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Information on EC 3.1.1.59 - juvenile-hormone esterase
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3.1.1.59 juvenile-hormone esteraseIUBMB Comments
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
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Word Map
- 3.1.1.59
- hemolymph
-
instar
-
metamorphosis
-
trichoplusia
- virescens
- sexta
- manduca
- ecdysteroids
- heliothis
-
pupation
-
stadium
-
diapause
- gryllus
- methoprene
- cricket
- allata
- budworm
- virilis
- farnesoate
- fumiferana
- choristoneura
- acnpv
- trifluoromethylketone
- nucleopolyhedroviruses
- synthesis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
jhe, juvenile hormone esterase, jh esterase, jh-esterase, jhedup, eat43357, jh-specific esterase, jh iii esterase, juvenile hormone esterase-like, phjhe, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Esterase, juvenile hormone
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JH esterase
JH-esterase
JHE
Juvenile hormone analog esterase
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Juvenile hormone carboxyesterase
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Juvenile hormone esterase
JH esterase
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JH-esterase
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Juvenile hormone esterase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
juvenile hormone I + H2O = juvenile hormone I acid + methanol
(1)
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-
-
juvenile hormone III + H2O = juvenile hormone III acid + methanol
(2)
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
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-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
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CAS REGISTRY NUMBER
COMMENTARY
50812-15-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-Naphthyl methylcarbonate + H2O
1-Naphthol + methylcarbonate
-
6% of the activity with juvenile hormone I
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-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
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69% of the activity with juvenile hormone I, slightly more active than with juvenile hormone III
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-
?
4-Nitrophenyl methylcarbonate + H2O
4-Nitrophenol + methylcarbonate
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5% of the activity with juvenile hormone I
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-
?
juvenile hormone III diol + H2O
?
although hydrogen bonding appears not to occur between juvenile hormone III diol and Thr-314, the hydroxyls of the diol (at C10 and C11) are within hydrogen bonding distance of the main chain carbonyl oxygen atoms of Phe-259 and Phe-311
-
-
?
methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O
(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol
juvenile hormone esterase plays an important role in regulating juvenile hormone titers
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-
?
saturated juvenile hormone III + H2O
saturated juvenile hormone III acid + methanol
alpha,beta-saturated methyl ester
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-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
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13% of the activity with juvenile hormone I
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-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
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lower activity than with alpha-naphthyl propionate
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
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specific activities of several developmental stages
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?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
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lower activity than with alpha-naphthyl propionate
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
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higher activity than with alpha-naphthyl acetate, activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
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activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
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higher activity than with alpha-naphthyl acetate, activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
juvenile hormone + H2O
?
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juvenile hormone esterase activity
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?
juvenile hormone + H2O
?
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endocrine regulator, degrades and inactivates a key developmental and reproductive hormone, juvenile hormone
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?
juvenile hormone + H2O
?
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selective enzyme, hydrolyzes the methyl ester of juvenile hormone
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?
juvenile hormone + H2O
?
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plays an important role in the regulation of metamorphosis in caterpillars, JHE is implicated in additional roles in development and reproduction
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?
juvenile hormone + H2O
?
selective enzyme, juvenile hormone metabolism, alters the activity of juvenile hormone, which regulates development and reproduction
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?
juvenile hormone + H2O
Juvenile hormone acid + methanol
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key enzyme in the regulation of juvenile hormone level
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-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
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juvenile hormone I
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-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
JHE catabolizes juvenile hormone
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?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone III
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-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone III
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-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
key enzyme in the regulation of juvenile hormone level, degradation of juvenile hormone is required for proper insect development
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?
juvenile hormone + H2O
Juvenile hormone acid + methanol
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C16 juvenile hormone-23H
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-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone II
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-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone III
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-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone I
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?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
key enzyme in the regulation of juvenile hormone level
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-
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
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?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
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?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
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?
juvenile hormone III + H2O
?
BmJHE is a juvenile hormone-selective esterase. Of the CCEs containing a GQSAG motif only BmJHE can function as a JH-specific degradation enzyme in the silkworm
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-
?
juvenile hormone III + H2O
?
BmCCE-5 has the ability to degrade juvenile hormone, however, the protein might not function as a JH-specific esterase in vivo as it has a high Km value for juvenile hormone
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?
juvenile hormone III + H2O
?
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JHE is highly selective for JHIII and JHIII bisepoxide
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?
juvenile hormone III + H2O
?
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JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
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?
juvenile hormone III + H2O
?
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high affinity for juvenile hormone III
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?
juvenile hormone III + H2O
?
hydrolyzes the methyl ester of juvenile hormone, highest specificity for juvenile hormone III
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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JH esterase hydrolyzes the methyl ester to produce juvenile hormone acid
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
10R-juvenile hormone III is the natural isomer
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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racemic
juvenile hormone acid is the sole product
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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specific activities of several developmental stages, highest specific activity
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
juvenile hormone III fits very tightly within the substrate binding pocket of JHE. This tight fit places two noncatalytic amino acid residues, Phe-259 and Thr-314, within the appropriate distance and geometry to potentially interact with the R,beta-unsaturated ester and epoxide, respectively, of juvenile hormone III. Neither nucleophilic attack of the resonance-stabilized ester by the catalytic serine nor the availability of a water molecule for attack of the acyl-enzyme intermediate appears to be a rate-determining step in the hydrolysis. Release of the juvenile hormone III acid metabolite from the substrate binding pocket limits the catalytic cycle. Chemical bond strength does not necessarily correlate with how reactive the bond will be to metabolism
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-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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-
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
highest specific activity
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
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-
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?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
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?
juvenile hormone III bisepoxide + H2O
?
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JHE is highly selective for JHIII and JHIII bisepoxide
-
?
juvenile hormone III bisepoxide + H2O
?
-
JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
-
?
methyl heptylthioacetothioate + H2O
?
D7US45
the recombinant JHE has a strong ability to degrade methyl hepthylthioacetothioate, HEPTAT, as a synthetic substrate
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-
?
methyl hexylthio acetothioate + H2O
?
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putative surrogate substrate for juvenile hormone, specific activities of several developmental stages
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?
methyl hexylthio acetothioate + H2O
?
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putative surrogate substrate for juvenile hormone
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?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
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higher specific activity than for p-nitrophenyl valerate
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
higher specific activity than for p-nitrophenyl valerate
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
higher specific activity than for p-nitrophenyl valerate
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
lower specific activity than for p-nitrophenyl acetate
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
lower specific activity than for p-nitrophenyl acetate
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
lower specific activity than for p-nitrophenyl acetate
-
?
additional information
?
-
clearance of juvenile hormone during larval-pupal metamorphosis
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-
?
additional information
?
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clearance of juvenile hormone during larval-pupal metamorphosis
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?
additional information
?
-
deficiency in Amjhe-like results in 6fold increase in juvenile hormone titer (adult, 4 day-old worker bee)
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-
?
additional information
?
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deficiency in Amjhe-like results in 6fold increase in juvenile hormone titer (adult, 4 day-old worker bee)
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?
additional information
?
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likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
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?
additional information
?
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the enzymes encoded by genes Bmcce-1-4 are not active on juvenile hormone
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?
additional information
?
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the enzymes encoded by genes Bmcce-1-4 are not active on juvenile hormone
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?
additional information
?
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hormonal regulation of enzyme
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?
additional information
?
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structural features promoting substrate binding at the active site of JHE
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?
additional information
?
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there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity
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?
additional information
?
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there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity
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-
?
additional information
?
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no activity with juvenile hormone II
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?
additional information
?
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no activity with juvenile hormone II
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-
?
additional information
?
-
-
the enzyme plays a profound role in metamorphosis and reproduction
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-
?
additional information
?
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-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
the enzyme is also active on alpha-naphthyl propionate, alpha-naphthyl butyrate, and 2-carbon substrate alpha-naphthyl acetate
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
effectiveness of thioester compounds as surrogate substrates
-
-
?
additional information
?
-
-
low activity with hydroprene and methoprene
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?