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[phosphatase 2A protein]-leucine methyl ester + H2O
[phosphatase 2A protein]-leucine + methanol
[protein phosphatase 2A catalytic subunit]-leucine methyl ester + H2O
[protein phosphatase 2A catalytic subunit]-leucine + methanol
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reversible methylation and demethylation at C-terminal residue Leu309. The activity of protein phosphatase 2A is largely unaffected by the addition of enzyme. Mutant versions of substrate protein phosphatase 2A containing an alanine residue in place of Leu309, and a deletion of Leu309 both exhibit phosphatase activity
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additional information
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spliced isoform PP2Acalpha2 (lacking exon 5) does not interact with PME-1. Only the longer isoform of PP2A interacts with PME-1
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[phosphatase 2A protein]-leucine methyl ester + H2O
[phosphatase 2A protein]-leucine + methanol
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[phosphatase 2A protein]-leucine methyl ester + H2O
[phosphatase 2A protein]-leucine + methanol
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[phosphatase 2A protein]-leucine methyl ester + H2O
[phosphatase 2A protein]-leucine + methanol
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[phosphatase 2A protein]-leucine methyl ester + H2O
[phosphatase 2A protein]-leucine + methanol
the enzyme negatively regulates protein phosphatase 2A activity by highly complex mechanisms
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Adenocarcinoma
Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer.
Alzheimer Disease
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.
Carcinoma
DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p.
Choriocarcinoma
IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1.
Colorectal Neoplasms
Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer.
Glioblastoma
Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.
Lung Neoplasms
Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.
Neoplasms
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.
Neoplasms
DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p.
Neoplasms
Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.
Neoplasms
Long non-coding RNA HOTAIR/microRNA-761 sponge regulates PPME1 and further influences cell biological functions in thyroid carcinoma.
Neoplasms
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Neoplasms
Recent Trends in the Design, Synthesis and Biological Exploration of ?-Lactams.
Stomach Neoplasms
Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.
Thyroid Neoplasms
Long non-coding RNA HOTAIR/microRNA-761 sponge regulates PPME1 and further influences cell biological functions in thyroid carcinoma.
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Longin, S.; Zwaenepoel, K.; Martens, E.; Louis, J.; Rondelez, E.; Goris, J.; Janssens, V.
Spatial control of protein phosphatase 2A (de)methylation
Exp. Cell Res.
314
68-81
2008
Homo sapiens
brenda
Ikehara, T.; Ikehara, S.; Imamura, S.; Shinjo, F.; Yasumoto, T.
Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B)
Biochem. Biophys. Res. Commun.
354
1052-1057
2007
Homo sapiens
brenda
Xing, Y.; Li, Z.; Chen, Y.; Stock, J.; Jeffrey, P.; Shi, Y.
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
Cell
133
154-163
2008
Homo sapiens (Q9Y570)
brenda
Ogris, E.; Du, X.; Nelson, K.; Mak, E.; Yu, X.; Lane, W.; Pallas, D.
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A
J. Biol. Chem.
274
14382-14391
1999
Homo sapiens (Q9Y570), Homo sapiens
brenda
DeGrande, S.; Little, S.; Nixon, D.; Wright, P.; Snyder, J.; Dun, W.; Murphy, N.; Kilic, A.; Higgins, R.; Binkley, P.; Boyden, P.; Carnes, C.; Anderson, M.; Hund, T.; Mohler, P.
Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart
J. Biol. Chem.
288
1032-1046
2013
Homo sapiens
brenda
Bachovchin, D.A.; Zuhl, A.M.; Speers, A.E.; Wolfe, M.R.; Weerapana, E.; Brown, S.J.; Rosen, H.; Cravatt, B.F.
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1
J. Med. Chem.
54
5229-5236
2011
Homo sapiens
brenda
Bachovchin, D.A.; Mohr, J.T.; Speers, A.E.; Wang, C.; Berlin, J.M.; Spicer, T.P.; Fernandez-Vega, V.; Chase, P.; Hodder, P.S.; Schuerer, S.C.; Nomura, D.K.; Rosen, H.; Fu, G.C.; Cravatt, B.F.
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
Proc. Natl. Acad. Sci. USA
108
6811-6816
2011
Homo sapiens
brenda
Migueleti, D.; Smetana, J.; Nunes, H.; Kobarg, J.; Zanchin, N.
Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aalpha catalytic subunit
J. Biol. Chem.
287
4853-4862
2012
Homo sapiens
brenda
Lee, C.W.; Yang, F.C.; Chang, H.Y.; Chou, H.; Tan, B.C.; Lee, S.C.
Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1
J. Biol. Chem.
289
21108-21119
2014
Homo sapiens
brenda
Kaur, A.; Westermarck, J.
Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1
Biochem. Soc. Trans.
44
1683-1693
2016
Mus musculus (Q8BVQ5), Homo sapiens (Q9Y570), Homo sapiens
brenda
Pusey, M.; Bail, S.; Xu, Y.; Buiakova, O.; Nestor, M.; Yang, J.J.; Rice, L.M.
Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models
Tumour Biol.
37
11835-11842
2016
Homo sapiens (Q9Y570)
brenda