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Information on EC 3.1.1.59 - juvenile-hormone esterase
for references in articles please use BRENDA:EC3.1.1.59
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EC Tree 3 Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.59 juvenile-hormone esterase
IUBMB Comments
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
The enzyme appears in viruses and cellular organisms
- 3.1.1.59
- hemolymph
-
instar
-
metamorphosis
-
trichoplusia
- virescens
- sexta
- manduca
- ecdysteroids
- heliothis
-
pupation
-
stadium
-
diapause
- gryllus
- methoprene
- cricket
- allata
- budworm
- virilis
- farnesoate
- fumiferana
- choristoneura
- acnpv
- trifluoromethylketone
- nucleopolyhedroviruses
- synthesis
Reaction Schemes
showSynonyms
jhe, juvenile hormone esterase, jh esterase, jh-esterase, jhedup, eat43357, jh-specific esterase, jh iii esterase, juvenile hormone esterase-like, phjhe, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Esterase, juvenile hormone
-
-
-
-
JH esterase
JH-esterase
JHE
Juvenile hormone analog esterase
-
-
-
-
Juvenile hormone carboxyesterase
-
-
-
-
Juvenile hormone esterase
JH esterase
-
-
-
-
JH-esterase
-
-
-
-
Juvenile hormone esterase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
juvenile hormone I + H2O = juvenile hormone I acid + methanol
(1)
-
-
-
juvenile hormone III + H2O = juvenile hormone III acid + methanol
(2)
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
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CAS REGISTRY NUMBER
COMMENTARY
50812-15-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-Naphthyl methylcarbonate + H2O
1-Naphthol + methylcarbonate
-
Substrates: 6% of the activity with juvenile hormone I
Products: -
Products: -
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
Substrates: 69% of the activity with juvenile hormone I, slightly more active than with juvenile hormone III
Products: -
Products: -
?
4-Nitrophenyl methylcarbonate + H2O
4-Nitrophenol + methylcarbonate
-
Substrates: 5% of the activity with juvenile hormone I
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
?
-
Substrates: artificial substrate
Products: -
Products: -
?
ethyl butanoate + H2O
ethanol + butanoate
-
Substrates: -
Products: -
Products: -
?
ethyl propionate + H2O
ethanol + propionate
-
Substrates: -
Products: -
Products: -
?
HEPTAT + H2O
?
Substrates: synthetic juvenile hormone analog
Products: -
Products: -
?
juvenile hormone III diol + H2O
?
Substrates: although hydrogen bonding appears not to occur between juvenile hormone III diol and Thr-314, the hydroxyls of the diol (at C10 and C11) are within hydrogen bonding distance of the main chain carbonyl oxygen atoms of Phe-259 and Phe-311
Products: -
Products: -
?
methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O
(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol
Substrates: juvenile hormone esterase plays an important role in regulating juvenile hormone titers
Products: -
Products: -
?
methyl 1-heptylthioacetothioate + H2O
?
Substrates: HEPTAT
Products: -
Products: -
?
methyl farnesoate + H2O
methanol + farnesoic acid
Substrates: -
Products: -
Products: -
?
saturated juvenile hormone III + H2O
saturated juvenile hormone III acid + methanol
Substrates: alpha,beta-saturated methyl ester
Products: -
Products: -
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
Substrates: -
Products: -
Products: -
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
Substrates: -
Products: -
Products: -
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
Substrates: -
Products: -
Products: -
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
Substrates: 13% of the activity with juvenile hormone I
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
Substrates: lower activity than with alpha-naphthyl propionate
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
Substrates: specific activities of several developmental stages
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
Substrates: -
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
Substrates: -
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
Substrates: -
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
Substrates: lower activity than with alpha-naphthyl propionate
Products: -
Products: -
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
Substrates: -
Products: -
Products: -
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
Products: -
Products: -
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
Products: -
Products: -
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
Products: -
Products: -
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
Products: -
Products: -
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
Products: -
Products: -
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
Products: -
Products: -
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
Products: -
Products: -
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
Products: -
Products: -
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
Products: -
Products: -
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
-
Substrates: higher activity than with alpha-naphthyl acetate, activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
Products: -
Products: -
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
-
Substrates: activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
Products: -
Products: -
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
-
Substrates: higher activity than with alpha-naphthyl acetate, activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
Products: -
Products: -
?
juvenile hormone + H2O
?
-
Substrates: juvenile hormone esterase activity
Products: -
Products: -
?
juvenile hormone + H2O
?
-
Substrates: endocrine regulator, degrades and inactivates a key developmental and reproductive hormone, juvenile hormone
Products: -
Products: -
?
juvenile hormone + H2O
?
-
Substrates: juvenile hormone degradation
Products: -
Products: -
?
juvenile hormone + H2O
?
-
Substrates: selective enzyme, hydrolyzes the methyl ester of juvenile hormone
Products: -
Products: -
?
juvenile hormone + H2O
?
-
Substrates: plays an important role in the regulation of metamorphosis in caterpillars, JHE is implicated in additional roles in development and reproduction
Products: -
Products: -
?
juvenile hormone + H2O
?
Substrates: selective enzyme, juvenile hormone metabolism, alters the activity of juvenile hormone, which regulates development and reproduction
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: key enzyme in the regulation of juvenile hormone level
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: juvenile hormone I
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: JHE catabolizes juvenile hormone
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: juvenile hormone III
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: juvenile hormone III
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
Substrates: key enzyme in the regulation of juvenile hormone level, degradation of juvenile hormone is required for proper insect development
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: C16 juvenile hormone-23H
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: juvenile hormone II
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: juvenile hormone III
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: juvenile hormone I
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: key enzyme in the regulation of juvenile hormone level
Products: -
Products: -
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
Substrates: -
Products: -
Products: -
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone II + H2O
juvenile hormone II acid + methanol
Substrates: -
Products: -
Products: -
?
juvenile hormone II + H2O
juvenile hormone II acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
?
Substrates: BmJHE is a juvenile hormone-selective esterase. Of the CCEs containing a GQSAG motif only BmJHE can function as a JH-specific degradation enzyme in the silkworm
Products: -
Products: -
?
juvenile hormone III + H2O
?
Substrates: BmCCE-5 has the ability to degrade juvenile hormone, however, the protein might not function as a JH-specific esterase in vivo as it has a high Km value for juvenile hormone
Products: -
Products: -
?
juvenile hormone III + H2O
?
-
Substrates: JHE is highly selective for JHIII and JHIII bisepoxide
Products: -
Products: -
?
juvenile hormone III + H2O
?
-
Substrates: JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
Products: -
Products: -
?
juvenile hormone III + H2O
?
-
Substrates: high affinity for juvenile hormone III
Products: -
Products: -
?
juvenile hormone III + H2O
?
Substrates: hydrolyzes the methyl ester of juvenile hormone, highest specificity for juvenile hormone III
Products: -
Products: -
?
juvenile hormone III + H2O
?
D7US45
Substrates: degradation
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: JH esterase hydrolyzes the methyl ester to produce juvenile hormone acid
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
Substrates: 10R-juvenile hormone III is the natural isomer
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: racemic
Products: juvenile hormone acid is the sole product
Products: juvenile hormone acid is the sole product
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: specific activities of several developmental stages, highest specific activity
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
Substrates: juvenile hormone III fits very tightly within the substrate binding pocket of JHE. This tight fit places two noncatalytic amino acid residues, Phe-259 and Thr-314, within the appropriate distance and geometry to potentially interact with the R,beta-unsaturated ester and epoxide, respectively, of juvenile hormone III. Neither nucleophilic attack of the resonance-stabilized ester by the catalytic serine nor the availability of a water molecule for attack of the acyl-enzyme intermediate appears to be a rate-determining step in the hydrolysis. Release of the juvenile hormone III acid metabolite from the substrate binding pocket limits the catalytic cycle. Chemical bond strength does not necessarily correlate with how reactive the bond will be to metabolism
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: highest specific activity
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone III bisepoxide + H2O
?
-
Substrates: JHE is highly selective for JHIII and JHIII bisepoxide
Products: -
Products: -
?
juvenile hormone III bisepoxide + H2O
?
-
Substrates: JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
Products: -
Products: -
?
methyl heptylthioacetothioate + H2O
?
Substrates: a synthetic substrate
Products: -
Products: -
?
methyl heptylthioacetothioate + H2O
?
D7US45
Substrates: the recombinant JHE has a strong ability to degrade methyl hepthylthioacetothioate, HEPTAT, as a synthetic substrate
Products: -
Products: -
?
methyl hexylthio acetothioate + H2O
?
-
Substrates: putative surrogate substrate for juvenile hormone, specific activities of several developmental stages
Products: -
Products: -
?
methyl hexylthio acetothioate + H2O
?
-
Substrates: putative surrogate substrate for juvenile hormone
Products: -
Products: -
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
Substrates: higher specific activity than for p-nitrophenyl valerate
Products: -
Products: -
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
Substrates: higher specific activity than for p-nitrophenyl valerate
Products: -
Products: -
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
Substrates: -
Products: -
Products: -
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
Substrates: higher specific activity than for p-nitrophenyl valerate
Products: -
Products: -
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
Substrates: -
Products: -
Products: -
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
Substrates: lower specific activity than for p-nitrophenyl acetate
Products: -
Products: -
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
Substrates: lower specific activity than for p-nitrophenyl acetate
Products: -
Products: -
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
Substrates: lower specific activity than for p-nitrophenyl acetate
Products: -
Products: -
?
additional information
?
-
Substrates: clearance of juvenile hormone during larval-pupal metamorphosis
Products: -
Products: -
?
additional information
?
-
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Substrates: clearance of juvenile hormone during larval-pupal metamorphosis
Products: -
Products: -
?
additional information
?
-
Substrates: deficiency in Amjhe-like results in 6fold increase in juvenile hormone titer (adult, 4 day-old worker bee)
Products: -
Products: -
?
additional information
?
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Substrates: deficiency in Amjhe-like results in 6fold increase in juvenile hormone titer (adult, 4 day-old worker bee)
Products: -
Products: -
?
additional information
?
-
-
Substrates: likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzymes encoded by genes Bmcce-1-4 are not active on juvenile hormone
Products: -
Products: -
?
additional information
?
-
Substrates: the enzymes encoded by genes Bmcce-1-4 are not active on juvenile hormone
Products: -
Products: -
?
additional information
?
-
-
Substrates: hormonal regulation of enzyme
Products: -
Products: -
?
additional information
?
-
-
Substrates: structural features promoting substrate binding at the active site of JHE
Products: -
Products: -
?
additional information
?
-
Substrates: there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity
Products: -
Products: -
?
additional information
?
-
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Substrates: there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with juvenile hormone II
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with juvenile hormone II
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme plays a profound role in metamorphosis and reproduction
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
additional information
?
-
-
Substrates: likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
Products: -
Products: -
?
additional information
?
-
Substrates: likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
-
-
Substrates: likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
Products: -
Products: -
?
additional information
?
-
-
Substrates: likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
additional information
?
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-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
-
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Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
additional information
?
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Substrates: the enzyme is also active on alpha-naphthyl propionate, alpha-naphthyl butyrate, and 2-carbon substrate alpha-naphthyl acetate
Products: -
Products: -
?
additional information
?
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-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
additional information
?
-
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Substrates: effectiveness of thioester compounds as surrogate substrates
Products: -
Products: -
?
additional information
?
-
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Substrates: low activity with hydroprene and methoprene
Products: -
Products: -
?
additional information
?
-
-
Substrates: demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
Products: -
Products: -
?
additional information
?
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Substrates: likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
Products: -
Products: -
?
additional information
?
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Substrates: demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
Substrates: JH esterase hydrolyzes the methyl ester to produce juvenile hormone acid
Products: -
Products: -
?
juvenile hormone III bisepoxide + H2O
?
-
Substrates: JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
Products: -
Products: -
?
methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O
(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol
Substrates: juvenile hormone esterase plays an important role in regulating juvenile hormone titers
Products: -
Products: -
?
juvenile hormone + H2O
?
-
Substrates: endocrine regulator, degrades and inactivates a key developmental and reproductive hormone, juvenile hormone
Products: -
Products: -
?
juvenile hormone + H2O
?
-
Substrates: juvenile hormone degradation
Products: -
Products: -
?
juvenile hormone + H2O
?
-
Substrates: plays an important role in the regulation of metamorphosis in caterpillars, JHE is implicated in additional roles in development and reproduction
Products: -
Products: -
?
juvenile hormone + H2O
?
Substrates: selective enzyme, juvenile hormone metabolism, alters the activity of juvenile hormone, which regulates development and reproduction
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: key enzyme in the regulation of juvenile hormone level
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: JHE catabolizes juvenile hormone
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
Substrates: key enzyme in the regulation of juvenile hormone level, degradation of juvenile hormone is required for proper insect development
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: -
Products: -
Products: -
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
Substrates: key enzyme in the regulation of juvenile hormone level
Products: -
Products: -
?
juvenile hormone III + H2O
?
Substrates: BmJHE is a juvenile hormone-selective esterase. Of the CCEs containing a GQSAG motif only BmJHE can function as a JH-specific degradation enzyme in the silkworm
Products: -
Products: -
?
juvenile hormone III + H2O
?
-
Substrates: JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
Products: -
Products: -
?
juvenile hormone III + H2O
?
D7US45
Substrates: degradation
Products: -
Products: -
?
additional information
?
-
Substrates: clearance of juvenile hormone during larval-pupal metamorphosis
Products: -
Products: -
?
additional information
?
-
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Substrates: clearance of juvenile hormone during larval-pupal metamorphosis
Products: -
Products: -
?
additional information
?
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