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Disease on EC 3.1.11.3 - exodeoxyribonuclease (lambda-induced)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
[Clinical application of TCGA molecular classification in endometrial endometrioid carcinoma].
Adenocarcinoma of Lung
Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384.
Adenoma
A mutation in POLE predisposing to a multi-tumour phenotype.
Germline and somatic polymerase ? and ? mutations define a new class of hypermutated colorectal and endometrial cancers.
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.
Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps.
POLE mutations in families predisposed to cutaneous melanoma.
Replicative DNA polymerase mutations in cancer.
Adenomatous Polyps
Role of POLE and POLD1 in familial cancer.
Anemia
TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.
Arthritis
Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis.
Arthritis, Experimental
Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis.
Arthritis, Rheumatoid
Trex-1 deficiency in rheumatoid arthritis synovial fibroblasts.
Ataxia Telangiectasia
The use of recombinant DNA plasmids for the determination of DNA-repair and recombination in cultured mammalian cells.
Atherosclerosis
IL-24 Gene Polymorphisms Are Associated with Cardiometabolic Parameters and Cardiovascular Risk Factors But Not with Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease Mexican Study.
Autoimmune Diseases
Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion.
An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis.
Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Systemic lupus erythematosus overlapping dermatomyositis owing to a heterozygous TREX1 Asp130Asn missense mutation.
TREX1 as a Novel Immunotherapeutic Target.
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
Brain Neoplasms
The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan.
Breast Neoplasms
An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification.
Metastasis suppressor function of NM23-H1 requires its 3';-5' exonuclease activity.
Problem-solving test: Real-time polymerase chain reaction.
The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites.
Carcinogenesis
DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing.
Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells.
Carcinoma
Germline and somatic polymerase ? and ? mutations define a new class of hypermutated colorectal and endometrial cancers.
Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps.
Mixed and Ambiguous Endometrial Carcinomas: A Heterogenous Group of Tumors With Different Clinicopathologic and Molecular Genetic Features.
Molecular genetic heterogeneity in undifferentiated endometrial carcinomas.
Molecular insights into the classification of high-grade endometrial carcinoma.
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Quantitative multiplex PCR assay for the detection of the seven clinically most relevant high-risk HPV types.
Replicative DNA polymerase mutations in cancer.
Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
Undifferentiated Endometrial Carcinomas Show Frequent Loss of Core Switch/Sucrose Nonfermentable Complex Proteins.
Carcinoma, Ehrlich Tumor
The subcellular distribution of poly-A-degrading activity in mouse kidney.
Carcinoma, Endometrioid
Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.
Molecular insights into the classification of high-grade endometrial carcinoma.
POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium.
Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma.
Carcinoma, Hepatocellular
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases.
Cerebellar Ataxia
Homozygous c.359del variant in MGME1 is associated with early onset cerebellar ataxia.
Cockayne Syndrome
Repair of persistent strand breaks in the mitochondrial genome.
Colitis, Ulcerative
Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD.
Colonic Neoplasms
Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study.
Colorectal Neoplasms
A mutation in POLE predisposing to a multi-tumour phenotype.
Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer.
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.
DNA polymerase {epsilon} and ? exonuclease domain mutations in endometrial cancer.
Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction.
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.
High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation.
Mutagenic mechanisms of cancer-associated DNA polymerase ? alleles.
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.
Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment.
POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East.
POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance.
POLE and POLD1 screening in 155 patients with multiple polyps and early-onset colorectal cancer.
POLE mutations in families predisposed to cutaneous melanoma.
POLE somatic mutations in advanced colorectal cancer.
Polymerase proofreading-associated polyposis: a new, dominantly inherited syndrome of hereditary colorectal cancer predisposition.
Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1.
Role of POLE and POLD1 in familial cancer.
Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer.
The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan.
The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes.
Unraveling the genomic landscape of colorectal cancer through mutational signatures.
