Disease on EC 3.1.1.79 - hormone-sensitive lipase

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DISEASE
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Adenocarcinoma
Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29.
Arthritis
Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation.
Atherosclerosis
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages.
Reduced atherosclerosis in hormone-sensitive lipase transgenic mice overexpressing cholesterol acceptors.
Breast Neoplasms
Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-?B) signaling in cancer cells.
Carcinoma, Hepatocellular
?-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure.
Comparison of the changes in lipid metabolism between hepatoma-bearing and lipopolysaccharide-treated rats.
Effects of sulfur amino acids, L: -methionine, L: -cystine and L: -cysteine on lipoprotein lipase and hormone-sensitive lipase in differentiated mouse 3T3-L1 adipocytes.
Metabolic characteristics of a human hepatoma cell line stably transfected with hormone-sensitive lipase.
Cardiomyopathies
Inborn errors of cytoplasmic triglyceride metabolism.
Cardiovascular Diseases
Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans.
Dandruff
Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.
Dermatitis
Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.
Diabetes Mellitus
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Cyclipostins, novel hormone-sensitive lipase inhibitors from Streptomyces sp. DSM 13381. II. Isolation, structure elucidation and biological properties.
Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion.
The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity.
Diabetes Mellitus, Type 2
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Downregulation of islet hormone-sensitive lipase during long-term high-fat feeding.
Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes.
Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion.
Human hormone-sensitive lipase: genetic mapping, identification of a new dinucleotide repeat, and association with obesity and NIDDM.
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.
Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose.
Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.
[Multivariate logistic regression analysis on the risk factors of type 2 diabetes mellitus]
Diabetic Cardiomyopathies
Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice.
Dyslipidemias
[Diagnosis of Secondary Hyperlipidemia due to Diabetes].
Epilepsy
Fold prediction and comparative modeling of Bdm1: a probable alpha/beta hydrolase associated with hot water epilepsy.
Fatty Liver
Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice.
Risk interaction of obesity, insulin resistance and hormone-sensitive lipase promoter polymorphisms (LIPE-60 C > G) in the development of fatty liver.
Glucose Intolerance
Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal.
Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.
HIV-Associated Lipodystrophy Syndrome
Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome.
hormone-sensitive lipase deficiency
Hormone-sensitive lipase deficiency alters gene expression and cholesterol content of mouse testis.
Hormone-sensitive lipase deficiency disturbs lipid composition of plasma membrane microdomains from mouse testis.
Hormone-sensitive lipase deficiency disturbs the fatty acid composition of mouse testis.
Hormone-sensitive lipase deficiency in humans.
Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis.
Hormone-sensitive lipase deficiency in mice causes lipid storage in the adrenal cortex and impaired corticosterone response to corticotropin stimulation.
Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle.
Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.
Infertility and testicular defects in hormone-sensitive lipase-deficient mice.
Letting lipids go: hormone-sensitive lipase.
The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice.
Hyperglycemia
FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity.
Hyperinsulinism
Chronic exposure of rat fat cells to insulin enhances lipolysis and activation of partially purified hormone-sensitive lipase.
FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity.
Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance.
Muscle type-dependent responses to insulin in intramyocellular triglyceride turnover in obese rats.
Hyperlipidemia, Familial Combined
Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome.
C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients.
In vivo modulation of plasma free fatty acids in patients with familial combined hyperlipidemia using lipid-lowering medication.
Hyperlipidemias
Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome.
C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients.
Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes.
Effects of sulfur amino acids, L: -methionine, L: -cystine and L: -cysteine on lipoprotein lipase and hormone-sensitive lipase in differentiated mouse 3T3-L1 adipocytes.
FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity.
In vivo modulation of plasma free fatty acids in patients with familial combined hyperlipidemia using lipid-lowering medication.
Hyperthyroidism
Adrenergic binding sites and enzyme activities in the heart of hyperthyroid rats.
Catecholamine-induced adipocyte lipolysis in human hyperthyroidism.
The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients.
Hypertriglyceridemia
Inborn errors of cytoplasmic triglyceride metabolism.
Hypothyroidism
Adrenergic regulation of lipolysis in fat cells from hyperthyroid and hypothyroid patients.
Ichthyosis
Inborn errors of cytoplasmic triglyceride metabolism.
Infections
A secreted lipase of Fusarium graminearum is a virulence factor required for infection of cereals.
Clofazimine modulates the expression of lipid metabolism proteins in Mycobacterium leprae-infected macrophages.
