Disease on EC 3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase
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Carcinoma
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Carcinoma, Hepatocellular
Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF.
Colonic Neoplasms
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Colorectal Neoplasms
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Colorectal Neoplasms
Novel insights into Notum and glypicans regulation in colorectal cancer.
Diabetes Mellitus, Type 2
Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum.
Hepatitis C
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Infections
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Liver Cirrhosis
Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways.
Liver Neoplasms
Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells.
Neoplasms
Induction of tumor clones in D. melanogaster wts/+ heterozygotes with chemical carcinogens.
Neoplasms
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Neoplasms
Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer.
Obesity
NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice.
Periodontitis
Notum suppresses the osteogenic differentiation of periodontal ligament stem cells through the Wnt/Beta catenin signaling pathway.
Pulmonary Disease, Chronic Obstructive
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Pulmonary Fibrosis
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
[wnt protein] o-palmitoleoyl-l-serine hydrolase deficiency
Notum Deletion From Late-Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition.
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