Colorectal Neoplasms, Hereditary Nonpolyposis
Endometrial Carcinomas with a "Serous" Component in Young Women Are Enriched for DNA Mismatch Repair Deficiency, Lynch Syndrome, and POLE Exonuclease Domain Mutations.
Coronary Artery Disease
Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study.
COVID-19
Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics.
Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening.
Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir.
Deafness
Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis.
POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features.
Dengue
Development of a fluorogenic RT-PCR system for quantitative identification of dengue virus serotypes 1-4 using conserved and serotype-specific 3' noncoding sequences.
Diffuse Cerebral Sclerosis of Schilder
Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study.
Disorders of Sex Development
Clinical applicability of rapid detection of SRY and DYS14 genes in patients with disorders of sex development using an indigenously developed 5' exonuclease based assay.
Endometrial Neoplasms
An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy.
Analysis of 108 patients with endometrial carcinoma using the PROMISE classification and additional genetic analyses for MMR-D.
Analysis of the immune checkpoint V-domain Ig-containing suppressor of T-cell activation (VISTA) in endometrial cancer.
Blinded histopathological characterisation of POLE exonuclease domain-mutant endometrial cancers: sheep in wolf's clothing.
Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer.
Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.
Clinicopathological characteristics and prognostic value of POLE mutations in endometrial cancer: A systematic review and meta-analysis.
DNA polymerase ? and its roles in genome stability.
DNA polymerase {epsilon} and ? exonuclease domain mutations in endometrial cancer.
Endometrial Carcinomas with a "Serous" Component in Young Women Are Enriched for DNA Mismatch Repair Deficiency, Lynch Syndrome, and POLE Exonuclease Domain Mutations.
Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
First description of ultramutated endometrial cancer caused by germline loss-of-function and somatic exonuclease domain mutations in POLE gene.
Flow cytometric DNA and 5'-nucleotide phosphodiesterase in endometrium.
Interobserver Agreement in Endometrial Carcinoma Histotype Diagnosis Varies Depending on The Cancer Genome Atlas (TCGA)-based Molecular Subgroup.
Interpretation of somatic POLE mutations in endometrial carcinoma.
Molecular characterization in the prediction of disease extent in endometrial carcinoma.
Molecular genetic heterogeneity in undifferentiated endometrial carcinomas.
Molecular Heterogeneity of Endometrioid Ovarian Carcinoma: An Analysis of 166 Cases Using the Endometrial Cancer Subrogate Molecular Classification.
Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups.
p53, Mismatch Repair Protein, and POLE Abnormalities in Ovarian Clear Cell Carcinoma: An Outcome-based Clinicopathologic Analysis.
p53abn Endometrial Cancer: understanding the most aggressive endometrial cancers in the era of molecular classification.
PD-L1 expression in tumor cells is associated with a favorable prognosis in patients with high-risk endometrial cancer.
POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium.
POLE Mutation Characteristics in a Chinese Cohort with Endometrial Carcinoma.
POLE mutations improve the prognosis of endometrial cancer via regulating cellular metabolism through AMF/AMFR signal transduction.
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Polymerase ? (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing.
Polymerase proofreading-associated polyposis: a new, dominantly inherited syndrome of hereditary colorectal cancer predisposition.
Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence: A Subanalysis.
The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan.
The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions.
Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
exodeoxyribonuclease (lambda-induced) deficiency
A Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, And Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1.
Construction of a highly error-prone DNA polymerase for developing organelle mutation systems.
DNA structures generated during recombination initiated by mismatch repair of UV-irradiated nonreplicating phage DNA in Escherichia coli: requirements for helicase, exonucleases, and RecF and RecBCD functions.
Identification of RNase T as a high-copy suppressor of the UV sensitivity associated with single-strand DNA exonuclease deficiency in Escherichia coli.
Mismatch repair and DNA polymerase ? proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ? variant.
Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities.
Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli.
The effect of the 3'-->5' exonuclease of T7 DNA polymerase on frameshifts and deletions.
TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders.
exodeoxyribonuclease vii deficiency
Pyrimidine dimer excision in Escherichia coli strains deficient in exonucleases V and VII and in the 5' leads to 3' exonuclease of DNA polymerase I.
Fanconi Anemia
Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.
G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex.
Genetic Diseases, Inborn
Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.
The role of SOS and flap processing in microsatellite instability in Escherichia coli.
TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders.
Glioma
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.
Gout
No association of microRNA-146a rs2910164 polymorphism and risk of primary gout development in Chinese Han populations: a case-control study.
Hepatitis
Interferon-stimulated gene 20 kDa protein serum levels and clinical outcome of hepatitis B virus-related liver diseases.
Hepatitis B
Differential expression of ISG20 in chronic hepatitis B patients and relation to interferon-alpha therapy response.
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts.
T5 exonuclease hydrolysis of Hepatitis B Virus replicative intermediates allows reliable quantification and fast drug efficacy testing of covalently closed circular DNA by PCR.
Hepatitis C
A highly sensitive and selective fluorescence biosensor for hepatitis C virus DNA detection based on ?-FeOOH and exonuclease III-assisted signal amplification.
Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics.
Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication.
Interferon stimulated exonuclease gene 20?kDa links psychiatric events to distinct hepatitis C virus responses in human immunodeficiency virus positive patients.
miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation.
RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
[Antiviral activities of ISG20 against hepatitis C virus].
Hepatitis C, Chronic
[Antiviral activities of ISG20 against hepatitis C virus].
Herpes Simplex
3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity.
A Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, And Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1.
Anatomy of herpes simplex virus DNA. V. Terminally repetitive sequences.
Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins.
DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes.
Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA.
Effects of exonuclease activity and nucleotide selectivity of the herpes simplex virus DNA polymerase on the fidelity of DNA replication in vivo.
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Electron microscopic mapping of proteins bound to herpes simplex virus DNA.
Exonuclease-deficient polymerase mutant of herpes simplex virus type 1 induces altered spectra of mutations.
Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain.
Herpes simplex virus type I DNA polymerase. Kinetic properties of the associated 3'-5' exonuclease activity and its role in araAMP incorporation.
High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein.
High-Resolution Characterization of Herpes Simplex Virus Type 1 Transcripts Encoding Alkaline Exonuclease and a 50,000-Dalton Protein Tentatively Identified as a Capsid Protein.
Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.
Improved band shift assay for the simultaneous analysis of protein-DNA interactions and enzymatic functions of DNA polymerases.
Intranuclear localization of herpes simplex virus immediate-early and delayed-early proteins: evidence that ICP 4 is associated with progeny virus DNA.
mRNA- and DNA-directed synthesis of herpes simplex virus-coded exonuclease in Xenopus laevis oocytes.
Mutation spectra of herpes simplex virus type 1 thymidine kinase mutants.
Novel interaction of aphidicolin with herpes simplex virus DNA polymerase and polymerase-associated exonuclease.
On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase.
Physical Interaction between the Herpes Simplex Virus Type 1 Exonuclease, UL12, and the DNA double strand break sensing MRN complex.
Physical mapping of the herpes simplex virus type 2 nuc- lesion affecting alkaline exonuclease activity by using herpes simplex virus type 1 deletion clones.
Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated.
Processive replication of single-stranded DNA templates by the herpes simplex virus-induced DNA polymerase.
Properties of herpes simplex virus DNA polymerase and characterization of its associated exonuclease activity.
Purification and characterization of herpes simplex virus type 1 alkaline exonuclease expressed in Escherichia coli.
Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence.
Structural and functional properties of DNA polymerase delta from rabbit bone marrow.
Structure-function analysis of the herpes simplex virus type 1 UL12 gene: correlation of deoxyribonuclease activity in vitro with replication function.
The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions.
The exonuclease activity of HSV-1 UL12 is required for the production of viral DNA that can be packaged to produce infectious virus.
The Role of Marek's Disease Virus UL12 and UL29 in DNA Recombination and the Virus Lifecycle.
Hyperemia
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.
Hypersensitivity
Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance.
DNA helicases Sgs1 and BLM promote DNA double-strand break resection.
Functional variants of human APE1 rescue the DNA repair defects of the yeast AP endonuclease/3'-diesterase-deficient strain.
Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae.
Structure of chromatin at deoxyribonucleic acid replication forks: nuclease hypersensitivity results from both prenucleosomal deoxyribonucleic acid and an immature chromatin structure.
Infarction, Middle Cerebral Artery
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.
Infections
A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.
Comparative transcriptomic analysis of Rickettsia conorii during in vitro infection of human and tick host cells.
Comparison of the sensitivity and specificity of real-time PCR and in situ hybridization in HPV16 and 18 detection in archival cervical cancer specimens.
Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus.
Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication.
Expression of the phage lambda recombination genes exo and bet under lacPO control on a multi-copy plasmid.
Extracellular DNA is required for root tip resistance to fungal infection.
Formation of phage T1 concatemers by the RecE recombination pathway of Escherichia coli.
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases.
HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection.
Human Three Prime Repair Exonuclease 1 Promotes HIV-1 Integration by Preferentially Degrading Unprocessed Viral DNA.
Identification of in vivo regulators of the Vibrio cholerae?xds gene using a high-throughput genetic selection.
Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors.
Intranuclear localization of herpes simplex virus immediate-early and delayed-early proteins: evidence that ICP 4 is associated with progeny virus DNA.
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication.
Repression of lambda-Associated Enzyme Synthesis After lambda(vir) Superinfection of Lysogenic Hosts.
Role of gene 6 exonuclease in the replication and packaging of bacteriophage T7 DNA.
SAMHD1's protein expression profile in humans.
Separation and characterization of deoxyribonucleases of Escherichia coli B. II. Further purification and properties of an exonuclease induced by infection with bacteriophage T2.
Silencing the shutoff protein of Epstein-Barr virus in productively infected B cells points to (innate) targets for immune evasion.
Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
The "Bridge" in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection.
The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-? during Chlamydia trachomatis infection.
The DNase Activity of KSHV SOX Protein Serves an Important Role in Viral Genome Processing During Lytic Replication.
The PHP domain of PolX from Staphylococcus aureus aids high fidelity DNA synthesis through the removal of misincorporated deoxyribo-, ribo- and oxidized nucleotides.
The SET complex acts as a barrier to autointegration of HIV-1.
The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production.
Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.
[Biosynthesis of early enzymes induced by bacteriophage T4]
[Study of the lambda-exonuclease activity of Escherichia coli during induction of the vegetative phage and infection with temperate phage lambda]
Influenza in Birds
Ultrasensitive SERS determination of avian influenza A H7N9 virus via exonuclease III-assisted cycling amplification.
Influenza, Human
Fluorometric detection of influenza viral RNA using graphene oxide.
Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.
Laryngeal Neoplasms
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.
Lassa Fever
Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES).
Leukemia
A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate.
Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells.
p53-associated 3'-->5' exonuclease activity in nuclear and cytoplasmic compartments of cells.
Leukoencephalopathies
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.
Lipodystrophy
Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis.
Liver Neoplasms, Experimental
Interaction of mammalian deoxyribonuclease V, a double strand 3' to 5' and 5' to 3' exonuclease, with deoxyribonucleic acid polymerase-beta from the Novikoff hepatoma.
Lupus Erythematosus, Systemic
An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis.
Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice.
Intrinsic self-DNA triggers inflammatory disease dependent on STING.
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
TREX1 variants in Sjogren's syndrome related lymphomagenesis.
Lyme Disease
SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories.
Lymphoma
Effect of (211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes.
Novel 5' exonuclease-based real-time PCR assay for the detection of t(14;18)(q32;q21) in patients with follicular lymphoma.
Lymphoma, B-Cell
Increased sensitivity of B-cell clonality analysis in formalin-fixed and paraffin-embedded B-cell lymphoma samples using an enzyme blend with both 5'-->3' DNA polymerase and 3'-->5' exonuclease activity.
Malaria
Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization.
Melanoma
Carboplatin activates the cGAS-STING pathway by upregulating the TREX-1 (three prime repair exonuclease 1) expression in human melanoma.
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.
POLE mutations in families predisposed to cutaneous melanoma.
Meningococcal Infections
5' exonuclease assay for detection of serogroup Y Neisseria meningitidis.
Mouth Neoplasms
ISG20 is overexpressed in clinically relevant radioresistant oral cancer cells.
Multiple Myeloma
Exonuclease domain mutants of yeast DIS3 display genome instability.
Mycoses
Extracellular DNA: The tip of root defenses
Extracellular DNA: the tip of root defenses?
Myocardial Infarction
The Matrix Metalloproteinase 2-1575 gene Polymorphism is Associated with the Risk of Developing Myocardial Infarction in Mexican Patients.
Myocarditis
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.
Myotonic Dystrophy
Fen1 does not control somatic hypermutability of the (CTG)(n).(CAG)(n) repeat in a knock-in mouse model for DM1.
Neoplasm Metastasis
Metastasis suppressor function of NM23-H1 requires its 3';-5' exonuclease activity.
Neoplasms
A Common Cancer-Associated DNA Polymerase {varepsilon} Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading.
A proposal for updating the staging of endometrial cancer.
A recurrent cancer-associated substitution in DNA polymerase ? produces a hyperactive enzyme.
A role for WRN in telomere-based DNA damage responses.
Additional value of K-ras point mutations in bronchial wash fluids for diagnosis of peripheral lung tumours.
An exonuclease protection and CRISPR/Cas12a integrated biosensor for the turn-on detection of transcription factors in cancer cells.
Analysis of CNOT Family Gene Expression, Clinicopathological Features, and Prognosis Value in Hepatocellular Carcinoma.
Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.
APE1 senses DNA single-strand breaks for repair and signaling.
Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade.
Classification of Endometrial Carcinoma: New Perspectives Beyond Morphology.
Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.
Clinicopathological and molecular characterisation of 'multiple-classifier' endometrial carcinomas.
Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene.
Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers.
Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.
Corded and Hyalinized and Spindled Endometrioid Endometrial Carcinoma: A Clinicopathologic and Molecular Analysis of 9 Tumors Based on the TCGA Classifier.
Cytoplasmic p53 contributes to the removal of uracils misincorporated by HIV-1 reverse transcriptase.
Dedifferentiated endometrial carcinomas with neuroendocrine features: a clinicopathologic, immunohistochemical, and molecular genetic study.
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.
DNA polymerase ? and its roles in genome stability.
DNA Polymerase ? Deficiency Leading to an Ultramutator Phenotype: A Novel Clinically Relevant Entity.
DNA-Conjugated Amphiphilic Aggregation-Induced Emission Probe for Cancer Tissue Imaging and Prognosis Analysis.
Does a p53 "Wild-type" Immunophenotype Exclude a Diagnosis of Endometrial Serous Carcinoma?
Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
Excision of nucleoside analogs in mitochondria by p53 protein.
Exonuclease enhances hybridization efficiency: improved direct cycle sequencing and point mutation detection.
Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication.
FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair.
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer.
Fidelity of DNA replication-a matter of proofreading.
Fluorescence detection of telomerase activity in cancer cell extracts based on autonomous exonuclease III-assisted isothermal cycling signal amplification.
Functional Analysis of Cancer-Associated DNA Polymerase ? Variants in
Functional role of circular RNAs in cancer development and progression.
Genomic organization of human transcription initiation complexes.
Germline PMS2 and somatic POLEexo mutations cause hypermutability of the leading DNA strand in Biallelic Mismatch Repair Deficiency syndrome brain tumors.
Germline RAD54L with somatic POLE defect implicated in Hypermutation phenotype: case report.
High expression of ISG20 predicts a poor prognosis in acute myeloid leukemia.
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading.
High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation.
Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors.
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.
Hydrolysis of deoxyribo-oligonucleotides bearing 3'-monoesterified phosphate by mouse mammary tumor exonuclease.
Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine.
Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis.
Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.
Interpretation of somatic POLE mutations in endometrial carcinoma.
ISG20 is overexpressed in clinically relevant radioresistant oral cancer cells.
ISG20 promotes local tumor immunity and contributes to poor survival in human glioma.
Mismatch repair and DNA polymerase ? proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ? variant.
Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Molecularly Classified Endometrial Carcinoma.
Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer.
Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment.
Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy.
Molecular genetic heterogeneity in undifferentiated endometrial carcinomas.
Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups.
Multiple hits for the association of uterine fibroids on human chromosome 1q43.
Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain.
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.
Normal junctional diversification of immune receptors in p53-deficient mice.
Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase ? mutation in human cells.
p53 enhances the fidelity of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.
p53 in cytoplasm exerts 3'-->5' exonuclease activity with dsRNA.
P53 in cytoplasm may enhance the accuracy of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.
p53 in the mitochondria, as a trans-acting protein, provides error-correction activities during the incorporation of non-canonical dUTP into DNA.
p53 Modulates the exonuclease activity of Werner syndrome protein.
p53-associated 3'-->5' exonuclease activity in nuclear and cytoplasmic compartments of cells.
p53abn Endometrial Cancer: understanding the most aggressive endometrial cancers in the era of molecular classification.
Phenotype of POLE-mutated endometrial cancer.
POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features.
POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status.
Polymerase epsilon mutations and concomitant ?2-microglobulin mutations in cancer.
Pre-treatment risk assessment of women with endometrial cancer: differences in outcomes of molecular and clinical classifications in the Slovenian patient cohort.
Quantification of human cells in NOD/SCID mice by duplex real-time polymerase-chain reaction.
Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles.
Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study.
Regression of chemotherapy-resistant Polymerase epsilon (POLE) ultra-mutated and MSH6 hyper-mutated endometrial tumors with nivolumab.
Removal of ribonucleotides by p53 protein incorporated during DNA synthesis by HIV-1 reverse transcriptase.
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.
Role of POLE and POLD1 in familial cancer.
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue.
Significant contribution of the 3'?5' exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ?.
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer.
Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells.
Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo.
The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas.
The subcellular distribution of poly-A-degrading activity in mouse kidney.
The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.
TREX1 dictates the immune fate of irradiated cancer cells.
Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review).
Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
Undifferentiated Endometrial Carcinomas Show Frequent Loss of Core Switch/Sucrose Nonfermentable Complex Proteins.
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Neuroblastoma
Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses.
Neurodegenerative Diseases
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
Neutropenia
Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.
Ophthalmoplegia
Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Removal of anti-human immunodeficiency virus 2',3'-dideoxynucleoside monophosphates from DNA by a novel human cytosolic 3'-->5' exonuclease.
Progeria
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.
Pseudorabies
Pseudorabies virus DNA-binding protein stimulates the exonuclease activity and regulates the processivity of pseudorabies virus DNase.
Psoriasis
Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis.
The Exonuclease Trex2 Shapes Psoriatic Phenotype.
Retinitis
The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage.
Sarcoma
An exonuclease possibly involved in the initiation of repair of bleomycin-damaged DNA in mouse ascites sarcoma cells.
DNA damage by peplomycin and its repair in an in vitro system.
Repair of X-ray-induced single-strand breaks by a cell-free system.
Using mRNA deep sequencing to analyze differentially expressed genes during Panax notoginseng saponin treatment of ischemic stroke.
Werner syndrome gene variants in human sarcomas.