Legionella pneumophila genes that encode lipase and phospholipase C activities.
Overexpression of Rv3097c in Mycobacterium bovis BCG abolished the efficacy of BCG vaccine to protect against Mycobacterium tuberculosis infection in mice.
RAS2 regulates growth and pathogenesis in Fusarium graminearum.
Resistance of callose synthase activity to free fatty acid inhibition as an indicator of Fusarium head blight resistance in wheat.
Secretome analysis reveals an Arabidopsis lipase involved in defense against Alternaria brassicicola.
Infertility
The N-terminal His-tag affects the triglyceride lipase activity of hormone-sensitive lipase in testis.
Infertility, Male
Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity.
The testicular form of hormone-sensitive lipase HSLtes confers rescue of male infertility in HSL-deficient mice.
Influenza, Human
Hepatic steatosis during convalescence from influenza B infection in ferrets with postprandial hyperinsulinemia.
Insulin Resistance
Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome.
Adipose triglyceride lipase and hormone-sensitive lipase protein expression in subcutaneous adipose tissue is decreased after an isoenergetic low-fat high-complex carbohydrate diet in the metabolic syndrome.
Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state.
Antiobesity Effect of a Small Molecule Repressor of ROR?.
Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue.
Carbazates as potent inhibitors of hormone-sensitive lipase.
FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity.
High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle.
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.
Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact.
Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance?
In vivo modulation of plasma free fatty acids in patients with familial combined hyperlipidemia using lipid-lowering medication.
Male hypogonadism: The unrecognized cardiovascular risk factor.
Omics Analyses Reveal a Potential Link between Hormone-Sensitive Lipase and Polyamine Metabolism.
Peroxisome proliferator-activated receptor-alpha,gamma-agonist improves insulin sensitivity and prevents loss of left ventricular function in obese dyslipidemic mice.
Peroxisome proliferator-activated receptor-gamma transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1.
Risk interaction of obesity, insulin resistance and hormone-sensitive lipase promoter polymorphisms (LIPE-60 C > G) in the development of fatty liver.
Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose.
The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank.
Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal.
[Diagnosis of Secondary Hyperlipidemia due to Diabetes].
Ketosis
Concentrations of Plasma Metabolites, Hormones, and mRNA Abundance of Adipose Leptin and Hormone-Sensitive Lipase in Ketotic and Nonketotic Dairy Cows.
Lipidoses
Metabolic and hormonal alterations in cats with hepatic lipidosis.
Lipoma
Lipoprotein lipase and hormone-sensitive lipase activities in human subcutaneous lipomas: comparison with normal subcutaneous adipose tissue.
Liver Diseases
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Lymphoma, B-Cell
Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure.
Marek Disease
vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virus.
Metabolic Syndrome
Adipose triglyceride lipase and hormone-sensitive lipase protein expression in subcutaneous adipose tissue is decreased after an isoenergetic low-fat high-complex carbohydrate diet in the metabolic syndrome.
Effect of Glycine on Adipocyte Hypertrophy in a Metabolic Syndrome Rat Model.
Genetics of the metabolic syndrome.
Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.
Muscular Atrophy
The alleviative effects and related mechanisms of taurine supplementation on growth performance and carcass characteristics in broilers exposed to chronic heat stress.
Muscular Diseases
Inborn errors of cytoplasmic triglyceride metabolism.
Neoplasms
1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin Inhibits Adipocyte Differentiation of 3T3-L1 Fibroblasts.
A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q.
Aberrations in normal systemic lipid metabolism in ovarian cancer patients.
Activity and tissue-specific expression of lipases and tumor-necrosis factor alpha in lean and obese cats.
Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis.
An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines.
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Cancer cachexia.
Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation.
Depot-related gene expression in human subcutaneous and omental adipocytes.
Effect of dermcidin, an antimicrobial peptide, on body fat mobilization in normal mice.
Expression of Lipid Metabolism-Related Proteins Differs between Invasive Lobular Carcinoma and Invasive Ductal Carcinoma.
High expression of the evolutionarily conserved alpha/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors.
Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients.
Lipases and lipid droplet-associated protein expression in subcutaneous white adipose tissue of cachectic patients with cancer.
Mechanisms to explain wasting of muscle and fat in cancer cachexia.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Normal and pathological human testes express hormone-sensitive lipase and the lipid receptors CLA-1/SR-BI and CD36.
Obesity and polymorphisms in genes regulating human adipose tissue.
Obesity--a genetic disease of adipose tissue?
Phosphorylated glucosamine inhibits adipogenesis in 3T3-L1 adipocytes.
Regulation of adipocytes lipolysis by n-3 HUFA in grass carp (Ctenopharyngodon idellus) in vitro and in vivo.
Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-? (TNF-?)-induced lipolysis in adipocytes.
Role of beta1-adrenoceptor in increased lipolysis in cancer cachexia.
The human breast carcinoma cell line HBL-100 acquires exogenous cholesterol from high-density lipoprotein via CLA-1 (CD-36 and LIMPII analogous 1)-mediated selective cholesteryl ester uptake.
Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase.
Wheat gluten intake increases weight gain and adiposity associated with reduced thermogenesis and energy expenditure in an animal model of obesity.
Non-alcoholic Fatty Liver Disease
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Obesity
A common hormone-sensitive lipase i6 gene polymorphism is associated with decreased human adipocyte lipolytic function.
Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
Adipocyte lipolysis in normal weight subjects with obesity among first-degree relatives.
Adiponectin expression and adipose tissue lipolytic activity in lean and obese women.
Antiobesity Effect of a Small Molecule Repressor of ROR?.
Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis.
Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects.
Depot-specific differences in perilipin and hormone-sensitive lipase expression in lean and obese.
Effect of diet on fat cell size and hormone-sensitive lipase activity.
Effect of Glycine on Adipocyte Hypertrophy in a Metabolic Syndrome Rat Model.
Effect of Physical Training on the Adipose Tissue of Diet-induced Obesity Mice: Interaction Between Reactive Oxygen Species and Lipolysis.
Effect of pu-erh tea on body fat and lipid profiles in rats with diet-induced obesity.
Expression of nitric oxide synthases in subcutaneous adipose tissue of nonobese and obese humans.
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
Genetic variance and lipolysis regulation: implications for obesity.
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.
Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation.
Human hormone-sensitive lipase (HSL): expression in white fat corrects the white adipose phenotype of HSL-deficient mice.
Human hormone-sensitive lipase: genetic mapping, identification of a new dinucleotide repeat, and association with obesity and NIDDM.
Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis.
Inhibitory effects of grape seed extract on lipases.
Ishige okamurae Extract Suppresses Obesity and Hepatic Steatosis in High Fat Diet-Induced Obese Mice.
Letting lipids go: hormone-sensitive lipase.
Millennium fat-cell lipolysis reveals unsuspected novel tracks.
Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice.
Risk interaction of obesity, insulin resistance and hormone-sensitive lipase promoter polymorphisms (LIPE-60 C > G) in the development of fatty liver.
Skeletal Muscle Lipase Content and Activity in Obesity and Type 2 Diabetes.
Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity.
The hormone-sensitive lipase (LIPE) gene located on chromosome 19q13.1-->13.2 is not duplicated on 19p13.3.
Zinc-alpha2-glycoprotein in cachexia and obesity.
[Expression of hormone-sensitive lipase mRNA in diet-induced obesity resistant rats]
Obesity, Abdominal
The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity.
Pancreatic Neoplasms
Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice.
Paralysis
Phenytoin alters transcript levels of hormone-sensitive lipase in muscle from horses with hyperkalemic periodic paralysis.
Paralysis, Hyperkalemic Periodic
Phenytoin alters transcript levels of hormone-sensitive lipase in muscle from horses with hyperkalemic periodic paralysis.
Polycystic Ovary Syndrome
Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome.
Pulmonary Emphysema
Age-related pulmonary emphysema in mice lacking alpha/beta hydrolase domain containing 2 gene.
Sarcoma
High expression of the evolutionarily conserved alpha/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors.
Starvation
A Novel Lipase Belonging to the Hormone-sensitive Lipase Family Induced under Starvation to Utilize Stored Triacylglycerol in Mycobacterium tuberculosis.
Effect of nutritional status on swine adipose tissue lipolytic activities.
Effect of starvation on activities and mRNA expression of lipoprotein lipase and hormone-sensitive lipase in tilapia (Oreochromis niloticus x O. areus).
Mechanism of actions of adrenaline and ACTH in fat mobilization.
Tuberculosis
A Novel Lipase Belonging to the Hormone-sensitive Lipase Family Induced under Starvation to Utilize Stored Triacylglycerol in Mycobacterium tuberculosis.
MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth.
Overexpression of Rv3097c in Mycobacterium bovis BCG abolished the efficacy of BCG vaccine to protect against Mycobacterium tuberculosis infection in mice.
Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases.