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BRENDA support

Information on EC 3.1.1.57 - 2-pyrone-4,6-dicarboxylate lactonase

for references in articles please use BRENDA:EC3.1.1.57

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IUBMB Comments

The product is most likely the keto-form of 4-oxalomesaconate (shown) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC 5.3.2.8, 4-oxalomesaconate tautomerase .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
2-pyrone-4,6-dicarboxylate hydrolase, 2-pyrone-4,6-dicarboxylate lactonase, pdc hydrolase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
show the reaction diagram
the product isomerizes to 4-oxalmesaconate
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