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Disease on EC 3.1.1.5 - lysophospholipase and Organism(s) Homo sapiens and UniProt Accession Q6P4A8

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Lysophosphatidylcholine metabolism in the rabbit heart. Characterization of metabolic pathways and partial purification of myocardial lysophospholipase-transacylase.
Regulation of lysophosphatidylcholine-metabolizing enzymes in isolated myocardial cells from rat heart.
Acute Kidney Injury
Role of phospholipase A in multiorgan failure with special reference to ARDS and acute renal failure (ARF).
Acute Lung Injury
Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin.
acylglycerol kinase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Adenomatous Polyposis Coli
Impact of group IVA cytosolic phospholipase A ( 2 ) gene polymorphisms on phenotypic features of patients with familial adenomatous polyposis.
Alveolar Bone Loss
A low level of lysophosphatidic acid in human gingival crevicular fluid from patients with periodontitis due to high soluble lysophospholipase activity: Its potential protective role on alveolar bone loss by periodontitis.
Erratum to "A low level of lysophosphatidic acid in human gingival crevicular fluid from patients with periodontitis due to high soluble lysophospholipase activity: Its potential protective role on alveolar bone loss by periodontitis" [BBA - Mol. Cell Biol. L. 1865/7 (July 2020) Article number: 158698].
Amyotrophic Lateral Sclerosis
Neuropathy target esterase gene mutations cause motor neuron disease.
Anaphylaxis
Evaluation of bee sting allergy by skin tests and serum antibody assays.
Arthritis
[Change in phospholipid composition of synovial fluid in children with various types of arthritis]
Arthritis, Juvenile
[Change in phospholipid composition of synovial fluid in children with various types of arthritis]
Asthma
Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy.
Combined activities of secretory phospholipases and eosinophil lysophospholipases induce pulmonary surfactant dysfunction by phospholipid hydrolysis.
Hydrolysis of surfactant phospholipids catalyzed by phospholipase A2 and eosinophil lysophospholipases causes surfactant dysfunction: a mechanism for small airway closure in asthma.
Key role of group v secreted phospholipase A2 in th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling.
Mepolizumab decreased the levels of serum galectin-10 and eosinophil cationic protein in asthma.
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Asthma, Aspirin-Induced
Galectin-10 mRNA is overexpressed in peripheral blood of aspirin-induced asthma.
Ataxia
Effects of organophosphate phenyl saligenin phosphate and polyether carboxylic ionophore lasalocid on motor nerve conduction velocity, neuropathy target esterase enzyme activity, and clinical ataxia in chickens.
ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration.
NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.
Protective effect of nimodipine on dichlorvos-induced delayed neurotoxicity in rat brain(1).
Relationship of neuropathy target esterase inhibition to neuropathology and ataxia in hens given organophosphorus esters.
Use of the biventer cervicis nerve-muscle preparation to detect early changes following exposure to organophosphates inducing delayed neuropathy.
Atherosclerosis
Association of lipoprotein-associated phospholipase A
Changes in phospholipase A, lipase and cholesterol esterase activity in the aorta in experimental atherosclerosis in the rabbit and rat.
Evaluation of Inhibitory Actions of Flavonols and Related Substances on Lysophospholipase D Activity of Serum Autotaxin by a Convenient Assay Using a Chromogenic Substrate.
Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice.
Phospholipase A 2 is an inflammatory predictor in Cardiovascular Diseases: Is there any spacious room to prove the causation?
Atrial Fibrillation
Association of lipoprotein-associated phospholipase A
Bacterial Infections
Lung lysophospholipase activity in specific-pathogen-free rats infected with Pasteurella pneumotropica or Mycoplasma pulmonis.
Phospholipase A as a potent virulence factor of Vibrio vulnificus.
Barth Syndrome
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Blindness
Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.
NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.
Breast Neoplasms
Estrogen, phospholipase A and breast cancer.
Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration.
Candidiasis
Detection of antibodies to phospholipase B in patients infected with Cryptococcus neoformans by enzyme-linked immunosorbent assay (ELISA).
Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections.
Hydrolytic gene expression during oroesophageal and gastric candidiasis in immunocompetent and immunodeficient gnotobiotic mice.
Reintroduction of the PLB1 gene into Candida albicans restores virulence in vivo.
Carcinogenesis
Hypolipidemic effect of ginger in 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis.
Stat3 mediates expression of autotaxin in breast cancer.
Carcinoma
The substrate specificities of four different lysophospholipases as determined by a novel fluorescence assay.
Carcinoma, Ehrlich Tumor
Hypotonic cell swelling induces translocation of the alpha isoform of cytosolic phospholipase A2 but not the gamma isoform in Ehrlich ascites tumor cells.
Carcinoma, Embryonal
Silencing of PNPLA6, the neuropathy target esterase (NTE) codifying gene, alters neurodifferentiation of human embryonal carcinoma stem cells (NT2).
Carcinoma, Hepatocellular
Alteration of mitochondrial function and lipid composition in Morris 7777 hepatoma.
Phospholipase A in the plasma membranes in ascites hepatomas and of normal livers in rat.
Carcinoma, Squamous Cell
[Screening and functional analysis of microRNA expression in HPV16-positive squamous carcinoma of the cervix ?in the Uygur of southern Xinjiang].
Cardiomyopathies
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Cardiotoxicity
Inhibition of toxic actions of phospholipase A 2 isolated & characterized from the Indian Banded Krait (Bungarus fasciatus) venom by synthetic herbal compounds.
Cardiovascular Diseases
Phospholipase A 2 is an inflammatory predictor in Cardiovascular Diseases: Is there any spacious room to prove the causation?
Cataract
Effects of lysophosphatidyl choline and phospholipase A on the lens.
Celiac Disease
Galectin-10, eosinophils, and celiac disease.
Cholera
Lysophospholipase L2 of Vibrio cholerae O1 affects cholera toxin production.
choline kinase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Clonorchiasis
Molecular characterization and serodiagnosis analysis of a novel lysophospholipase from Clonorchis sinensis.
Colitis
Group III phospholipase A
Colorectal Neoplasms
Group III phospholipase A
Confusion
Activated complex of L-cells and Rickettsia prowazekii with N-ethylmaleimide-insensitive phospholipase A.
Contracture
Neurotoxic and myotoxic effects of crotalus phospholipase A and its complex with crotapotin.
Coronary Artery Disease
Lipoprotein associated phospholipase A2 activity & its correlation with oxidized LDL & glycaemic status in early stages of type-2 diabetes mellitus.
COVID-19
Group IIA Secreted Phospholipase A 2 Plays a Central Role in the Pathobiology of COVID-19.
Crohn Disease
Decreased lysophospholipase and increased phospholipase A2 activity in ileal mucosa from patients with Crohn's disease.
Cryptococcosis
Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.
Cystadenoma, Mucinous
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Cystic Fibrosis
Activity of phospholipase A in serum from patients with cystic fibrosis.
Demyelinating Diseases
Structural specificity in demyelination induced by lysophospholipids.
Dermatitis, Atopic
Elevated Galectin-10 Expression of IL-22 Producing T Cells in Atopic Dermatitis Patients.
Elevated Galectin-10 Expression of IL-22-Producing T Cells in Patients with Atopic Dermatitis.
Dermoid Cyst
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Diabetes Mellitus
Effect of intensive insulin treatment on plasma levels of lipoprotein-associated phospholipase A
Diabetes Mellitus, Type 2
Effect of intensive insulin treatment on plasma levels of lipoprotein-associated phospholipase A
Drug Hypersensitivity
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Duodenogastric Reflux
Phospholipase A2 activity of rat stomach.
Eczema
Isolation of two triterpenoids and a biflavanone with anti-Inflammatory activity from Schinus molle fruits.
Encephalitis
The action of phospholipase A and lipid solvents on Murray Valley encephalitis virus.
Eosinophilia
Characterizing the proteome of bullous pemphigoid blister fluid utilizing tandem mass tag labeling coupled with LC-MS/MS.
Charcot-Leyden Crystal Protein in Nasal Secretions of Patients with Nonallergic Rhinitis with Eosinophilia Syndrome.
Effect of anti-eosinophil serum on phospholipase B activity in mice infected with Trichinella spiralis.
Effect of anti-thymocyte serum on the eosinophil and lysophospholipase responses in mice infected with Trichinella spiralis.
Eosinophilia and elevated serum levels of eosinophil major basic protein and Charcot-Leyden crystal protein (lysophospholipase) after treatment of patients with Bancroft's filariasis.
Galectin-10, a potential biomarker of eosinophilic airway inflammation.
Intestinal phospholipase B activity in swine inoculated with Trichinella spiralis.
Kinetics of mast cells, eosinophils and phospholipase B activity in the spontaneous-cure response of two strains of mice (rapid and slow responder) to the cestode Hymenolepis nana.
Lung lysophospholipase activity in specific-pathogen-free rats infected with Pasteurella pneumotropica or Mycoplasma pulmonis.
Phospholipase B activity in congenitally athymic (nude) mice infected with Trichinella spiralis.
Suppression of Nippostrongylus brasiliensis (Nematoda)-induced lysophospholipase activity and peripheral eosinophilia by Eimeria nieschulzi (Apicomplexa).
Exocrine Pancreatic Insufficiency
Increased intestinal phospholipase A(2) activity catalyzed by phospholipase B/lipase in WBN/Kob rats with pancreatic insufficiency.
Pancreatic Phospholipase A Activity in Duodenal Aspirates.
Eye Diseases
New aspects of mast cell biology.
Fasciculation
A comparative study of properties and toxic constituents of funnel web spider (Atrax) venoms.
The intermediate syndrome in organophosphate poisoning: an overview of experimental and clinical observations.
Filariasis
Eosinophilia and elevated serum levels of eosinophil major basic protein and Charcot-Leyden crystal protein (lysophospholipase) after treatment of patients with Bancroft's filariasis.
Gallstones
The role of phospholipase A in gallstone formation.
Gastroenteritis
Intestinal phospholipase B activity in pigs inoculated with transmissible gastroenteritis virus.
Genital Diseases, Female
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Glomerulonephritis, Membranous
Intravitreal Antivascular Endothelial Growth Factor Therapy May Induce Proteinuria and Antibody Mediated Injury in Renal Allografts.
Tissue staining for THSD7A in glomeruli correlates with serum antibodies in primary membranous nephropathy: a clinicopathological study.
Graft vs Host Disease
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Granulomatosis with Polyangiitis
Eosinophil ETosis-Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis.
Heart Diseases
The rs1051931 G>A Polymorphism in the PLA2G7 Gene Confers Resistance to Immunoglobulin Therapy in Kawasaki Disease in a Southern Chinese Population.
Hematologic Diseases
Serum phospholipase A in hematological diseases.
Hemoglobinuria
Studies on hemoglobinuria produced by venom from the Australian snake Tropidechis carinatus (rough-scaled snake).
Hermanski-Pudlak Syndrome
Studies on a new variant of the Hermansky-Pudlak syndrome: qualitative, ultrastructural, and functional abnormalities of the platelet-dense bodies associated with a phospholipase A defect.
Hypereosinophilic Syndrome
Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome.
Hypersensitivity
Allergy to insect stings. II. Phospholipase A: the major allergen in honeybee venom.
Allergy to insect stings. IV. Diagnosis by radioallergosorbent test (R.A.S.T.).
Charcot-Leyden crystals: pathology and diagnostic utility.
Comparative proteomics of nasal fluid in seasonal allergic rhinitis.
The evaluation of the common diagnostic methods of hypersensitivity for bee and yellow jacket venom by means of an in-hospital insect sting.
[Significance of serological studies in the diagnosis and therapy of insect-sting allergy]
Hyperthyroidism
Influence of hypo- and hyperthyroidism on rat liver glycerophospholipid metabolism.
Hypogonadism
Androgen-dependent miR-125a-5p targets LYPLA1 and regulates global protein palmitoylation level in late-onset hypogonadism males.
Hypothyroidism
Influence of hypo- and hyperthyroidism on rat liver glycerophospholipid metabolism.
Infections
Altered lysophospholipase B responsiveness in lactating mice infected with intestinal nematode parasites.
An enzymatic method (phospholipase B) for studies on cestode infection (Hymenolepis nana) and its suppression by chemotherapy.
Analysis of hydrolytic products from choline-labeled host cell phospholipids during growth of Rickettsia prowazekii.
Angiostrongylus cantonensis: phospholipase in nonsensitized and sensitized rats after challenge.
Biphasic regulation of Fc-receptor mediated phagocytosis of rabbit alveolar macrophages by surfactant phospholipids.
Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy.
Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans.
Cryptococcal Phospholipase B1 (Plb1) is required for intracellular proliferation and control of titan cell morphology during macrophage infection.
Detection of antibodies to phospholipase B in patients infected with Cryptococcus neoformans by enzyme-linked immunosorbent assay (ELISA).
Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections.
Elevated levels of phospholipase B in mice infected and challenged with Plasmodium yoelii.
Expression of Arabidopis phospholipase A genes in Petunia x hybrida. Increased hypersensitive-like response after infection with Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000 demonstrates a function for phospholipase A in pathogen defence.
Extracellular Paracoccidioides brasiliensis phospholipase B involvement in alveolar macrophage interaction.
Inhibition of Plasmodium falciparum lysophospholipase by anti-malarial drugs and sulphydryl reagents.
Intestinal phospholipase B activity in swine inoculated with Trichinella spiralis.
Kinetics of mast cells, eosinophils and phospholipase B activity in the spontaneous-cure response of two strains of mice (rapid and slow responder) to the cestode Hymenolepis nana.
Legionella pneumophila major acid phosphatase and its role in intracellular infection.
Lung lysophospholipase activity in specific-pathogen-free rats infected with Pasteurella pneumotropica or Mycoplasma pulmonis.
Phospholipase A activity associated with the growth of Rickettsia prowazekii in L929 cells.
Phospholipase B activity enhances adhesion of Cryptococcus neoformans to a human lung epithelial cell line.
Phospholipase B activity in congenitally athymic (nude) mice infected with Trichinella spiralis.
Phospholipase B in nonsensitized and sensitized rats after challenge with Strongyloides ratti.
Phospholipase B levels in fecal pellets from mice infected with Trichinella spiralis, Hymenolepis nana, and Schistosoma mansoni.
Role and mechanism of phosphatidylinositol-specific phospholipase C in survival and virulence of Cryptococcus neoformans.
SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans.
The importance of black-pigmented gram-negative anaerobes in human infections.
The interplay between membrane lipids and phospholipase A family members in grapevine resistance against Plasmopara viticola.
Infertility
Phospholipase A activity in seminal plasma of men attending an infertility clinic.
Inflammatory Bowel Diseases
New aspects of mast cell biology.
Insulin Resistance
Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression.
Intellectual Disability
ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration.
Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.
NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.
Keratoconjunctivitis
Eosinophil granule major basic protein and Charcot-Leyden crystal protein in human tears.
Legionnaires' Disease
In vitro secretion kinetics of proteins from Legionella pneumophila in comparison to proteins from non-pneumophila species.
Leiomyoma
Role of lysophosphatidic acid in the regulation of uterine leiomyoma cell proliferation by phospholipase D and autotaxin.
Liver Cirrhosis
Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis.
Liver Neoplasms
Metabolomic study of the intervention effects of Shuihonghuazi Formula, a Traditional Chinese Medicinal formulae, on hepatocellular carcinoma (HCC) rats using performance HPLC/ESI-TOF-MS.
Liver Neoplasms, Experimental
Properties of microsomal phospholipases in rat liver and hepatoma.
Lung Diseases
Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids.
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Lung Neoplasms
Inhibition of cell proliferation and migration in non?small cell lung cancer cells through the suppression of LYPLA1.
Melanoma
Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid.
Motor Neuron Disease
Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.
Motor neuron disease due to neuropathy target esterase gene mutation: clinical features of the index families.
Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.
Neuropathy target esterase gene mutations cause motor neuron disease.
Mucolipidoses
Phospholipids accumulation in mucolipidosis IV cultured fibroblasts.
Muscle Weakness
The intermediate syndrome in organophosphate poisoning: an overview of experimental and clinical observations.
Muscular Diseases
Neuropsychopathological changes by organophosphorus compounds--a review.
Muscular Dystrophies
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Elevated erythrocyte phospholipase A associated with Duchenne and myotonic muscular dystrophy.
Erythrocyte membrane lysophospholipase activity in muscular dystrophy.
Muscular Dystrophy, Duchenne
Erythrocyte membrane lysophospholipase activity in muscular dystrophy.
Myocardial Infarction
[Blood phospholipase A activity in acute myocardial infarct]
Myocardial Ischemia
Cytosolic lysophospholipase in cardiac myocytes and its inhibition by L-palmitoyl carnitine.
Regulation of lysophosphatidylcholine-metabolizing enzymes in isolated myocardial cells from rat heart.
Myoglobinuria
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Isolation and characterization of a lethal myotoxic phospholipase A from the venom of the common sea snake Enhydrina schistosa causing myoglobinuria in mice.
Myotoxicity
Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo).
Inhibition of toxic actions of phospholipase A 2 isolated & characterized from the Indian Banded Krait (Bungarus fasciatus) venom by synthetic herbal compounds.
Isolation of a myotoxin from Bothrops asper venom: partial characterization and action on skeletal muscle.
Nasal Polyps
Galectin-10 is released in the nasal lavage fluid of patients with aspirin-sensitive respiratory disease.
Predictive Significance of Charcot-Leyden Crystal Protein in Nasal Secretions in Recurrent Chronic Rhinosinusitis with Nasal Polyps.
[Expression and pathological role of galectin-10 in different types of nasal polyps].
Neoplasm Metastasis
Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid.
Neoplasms
alpha-Substituted Phosphonate Analogues of Lysophosphatidic Acid (LPA) Selectively Inhibit Production and Action of LPA.
Anticarcinogenic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione a curcumin analog on DMH-induced colon cancer model.
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation.
Elevated phospholipase A2 activities in plasma samples from multiple cancers.
Evaluation of Inhibitory Actions of Flavonols and Related Substances on Lysophospholipase D Activity of Serum Autotaxin by a Convenient Assay Using a Chromogenic Substrate.
Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer.
Hypotonic cell swelling induces translocation of the alpha isoform of cytosolic phospholipase A2 but not the gamma isoform in Ehrlich ascites tumor cells.
Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells.
Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry.
New aspects of mast cell biology.
Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells.
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer.
Phospholipase A stimulation in tumor cells by subtoxic concentration of tert-butyl hydroperoxide.
Scalable purification and characterization of the extracellular domain of human autotaxin from prokaryotic cells.
Stat3 mediates expression of autotaxin in breast cancer.
Synergistic Effects of Secretory Phospholipase A 2 from the Venom of Agkistrodon piscivorus piscivorus with Cancer Chemotherapeutic Agents.
The Ribosomal Protein RPLP0 Mediates PLAAT4-induced Cell Cycle Arrest and Cell Apoptosis.
Translocation and activation of sphingosine kinase 1 by ceramide-1-phosphate.
Two novel approaches targeting cancer cell membrane for tumor therapy.
Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas.
Neoplasms, Glandular and Epithelial
Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas.
Nephrotic Syndrome
Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome.
Neuroaxonal Dystrophies
Neuronal phospholipid deacylation is essential for axonal and synaptic integrity.
Neuroblastoma
Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity.
Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells.
Esterase comparison in neuroblastoma cells of human and rodent origin.
In vitro study of the neuropathic potential of the organophosphorus compounds fenamiphos and profenofos: Comparison with mipafox and paraoxon.
In vitro study of the neuropathic potential of the organophosphorus compounds trichlorfon and acephate.
Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity.
Inhibition of neuropathy target esterase expressing by antisense RNA does not affect neural differentiation in human neuroblastoma (SK-N-SH) cell line.
Modification of mipafox-induced inhibition of neuropathy target esterase in neuroblastoma cells of human origin.
Neuropathy target esterase inhibition by organophosphorus esters in human neuroblastoma cells.
Reduction of neuropathy target esterase does not affect neuronal differentiation, but moderate expression induces neuronal differentiation in human neuroblastoma (SK-N-SH) cell line.
Neurodegenerative Diseases
High concentration of trichlorfon (1mM) disrupts axonal cytoskeleton and decreases the expression of plasticity-related proteins in SH-SY5Y cells.
Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN).
Neurotoxicity Syndromes
Interaction between substrates suggests a relationship between organophosphorus-sensitive phenylvalerate- and acetylcholine-hydrolyzing activities in chicken brain.
Interactions of neuropathy inducers and potentiators/promoters with soluble esterases.
Newcastle Disease
Studies on the inactivation of cell-fusing property of Newcastle disease virus by phospholipase A.
Niemann-Pick Diseases
Acidic phospholipases in cultured human fibroblasts: deficiency of phospholipase C in Niemann-Pick disease.
Degradation of lysophosphatidylcholine by lysosomes. Stimulation of lysophospholipase C by taurocholate and deficiency in Niemann-Pick fibroblasts.
Obstetric Labor, Premature
Altered activity of lysophospholipase D, which produces bioactive lysophosphatidic acid and choline, in serum from women with pathological pregnancy.
Osteoarthritis
[Cytokines, prostaglandin E2, phospholipase A and metalloproteases in synovial fluid in osteoarthritis]
Ovarian Neoplasms
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Pancreatic Pseudocyst
Characterization of phospholipase A2 activity in aspirates of human pancreatic pseudocysts after isolation by reversed-phase high performance liquid chromatography.
Pancreatitis
Amylase, lipase, pancreatic isoamylase, and phospholipase A in diagnosis of acute pancreatitis.
Biochemical evaluation of patients with acute pancreatitis.
Diagnostic and prognostic utility of phospholipase A activity in patients with acute pancreatitis: comparison with amylase and lipase.
Experimental acute pancreatitis in dogs. IV. The relationship between phospholipase A and the histamine-releasing and hypotensive effects of pancreatic exudate.
Experimental pancreatitis in the rat. The role of phospholipase A in sodium taurocholate-induced acute haemorrhagic pancreatitis.
Inflammatory response in the early prediction of severity in human acute pancreatitis.
Oleic acid induced pancreatitis in pigs.
On the etiology and pathophysiology of acute pancreatitis, with special reference to participation of phospholipase A.
Pancreatic phospholipase A activity in duodenal aspirates. A study in normals and patients with chronic pancreatitis.
Phospholipase A activities in ascites, serum, lymph, and urine in acute pancreatitis following pancreas stimulation with secretin-ceruletid.
Prognostic value of serum phospholipase A in acute pancreatitis.
Role of interleukin-6 in acute pancreatitis. Comparison with C-reactive protein and phospholipase A.
Serum phospholipase--regulatory and pathophysiological aspects.
The lung lysosomal hydrolases and phospholipase A in acute experimental pancreatitis with reference to heparin treatment.
The possible role of phospholipase A in the pathogenesis of acute pancreatitis.
The role of phospholipase A in acute pancreatitis.
Turbidimetric serum phospholipase A activity in acute pancreatitis.
[Acute pancreatitis--etiology, pathological anatomy and pathogenesis]
[Acute pancreatitis. Risk predictors and the role of phospholipase A]
[Diagnosis and treatment of acute pancreatitis]
[Effects of bovine pancreatic polypeptide on phospholipase A and trypsin activities in pancreatic tissue in rats with acute pancreatitis]
[Enzyme liberation and activation of the kallikrein-kinin system in experimental pancreatitis. Studies of portal vein blood, pancreatic lymph and peritoneal effusion]
[Phospholipase A activity in ascitic fluids during acute pancreatitis]
[Phospholipase A and acute pancreatitis]
[Significance of phospholipase A in acute pancreatitis]
[The effect of p-bromophenacylbromide, a phospholipase A inhibitor, in experimental acute pancreatitis in rats]
[Therapy of acute pancreatitis with a synthetic protease and phospholipase A2 inhibitor gabexate mesilate]
Pancreatitis, Acute Necrotizing
Biochemical evaluation of patients with acute pancreatitis.
Pancreatitis, Chronic
Pancreatic Phospholipase A Activity in Duodenal Aspirates.
Pancreatic phospholipase A activity in duodenal aspirates. A study in normals and patients with chronic pancreatitis.
Pantothenate Kinase-Associated Neurodegeneration
Neurodegeneration with brain iron accumulation.
Paralysis
A mechanism for organophosphate-induced delayed neuropathy.
Impairment of glutamate signaling in mouse central nervous system neurons in vitro by tri-ortho-cresyl phosphate at noncytotoxic concentrations.
Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness.
Neuropathy target esterase and phospholipid deacylation.
Organophosphates induce distal axonal damage, but not brain oedema, by inactivating neuropathy target esterase.
Role of phospholipase A activity in the neuromuscular paralysis produced by some components isolated from the venom of the seasnake, Laticauda semifasciata.
Paraplegia
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.
NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.
Parasitic Diseases
Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy.
Enhanced lysophospholipase activity in sensitized mice challenged with Trichinella spiralis: a role for cell-cooperation.
Intestinal phospholipase B activity in swine inoculated with Trichinella spiralis.
Phospholipase and lysophospholipase activity of rat eosinophil leukocytes.
Periodontal Diseases
Treponema lecithinolyticum sp. nov., a small saccharolytic spirochaete with phospholipase A and C activities associated with periodontal diseases.
Periodontitis
A low level of lysophosphatidic acid in human gingival crevicular fluid from patients with periodontitis due to high soluble lysophospholipase activity: Its potential protective role on alveolar bone loss by periodontitis.
Erratum to "A low level of lysophosphatidic acid in human gingival crevicular fluid from patients with periodontitis due to high soluble lysophospholipase activity: Its potential protective role on alveolar bone loss by periodontitis" [BBA - Mol. Cell Biol. L. 1865/7 (July 2020) Article number: 158698].
Peripheral Nervous System Diseases
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Pheochromocytoma
Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells.
Pneumonia
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Polyneuropathies
Acute poisoning with methidathion: a case.
An alternative in vitro method for detecting neuropathic compounds based on acetylcholinesterase inhibition and on inhibition and aging of neuropathy target esterase (NTE).
Anomalous biochemical responses in tests of the delayed neuropathic potential of methamidophos (O,S-dimethyl phosphorothioamidate), its resolved isomers and of some higher O-alkyl homologues.
Biochemical and clinical tests of the delayed neuropathic potential of some O-alkyl O-dichlorophenyl phosphoramidate analogues of methamidophos (O,S-dimethyl phosphorothioamidate).
Discrimination of carboxylesterases of chicken neural tissue by inhibition with a neuropathic, non-neuropathic organophosphorus compounds and neuropathy promoter.
Do carbamates cause polyneuropathy?
Effects of S-ethyl hexahydro-1H-azepine-1-carbothioate (molinate) on di-n-butyl dichlorovinyl phosphate (DBDCVP) neuropathy.
High doses of soman protect against organophosphorus-induced delayed polyneuropathy but tabun does not.
Hydrolysis of chiral organophosphorus compounds by phosphotriesterases and mammalian paraoxonase-1.
Improved in vitro method for screening organophosphate-induced delayed polyneuropathy.
In vivo and in vitro regional differential sensitivity of neuropathy target esterase to di-n-butyl-2,2-dichlorovinyl phosphate.
Inhibition of lymphocytic neuropathy target esterase predicts the development of organophosphate-induced delayed polyneuropathy.
Interactions between neuropathy target esterase and its inhibitors and the development of polyneuropathy.
Low non-neuropathic tri-o-cresyl phosphate (TOCP) doses inhibit neuropathy target esterase near the neuropathic threshold in n-hexane pretreated hens.
Neuropathy target esterase (NTE) and organophosphorus-induced delayed polyneuropathy (OPIDP): recent advances.
Neuropathy target esterase in human lymphocytes.
Organophosphate neuropathy due to methamidophos: biochemical and neurophysiological markers.
Organophosphate polyneuropathy and neuropathy target esterase: studies with methamidophos and its resolved optical isomers.
Organophosphorus inhibition and heat inactivation kinetics of particulate and soluble forms of peripheral nerve neuropathy target esterase.
Organophosphorus Insecticide Poisoning.
Partial characterization of neuropathy target esterase and related phenyl valerate esterases from bovine adrenal medulla.
Phenyl di-n-pentylphosphinate: a convenient reactivatible inhibitor for studies on neuropathy target esterase (NTE) and protection against organophosphate-induced delayed polyneuropathy.
Phenyl valerate esterases other than neuropathy target esterase and the promotion of organophosphate polyneuropathy.
Promoters and promotion of axonopathies.
Reversible inhibition can profoundly mislead studies on progressive inhibition of enzymes: the interaction of paraoxon with soluble neuropathy target esterase.
Sciatic nerve neuropathy target esterase. Methods of assay, proximo-distal distribution and regeneration.
Silencing of PNPLA6, the neuropathy target esterase (NTE) codifying gene, alters neurodifferentiation of human embryonal carcinoma stem cells (NT2).
Soluble and particulate forms of the organophosphorus neuropathy target esterase in hen sciatic nerve.
Soluble and particulate organophosphorus neuropathy target esterase in brain and sciatic nerve of the hen, cat, rat, and chick.
Sulfonyl fluorides and the promotion of diisopropyl fluorophosphate neuropathy.
Symposium introduction: retrospect and prospects for neuropathy target esterase (NTE) and the delayed polyneuropathy (OPIDP) induced by some organophosphorus esters.
The influence of chirality on the delayed neuropathic potential of some organophosphorus esters: neuropathic and prophylactic effects of stereoisomeric esters of ethyl phenylphosphonic acid (EPN oxon and EPN) correlate with quantities of aged and unaged neuropathy target esterase in vivo.
The phosphorothioic acid O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl ester exacerbates organophosphate polyneuropathy without inhibition of neuropathy target esterase.
The relevance of inhibitor-substrate interactions when measuring neuropathy target esterase inhibition.
The search for the physiological functions of NTE; is NTE a receptor?
The search of the target of promotion: Phenylbenzoate esterase activities in hen peripheral nerve.
Toxicological assessment of isomeric pesticides: a strategy for testing of chiral organophosphorus (OP) compounds for delayed polyneuropathy in a regulatory setting.
Pre-Eclampsia
Altered activity of lysophospholipase D, which produces bioactive lysophosphatidic acid and choline, in serum from women with pathological pregnancy.
Down-Regulation of Neuropathy Target Esterase in Preeclampsia Placenta Inhibits Human Trophoblast Cell Invasion via Modulating MMP-9 Levels.
Reduced neuropathy target esterase in pre-eclampsia suppresses tube formation of HUVECs via dysregulation of phospholipid metabolism.
Prostatic Neoplasms
Group IIA phospholipase A as a prognostic marker in prostate cancer: relevance to clinicopathological variables and disease-specific mortality.
Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients.
Pruritus
Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders.
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin and responds to therapeutic interventions.
Pulmonary Eosinophilia
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Respiratory Distress Syndrome
Acute pancreatitis: a multisystem disease.
Familial respiratory distress syndrome in three consecutive full-term infants. Case reports and documentation of lung enzyme activities.
Role of phospholipase A in multiorgan failure with special reference to ARDS and acute renal failure (ARF).
Rhinitis
Charcot-Leyden Crystal Protein in Nasal Secretions of Patients with Nonallergic Rhinitis with Eosinophilia Syndrome.
[Expression and pathological role of galectin-10 in different types of nasal polyps].
Rhinitis, Allergic
[Expression and pathological role of galectin-10 in different types of nasal polyps].
Sarcoma
[Effects of gamma rays on the phospholipase A activity of the Sticker sarcoma]
Schistosomiasis haematobia
Lysophospholipase from the human blood fluke, Schistosoma japonicum.
Scleroderma, Systemic
A potential contribution of decreased serum galectin-10 levels to systemic inflammation and pulmonary vascular involvement in systemic sclerosis.
Sepsis
Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure.
Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin.
Phospholipase A--a parameter of sepsis? A comparison of PLA and Stevens' Sepsis Severity Score.
Tumor necrosis factor is a mediator of phospholipase release during bacteremia in baboons.
Shock, Septic
Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure.
Sick Building Syndrome
Association of sick building syndrome with neuropathy target esterase (NTE) activity in Japanese.
Spastic Paraplegia, Hereditary
Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish.
Neuronal phospholipid deacylation is essential for axonal and synaptic integrity.
Spinal Cord Injuries
Computational Exploration of Natural Compounds to Target Cytosolic Phospholipase A 2 Protein: A Novel Therapeutic Target for Spinal Cord Injury.
Squamous Cell Carcinoma of Head and Neck
Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry.
Stroke
Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks: Results of an Analysis of 13 Biomarkers From the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trial.
Tetanus
Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures.
Thrombosis
Acute pancreatitis: a multisystem disease.
Tuberculosis
Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids.
Typhus, Epidemic Louse-Borne
Partial purification and characterization of the major species-specific protein antigens of Rickettsia typhi and Rickettsia prowazekii identified by rocket immunoelectrophoresis.
Urinary Bladder Neoplasms
Search for the tumor-related proteins of transition cell carcinoma in Taiwan by proteomic analysis.
Vascular Diseases
ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation: Role of PKCs-dependent NADPH oxidase/ROS generation.
Overexpression of porcine lipoprotein-associated phospholipase A2 in swine.
Vasculitis
Eosinophil ETosis-Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis.
Virus Diseases
Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.
Intestinal phospholipase B activity in pigs inoculated with transmissible gastroenteritis virus.
Phospholipase B enzyme expression is not associated with other virulence attributes in Candida albicans isolates from patients with human immunodeficiency virus infection.
Vitamin E Deficiency
[Activation of lipoxygenase, neuraminidase and phospholipase A in cellular and subcellular membranes in carbon tetrachloride poisoning and vitamin E deficiency]
Whooping Cough
Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain.
Cytokine regulation of adenylate cyclase activity in LLC-PK1 cells.
Ornithine-containing lipid of Bordetella pertussis, a new type of hemagglutinin.
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro.