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Information on EC 3.1.11.1 - exodeoxyribonuclease I and Organism(s) Bacillus subtilis and UniProt Accession P37454

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Bacillus subtilis
UNIPROT: P37454 not found.
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The taxonomic range for the selected organisms is: Bacillus subtilis
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphodiesterase, dna polymerase i, exonuclease i, exonuclease 1, exo i, hexo1, polb1, 3'-to-5' exonuclease, sbcb15, drpase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3'->5'exonuclease
-
3'5' exonuclease
-
-
-
-
DNA deoxyribophosphodiesterase
-
-
-
-
dRPase
-
-
-
-
E. coli exonuclease I
-
-
-
-
Escherichia coli exonuclease I
-
-
-
-
exonuclease I
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9037-46-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-end 3'-dAMP-labeled (5R,6S)-thymine glycol-thymidine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 1,N6-ethenoadenine-thymidine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 5,6-dihydrothymine-adenosine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 5,6-dihydrouracil-guanine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 5-hydroxycytosine-guanine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 7,8-dihydro-8-oxoguanine-cytosine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled alpha-anomeric 2'-deoxyadenosine-thymidine duplex + H2O
?
show the reaction diagram
low efficiency
-
-
?
3'-end 3'-dAMP-labeled tetrahydrofuran-T duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled uracil-guanine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled urea-thymidine duplex + H2O
?
show the reaction diagram
-
-
-
?
5 mC-G duplex + H2O
?
show the reaction diagram
-
-
-
?
5 ohmC-G duplex + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-end 3'-dAMP-labeled (5R,6S)-thymine glycol-thymidine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 1,N6-ethenoadenine-thymidine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 5,6-dihydrothymine-adenosine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 5,6-dihydrouracil-guanine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 5-hydroxycytosine-guanine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled 7,8-dihydro-8-oxoguanine-cytosine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled alpha-anomeric 2'-deoxyadenosine-thymidine duplex + H2O
?
show the reaction diagram
low efficiency
-
-
?
3'-end 3'-dAMP-labeled tetrahydrofuran-T duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled uracil-guanine duplex + H2O
?
show the reaction diagram
-
-
-
?
3'-end 3'-dAMP-labeled urea-thymidine duplex + H2O
?
show the reaction diagram
-
-
-
?
5 mC-G duplex + H2O
?
show the reaction diagram
-
-
-
?
5 ohmC-G duplex + H2O
?
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
sitting drop vapor diffusion method, using 16% (w/v) PEG 4000, 0.1 M Tris pH 8.5, 0.2 M CaCl2
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Q-Sepharose column chromatography and HiTrap-heparin column chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BH110(DE3) cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Redrejo-Rodriguez, M.; Vigouroux, A.; Mursalimov, A.; Grin, I.; Alili, D.; Koshenov, Z.; Akishev, Z.; Maksimenko, A.; Bissenbaev, A.; Matkarimov, B.; Saparbaev, M.; Ishchenko, A.; Morera, S.
Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA
Biochimie
128-129
20-33
2016
Bacillus subtilis (P37454), Bacillus subtilis 168 (P37454)
Manually annotated by BRENDA team