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Disease on EC 3.1.1.52 - phosphatidylinositol deacylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Arthritis, Experimental
Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.
Arthritis, Rheumatoid
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
Asthma
Cytosolic phospholipase A2 group IVA influence on GM-CSF expression in human lung cells: a pilot study.
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
Atherosclerosis
Participation of ATP7A in macrophage mediated oxidation of low density lipoprotein.
Bacterial Infections
Critical role of cytosolic phospholipase a2{alpha} in bronchial mucus hyper-secretion in CFTR-deficient mice.
Bone Diseases
An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation.
Bone Resorption
An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation.
Brain Ischemia
Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice.
Carcinoma, Ehrlich Tumor
Hypotonic cell swelling induces translocation of the alpha isoform of cytosolic phospholipase A2 but not the gamma isoform in Ehrlich ascites tumor cells.
Carcinoma, Non-Small-Cell Lung
Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2alpha in phorbol ester-treated non-small cell lung cancer A549 cells.
Cholangiocarcinoma
A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.
Dehydration
Critical role of cytosolic phospholipase a2{alpha} in bronchial mucus hyper-secretion in CFTR-deficient mice.
Lung Neoplasms
Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2alpha in phorbol ester-treated non-small cell lung cancer A549 cells.
Neoplasms
Hypotonic cell swelling induces translocation of the alpha isoform of cytosolic phospholipase A2 but not the gamma isoform in Ehrlich ascites tumor cells.
Roles of cPLA2alpha and arachidonic acid in cancer.
Transforming growth factor-beta (TGF-beta) activates cytosolic phospholipase A2alpha (cPLA2alpha)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated receptor-gamma (PPAR-gamma)/Smad signaling pathways in human liver cancer cells. A novel mechanism for subversion of TGF-beta-induced mitoinhibition.
Osteoarthritis
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
Pheochromocytoma
Decrease in cytosolic phospholipase A2alpha mRNA levels by reactive oxygen species via MAP kinase pathways in PC12 cells: effects of dopaminergic neurotoxins.
phosphatidylinositol deacylase deficiency
Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development.
Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha.
Pneumonia
Critical role of cytosolic phospholipase a2{alpha} in bronchial mucus hyper-secretion in CFTR-deficient mice.