Disease on EC 3.1.11.3 - exodeoxyribonuclease (lambda-induced)
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Adenocarcinoma
[Clinical application of TCGA molecular classification in endometrial endometrioid carcinoma].
Adenocarcinoma of Lung
Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384.
Adenoma
Germline and somatic polymerase ? and ? mutations define a new class of hypermutated colorectal and endometrial cancers.
Adenoma
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.
Adenoma
Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps.
Anemia
TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.
Arthritis
Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis.
Arthritis, Experimental
Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis.
Ataxia Telangiectasia
The use of recombinant DNA plasmids for the determination of DNA-repair and recombination in cultured mammalian cells.
Atherosclerosis
IL-24 Gene Polymorphisms Are Associated with Cardiometabolic Parameters and Cardiovascular Risk Factors But Not with Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease Mexican Study.
Autoimmune Diseases
Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion.
Autoimmune Diseases
An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis.
Autoimmune Diseases
Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.
Autoimmune Diseases
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Autoimmune Diseases
Systemic lupus erythematosus overlapping dermatomyositis owing to a heterozygous TREX1 Asp130Asn missense mutation.
Autoimmune Diseases
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
Brain Neoplasms
The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan.
Breast Neoplasms
An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification.
Breast Neoplasms
Metastasis suppressor function of NM23-H1 requires its 3';-5' exonuclease activity.
Breast Neoplasms
The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites.
Carcinogenesis
DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing.
Carcinogenesis
Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.
Carcinogenesis
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Carcinogenesis
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
Carcinogenesis
Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells.
Carcinoma
Germline and somatic polymerase ? and ? mutations define a new class of hypermutated colorectal and endometrial cancers.
Carcinoma
Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps.
Carcinoma
Mixed and Ambiguous Endometrial Carcinomas: A Heterogenous Group of Tumors With Different Clinicopathologic and Molecular Genetic Features.
Carcinoma
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Carcinoma
Quantitative multiplex PCR assay for the detection of the seven clinically most relevant high-risk HPV types.
Carcinoma
Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
Carcinoma
Undifferentiated Endometrial Carcinomas Show Frequent Loss of Core Switch/Sucrose Nonfermentable Complex Proteins.
Carcinoma, Ehrlich Tumor
The subcellular distribution of poly-A-degrading activity in mouse kidney.
Carcinoma, Endometrioid
Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.
Carcinoma, Endometrioid
Molecular insights into the classification of high-grade endometrial carcinoma.
Carcinoma, Endometrioid
POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium.
Carcinoma, Endometrioid
Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma.
Carcinoma, Hepatocellular
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases.
Cerebellar Ataxia
Homozygous c.359del variant in MGME1 is associated with early onset cerebellar ataxia.
Colitis, Ulcerative
Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD.
Colonic Neoplasms
Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study.
Colorectal Neoplasms
Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer.
Colorectal Neoplasms
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.
Colorectal Neoplasms
DNA polymerase {epsilon} and ? exonuclease domain mutations in endometrial cancer.
Colorectal Neoplasms
Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction.
Colorectal Neoplasms
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.
Colorectal Neoplasms
High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation.
Colorectal Neoplasms
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.
Colorectal Neoplasms
Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment.
Colorectal Neoplasms
POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East.
Colorectal Neoplasms
POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance.
Colorectal Neoplasms
POLE and POLD1 screening in 155 patients with multiple polyps and early-onset colorectal cancer.
Colorectal Neoplasms
Polymerase proofreading-associated polyposis: a new, dominantly inherited syndrome of hereditary colorectal cancer predisposition.
Colorectal Neoplasms
Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1.
Colorectal Neoplasms
Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer.
Colorectal Neoplasms
The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan.
Colorectal Neoplasms
The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes.
Colorectal Neoplasms
Unraveling the genomic landscape of colorectal cancer through mutational signatures.
Colorectal Neoplasms, Hereditary Nonpolyposis
Endometrial Carcinomas with a "Serous" Component in Young Women Are Enriched for DNA Mismatch Repair Deficiency, Lynch Syndrome, and POLE Exonuclease Domain Mutations.
Coronary Artery Disease
Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study.
COVID-19
Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics.
COVID-19
Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening.
COVID-19
Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir.
Deafness
Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis.
Deafness
POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features.
Dengue
Development of a fluorogenic RT-PCR system for quantitative identification of dengue virus serotypes 1-4 using conserved and serotype-specific 3' noncoding sequences.
Diffuse Cerebral Sclerosis of Schilder
Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study.
Disorders of Sex Development
Clinical applicability of rapid detection of SRY and DYS14 genes in patients with disorders of sex development using an indigenously developed 5' exonuclease based assay.
Endometrial Neoplasms
An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy.
Endometrial Neoplasms
Analysis of 108 patients with endometrial carcinoma using the PROMISE classification and additional genetic analyses for MMR-D.
Endometrial Neoplasms
Analysis of the immune checkpoint V-domain Ig-containing suppressor of T-cell activation (VISTA) in endometrial cancer.
Endometrial Neoplasms
Blinded histopathological characterisation of POLE exonuclease domain-mutant endometrial cancers: sheep in wolf's clothing.
Endometrial Neoplasms
Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer.
Endometrial Neoplasms
Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.
Endometrial Neoplasms
Clinicopathological characteristics and prognostic value of POLE mutations in endometrial cancer: A systematic review and meta-analysis.
Endometrial Neoplasms
DNA polymerase {epsilon} and ? exonuclease domain mutations in endometrial cancer.
Endometrial Neoplasms
Endometrial Carcinomas with a "Serous" Component in Young Women Are Enriched for DNA Mismatch Repair Deficiency, Lynch Syndrome, and POLE Exonuclease Domain Mutations.
Endometrial Neoplasms
Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
Endometrial Neoplasms
First description of ultramutated endometrial cancer caused by germline loss-of-function and somatic exonuclease domain mutations in POLE gene.
Endometrial Neoplasms
Flow cytometric DNA and 5'-nucleotide phosphodiesterase in endometrium.
Endometrial Neoplasms
Interobserver Agreement in Endometrial Carcinoma Histotype Diagnosis Varies Depending on The Cancer Genome Atlas (TCGA)-based Molecular Subgroup.
Endometrial Neoplasms
Molecular characterization in the prediction of disease extent in endometrial carcinoma.
Endometrial Neoplasms
Molecular genetic heterogeneity in undifferentiated endometrial carcinomas.
Endometrial Neoplasms
Molecular Heterogeneity of Endometrioid Ovarian Carcinoma: An Analysis of 166 Cases Using the Endometrial Cancer Subrogate Molecular Classification.
Endometrial Neoplasms
Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups.
Endometrial Neoplasms
p53, Mismatch Repair Protein, and POLE Abnormalities in Ovarian Clear Cell Carcinoma: An Outcome-based Clinicopathologic Analysis.
Endometrial Neoplasms
p53abn Endometrial Cancer: understanding the most aggressive endometrial cancers in the era of molecular classification.
Endometrial Neoplasms
PD-L1 expression in tumor cells is associated with a favorable prognosis in patients with high-risk endometrial cancer.
Endometrial Neoplasms
POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium.
Endometrial Neoplasms
POLE Mutation Characteristics in a Chinese Cohort with Endometrial Carcinoma.
Endometrial Neoplasms
POLE mutations improve the prognosis of endometrial cancer via regulating cellular metabolism through AMF/AMFR signal transduction.
Endometrial Neoplasms
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Endometrial Neoplasms
Polymerase ? (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing.
Endometrial Neoplasms
Polymerase proofreading-associated polyposis: a new, dominantly inherited syndrome of hereditary colorectal cancer predisposition.
Endometrial Neoplasms
Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence: A Subanalysis.
Endometrial Neoplasms
The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan.
Endometrial Neoplasms
The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions.
Endometrial Neoplasms
Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
exodeoxyribonuclease (lambda-induced) deficiency
A Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, And Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1.
exodeoxyribonuclease (lambda-induced) deficiency
Construction of a highly error-prone DNA polymerase for developing organelle mutation systems.
exodeoxyribonuclease (lambda-induced) deficiency
DNA structures generated during recombination initiated by mismatch repair of UV-irradiated nonreplicating phage DNA in Escherichia coli: requirements for helicase, exonucleases, and RecF and RecBCD functions.
exodeoxyribonuclease (lambda-induced) deficiency
Identification of RNase T as a high-copy suppressor of the UV sensitivity associated with single-strand DNA exonuclease deficiency in Escherichia coli.
exodeoxyribonuclease (lambda-induced) deficiency
Mismatch repair and DNA polymerase ? proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ? variant.
exodeoxyribonuclease (lambda-induced) deficiency
Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities.
exodeoxyribonuclease (lambda-induced) deficiency
Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli.
exodeoxyribonuclease (lambda-induced) deficiency
The effect of the 3'-->5' exonuclease of T7 DNA polymerase on frameshifts and deletions.
exodeoxyribonuclease (lambda-induced) deficiency
TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders.
exodeoxyribonuclease vii deficiency
Pyrimidine dimer excision in Escherichia coli strains deficient in exonucleases V and VII and in the 5' leads to 3' exonuclease of DNA polymerase I.
Fanconi Anemia
Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.
Fanconi Anemia
G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex.
Genetic Diseases, Inborn
Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.
Genetic Diseases, Inborn
The role of SOS and flap processing in microsatellite instability in Escherichia coli.
Genetic Diseases, Inborn
TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders.
Glioma
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.
Gout
No association of microRNA-146a rs2910164 polymorphism and risk of primary gout development in Chinese Han populations: a case-control study.
Hepatitis
Interferon-stimulated gene 20 kDa protein serum levels and clinical outcome of hepatitis B virus-related liver diseases.
Hepatitis B
Differential expression of ISG20 in chronic hepatitis B patients and relation to interferon-alpha therapy response.
Hepatitis B
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts.
Hepatitis B
T5 exonuclease hydrolysis of Hepatitis B Virus replicative intermediates allows reliable quantification and fast drug efficacy testing of covalently closed circular DNA by PCR.
Hepatitis C
A highly sensitive and selective fluorescence biosensor for hepatitis C virus DNA detection based on ?-FeOOH and exonuclease III-assisted signal amplification.
Hepatitis C
Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics.
Hepatitis C
Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication.
Hepatitis C
Interferon stimulated exonuclease gene 20?kDa links psychiatric events to distinct hepatitis C virus responses in human immunodeficiency virus positive patients.
Hepatitis C
miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation.
Hepatitis C
RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
Herpes Simplex
3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity.
Herpes Simplex
A Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, And Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1.
Herpes Simplex
Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins.
Herpes Simplex
DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes.
Herpes Simplex
Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA.
Herpes Simplex
Effects of exonuclease activity and nucleotide selectivity of the herpes simplex virus DNA polymerase on the fidelity of DNA replication in vivo.
Herpes Simplex
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Herpes Simplex
Exonuclease-deficient polymerase mutant of herpes simplex virus type 1 induces altered spectra of mutations.
Herpes Simplex
Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain.
Herpes Simplex
Herpes simplex virus type I DNA polymerase. Kinetic properties of the associated 3'-5' exonuclease activity and its role in araAMP incorporation.
Herpes Simplex
High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein.
Herpes Simplex
High-Resolution Characterization of Herpes Simplex Virus Type 1 Transcripts Encoding Alkaline Exonuclease and a 50,000-Dalton Protein Tentatively Identified as a Capsid Protein.
Herpes Simplex
Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.
Herpes Simplex
Improved band shift assay for the simultaneous analysis of protein-DNA interactions and enzymatic functions of DNA polymerases.
Herpes Simplex
Intranuclear localization of herpes simplex virus immediate-early and delayed-early proteins: evidence that ICP 4 is associated with progeny virus DNA.
Herpes Simplex
mRNA- and DNA-directed synthesis of herpes simplex virus-coded exonuclease in Xenopus laevis oocytes.
Herpes Simplex
Novel interaction of aphidicolin with herpes simplex virus DNA polymerase and polymerase-associated exonuclease.
Herpes Simplex
On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase.
Herpes Simplex
Physical Interaction between the Herpes Simplex Virus Type 1 Exonuclease, UL12, and the DNA double strand break sensing MRN complex.
Herpes Simplex
Physical mapping of the herpes simplex virus type 2 nuc- lesion affecting alkaline exonuclease activity by using herpes simplex virus type 1 deletion clones.
Herpes Simplex
Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated.
Herpes Simplex
Processive replication of single-stranded DNA templates by the herpes simplex virus-induced DNA polymerase.
Herpes Simplex
Properties of herpes simplex virus DNA polymerase and characterization of its associated exonuclease activity.
Herpes Simplex
Purification and characterization of herpes simplex virus type 1 alkaline exonuclease expressed in Escherichia coli.
Herpes Simplex
Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence.
Herpes Simplex
Structural and functional properties of DNA polymerase delta from rabbit bone marrow.
Herpes Simplex
Structure-function analysis of the herpes simplex virus type 1 UL12 gene: correlation of deoxyribonuclease activity in vitro with replication function.
Herpes Simplex
The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions.
Herpes Simplex
The exonuclease activity of HSV-1 UL12 is required for the production of viral DNA that can be packaged to produce infectious virus.
Herpes Simplex
The Role of Marek's Disease Virus UL12 and UL29 in DNA Recombination and the Virus Lifecycle.
Hyperemia
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.
Hypersensitivity
Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance.
Hypersensitivity
Functional variants of human APE1 rescue the DNA repair defects of the yeast AP endonuclease/3'-diesterase-deficient strain.
Hypersensitivity
Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae.
Hypersensitivity
Structure of chromatin at deoxyribonucleic acid replication forks: nuclease hypersensitivity results from both prenucleosomal deoxyribonucleic acid and an immature chromatin structure.
Infarction, Middle Cerebral Artery
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.
Infections
A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.
Infections
Comparative transcriptomic analysis of Rickettsia conorii during in vitro infection of human and tick host cells.
Infections
Comparison of the sensitivity and specificity of real-time PCR and in situ hybridization in HPV16 and 18 detection in archival cervical cancer specimens.
Infections
Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus.
Infections
Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication.
Infections
Expression of the phage lambda recombination genes exo and bet under lacPO control on a multi-copy plasmid.
Infections
Formation of phage T1 concatemers by the RecE recombination pathway of Escherichia coli.
Infections
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases.
Infections
HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection.
Infections
Human Three Prime Repair Exonuclease 1 Promotes HIV-1 Integration by Preferentially Degrading Unprocessed Viral DNA.
Infections
Identification of in vivo regulators of the Vibrio cholerae?xds gene using a high-throughput genetic selection.
Infections
Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors.
Infections
Intranuclear localization of herpes simplex virus immediate-early and delayed-early proteins: evidence that ICP 4 is associated with progeny virus DNA.
Infections
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication.
Infections
Repression of lambda-Associated Enzyme Synthesis After lambda(vir) Superinfection of Lysogenic Hosts.
Infections
Role of gene 6 exonuclease in the replication and packaging of bacteriophage T7 DNA.
Infections
Separation and characterization of deoxyribonucleases of Escherichia coli B. II. Further purification and properties of an exonuclease induced by infection with bacteriophage T2.
Infections
Silencing the shutoff protein of Epstein-Barr virus in productively infected B cells points to (innate) targets for immune evasion.
Infections
Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Infections
The "Bridge" in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection.
Infections
The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-? during Chlamydia trachomatis infection.
Infections
The DNase Activity of KSHV SOX Protein Serves an Important Role in Viral Genome Processing During Lytic Replication.
Infections
The PHP domain of PolX from Staphylococcus aureus aids high fidelity DNA synthesis through the removal of misincorporated deoxyribo-, ribo- and oxidized nucleotides.
Infections
The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production.
Infections
Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.
Infections
[Study of the lambda-exonuclease activity of Escherichia coli during induction of the vegetative phage and infection with temperate phage lambda]
Influenza in Birds
Ultrasensitive SERS determination of avian influenza A H7N9 virus via exonuclease III-assisted cycling amplification.
Influenza, Human
Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.
Laryngeal Neoplasms
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.
Lassa Fever
Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES).
Leukemia
A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate.
Leukemia
Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells.
Leukemia
p53-associated 3'-->5' exonuclease activity in nuclear and cytoplasmic compartments of cells.
Leukoencephalopathies
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.
Lipodystrophy
Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis.
Liver Neoplasms, Experimental
Interaction of mammalian deoxyribonuclease V, a double strand 3' to 5' and 5' to 3' exonuclease, with deoxyribonucleic acid polymerase-beta from the Novikoff hepatoma.
Lupus Erythematosus, Systemic
An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis.
Lupus Erythematosus, Systemic
Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice.
Lupus Erythematosus, Systemic
Intrinsic self-DNA triggers inflammatory disease dependent on STING.
Lupus Erythematosus, Systemic
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
TREX1 variants in Sjogren's syndrome related lymphomagenesis.
Lyme Disease
SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories.
Lymphoma
Effect of (211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes.
Lymphoma
Novel 5' exonuclease-based real-time PCR assay for the detection of t(14;18)(q32;q21) in patients with follicular lymphoma.
Lymphoma, B-Cell
Increased sensitivity of B-cell clonality analysis in formalin-fixed and paraffin-embedded B-cell lymphoma samples using an enzyme blend with both 5'-->3' DNA polymerase and 3'-->5' exonuclease activity.
Malaria
Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization.
Melanoma
Carboplatin activates the cGAS-STING pathway by upregulating the TREX-1 (three prime repair exonuclease 1) expression in human melanoma.
Melanoma
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.
Meningococcal Infections
5' exonuclease assay for detection of serogroup Y Neisseria meningitidis.
Mouth Neoplasms
ISG20 is overexpressed in clinically relevant radioresistant oral cancer cells.
Myocardial Infarction
The Matrix Metalloproteinase 2-1575 gene Polymorphism is Associated with the Risk of Developing Myocardial Infarction in Mexican Patients.
Myocarditis
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.
Myotonic Dystrophy
Fen1 does not control somatic hypermutability of the (CTG)(n).(CAG)(n) repeat in a knock-in mouse model for DM1.
Neoplasm Metastasis
Metastasis suppressor function of NM23-H1 requires its 3';-5' exonuclease activity.
Neoplasms
A Common Cancer-Associated DNA Polymerase {varepsilon} Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading.
Neoplasms
A recurrent cancer-associated substitution in DNA polymerase ? produces a hyperactive enzyme.
Neoplasms
Additional value of K-ras point mutations in bronchial wash fluids for diagnosis of peripheral lung tumours.
Neoplasms
An exonuclease protection and CRISPR/Cas12a integrated biosensor for the turn-on detection of transcription factors in cancer cells.
Neoplasms
Analysis of CNOT Family Gene Expression, Clinicopathological Features, and Prognosis Value in Hepatocellular Carcinoma.
Neoplasms
Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.
Neoplasms
Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade.
Neoplasms
Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.
Neoplasms
Clinicopathological and molecular characterisation of 'multiple-classifier' endometrial carcinomas.
Neoplasms
Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene.
Neoplasms
Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers.
Neoplasms
Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.
Neoplasms
Corded and Hyalinized and Spindled Endometrioid Endometrial Carcinoma: A Clinicopathologic and Molecular Analysis of 9 Tumors Based on the TCGA Classifier.
Neoplasms
Cytoplasmic p53 contributes to the removal of uracils misincorporated by HIV-1 reverse transcriptase.
Neoplasms
Dedifferentiated endometrial carcinomas with neuroendocrine features: a clinicopathologic, immunohistochemical, and molecular genetic study.
Neoplasms
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.
Neoplasms
DNA Polymerase ? Deficiency Leading to an Ultramutator Phenotype: A Novel Clinically Relevant Entity.
Neoplasms
DNA-Conjugated Amphiphilic Aggregation-Induced Emission Probe for Cancer Tissue Imaging and Prognosis Analysis.
Neoplasms
Does a p53 "Wild-type" Immunophenotype Exclude a Diagnosis of Endometrial Serous Carcinoma?
Neoplasms
Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
Neoplasms
Exonuclease enhances hybridization efficiency: improved direct cycle sequencing and point mutation detection.
Neoplasms
Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication.
Neoplasms
FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair.
Neoplasms
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer.
Neoplasms
Fluorescence detection of telomerase activity in cancer cell extracts based on autonomous exonuclease III-assisted isothermal cycling signal amplification.
Neoplasms
Germline PMS2 and somatic POLEexo mutations cause hypermutability of the leading DNA strand in Biallelic Mismatch Repair Deficiency syndrome brain tumors.
Neoplasms
Germline RAD54L with somatic POLE defect implicated in Hypermutation phenotype: case report.
Neoplasms
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading.
Neoplasms
High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation.
Neoplasms
Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors.
Neoplasms
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.
Neoplasms
Hydrolysis of deoxyribo-oligonucleotides bearing 3'-monoesterified phosphate by mouse mammary tumor exonuclease.
Neoplasms
Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine.
Neoplasms
Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis.
Neoplasms
Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.
Neoplasms
ISG20 promotes local tumor immunity and contributes to poor survival in human glioma.
Neoplasms
Mismatch repair and DNA polymerase ? proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ? variant.
Neoplasms
Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Molecularly Classified Endometrial Carcinoma.
Neoplasms
Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer.
Neoplasms
Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment.
Neoplasms
Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy.
Neoplasms
Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups.
Neoplasms
Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain.
Neoplasms
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.
Neoplasms
Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase ? mutation in human cells.
Neoplasms
p53 enhances the fidelity of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.
Neoplasms
P53 in cytoplasm may enhance the accuracy of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.
Neoplasms
p53 in the mitochondria, as a trans-acting protein, provides error-correction activities during the incorporation of non-canonical dUTP into DNA.
Neoplasms
p53-associated 3'-->5' exonuclease activity in nuclear and cytoplasmic compartments of cells.
Neoplasms
p53abn Endometrial Cancer: understanding the most aggressive endometrial cancers in the era of molecular classification.
Neoplasms
POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features.
Neoplasms
POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status.
Neoplasms
Polymerase epsilon mutations and concomitant ?2-microglobulin mutations in cancer.
Neoplasms
Pre-treatment risk assessment of women with endometrial cancer: differences in outcomes of molecular and clinical classifications in the Slovenian patient cohort.
Neoplasms
Quantification of human cells in NOD/SCID mice by duplex real-time polymerase-chain reaction.
Neoplasms
Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles.
Neoplasms
Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study.
Neoplasms
Regression of chemotherapy-resistant Polymerase epsilon (POLE) ultra-mutated and MSH6 hyper-mutated endometrial tumors with nivolumab.
Neoplasms
Removal of ribonucleotides by p53 protein incorporated during DNA synthesis by HIV-1 reverse transcriptase.
Neoplasms
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.
Neoplasms
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Neoplasms
Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue.
Neoplasms
Significant contribution of the 3'?5' exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ?.
Neoplasms
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
Neoplasms
Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer.
Neoplasms
Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells.
Neoplasms
Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo.
Neoplasms
The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas.
Neoplasms
The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.
Neoplasms
Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review).
Neoplasms
Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis.
Neoplasms
Undifferentiated Endometrial Carcinomas Show Frequent Loss of Core Switch/Sucrose Nonfermentable Complex Proteins.
Neuroblastoma
Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses.
Neurodegenerative Diseases
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
Neutropenia
Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Removal of anti-human immunodeficiency virus 2',3'-dideoxynucleoside monophosphates from DNA by a novel human cytosolic 3'-->5' exonuclease.
Progeria
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
Progeria
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.
Pseudorabies
Pseudorabies virus DNA-binding protein stimulates the exonuclease activity and regulates the processivity of pseudorabies virus DNase.
Psoriasis
Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis.
Retinitis
The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage.
Sarcoma
An exonuclease possibly involved in the initiation of repair of bleomycin-damaged DNA in mouse ascites sarcoma cells.
Sarcoma
Using mRNA deep sequencing to analyze differentially expressed genes during Panax notoginseng saponin treatment of ischemic stroke.
Sarcoma 180
A 5' exoribonuclease from cytoplasmic extracts of mouse sarcoma 180 ascites cells.
Schistosomiasis
Schistosoma mansoni: localisation of antigenic regions on the 31 kilodalton diagnostic protein.
Severe Acute Respiratory Syndrome
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.
Spinocerebellar Degenerations
Homozygous c.359del variant in MGME1 is associated with early onset cerebellar ataxia.
Stomach Neoplasms
Two-stage cyclic enzymatic amplification method for ultrasensitive electrochemical assay of microRNA-21 in the blood serum of gastric cancer patients.
Stroke
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations.
Superinfection
Repression of lambda-Associated Enzyme Synthesis After lambda(vir) Superinfection of Lysogenic Hosts.
Takayasu Arteritis
Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients.
Thymoma
Studies of c-myb gene regulation in MRL-lpr/lpr mice. Identification of a 5' c-myb nuclear protein binding site and high levels of binding factors in nuclear extracts of lpr/lpr lymph node cells.
Tuberculosis
M. tuberculosis class II apurinic/ apyrimidinic-endonuclease/3'-5' exonuclease (XthA) engages with NAD+-dependent DNA ligase A (LigA) to counter futile cleavage and ligation cycles in base excision repair.
Tuberculosis
Mechanistic insights into the enzymatic activity and inhibition of the replicative polymerase exonuclease domain from Mycobacterium tuberculosis.
Tuberculosis
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine.
Tuberculosis
The ?2 clamp in the Mycobacterium tuberculosis DNA polymerase III ??2? replicase promotes polymerization and reduces exonuclease activity.
Tuberculosis
The construction of Mycobacterium tuberculosis 16S rDNA MSPQC sensor based on Exonuclease III-assisted cyclic signal amplification.
Vaccinia
Action of ATP-dependent DNase from Hemophilus influenzae on cross-linked DNA molecules.
Vaccinia
Cellular 5'-3' mRNA Exonuclease Xrn1 Controls Double-Stranded RNA Accumulation and Anti-Viral Responses.
Vaccinia
Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand.
Vaccinia
Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate.
Vaccinia
Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype.
Vaccinia
Virus-associated nucleases: evidence for endonuclease and exonuclease activity in rabbitpox and vaccinia viruses.
Virus Diseases
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo.
Virus Diseases
Early transcriptome profile of goat peripheral blood mononuclear cells (PBMCs) infected with peste des petits ruminant's vaccine virus (Sungri/96) revealed induction of antiviral response in an interferon independent manner.
Virus Diseases
Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease.
Werner Syndrome
A gene encoding an RNase D exonuclease-like protein is required for post-transcriptional silencing in Arabidopsis.
Werner Syndrome
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.
Werner Syndrome
Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome protein.
Werner Syndrome
Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA.
Werner Syndrome
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
Werner Syndrome
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
Werner Syndrome
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease.
Werner Syndrome
DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA.
Werner Syndrome
Functional interaction between Ku and the werner syndrome protein in DNA end processing.
Werner Syndrome
Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and Ataxia.
Werner Syndrome
Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity.
Werner Syndrome
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.
Werner Syndrome
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains.
Werner Syndrome
Loss of Werner syndrome protein function promotes aberrant mitotic recombination.
Werner Syndrome
Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease.
Werner Syndrome
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
Werner Syndrome
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
Werner Syndrome
Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity.
Werner Syndrome
Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review.
Werner Syndrome
Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity.
Werner Syndrome
The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase ?
Werner Syndrome
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
Werner Syndrome
The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.
Werner Syndrome
The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.
Werner Syndrome
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
Werner Syndrome
The Werner syndrome protein has separable recombination and survival functions.
Werner Syndrome
TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.
Werner Syndrome
Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.
Werner Syndrome
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.
Werner Syndrome
Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.
Werner Syndrome
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.
Werner Syndrome
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
Werner Syndrome
Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease.
Werner Syndrome
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.
Werner Syndrome
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Zika Virus Infection
Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection.
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