The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.
The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.
the optimized N-hydroxyhydantoin carbamate inhibitor preserves Wnt-mediated cell signaling in the presence of NOTUM and is also converted into an activity-based protein profiling (ABPP) probe for visualizing NOTUM in native biological systems. NOTUM inhibitors have potential for treating degenerative diseases
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
at 24 h post fertilization, expression is particularly pronounced in the central nervous system, including the dorsal neural tube and the midbrain-hindbrain boundary
Notum1a is expressed in the lateral edges and midline of the posterior neural plate. During segmentation, it is expressed in stripes at the lateral edges and adjacent to the midline of the neural plate
Notum is expressed dynamically during Xenopus embryogenesis, expression is required for head formation and neural induction. Notum functions in the prostective ectoderm
Notum hydrolyzes the Wnt palmitoleoylate adduct extracellularly, resulting in inactivated Wnt proteins that form oxidized oligomers incapable of receptor binding. Notum is a Wnt deacylase, and palmitoleoylation is obligatory for the Wnt structure that maintains its active monomeric conformation. Notum is critical for neural and head induction by acting within the presumptive neuroectoderm
Notum1a contributes to a self-regulatory loop that restricts Wnt/betA-catenin signaling. Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity pathway, but plays specific role in the developing vertebrate embryo. In cultured cells, Notum1a inhibits Wnt/beta-catenin signaling
Notum requires glypicans to suppress Wnt signalling, but does not cleave their glycophosphatidylinositol anchor. Glycosaminoglycan binding sites on Notum probably help to co-localize with Wnt proteins. A large hydrophobic pocket at the active site accommodates palmitoleate
Notum requires glypicans to suppress Wnt signalling, but does not cleave their glycophosphatidylinositol anchor. Glycosaminoglycan binding sites on Notum probably help to co-localize with Wnt proteins. A large hydrophobic pocket at the active site accommodates palmitoleate
notum has a role in promoting brain cell numbers during conditions of brain cell loss through tissue remodeling. Notum inhibits wnt11-6 to control brain size in regenerative degrowth and growth. Notum and wnt11-6 antagonism acts in an essentially constitutive process to control brain cell number, potentially through the determination and maintenance of a size set-point for the planarian brain. Notum and wnt11-6 regulate neoblast differentiation to influence brain size. Inhibition of notum does not significantly alter the density of neurons within the brain or average neuronal cell size, indicating that notum is likely to regulate brain:body proportion principally through the regulation of brain cell number
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Notum is expressed dynamically during Xenopus embryogenesis, expression is required for head formation and neural induction. Notum functions in the prostective ectoderm
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3.1.1.98 [Wnt protein] O-palmitoleoyl-L-serine hydrolase
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