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Information on EC 3.1.1.4 - phospholipase A2

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.4 phospholipase A2
IUBMB Comments
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
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This record set is specific for:
UNIPROT: P58399
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
phospholipase a2, cpla2, spla2, spla(2), prdx6, cytosolic phospholipase a2, crotoxin, pla2s, ipla2, spla2-iia, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Lys49-phospholipase A2 homologue
-
14 kDa phospholipase A2
-
-
-
-
Agkistrotoxin
-
-
-
-
amdI1
-
-
-
-
Ammodytin I2
-
-
-
-
APLA
-
-
-
-
APP-D-49
-
-
-
-
ASPLA1
-
-
-
-
ASPLA10
-
-
-
-
ASPLA11
-
-
-
-
ASPLA12
-
-
-
-
ASPLA13
-
-
-
-
ASPLA14
-
-
-
-
ASPLA15
-
-
-
-
ASPLA16
-
-
-
-
ASPLA17
-
-
-
-
ASPLA2
-
-
-
-
ASPLA3
-
-
-
-
ASPLA4
-
-
-
-
ASPLA5
-
-
-
-
ASPLA6
-
-
-
-
ASPLA7
-
-
-
-
ASPLA8
-
-
-
-
ASPLA9
-
-
-
-
ATX
-
-
-
-
Basic protein I/II
-
-
-
-
BJ-PLA2
-
-
-
-
BJUPLA2
-
-
-
-
BPI/BPII
-
-
-
-
CaI-PLA2
-
-
-
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Caudoxin
-
-
-
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cPm09
-
-
-
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Enhancing factor
-
-
-
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GIIC sPLA2
-
-
-
-
GIID sPLA2
-
-
-
-
GIIE sPLA2
-
-
-
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GIIF sPLA2
-
-
-
-
GIII sPLA2
-
-
-
-
Group IB phospholipase A2
-
-
-
-
Group IIA phospholipase A2
-
-
-
-
Group V phospholipase A2
-
-
-
-
Group VI phospholipase A2
-
-
-
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GVI PLA2
-
-
-
-
GX sPLA2
-
-
-
-
GXII sPLA2
-
-
-
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GXIII sPLA2
-
-
-
-
iPLA2
-
-
-
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lecithinase A
-
-
-
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MP-III 4R
-
-
-
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Muscarinic inhibitor
-
-
-
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Myotoxin
-
-
-
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NAJPLA-2A
-
-
-
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NAJPLA-2B
-
-
-
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NAJPLA-2C
-
-
-
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Nigexine
-
-
-
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Non-pancreatic secretory phospholipase A2
-
-
-
-
Notechis 11'2
-
-
-
-
Notexin
-
-
-
-
NPLA
-
-
-
-
NPS-PLA2
-
-
-
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OHV A-PLA2
-
-
-
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OHV-APLA2
-
-
-
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pgPLA 1a/pgPLA 2a
-
-
-
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phosphatidase
-
-
-
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phosphatide 2-acylhydrolase
-
-
-
-
phosphatidolipase
-
-
-
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Phosphatidylcholine 2-acylhydrolase
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-
-
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Phosphatidylcholine 2-acylhydrolase GIIC
-
-
-
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Phosphatidylcholine 2-acylhydrolase GIID
-
-
-
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Phosphatidylcholine 2-acylhydrolase GIIE
-
-
-
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Phosphatidylcholine 2-acylhydrolase GIIF
-
-
-
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Phosphatidylcholine 2-acylhydrolase GIII
-
-
-
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Phosphatidylcholine 2-acylhydrolase GX
-
-
-
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Phosphatidylcholine 2-acylhydrolase GXII
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-
-
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Phosphatidylcholine 2-acylhydrolase GXIII
-
-
-
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phospholipase A
-
-
-
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Phospholipase A2 inhibitor
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-
-
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pkP5
-
-
-
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PLA2-10
-
-
-
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PLA2-VI
-
-
-
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PLA2-VII
-
-
-
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PLA2IID
-
-
-
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platelet activating factor acetyl hydrolase
-
-
-
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Pt-PLA1
-
-
-
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Pt-PLA2
-
-
-
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Secretory-type PLA, stroma-associated homolog
-
-
-
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sPLA(2)-IID
-
-
-
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sPLA(2)-IIE
-
-
-
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sPLA(2)-IIF
-
-
-
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TMV-K49
-
-
-
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Toxin VI
-
-
-
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Toxin VI:5
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine 2-acylhydrolase
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-84-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PrTX-1, a noncatalytic, myotoxic Lys49-phospholipase A2 homologue
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PA2H1_BOTPI
121
0
13729
Swiss-Prot
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PrTX-1 in complex with 4-bromophenacyl bromide and alpha-tocopherol and alpha-tocopherol acetate inhibitors, X-ray diffraction structure determination and analysis at 1.65-2.42 A resolution
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
dos Santos, J.I.; Marchi-Salvador, D.P.; Fernandes, C.A.; Silveira, L.B.; Soares, A.M.; Fontes, M.R.
Preliminary X-ray crystallographic studies of a Lys49-phospholipase A2 homologue from Bothrops pirajai venom complexed with p-bromo-phenacyl bromide and alpha-tocopherol inhibitors
Protein Pept. Lett.
14
698-701
2007
Bothrops pirajai (P58399), Bothrops pirajai
Manually annotated by BRENDA team