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Information on EC 3.1.12.2 - DNA-3'-diphospho-5'-guanosine diphosphatase

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IUBMB Comments
Aprataxin is a DNA-binding protein that catalyses (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8, 3'-phosphate/5'-hydroxy nucleic acid ligase) . The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release. The enzyme also possesses the activity of EC 3.1.11.7, adenosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.1.11.8, guanosine-5'-diphospho-5'-[DNA] diphosphatase.
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The expected taxonomic range for this enzyme is: Schizosaccharomyces pombe
Reaction Schemes
[DNA]-3'-diphospho-5'-guanosine
+
=
[DNA]-3'-phosphate
+
Synonyms
aprataxin, APTX, DNA-3'pp5'G guanylate hydrolase, HNT3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[DNA]-3'-diphospho-5'-guanosine + H2O = [DNA]-3'-phosphate + GMP
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