Sarcoma 180
A 5' exoribonuclease from cytoplasmic extracts of mouse sarcoma 180 ascites cells.
Sarcoma, Avian
DNA ligase and exonuclease activities in virions of rous sarcoma virus.
Schistosomiasis
Schistosoma mansoni: localisation of antigenic regions on the 31 kilodalton diagnostic protein.
Severe Acute Respiratory Syndrome
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.
Skin Diseases
The Exonuclease Trex2 Shapes Psoriatic Phenotype.
Spinocerebellar Degenerations
Homozygous c.359del variant in MGME1 is associated with early onset cerebellar ataxia.
Stomach Neoplasms
Two-stage cyclic enzymatic amplification method for ultrasensitive electrochemical assay of microRNA-21 in the blood serum of gastric cancer patients.
Stroke
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.
Superinfection
Repression of lambda-Associated Enzyme Synthesis After lambda(vir) Superinfection of Lysogenic Hosts.
Takayasu Arteritis
Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients.
Thymoma
Studies of c-myb gene regulation in MRL-lpr/lpr mice. Identification of a 5' c-myb nuclear protein binding site and high levels of binding factors in nuclear extracts of lpr/lpr lymph node cells.
Tuberculosis
M. tuberculosis class II apurinic/ apyrimidinic-endonuclease/3'-5' exonuclease (XthA) engages with NAD+-dependent DNA ligase A (LigA) to counter futile cleavage and ligation cycles in base excision repair.
Mechanistic insights into the enzymatic activity and inhibition of the replicative polymerase exonuclease domain from Mycobacterium tuberculosis.
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine.
The ?2 clamp in the Mycobacterium tuberculosis DNA polymerase III ??2? replicase promotes polymerization and reduces exonuclease activity.
The construction of Mycobacterium tuberculosis 16S rDNA MSPQC sensor based on Exonuclease III-assisted cyclic signal amplification.
Vaccinia
Action of ATP-dependent DNase from Hemophilus influenzae on cross-linked DNA molecules.
Analysis of SEC-SAXS data via EFA deconvolution and Scatter.
Cellular 5'-3' mRNA Exonuclease Xrn1 Controls Double-Stranded RNA Accumulation and Anti-Viral Responses.
Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand.
Duplex strand joining reactions catalyzed by vaccinia virus DNA polymerase.
In-fusion® cloning with vaccinia virus DNA polymerase.
Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate.
Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype.
Shope fibroma virus. II. Role of the virion-associated nucleases.
Virus-associated nucleases: evidence for endonuclease and exonuclease activity in rabbitpox and vaccinia viruses.
Virus Diseases
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo.
Early transcriptome profile of goat peripheral blood mononuclear cells (PBMCs) infected with peste des petits ruminant's vaccine virus (Sungri/96) revealed induction of antiviral response in an interferon independent manner.
Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease.
Werner Syndrome
A gene encoding an RNase D exonuclease-like protein is required for post-transcriptional silencing in Arabidopsis.
A role for WRN in telomere-based DNA damage responses.
Accumulation of Werner protein at DNA double-strand breaks in human cells.
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.
Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome protein.
Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA.
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
Disease-causing missense mutations in human DNA helicase disorders.
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease.
DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA.
Functional interaction between Ku and the werner syndrome protein in DNA end processing.
Genetic instability syndromes with progeroid features.
Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and Ataxia.
Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity.
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains.
Loss of Werner syndrome protein function promotes aberrant mitotic recombination.
Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease.
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
p53 Modulates the exonuclease activity of Werner syndrome protein.
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity.
Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review.
Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity.
The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase ?
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.
The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.
The Werner syndrome protein at the crossroads of DNA repair and apoptosis.
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
The Werner syndrome protein has separable recombination and survival functions.
TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.
Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.
Werner syndrome gene variants in human sarcomas.
Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.
Werner Syndrome Protein and DNA Replication.
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease.
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Wilms Tumor
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway.
Zika Virus Infection
Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection.