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Disease on EC 3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenoma
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Alzheimer Disease
Caffeine inhibits Notum activity by binding at the catalytic pocket.
Structural Insights into Notum Covalent Inhibition.
Carcinoma
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Carcinoma, Hepatocellular
Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF.
Colonic Neoplasms
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Colorectal Neoplasms
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
NOTUM Is Involved in the Progression of Colorectal Cancer.
Novel insights into Notum and glypicans regulation in colorectal cancer.
Dentin Dysplasia
Dentin Dysplasia in Notum Knockout Mice.
Diabetes Mellitus, Type 2
Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum.
Hepatitis C
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Infections
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Liver Cirrhosis
Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways.
Liver Neoplasms
Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells.
Neoplasms
Induction of tumor clones in D. melanogaster wts/+ heterozygotes with chemical carcinogens.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Novel insights into Notum and glypicans regulation in colorectal cancer.
Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer.
Small-molecule inhibitors of carboxylesterase Notum.
Neurodegenerative Diseases
Small-molecule inhibitors of carboxylesterase Notum.
Obesity
NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice.
Osteoporosis
Small-molecule inhibitors of carboxylesterase Notum.
Structural Insights into Notum Covalent Inhibition.
Periodontitis
Notum suppresses the osteogenic differentiation of periodontal ligament stem cells through the Wnt/Beta catenin signaling pathway.
Pulmonary Disease, Chronic Obstructive
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Pulmonary Fibrosis
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
[wnt protein] o-palmitoleoyl-l-serine hydrolase deficiency
Notum Deletion From Late-Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition.