Information on EC 3.1.1.71 - acetylalkylglycerol acetylhydrolase

for references in articles please use BRENDA:EC3.1.1.71
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.1.71
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RECOMMENDED NAME
GeneOntology No.
acetylalkylglycerol acetylhydrolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-Acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
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SYSTEMATIC NAME
IUBMB Comments
2-acetyl-1-alkyl-sn-glycerol acetylhydrolase
Hydrolysis of the acetyl group from the 1-alkyl-2-acetyl and 1-alkyl-3-acetyl substrates occurs at apparently identical rates. The enzyme from Erlich ascites cells is membrane-bound. It differs from lipoprotein lipase (EC 3.1.1.34) since 1,2-diacetyl-sn-glycerols are not substrates. It also differs from EC 3.1.1.47, 1-acetyl-2-alkyl-glycerophosphocholine esterase.
CAS REGISTRY NUMBER
COMMENTARY hide
76901-00-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-hexadecyl-2-acetyl-sn-glycerol
1-Hexadecyl-sn-glycerol + acetate
show the reaction diagram
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2-acetyl-1-alkyl-sn-glycerol
1-Alkyl-sn-glycerol + acetate
show the reaction diagram
2-Acetyl-1-alkyl-sn-glycerol + H2O
?
show the reaction diagram
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metabolic pathway for alkylacetylglycerols
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additional information
?
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the enzyme may play an important role in regulating the levels of platelet-activating factor synthesized by the de novo pathway via hydrolysis of the immediate precursor of platelet-activating factor
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-Acetyl-1-alkyl-sn-glycerol + H2O
?
show the reaction diagram
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metabolic pathway for alkylacetylglycerols
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additional information
?
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the enzyme may play an important role in regulating the levels of platelet-activating factor synthesized by the de novo pathway via hydrolysis of the immediate precursor of platelet-activating factor
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NaF
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10 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.045
1-Hexadecyl-2-acetyl-sn-glycerol
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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10% of total activity
Manually annotated by BRENDA team
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90% of total activity
Manually annotated by BRENDA team