Atherosclerosis, Ischemia/Reperfusion Injury and Organ Transplantation.
Myocardial Infarction
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
Myocardial Infarction
Reemergence of the fetal pattern of L-type calcium channel gene expression in non infarcted myocardium during left ventricular remodeling.
Myocardial Infarction
The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
Myocarditis
Electrical remodeling of the ventricular myocardium in myocarditis: studies of rat experimental autoimmune myocarditis.
Myocarditis
NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia.
Nasopharyngeal Carcinoma
Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumours.
Neoplasm Metastasis
Augmented expression of LCK message directed from the downstream promoter in human colorectal cancer specimens.
Neoplasm Metastasis
Different tendencies of changes in hydrolytic enzyme activities in sera from prostatic cancer patients with or without bone metastasis.
Neoplasm Metastasis
Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis.
Neoplasm Metastasis
Expression of multidrug resistance (p-glycoprotein) mdr1 and mdr2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors.
Neoplasm Metastasis
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis.
Neoplasm Metastasis
Influence of nutritional status on circulatory ribonuclease C levels in patients with cancer.
Neoplasm Metastasis
Intracellular CD24 inhibits cell invasion by posttranscriptional regulation of BART through interaction with G3BP.
Neoplasm Metastasis
Mutation Scanning of D1705 and D1709 in the RNAse IIIb Domain of MicroRNA Processing Enzyme Dicer in Cutaneous Melanoma.
Neoplasm, Residual
Detection of minimal residual disease B cell lymphoma by a PCR-mediated RNase protection assay.
Neoplasm, Residual
Molecular evaluation of bone marrow involvement in peripheral T-cell lymphoma with a PCR-mediated RNase protection assay.
Neoplasms
A chronic mouse model of myocardial ischemia-reperfusion: essential in cytokine studies.
Neoplasms
A Conserved Structural Determinant Located at the Interdomain Region of Mammalian Inositol-requiring Enzyme 1{alpha}.
Neoplasms
A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells.
Neoplasms
A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells.
Neoplasms
A multifunctional ribonuclease A-conjugated carbon dot cluster nanosystem for synchronous cancer imaging and therapy.
Neoplasms
A novel strategy for engineering of a smart generation of immune ribonucleases against EGFR+ cells.
Neoplasms
A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells.
Neoplasms
A v-H-ras-dependent hemopoietic tumor model involving progression from a clonal stage of transformation competence to autocrine interleukin 3 production.
Neoplasms
Aberrant expression of type I fibroblast growth factor receptor in human pancreatic adenocarcinomas.
Neoplasms
Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors.
Neoplasms
Action of bull seminal vesicle ribonuclease on mouse leukaemic cells BP-8 and EL-4.
Neoplasms
Affinity labelling and characterization of the ppp(A2'p)nA-dependent endoribonuclease from different mammalian sources.
Neoplasms
Alteration of cellular ribonucleases associated with murine oncogenic virus infection.
Neoplasms
Alterations in ribonuclease activities in the plasma, spleen, and thymus of tumor-bearing mice.
Neoplasms
Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumours.
Neoplasms
Alternative internal splicing in c-myb RNAs occurs commonly in normal and tumor cells.
Neoplasms
Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancers.
Neoplasms
Analysis of telomerase activity in ovarian cystadenomas, low-malignant-potential tumors, and invasive carcinomas.
Neoplasms
Antitumor action of bovine seminal ribonuclease. Cytostatic effect on human melanoma and mouse seminoma.
Neoplasms
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity.
Neoplasms
APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
Neoplasms
Application of a multiprobe RNase protection assay and junctional sequences to define V beta gene diversity in Sezary syndrome.
Neoplasms
Assessment of the clinical usefulness of serum ribonuclease assays: an indicator for the detection of pancreatic cancer.
Neoplasms
Augmented expression of LCK message directed from the downstream promoter in human colorectal cancer specimens.
Neoplasms
Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation.
Neoplasms
Biobanking of Fresh-Frozen Cancer Tissue: RNA Is Stable Independent of Tissue Type with Less Than 1 Hour of Cold Ischemia.
Neoplasms
Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery.
Neoplasms
Bovine seminal ribonuclease induces in vitro concentration dependent apoptosis in stimulated human lymphocytes and cells from human tumor cell lines.
Neoplasms
Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells.
Neoplasms
C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification and correlation with prognosis.
Neoplasms
Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis.
Neoplasms
CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
Neoplasms
Cell cycle-related differences in susceptibility of NIH/3T3 cells to ribonucleases.
Neoplasms
Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis.
Neoplasms
Characterization of the promoter for the human long pentraxin PTX3. Role of NF-kappaB in tumor necrosis factor-alpha and interleukin-1beta regulation.
Neoplasms
Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes.
Neoplasms
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers.
Neoplasms
Clinical and Molecular Characteristics May Alter Treatment Strategies of Thyroid Malignancies in DICER1-syndrome.
Neoplasms
Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil.
Neoplasms
Clinical significance of circ-MTHFD2 in diagnosis, pathological staging and prognosis of NSCLC.
Neoplasms
Coexpression of mRNA for the full-length neurotrophin receptor trk-C and trk-A in favourable neuroblastoma.
Neoplasms
Comparative base specificity, stability, and lectin activity of two lectins from eggs of Rana catesbeiana and R. japonica and liver ribonuclease from R. catesbeiana.
Neoplasms
Comparison of antitumor activities of pancreatic ribonuclease and its cross-linked dimer.
Neoplasms
Comparison of O6-methylguanine-DNA methyltransferase mRNA levels in Ha-ras mutated and non-mutated rat mammary tumors induced by N-methyl-N-nitrosourea.
Neoplasms
Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene.
Neoplasms
Control of endogenous mouse mammary tumor virus superantigen expression in SJL lymphomas by a promoter within the env region.
Neoplasms
Coordinate expression of Wilms' tumor genes correlates with Wilms' tumor phenotypes.
Neoplasms
Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion.
Neoplasms
Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo.
Neoplasms
Cytokines down-regulate alpha1-adrenergic receptor expression during endotoxemia.
Neoplasms
Cytosolic protein delivery via metabolic glycoengineering and bioorthogonal click reactions.
Neoplasms
Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter.
Neoplasms
Detection of in situ activation of transglutaminase during apoptosis: correlation with the cell cycle phase by multiparameter flow and laser scanning cytometry.
Neoplasms
Detection of minimal residual disease B cell lymphoma by a PCR-mediated RNase protection assay.
Neoplasms
Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay.
Neoplasms
Detection of tumor-associated circulating mRNA in patients with disseminated malignant melanoma.
Neoplasms
Dicer1 Promotes Colon Cancer Cell Invasion and Migration Through Modulation of tRF-20-MEJB5Y13 Expression Under Hypoxia.
Neoplasms
DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.
Neoplasms
DICER1 somatic mutations strongly impair miRNA processing even in benign thyroid lesions.
Neoplasms
Differential cytokine gene expression in the diaphragm in response to strenuous resistive breathing.
Neoplasms
Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung.
Neoplasms
Dinaciclib (SCH727965) Inhibits the Unfolded Protein Response through a CDK1- and 5-Dependent Mechanism.
Neoplasms
Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection.
Neoplasms
Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors.
Neoplasms
DNA array and biological characterization of the impact of the maturation status of mouse dendritic cells on their phenotype and antitumor vaccination efficacy.
Neoplasms
DNAzyme-Catalyzed Cellular Oxidative Stress Amplification for Pro-protein Activation in Living Cells.
Neoplasms
Ectopic production and processing of atrial natriuretic peptide in a small cell lung carcinoma cell line and tumor from a patient with hyponatremia.
Neoplasms
Effect of Cytostatic Drugs on the mRNA Expression Levels of Ribonuclease k in Breast and Ovarian Cancer Cells.
Neoplasms
Effect of native and modified bull seminal ribonuclease on tumour and testicular cells and phytohaemagglutinin-stimulated pig lymphocytes.
Neoplasms
Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P.
Neoplasms
Elevated expression of transforming growth factor betas and the tumor necrosis factor family in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Neoplasms
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Neoplasms
Epidermal growth factor gene expression in human breast cancer biopsy samples: relationship to estrogen and progesterone receptor gene expression.
Neoplasms
Epidermal growth factor receptor mRNA levels in human prostatic tumors and cell lines.
Neoplasms
Exploring the association between DICER1 mutations and differentiated thyroid carcinoma.
Neoplasms
Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis.
Neoplasms
Expression of Brca1 and splice variant Brca1delta11 RNA levels in mouse mammary gland during normal development and tumorigenesis.
Neoplasms
Expression of genes involved with cell cycle control, cell growth and chromatin modification are altered in hepatoblastomas.
Neoplasms
Expression of hepatocyte-enriched nuclear transcription factors in mouse liver tumours.
Neoplasms
Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemia.
Neoplasms
Expression of multidrug resistance (p-glycoprotein) mdr1 and mdr2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors.
Neoplasms
Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells.
Neoplasms
Expression of TGFß1 and its receptors is associated with biological features of ovarian cancer and sensitivity to paclitaxel/carboplatin.
Neoplasms
Expression of the cholecystokinin gene by cultured human primitive neuroepithelioma cell lines.
Neoplasms
Expression of the full-length form of gp2 of equine herpesvirus 1 (EHV-1) completely restores respiratory virulence to the attenuated EHV-1 strain KyA in CBA mice.
Neoplasms
Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma.
Neoplasms
Expression of the multidrug resistance protein (MRP) in squamous cell carcinoma of the oesophagus and response to pre-operative chemotherapy.
Neoplasms
Expression of the multidrug resistance-associated protein (MRP) gene in human cancers.
Neoplasms
Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.
Neoplasms
Expression of transforming growth factor beta mRNA isoforms in human breast cancer.
Neoplasms
Expressional profiling and clinical relevance of RNase ? in prostate cancer: a novel indicator of favorable progression-free survival.
Neoplasms
Feeding status and bacterial LPS-induced cytokine and neuropeptide gene expression in hypothalamus.
Neoplasms
Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate.
Neoplasms
Flow cytometric analysis of in vivo polyamine deprivation in Lewis lung carcinoma (3LL) cells using the monoclonal antibody SPM8-2.
Neoplasms
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
Neoplasms
FOXO3 and Related Transcription Factors in Development, Aging, and Exceptional Longevity.
Neoplasms
Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers.
Neoplasms
From housekeeper to microsurgeon: the diagnostic and therapeutic potential of ribonucleases.
Neoplasms
Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma.
Neoplasms
Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity.
Neoplasms
Genome-Wide Analysis of the Expression of Circular RNA Full-Length Transcripts and Construction of the circRNA-miRNA-mRNA Network in Cervical Cancer.
Neoplasms
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Neoplasms
Germline and Somatic DICER1 Mutations in a Well-Differentiated Fetal Adenocarcinoma of the Lung.
Neoplasms
Glioma cells deficient in urokinase plaminogen activator receptor expression are susceptible to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis.
Neoplasms
High expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukaemia.
Neoplasms
High-sensitivity sequencing reveals multi-organ somatic mosaicism causing DICER1 syndrome.
Neoplasms
HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand.
Neoplasms
Human Liver Stem Cell-Derived Microvesicles Inhibit Hepatoma Growth in SCID Mice by Delivering Antitumor MicroRNAs.
Neoplasms
Human recombinant truncated RNASET2, devoid of RNase activity; A potential cancer therapeutic agent.
Neoplasms
Human ribonuclease with a pendant poly(ethylene glycol) inhibits tumor growth in mice.
Neoplasms
Human tumor-cell growth modulatory effects of the aebs/hic-binding drugs used as single agents and in combination with a novel amphibian oocyte rnase.
Neoplasms
Hypoxia-sensitive supramolecular nanogels for the cytosolic delivery of ribonuclease A as a breast cancer therapeutic.
Neoplasms
Immunohistochemical demonstration of ribonuclease and amylase in normal and neoplastic parotid glands.
Neoplasms
Immunological assay of pancreatic ribonuclease in serum as an indicator of pancreatic cancer.
Neoplasms
In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB.
Neoplasms
In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells.
Neoplasms
In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease.
Neoplasms
In vivo evidence for progressive activation of parathyroid hormone-related peptide gene transcription with tumor growth and stimulation of osteoblastic bone formation at an early stage of humoral hypercalcemia of cancer.
Neoplasms
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.
Neoplasms
Increase in RNase and DPNase activities in ascites tumor cells induced by various cytostatic agents.
Neoplasms
Increased mRNA expression of the receptor-like protein tyrosine phosphatase alpha in late stage colon carcinomas.
Neoplasms
Independent regulation of ppp(A2'p)nA-dependent RNase in NIH 3T3, clone 1 cells by growth arrest and interferon treatment.
Neoplasms
Induction of TNF-alpha, uPA, IL-8 and MCP-1 by doxorubicin in human lung carcinoma cells.
Neoplasms
Influence of Capsaicin on Inflammatory Cytokines Induced by Lipopolysaccharide in Myoblast Cells Under In vitro Environment.
Neoplasms
Influence of nutritional status on circulatory ribonuclease C levels in patients with cancer.
Neoplasms
Influence of renal insufficiency on levels of serum ribonuclease in patients with multiple myeloma.
Neoplasms
Inhibition of cell proliferation by Rana catesbeiana and Rana japonica lectins belonging to the ribonuclease superfamily.
Neoplasms
Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen.
Neoplasms
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.
Neoplasms
Inhibition of TGF-beta modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma.
Neoplasms
Inhibitory effects of pyrrolidine dithiocarbamate on endotoxin-induced uveitis in Lewis rats.
Neoplasms
Interferon action. Covalent linkage of (2'-5')pppApApA(32P)pCp to (2'-5')(A)n-dependent ribonucleases in cell extracts by ultraviolet irradiation.
Neoplasms
Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra.
Neoplasms
Interleukin-1beta system (ligand, receptor type I, receptor accessory protein and receptor antagonist), TNF-alpha, TGF-beta1 and neuropeptide Y mRNAs in specific brain regions during bacterial LPS-induced anorexia.
Neoplasms
Isolation and properties of a single-strand 5'----3' exoribonuclease from Ehrlich ascites tumor cell nucleoli.
Neoplasms
Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24.
Neoplasms
Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes.
Neoplasms
Lipoteichoic acid induces delayed protection in the rat heart: A comparison with endotoxin.
Neoplasms
Loss of heterozygosity of the TP53 tumor suppressor gene and detection of point mutations by the non-isotopic RNAse cleavage assay in prostate cancer.
Neoplasms
Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma.
Neoplasms
Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end.
Neoplasms
Mechanism of the linkage between te electrophoretic mobility and oxygen uptake of ascites tumor cells.
Neoplasms
Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network.
Neoplasms
Methylation changes in the human IGF2 p3 promoter parallel IGF2 expression in the primary tumor, established cell line, and xenograft of a human hepatoblastoma.
Neoplasms
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
Neoplasms
MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival.
Neoplasms
Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins.
Neoplasms
MMP-2 and MMP-9 expression in breast cancer-derived human fibroblasts is differentially regulated by stromal-epithelial interactions.
Neoplasms
Modelling of electrokinetic phenomena for capture of PEGylated ribonuclease A in a microdevice with insulating structures.
Neoplasms
Molecular and mechanistic validation of delayed healing rat wounds as a model for human chronic wounds.
Neoplasms
Molecular characterization of the loss of p75(NTR) expression in human prostate tumor cells.
Neoplasms
Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase.
Neoplasms
Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily.
Neoplasms
Molecular docking and dynamics simulations of A.niger RNase from Aspergillus niger ATCC26550: for potential prevention of human cancer.
Neoplasms
MRP is frequently expressed in human lung-cancer cell lines, in non-small-cell lung cancer and in normal lungs.
Neoplasms
Murine myeloid leukemic cells with disrupted myb loci show splicing anomalies that account for heterogeneous sizes in myb proteins.
Neoplasms
Natural antisense RNA promotes 3' end processing and maturation of MALAT1 lncRNA.
Neoplasms
Negatively charged RNase-susceptible molecules on the surface of ascites tumor cells.
Neoplasms
Neuron-specific hel-N1 and HuD as novel molecular markers of neuroblastoma: a correlation of HuD messenger RNA levels with favorable prognostic features.
Neoplasms
Noncovalent Stabilization of Vesicular Polyion Complexes with Chemically Modified/Single-Stranded Oligonucleotides and PEG-b-guanidinylated Polypeptides for Intracavity Encapsulation of Effector Enzymes Aimed at Cooperative Gene Knockdown.
Neoplasms
Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors.
Neoplasms
Nonisotopic quantitation of mRNA using a novel RNase protection assay: measurement of erbB-2 mRNA in tumor cell lines.
Neoplasms
Novel human malignancy-associated gene (MAG) expressed in various tumors and in some tumor preexisting conditions.
Neoplasms
Organometallic dendrimers based on Ruthenium(II) N-heterocyclic carbenes and their implication as delivery systems of anticancer small interfering RNA.
Neoplasms
Ovarian tumors related to intronic mutations in DICER1: a report from the international ovarian and testicular stromal tumor registry.
Neoplasms
Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.
Neoplasms
Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells.
Neoplasms
Pancreatic elastase is proven to be a mannose-binding protein--implications for the systemic response to pancreatitis.
Neoplasms
PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors.
Neoplasms
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.
Neoplasms
Phase I/II trial of cure-oriented high-dose chemoradiotherapy with transplantation of CD34+ peripheral blood stem cells purified by the immunomagnetic bead method for refractory hematological malignancies. Nagoya CD34+ PBSCT Study Group.
Neoplasms
Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas.
Neoplasms
Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase.
Neoplasms
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.
Neoplasms
Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations.
Neoplasms
Postnatal lung development: immediate-early gene responses post ozone and LPS exposure.
Neoplasms
Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell.
Neoplasms
Presence and distribution of human papillomavirus sense and antisense RNA transcripts in genital cancers.
Neoplasms
Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines.
Neoplasms
Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development.
Neoplasms
Prostate, adrenocortical, and brown adipose tumors in fetal globin/T antigen transgenic mice.
Neoplasms
Purification and properties of a nuclear exoribonuclease from Ehrlich ascites tumor cells.
Neoplasms
Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors.
Neoplasms
Quantitative reevaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues.
Neoplasms
Radioimmunoassay for human pancreatic ribonuclease and measurement of serum immunoreactive pancreatic ribonuclease in patients with malignant tumors.
Neoplasms
Ranpirnase (frog RNase) targeted with a humanized, internalizing, anti-Trop-2 antibody has potent cytotoxicity against diverse epithelial cancer cells.
Neoplasms
Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding specificity and fail to associate productively with rat CD3 zeta.
Neoplasms
Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.
Neoplasms
Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour.
Neoplasms
Regulation of the conserved 3'-5' exoribonuclease EXOSC10/Rrp6 during cell division, development and cancer.
Neoplasms
Regulation of TL antigen expression. Analysis of the T18d promoter region and responses to IFN-gamma.
Neoplasms
Relationship of clone 4 estrogen receptor variant messenger RNA expression to some known prognostic variables in human breast cancer.
Neoplasms
Resistance of pancreatic carcinoma cells is reversed by coculturing NK-like T cells with dendritic cells pulsed with tumor-derived RNA and CA 19-9.
Neoplasms
Restoration of hair growth in mice with an alopecia areata-like disease using topical anthralin.
Neoplasms
Reverse transcriptase of RNA tumor viruses. V. In vitro proteolysis of reverse transcriptase from avian myeloblastosis virus and isolation of a polypeptide manifesting only RNase H activity.
Neoplasms
RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma.
Neoplasms
RNase 3 (ECP) is an extraordinarily stable protein among human pancreatic-type RNases.
Neoplasms
RNase MC2: a new Momordica charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of MAPKs and induction of caspase pathways.
Neoplasms
RNase non-sensitive and endocytosis independent siRNA delivery system: delivery of siRNA into tumor cells and high efficiency induction of apoptosis.
Neoplasms
Role of the N terminus in RNase A homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity.
Neoplasms
Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line.
Neoplasms
Secretion of ribonucleases by normal and immortalized cells grown in serum-free culture conditions.
Neoplasms
Sensitively distinguishing intracellular precursor and mature microRNA abundance.
Neoplasms
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Neoplasms
Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53.
Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Neoplasms
Specific and sensitive detection of CircRNA based on netlike hybridization chain reaction.
Neoplasms
Structure-function relationships of acid ribonucleases: lysosomal, vacuolar, and periplasmic enzymes.
Neoplasms
Studies on reverse transcriptase of RNA tumor viruses III. Properties of purified Moloney murine leukemia virus DNA polymerase and associated RNase H.
Neoplasms
Studies on reverse transcriptase of RNA tumor viruses. I. Localization of thermolabile DNA polymerase and RNase H activities on one polypeptide.
Neoplasms
Studies on the allosteric properties of nuclear exoribonuclease from Ehrlich ascites tumor.
Neoplasms
Synergistic cytotoxicity of Rana catesbeiana ribonuclease and IFN-gamma on hepatoma cells.
Neoplasms
Synthesis of adenosine-N6-methyl, propylthioether-N-pyridoxamine: an analog of a novel vitamin B6 tumor product.
Neoplasms
Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.
Neoplasms
Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology.
Neoplasms
Targeted knockdown of death-associated protein kinase expression induces TRAIL-mediated apoptosis in human endometrial adenocarcinoma cells.
Neoplasms
Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer.
Neoplasms
Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model.
Neoplasms
The activated Mlvi-4 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas encodes an env/Mlvi-4 fusion protein.
Neoplasms
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome.
Neoplasms
The human type VI collagen gene. mRNA and protein variants of the alpha 3 chain generated by alternative splicing of an additional 5-end exon.
Neoplasms
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.
Neoplasms
The short form of the alternatively spliced flt-4 but not its ligand vascular endothelial growth factor C is related to lymph node metastasis in human breast cancers.
Neoplasms
The therapeutic mechanisms of ranpirnase-induced enhancement of radiation response on A549 human lung cancer.
Neoplasms
The ubiquitous VA68 isoform of subunit A of the vacuolar H(+)-ATPase is highly expressed in human osteoclasts.
Neoplasms
The Value of DICER1 Mutation Analysis in "Subtle" Diagnostically Challenging Embryonal Rhabdomyosarcomas of the Uterine Cervix.
Neoplasms
Theiler's murine encephalomyelitis virus induces apoptosis in gamma interferon-activated M1 differentiated myelomonocytic cells through a mechanism involving tumor necrosis factor alpha (TNF-alpha) and TNF-alpha-related apoptosis-inducing ligand.
Neoplasms
Thoracic Sertoli-Leydig cell tumor: An alternative type of pleuropulmonary blastoma associated with DICER1 variation.
Neoplasms
Tissue-specific expression of functional isoforms of mouse folypoly-gamma-glutamae synthetase: a basis for targeting folate antimetabolites.
Neoplasms
Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes.
Neoplasms
Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review).
Neoplasms
Unique expression patterns of H19 in human testicular cancers of different etiology.
Neoplasms
Validation of a polymerase chain reaction aided transcript titration assay (PATTY) for topoisomerase II in lung cancer samples.
Neoplasms
Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability.
Neoplasms
Vascular endothelial growth factor-B and vascular endothelial growth factor-C expression in renal cell carcinomas: regulation by the von Hippel-Lindau gene and hypoxia.
Neoplasms
X-Ray Crystallographic Structure of Hericium erinaceus Ribonuclease, RNase He1 in Complex with Zinc.
Neoplasms
[Changes of plasma ribonuclease activities according to the method of treatment in gynecologic cancer patients (author's transl)]
Neoplasms
[Expression, purification and characterization of recombinant onconase expressed in Pichia pastoris].
Neoplasms
[Regulation of the RNAse activity of the saliva in healthy subjects and in stomach cancer]
Neoplasms
[The value of poly-C-specific serum ribonuclease and CEA in the diagnosis of pancreatic carcinoma (author's transl)]
Neoplasms, Germ Cell and Embryonal
DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.
Neoplasms, Germ Cell and Embryonal
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Neoplasms, Germ Cell and Embryonal
Unique expression patterns of H19 in human testicular cancers of different etiology.
Nephritis, Interstitial
Extracellular matrix accumulation in immune-mediated tubulointerstitial injury.
Nervous System Diseases
Age-related changes in the proportion of amyloid precursor protein mRNAs in Alzheimer's disease and other neurological disorders.
Neurilemmoma
Neurofibromatosis 2 phenotypes and germ-line NF2 mutations determined by an RNA mismatch method and loss of heterozygosity analysis in NF2 schwannomas.
Neuroblastoma
Bovine seminal ribonuclease induces in vitro concentration dependent apoptosis in stimulated human lymphocytes and cells from human tumor cell lines.
Neuroblastoma
Expression of the cholecystokinin gene by cultured human primitive neuroepithelioma cell lines.
Neuroblastoma
HepG2 and SK-N-MC: two human models to study alpha-2 adrenergic receptors of the alpha-2C subtype.
Neuroblastoma
In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.
Neuroblastoma
Loss of DCC expression in neuroblastoma is associated with disease dissemination.
Neuroblastoma
Nucleotide sequence and promoter-specific effect of a negative regulatory region located upstream of the mouse proliferating cell nuclear antigen gene.
Neuroblastoma
Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants.
Neuroblastoma
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.
Neuroblastoma
Single amino acid substitutions at the N-terminus of a recombinant cytotoxic ribonuclease markedly influence biochemical and biological properties.
Neurodegenerative Diseases
The cellular uptake of angiogenin, an angiogenic and neurotrophic factor is through multiple pathways and largely dynamin independent.
Neuroectodermal Tumors, Primitive
Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors.
Neuroectodermal Tumors, Primitive
Interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-1 receptor type I, IL-1 receptor antagonist, and TGF-beta 1 mRNAs in pediatric astrocytomas, ependymomas, and primitive neuroectodermal tumors.
Neurofibromatosis 2
Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancers.
Neurofibromatosis 2
Neurofibromatosis 2 phenotypes and germ-line NF2 mutations determined by an RNA mismatch method and loss of heterozygosity analysis in NF2 schwannomas.
Neuromuscular Diseases
Expression of foetal type acetylcholine receptor is restricted to type 1 muscle fibres in human neuromuscular disorders.
Opportunistic Infections
Relationship of in vivo and ex vivo levels of T(H)1 and T(H)2 cytokines with viremia in HAART patients with and without opportunistic infections.
Osteogenesis Imperfecta
Detection of mutations in human type I collagen mRNA in osteogenesis imperfecta by indirect RNase protection.
Osteosarcoma
Differential expression of cytokines in rat osteosarcoma and malignant fibrous histiocytoma cell lines induced by 4-(hydroxyamino)quinoline-1-oxide.
Osteosarcoma
Osteoprotegerin mRNA is expressed in primary human osteoblast-like cells: down-regulation by glucocorticoids.
Osteosarcoma
Relationship of bone morphogenetic protein expression during osteoblast differentiation to wild type p53.
Ovarian Neoplasms
Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells.
Ovarian Neoplasms
DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.
Ovarian Neoplasms
Effect of Cytostatic Drugs on the mRNA Expression Levels of Ribonuclease k in Breast and Ovarian Cancer Cells.
Ovarian Neoplasms
Germline BRCA1 alterations in a population-based series of ovarian cancer cases.
Ovarian Neoplasms
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.
Ovarian Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Ovarian Neoplasms
[Changes of plasma ribonuclease activities according to the method of treatment in gynecologic cancer patients (author's transl)]
Pancreatic Diseases
Renal factors in serum trypsinogen 1 metabolism and excretion in chronic pancreatic disease.
Pancreatic Diseases
[The value of poly-C-specific serum ribonuclease and CEA in the diagnosis of pancreatic carcinoma (author's transl)]
Pancreatic Neoplasms
"Plasma"-type ribonuclease in pancreatic cancer diagnosis: a critical appraisal.
Pancreatic Neoplasms
A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications.
Pancreatic Neoplasms
Acquired resistance of pancreatic cancer cells towards 5-Fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes.
Pancreatic Neoplasms
Assessment of the clinical usefulness of serum ribonuclease assays: an indicator for the detection of pancreatic cancer.
Pancreatic Neoplasms
Combined evaluation of serum ribonuclease and ferritin: any advantages in pancreatic cancer diagnosis?
Pancreatic Neoplasms
Crosstalk between Extrinsic and Intrinsic Cell Death Pathways in Pancreatic Cancer: Synergistic Action of Estrogen Metabolite and Ligands of Death Receptor Family.
Pancreatic Neoplasms
Immunological assay of pancreatic ribonuclease in serum as an indicator of pancreatic cancer.
Pancreatic Neoplasms
Radioimmunoassay for human pancreatic ribonuclease and measurement of serum immunoreactive pancreatic ribonuclease in patients with malignant tumors.
Pancreatic Neoplasms
Renal factors in serum trypsinogen 1 metabolism and excretion in chronic pancreatic disease.
Pancreatic Neoplasms
Ribonucleases expressed by human pancreatic adenocarcinoma cell lines.
Pancreatic Neoplasms
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Pancreatic Neoplasms
Serum deoxyribonuclease and ribonuclease in pancreatic cancer and chronic pancreatitis.
Pancreatic Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Pancreatic Neoplasms
[Changes of RNase activity on DIPN induced experimental pancreatic cancer (author's transl)]
Pancreatic Neoplasms
[Study on the diagnosis of pancreatic cancer by serum RNase (author's transl)]
Pancreatic Neoplasms
[The value of poly-C-specific serum ribonuclease and CEA in the diagnosis of pancreatic carcinoma (author's transl)]
Pancreatitis
"Plasma"-type ribonuclease in pancreatic cancer diagnosis: a critical appraisal.
Pancreatitis
Assessment of the clinical usefulness of serum ribonuclease assays: an indicator for the detection of pancreatic cancer.
Pancreatitis
Regulation of mouse pancreatitis-associated protein-I gene expression during caerulein-induced acute pancreatitis.
Pancreatitis
Relationship between pancreatic enzymes and pathological changes in the pancreas in acute pancreatitis. The significance of determination of serum deoxyribonuclease.
Pancreatitis
Serum ribonuclease activity in patients during parenteral nutrition, chronic hemodialysis and acute pancreatitis.
Pancreatitis
[The value of poly-C-specific serum ribonuclease and CEA in the diagnosis of pancreatic carcinoma (author's transl)]
Pancreatitis, Acute Necrotizing
Serum ribonuclease activity in the diagnosis of pancreatic disease.
Pancreatitis, Acute Necrotizing
Serum ribonuclease elevations and pancreatic necrosis in acute pancreatitis.
Pancreatitis, Chronic
"Plasma"-type ribonuclease in pancreatic cancer diagnosis: a critical appraisal.
Pancreatitis, Chronic
Combined evaluation of serum ribonuclease and ferritin: any advantages in pancreatic cancer diagnosis?
Pancreatitis, Chronic
Renal factors in serum trypsinogen 1 metabolism and excretion in chronic pancreatic disease.
Pancreatitis, Chronic
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Pancreatitis, Chronic
Serum deoxyribonuclease and ribonuclease in pancreatic cancer and chronic pancreatitis.
Pancreatitis, Chronic
[The value of poly-C-specific serum ribonuclease and CEA in the diagnosis of pancreatic carcinoma (author's transl)]
Papilloma
The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues.
Parasitemia
Optimisation of flow cytometric measurement of parasitaemia in plasmodium-infected mice.
Parathyroid Neoplasms
Reduced parathyroid vitamin D receptor messenger ribonucleic acid levels in primary and secondary hyperparathyroidism.
Paratuberculosis
Unexpected detection of DNA by nucleic acid sequence-based amplification technique.
Parkinson Disease
Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.
Parotitis
[Effect of a number of enzyme preparations on the course of experimental parotitis]
Pelvic Inflammatory Disease
Molecular cloning and nucleic acid sequencing of Chlamydia trachomatis 16S rRNA genes from patient samples lacking the cryptic plasmid.
Peritonitis
Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis.
Persistent Infection
Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs.
Persistent Infection
Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R.
Persistent Infection
Bovine viral diarrhea virus: prevention of persistent fetal infection by a combination of two mutations affecting Erns RNase and Npro protease.
Persistent Infection
Lipid Binding of the Amphipathic Helix Serving as Membrane Anchor of Pestivirus Glycoprotein Erns.
Persistent Infection
Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica.
Pestivirus Infections
Pestiviral E(rns) blocks TLR-3-dependent IFN synthesis by LL37 complexed RNA.
Pheochromocytoma
Inactivation of the p53 gene is not required for tumorigenesis of medullary thyroid carcinoma or pheochromocytoma.
Plasmacytoma
Influence of renal insufficiency on levels of serum ribonuclease in patients with multiple myeloma.
Pneumonia
T(H)2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages.
Polycystic Kidney Diseases
Nonselective Cyclooxygenase Inhibition Retards Cyst Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease.
Polyneuropathies
A novel variant of transthyretin (Glu89Lys) associated with familial amyloidotic polyneuropathy.
Polyneuropathies
Identification of a new transthyretin variant (Ile49) in familial amyloidotic polyneuropathy using electrospray ionization mass spectrometry and nonisotopic RNase cleavage assay.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6-deoxythioguanosine incorporation into DNA.
Prion Diseases
Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides.
Prostatic Hyperplasia
Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis.
Prostatic Hyperplasia
Quantification and distribution of alpha 1-adrenoceptor subtype mRNAs in human prostate: comparison of benign hypertrophied tissue and non-hypertrophied tissue.
Prostatic Neoplasms
A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells.
Prostatic Neoplasms
Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study.
Prostatic Neoplasms
Circular RNAs add diversity to androgen receptor isoform repertoire in castration-resistant prostate cancer.
Prostatic Neoplasms
Circulating microRNAs as stable blood-based markers for cancer detection.
Prostatic Neoplasms
Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates.
Prostatic Neoplasms
Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis.
Prostatic Neoplasms
Expressional profiling and clinical relevance of RNase ? in prostate cancer: a novel indicator of favorable progression-free survival.
Prostatic Neoplasms
Loss of heterozygosity of the TP53 tumor suppressor gene and detection of point mutations by the non-isotopic RNAse cleavage assay in prostate cancer.
Prostatic Neoplasms
The potential impact of adding genetic markers to clinical parameters in managing high-risk prostate cancer patients.
Psoriasis
Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury.
Psoriasis
[Distribution of DNase and RNase in psoriasis and their changes following PUVA--a study using immunohistochemical methods]
Pterygium
UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells.
Puberty, Precocious
Gonadotropin-releasing hormone and NMDA receptor gene expression and colocalization change during puberty in female rats.
Pulmonary Fibrosis
Small molecule inhibition of IRE1? kinase/RNase has anti-fibrotic effects in the lung.
Pyelonephritis
Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract.
Rabies
[Effect of trypsin and RNase on the morphology and biological properties of the rabies virus]
Rabies
[The antiviral activity of RNAse Bacillus intermedius in experiments with mice preinfected with street rabies virus]
Renal Insufficiency
Acid ribonuclease and alkaline ribonuclease isoenzymes in plasma of patients with decreased glomerular filtration rate.
Renal Insufficiency
Determining of actual activities of acid and alkaline ribonuclease in human serum and urine.
Renal Insufficiency
Influence of renal insufficiency on levels of serum ribonuclease in patients with multiple myeloma.
Renal Insufficiency
Radioimmunoassay for human pancreatic ribonuclease and measurement of serum immunoreactive pancreatic ribonuclease in patients with malignant tumors.
Renal Insufficiency
[The value of poly-C-specific serum ribonuclease and CEA in the diagnosis of pancreatic carcinoma (author's transl)]
Rhabdomyosarcoma, Embryonal
Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma.
Rhabdomyosarcoma, Embryonal
Unusual phenotypes in patients with a pathogenic germline variant in DICER1.
ribonuclease e deficiency
Effect of RNase E deficiency on translocon protein synthesis in an RNase E-inducible strain of enterohemorrhagic Escherichia coli O157:H7.
ribonuclease e deficiency
Influence of RNase E deficiency on the production of stx2-bearing phages and Shiga toxin in an RNase E-inducible strain of enterohaemorrhagic Escherichia coli (EHEC) O157:H7.
Sarcoidosis
NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia.
Sarcoma
Alteration of cellular ribonucleases associated with murine oncogenic virus infection.
Sarcoma
Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas.
Sarcoma
Evidence for the common origin of viral and cellular sequences involved in sarcomagenic transformation.
Sarcoma
Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end.
Sarcoma
Multiple DICER1-related tumors in a child with a large interstitial 14q32 deletion.
Sarcoma
Negatively charged RNase-susceptible molecules on the surface of ascites tumor cells.
Sarcoma
Physical map of the Kirsten sarcoma virus genome as determined by fingerprinting RNase T1-resistant oligonucleotides.
Sarcoma 180
A 5' exoribonuclease from cytoplasmic extracts of mouse sarcoma 180 ascites cells.
Sarcoma, Avian
Comparison of Rous sarcoma virus RNA processing in chicken and mouse fibroblasts: evidence for double-spliced RNA in nonpermissive mouse cells.
Sarcoma, Avian
Genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna viruses.
Sarcoma, Avian
Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end.
Sarcoma, Kaposi
Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P.
Sarcoma, Kaposi
In situ study of chemokine and chemokine-receptor expression in Kaposi sarcoma.
Scleroderma, Systemic
Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease.
Seizures
Differential regulation of cytokine expression following pilocarpine-induced seizure.
Seizures
Expression of the mas proto-oncogene in the rat hippocampal formation is regulated by neuronal activity.
Seizures
Seizures increase trkC mRNA expression in the dentate gyrus of rat hippocampus. Role of glutamate receptor activation.
Seminoma
Antitumor action of bovine seminal ribonuclease. Cytostatic effect on human melanoma and mouse seminoma.
Seminoma
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Sepsis
Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis.
Sepsis
The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery-A Pilot Study.
Sertoli-Leydig Cell Tumor
Germline and Somatic DICER1 Mutations in a Well-Differentiated Fetal Adenocarcinoma of the Lung.
Sertoli-Leydig Cell Tumor
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome.
Sertoli-Leydig Cell Tumor
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.
Severe Acute Respiratory Syndrome
Biochemical characterization of exoribonuclease encoded by SARS coronavirus.
Severe Acute Respiratory Syndrome
Computational Characterizations of the Interactions Between the Pontacyl Violet 6R and Exoribonuclease as a Potential Drug Target Against SARS-CoV-2.
Severe Acute Respiratory Syndrome
Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target.
Severe Acute Respiratory Syndrome
COVID-19 diagnostics for resource-limited settings: Evaluation of "unextracted" qRT-PCR.
Severe Acute Respiratory Syndrome
High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants.
Severe Acute Respiratory Syndrome
RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex.
Severe Acute Respiratory Syndrome
RNase in the saliva can affect the detection of severe acute respiratory syndrome coronavirus 2 by real-time one-step polymerase chain reaction using saliva samples.
Severe Acute Respiratory Syndrome
Synthesis in Escherichia coli cells and characterization of the active exoribonuclease of severe acute respiratory syndrome coronavirus.
Severe Acute Respiratory Syndrome
[Synthesis in Escherichia coli cells and characterization of the active exoribonuclease of severe acute respiratory syndrome coronavirus]
Severe Combined Immunodeficiency
Antibody targeted therapeutics for lymphoma: new focus on the CD22 antigen and RNA.
Severe Combined Immunodeficiency
Mutations in the RNA component of RNase mitochondrial RNA processing might cause Omenn syndrome.
Sex Cord-Gonadal Stromal Tumors
Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.
Sezary Syndrome
Application of a multiprobe RNase protection assay and junctional sequences to define V beta gene diversity in Sezary syndrome.
Silicosis
Effects of purified macrophage RNase on granuloma fibroblasts with reference to silicosis.
Sjogren's Syndrome
Immunohistochemical Localization of RNase 7 in Normal and Inflamed Oral Epithelia and Salivary Glands.
Skin Diseases
Partial purification and characterization of RNase P from human peripheral lymphocytes.
Small Cell Lung Carcinoma
Small cell lung carcinoma cell lines express mRNA for calcitonin and alpha- and beta-calcitonin gene related peptides.
Spinal Cord Diseases
Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines.
Squamous Cell Carcinoma of Head and Neck
Expression of retinoic acid receptor gamma correlates with retinoic acid sensitivity and metabolism in head and neck squamous cell carcinoma cell lines.
Squamous Cell Carcinoma of Head and Neck
Involvement of RNase 7 in the malignant potential of oral squamous cell carcinoma cells.
Staphylococcal Infections
Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin.
Starvation
A role for a bacterial ortholog of the Ro autoantigen in starvation-induced rRNA degradation.
Starvation
Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation.
Starvation
Degradation of ribosomal RNA during starvation: comparison to quality control during steady-state growth and a role for RNase PH.
Starvation
Elucidation of pathways of ribosomal RNA degradation: an essential role for RNase E.
Starvation
Isolation and characterization of a wound-inducible ribonuclease from Nicotiana glutinosa leaves.
Starvation
Isolation and characterization of cDNAs encoding xylogenesis-associated and wounding-induced ribonucleases in Zinnia elegans.
Starvation
Molecular characterisation of an S-like RNase of Nicotiana alata that is induced by phosphate starvation.
Starvation
RNase II regulates RNase PH and is essential for cell survival during starvation and stationary phase.
Starvation
Suppression of LX ribonuclease in tomato results in a delay of leaf senescence and abscission.
Starvation
The end1 gene of Schizosaccharomyces pombe coding for a DNase is identical with the pnu1 gene coding for an RNase.
Starvation
The RNase PD2 gene of almond (Prunus dulcis) represents an evolutionarily distinct class of S-like RNase genes.
Starvation
Tissue-specific expression of tomato Ribonuclease LX during phosphate starvation-induced root growth.
Steatorrhea
Comparison of ochratoxin, aflatoxin, and T-2 toxin for their effects on selected parameters related to digestion and evidence for specific metabolism of carotenoids in chickens.
Stomach Neoplasms
A multifunctional ribonuclease A-conjugated carbon dot cluster nanosystem for synchronous cancer imaging and therapy.
Stomach Neoplasms
Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1.
Stomach Neoplasms
Assessment of the clinical usefulness of serum ribonuclease assays: an indicator for the detection of pancreatic cancer.
Stomach Neoplasms
Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma.
Stomach Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Stomach Neoplasms
The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.
Stomach Neoplasms
[Regulation of the RNAse activity of the saliva in healthy subjects and in stomach cancer]
Stroke
New directions in inflammation and immunity: the multi-functional role of the extracellular RNA/RNase system.
Stroke
Protective Effect of RNase on Unilateral Nephrectomy-Induced Postoperative Cognitive Dysfunction in Aged Mice.
Stroke
RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute stroke.
Teratocarcinoma
Identification and characterization of novel human endogenous retroviral sequences prefentially expressed in undifferentiated embryonal carcinoma cells.
Teratocarcinoma
Transcription factor repression and activation of the human acetylcholinesterase gene.
Teratoma
Nucleotide sequence of the C-terminal region of the mouse epidermal growth factor receptor and expression in teratoma-derived cell lines with increased tumorigenic properties.
Testicular Neoplasms
Unique expression patterns of H19 in human testicular cancers of different etiology.
Tetanus
Contraceptive efficacy of recombinant fusion protein comprising zona pellucida glycoprotein-3 fragment and gonadotropin releasing hormone.
Tetanus
Immunogenicity and Contraceptive Efficacy of Escherichia coli-Expressed Recombinant Porcine Zona Pellucida Proteins.
Thrombosis
Arterial thrombosis is accelerated in histidine-rich glycoprotein deficient mice.
Thrombosis
Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation.
Thrombosis
Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor.
Thrombosis
New directions in inflammation and immunity: the multi-functional role of the extracellular RNA/RNase system.
Thrombosis
Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation.
Thrombosis
The expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells in homeostasis of the vascular system.
Thymoma
Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis.
Thyroid Cancer, Papillary
Gene profiling identifies genes specific for well-differentiated epithelial thyroid tumors.
Thyroid Neoplasms
Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site.
Thyroid Neoplasms
Inactivation of the p53 gene is not required for tumorigenesis of medullary thyroid carcinoma or pheochromocytoma.
Thyroid Nodule
DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association.
Tinea
Infection of keratinocytes with Trichophytum rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression.
Tuberculosis
A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis.
Tuberculosis
Characterization of a bifunctional ?-lactamase/ribonuclease and its interaction with a chaperone-like protein in the pathogen Mycobacterium tuberculosis H37Rv.
Tuberculosis
Functional role of putative critical residues in Mycobacterium tuberculosis RNase P protein.
Tuberculosis
Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.
Tuberculosis
Mycobacterium tuberculosis toxin Rv2872 is an RNase involved in vancomycin stress response and biofilm development.
Tuberculosis
Regulation of macrophage gene expression by Mycobacterium tuberculosis: down-regulation of mitochondrial cytochrome c oxidase.
Tuberculosis
RNase 7 but not psoriasin nor sPLA2-IIA associates with Mycobacterium tuberculosis during airway epithelial cell infection.
Tuberculosis
Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence.
Tuberculosis
The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains.
Tuberculosis
[Immunological reactivity during the pathogenetic treatment of experimental tuberculosis]
Urinary Bladder Neoplasms
Cyclic RNA Circ_0000735 sponges miR-502-5p to promote bladder cancer cell proliferation and invasion and inhibit apoptosis.
Urinary Bladder Neoplasms
Different angiogenic pathways characterize superficial and invasive bladder cancer.
Urinary Bladder Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Urinary Bladder Neoplasms
The angiogenic factor midkine is expressed in bladder cancer, and overexpression correlates with a poor outcome in patients with invasive cancers.
Urinary Bladder Neoplasms
Two mechanisms of basic fibroblast growth factor-induced angiogenesis in bladder cancer.
Urinary Tract Infections
Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection.
Uterine Cervical Neoplasms
Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer.
Uterine Cervical Neoplasms
Genome-Wide Analysis of the Expression of Circular RNA Full-Length Transcripts and Construction of the circRNA-miRNA-mRNA Network in Cervical Cancer.
Uterine Cervical Neoplasms
Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells.
Uterine Cervical Neoplasms
Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.
Uterine Cervical Neoplasms
Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer.
Uterine Neoplasms
Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis.
Vaccinia
2-5A accumulates to high levels in interferon-treated, vaccinia virus-infected cells in the absence of any inhibition of virus replication.
Vaccinia
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
Vaccinia
Analysis of vaccinia virus transcriptional complexity in vitro and in vivo: characterization of RNase T1-resistant 5'-terminal oligonucleotides.
Vaccinia
Behaviour of DNase and RNase in the chorioallantoic membranes of chick embryos infected with vaccinia virus and herpes.
Vaccinia
Modulation of ppp(A2'p)nA-dependent RNase by a temperature-sensitive mutant of vaccinia virus.
Vaccinia
Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants.
Vaccinia
Secreted respiratory syncytial virus G glycoprotein induces interleukin-5 (IL-5), IL-13, and eosinophilia by an IL-4-independent mechanism.
Varicose Ulcer
Differential expression of antimicrobial peptides in margins of chronic wounds.
Vascular Diseases
New directions in inflammation and immunity: the multi-functional role of the extracellular RNA/RNase system.
Vascular System Injuries
The expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells in homeostasis of the vascular system.
Vasculitis
Serum alkaline ribonuclease derived from vascular endothelial cells is raised in patients with rheumatoid vasculitis.
Virus Diseases
Alteration of cellular ribonucleases associated with murine oncogenic virus infection.
Virus Diseases
Analysis of short interfering RNA function in RNA interference by using Drosophila embryo extracts and schneider cells.
Virus Diseases
Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2'-5' oligoadenylate synthetase.
Virus Diseases
Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production.
Virus Diseases
Cell-type-specific effects of RNase L on viral induction of beta interferon.
Virus Diseases
Endophytic Bacillus spp. as a Prospective Biological Tool for Control of Viral Diseases and Non-vector Leptinotarsa decemlineata Say. in Solanum tuberosum L.
Virus Diseases
From housekeeper to microsurgeon: the diagnostic and therapeutic potential of ribonucleases.
Virus Diseases
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells.
Virus Diseases
In vitro and in vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions.
Virus Diseases
Inactivation of the RNase activity of glycoprotein E(rns) of classical swine fever virus results in a cytopathogenic virus.
Virus Diseases
Inhibition of the host proteasome facilitates papaya ringspot virus accumulation and proteosomal catalytic activity is modulated by viral factor HcPro.
Virus Diseases
Opposite Roles of RNase and Kinase Activities of Inositol-Requiring Enzyme 1 (IRE1) on HSV-1 Replication.
Virus Diseases
Over-expression of Oryza sativa Xrn4 confers plant resistance to virus infection.
Virus Diseases
Postimmunization activity of oligoadenylate synthetase in peripheral blood lymphocytes from healthy individuals.
Virus Diseases
Preventive Activity against Influenza (H1N1) Virus by Intranasally Delivered RNA-Hydrolyzing Antibody in Respiratory Epithelial Cells of Mice.
Virus Diseases
RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules.
Virus Diseases
RNase L contributes to experimentally induced type 1 diabetes onset in mice.
Virus Diseases
Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells.
Virus Diseases
Skin allograft rejection is suppressed in mice lacking the antiviral enzyme, 2',5'-oligoadenylate-dependent RNase L.
Virus Diseases
Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals.
Virus Diseases
Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.
Virus Diseases
Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.
Virus Diseases
The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.
Virus Diseases
Time course of serum nuclease activity in mice infected with plasmodium malariae.
Virus Diseases
Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains.
Visna
Genomic changes associated with antigenic variation of visna virus durig persistent infection.
Vitamin A Deficiency
Regulation of thyroid-stimulating hormone beta-subunit and growth hormone messenger ribonucleic acid levels in the rat: effect of vitamin A status.
Whooping Cough
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells.
Wilms Tumor
Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism.
Wilms Tumor
Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.
Wilms Tumor
Hotspot mutations in DICER1 causing GLOW Syndrome-associated macrocephaly via modulation of specific microRNA populations results in activation of PI3K/ATK/mTOR signaling.
Wilms Tumor
Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells.
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
strong interaction between NKRF-TAP and endogenous XRN2 in HeLa cells
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
NF-kappaB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'->3' exoribonuclease 2 and negative elongation factor. Interleukin-1 has a more drastic effect on NELF-E or XRN2 binding to NKRF than the M1 mutation
physiological function
interactions between NKRF, 5'->3' exoribonuclease 2 (XRN2) and the negative elongation factor (NELF)-E in HeLa cells. Interleukin IL-1 stimulation leads to decrease in NKRF amino acids 421-429 phosphorylation and dissociation of NELF-E and XRN2 by concomitant resumption of transcription elongation of a synthetic reporter or the endogenous NKRF target gene, interleukin IL-8. 5'->3' exoribonuclease 2 (XRN2) is implicated in inhibition of transcription elongation via the termination of initiated transcripts in many RNA Pol II-dependent promoters
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
human Rrp44 proteins shows an overall structure similar to that of Escherichia coli RNase II
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C425A
-
cannot be classified as polymorphic in the Japanese population. In the Korean, Mongolian, Ovambo, Turkish, and German DNA no genotype other than homozygotic 425C allele in RNASE2 at each single nucleotide polymorphism site is found
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 10-ml fractions containing 1 mg trypsin inhibitor carrier protein because RNase II loses activity under this conditions at protein concentrations below 0.1 mg/ml
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA fragments corresponding to the entire open reading frame in each gene are subcloned into a TA cloning vector
-
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RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ning Kwan, C.
A cytoplasmic exoribonuclease from HeLa cells
Biochim. Biophys. Acta
479
322-331
1977
Homo sapiens
brenda
Caruccio, N.; Ross, J.
Purification of a human polyribosome-associated 3'-5'exoribonuclease
J. Biol. Chem.
269
31814-31821
1994
Homo sapiens
brenda
Jiang, T.; Altman, S.
A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'->5' exoribonuclease activity
Proc. Natl. Acad. Sci. USA
99
5295-5300
2002
Homo sapiens
brenda
Espert, L.; Eldin, P.; Gongora, C.; Bayard, B.; Harper, F.; Chelbi-Alix, M.K.; Bertrand, E.; Degols, G.; Mechti, N.
The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes
J. Cell. Biochem.
98
1320-1333
2006
Homo sapiens
brenda
Espert, L.; Degols, G.; Lin, Y.L.; Vincent, T.; Benkirane, M.; Mechti, N.
Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1
J. Gen. Virol.
86
2221-2229
2005
Homo sapiens
brenda
Kennedy, S.; Wang, D.; Ruvkun, G.
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
Nature
427
645-649
2004
Caenorhabditis elegans, Homo sapiens
brenda
Bollenbach, T.J.; Schuster, G.; Stern, D.B.
Cooperation of endo- and exoribonucleases in chloroplast mRNA turnover
Prog. Nucleic Acid Res. Mol. Biol.
78
305-337
2004
Synechocystis sp., Saccharomyces cerevisiae, Caenorhabditis elegans, Chlamydomonas sp., Drosophila sp. (in: flies), Escherichia coli, Haloferax volcanii, Embryophyta, Homo sapiens, Mammalia, no activity in archaebacteria, Streptomyces coelicolor, uncultured Gammaproteobacteria bacterium
brenda
Barbas, A.; Matos, R.G.; Amblar, M.; Lpez-Vinas, E.; Gomez-Puertas, P.; Arraiano, C.M.
New insights into the mechanism of RNA degradation by ribonuclease II identification of the residue responsible for setting the RNase II end product
J. Biol. Chem.
283
13070-13076
2008
Homo sapiens, Escherichia coli (P30850), Escherichia coli
brenda
Ueki, M.; Takeshita, H.; Fujihara, J.; Takatsuka, H.; Yuasa, I.; Iida, R.; Yasuda, T.
Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations
Cell Biochem. Funct.
26
718-722
2008
Homo sapiens
brenda
Rother, S.; Bartels, M.; Schweda, A.T.; Resch, K.; Pallua, N.; Nourbakhsh, M.
NF-kappaB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'->3' exoribonuclease 2 and negative elongation factor
FASEB J.
30
174-185
2016
Homo sapiens (Q9H0D6)
brenda
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