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EC Tree
The taxonomic range for the selected organisms is: Mus musculus The enzyme appears in selected viruses and cellular organisms
Synonyms
phospholipase a, lysophospholipase, neuropathy target esterase, phospholipase b, lysopld, galectin-10, charcot-leyden crystal protein, lysophospholipase a, lysopl, cpla2gamma,
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Charcot-Leyden crystal protein
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Charcot-Leyden crystal protein homolog
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eosinophil lysophospholipases
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LCAT-like lysophospholipase
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Lysolecithin acylhydrolase
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lysophopholipase L2
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lysophosphatidase
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lysophosphatidylcholine hydrolase
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lysophospholipase A1
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hydrolysis of carboxylic ester
hydrolysis of carboxylic ester
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hydrolysis of carboxylic ester
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2-lysophosphatidylcholine acylhydrolase
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1-lauroyl-sn-glycero-3-phosphocholine + H2O
lauric acid + sn-glycero-3-phosphocholine
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1-linoleoyl-sn-glycero-3-phosphocholine + H2O
linoleic acid + glycerophosphorylcholine
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1-myristoyl-sn-glycero-3-phosphocholine + H2O
myristic acid + sn-glycero-3-phosphocholine
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1-oleoyl-sn-glycero-3-phosphocholine + H2O
oleic acid + glycerophosphorylcholine
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1-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
oleic acid + glycero-3-phosphoethanolamine
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1-palmitoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
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1-palmitoyl-sn-glycero-3-phosphocholine + H2O
palmitic acid + glycero-3-phosphocholine
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1-palmitoyl-sn-glycero-3-phosphoethanolamine + H2O
palmitic acid + glycero-3-phosphoethanolamine
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1-stearoyl-sn-glycero-3-phosphocholine + H2O
stearic acid + glycerophosphorylcholine
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1-stearoyl-sn-glycero-3-phosphoethanolamine + H2O
stearic acid + glycero-3-phosphoethanolamine
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2-lysophosphatidylcholine + H2O
glycerophosphocholine + a carboxylate
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2-palmitoyl-sn-glycero-3-phosphocholine + H2O
palmitic acid + glycero-3-phosphocholine
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lysophosphatidylcholine + H2O
glycerophosphorylcholine + unesterified fatty acid
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additional information
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additional information
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loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice. Even in a severe model of atherosclerosis, LCAT-like lysophospholipase exhibits a protective effect on atheroma formation at all stages and throughout the aortic tree in mice fed on normal diet
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additional information
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combined activities of secretory phospholipases and eosinophil lysophospholipases induce pulmonary surfactant dysfunction by phospholipid hydrolysis
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additional information
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hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid
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2-lysophosphatidylcholine + H2O
glycerophosphocholine + a carboxylate
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additional information
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additional information
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loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice. Even in a severe model of atherosclerosis, LCAT-like lysophospholipase exhibits a protective effect on atheroma formation at all stages and throughout the aortic tree in mice fed on normal diet
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additional information
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combined activities of secretory phospholipases and eosinophil lysophospholipases induce pulmonary surfactant dysfunction by phospholipid hydrolysis
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additional information
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hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid
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3(cis,cis-7,10)hexadecadienyl-4-hydroxy-2-butenolide
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chlorpyrifos pentyl oxon
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0.000076 mM, 50% inhibition
dichlorvos
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0.000028 mM, 50% inhibition
diphenyl fluorophosphinate
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2 mM, 52% inhibition
EPTC sulfoxide
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0.2 mM, 51% inhibition
ethyl octylphosphonofluoridate
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0.0000018 mM, 50% inhibition
Insulin
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insulin reduces NRE mRNA levels in a dose-dependent manner in 3T3-L1 adipocytes
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isopropyl dodecylphosphonofluoridate
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0.000002 mM, 50% inhibition
n-dodecyl-benzodioxaphosphorine 2-oxide
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0.000008 mM, 50% inhibition
phenyl N-benzylcarbamate
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0.2 mM, 47% inhibition
S-n-octyl-benzodioxaphosphorine 2-oxide
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0.000005 mM, 50% inhibition
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0.022
lysophosphatidylcholine
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substrate concentration between 0.015-0.2 mM
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SwissProt
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isoform lysophospholipase I only
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primary cultures of mouse neural cells. PLB activity is present in a variety of cultured mouse neural cell types but that acute loss of this activity is not cytotoxic
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macrophage-like
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LYPA2_MOUSE
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0
24794
Swiss-Prot
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27000
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x * 27000, lysophospholipase I, SDS-PAGE
28000
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x * 28000, lysophospholipase II, SDS-PAGE
30000
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lysophospholipase I, gel filtration
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x * 28000, lysophospholipase II, SDS-PAGE
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x * 27000, lysophospholipase I, SDS-PAGE
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6 - 8.5
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unstable below pH 6.0 and above pH 8.5
94401
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-20°C, in absence of glycerol, the enzyme loses all of its activity during the freezing and thawing process
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-20°C, enzyme concentration: 0.01-0.025 mg/ml, 60-70% glycerol, stable for several months
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4°C, stable for several weeks
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cytosolic fractions of COS7 cell extracts containing His-tagged NRE are loaded onto a Q-Sepharose column
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expression in Escherichia coli
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into the vectors pcDNA4HisMax and pEGFP-C1
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APT1 is released at high levels from RAW264.7 macrophage-like cells into the culture medium after stimulation with lipopolysaccharide, the mRNA level of lysophospholipase II in RAW264.7 cells is much less than APT1 and not changed by lipopolysaccharide treatment
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medicine
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LLPL activity is anti-atherogenic and the regulation of this enzyme might be a novel drug target for the treatment of atherosclerosis
medicine
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the phospholipases and lysophospholipases expressed by eosinophils or other airway cells may represent therapeutic targets for blocking surfactant degradation, dysfunction and peripheral airway closure in asthma
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Toyoda, T.; Sugimoto, H.; Yamashita, S.
Sequence, expression in Escherichia coli, and characterizatiom of lysophospholipase II
Biochim. Biophys. Acta
1437
182-193
1999
Mus musculus
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Zhang, Y.; Dennis, E.A.
Purification and characterization of a lysophospholipase from a macrophage-like cell line P388D1
J. Biol. Chem.
263
9965-9972
1988
Mus musculus
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Quistad, G.B.; Casida, J.E.
Lysophospholipase inhibition by organophosphorus toxicants
Toxicol. Appl. Pharmacol.
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319-326
2004
Mus musculus, Vibrio sp.
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Taniyama, Y.; Fuse, H.; Satomi, T.; Tozawa, R.; Yasuhara, Y.; Shimakawa, K.; Shibata, S.; Hattori, M.; Nakata, M.; Taketomi, S.
Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice
Biochem. Biophys. Res. Commun.
330
104-110
2005
Mus musculus
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Kwatia, M.A.; Doyle, C.B.; Cho, W.; Enhorning, G.; Ackerman, S.J.
Combined activities of secretory phospholipases and eosinophil lysophospholipases induce pulmonary surfactant dysfunction by phospholipid hydrolysis
J. Allergy Clin. Immunol.
119
838-847
2007
Mus musculus, Homo sapiens (Q05315)
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Read, D.J.; Langford, L.; Barbour, H.R.; Forshaw, P.J.; Glynn, P.
Phospholipase B activity and organophosphorus compound toxicity in cultured neural cells
Toxicol. Appl. Pharmacol.
219
190-195
2007
Mus musculus (Q3TTY0), Mus musculus
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Kienesberger, P.C.; Lass, A.; Preiss-Landl, K.; Wolinski, H.; Kohlwein, S.D.; Zimmermann, R.; Zechner, R.
Identification of an Insulin-regulated Lysophospholipase with homology to neuropathy target esterase
J. Biol. Chem.
283
5908-5917
2008
Mus musculus
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Satou, M.; Nishi, Y.; Yoh, J.; Hattori, Y.; Sugimoto, H.
Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium
Endocrinology
151
4765-4775
2010
Bos taurus, Homo sapiens, Rattus norvegicus, Mus musculus (Q9WTL7)
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