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EC Tree
IUBMB Comments Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
The taxonomic range for the selected organisms is: Bothrops asper The enzyme appears in selected viruses and cellular organisms
Synonyms
phospholipase a2, cpla2, spla2, spla(2), prdx6, cytosolic phospholipase a2, crotoxin, pla2s, ipla2, spla2-iia,
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14 kDa phospholipase A2
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Basic protein I/II
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Group IB phospholipase A2
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Group IIA phospholipase A2
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Group V phospholipase A2
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Group VI phospholipase A2
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Muscarinic inhibitor
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Non-pancreatic secretory phospholipase A2
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pgPLA 1a/pgPLA 2a
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phosphatide 2-acylhydrolase
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phosphatidolipase
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Phosphatidylcholine 2-acylhydrolase
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Phosphatidylcholine 2-acylhydrolase GIIC
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Phosphatidylcholine 2-acylhydrolase GIID
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Phosphatidylcholine 2-acylhydrolase GIIE
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Phosphatidylcholine 2-acylhydrolase GIIF
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Phosphatidylcholine 2-acylhydrolase GIII
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Phosphatidylcholine 2-acylhydrolase GX
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Phosphatidylcholine 2-acylhydrolase GXII
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Phosphatidylcholine 2-acylhydrolase GXIII
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Phospholipase A2 inhibitor
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platelet activating factor acetyl hydrolase
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Secretory-type PLA, stroma-associated homolog
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additional information
the enzyme belongs to the group II phospholipases A2
additional information
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the enzyme belongs to the group II PLA2s
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hydrolysis of carboxylic ester
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-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
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phosphatidylcholine 2-acylhydrolase
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
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egg yolk phospholipid + H2O
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sn-3-phosphatidylcholine + H2O
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additional information
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additional information
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CTX shows myotoxic and neurotoxic activity requiring calcineurin, overview
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additional information
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CTX shows myotoxic and neurotoxic activity requiring calcineurin, overview
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additional information
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additional information
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CTX shows myotoxic and neurotoxic activity requiring calcineurin, overview
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additional information
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CTX shows myotoxic and neurotoxic activity requiring calcineurin, overview
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AnMIP
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a PLA2 inhibitor isolated from Atropoides nummifer plasma, inhibitor protein DNA and amino acid sequence determination and phylogenetic analysis, 22247-22301 Da, pI 4.1-4.7, trimeric structure, inhibitory profile, overview
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Calcineurin
required for CTX myotoxic and neurotoxic activity, overview
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UniProt
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precursor
UniProt
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physiological function
acidic PLA2-II, in contrast to the basic Asp49 counterparts present in the same venom, lacks myotoxic, cytotoxic, and anticoagulant activities. It does not show hypotensive and anti-platelet aggregation activities and is not lethal to mice at intravenous doses up to 100 microg (5.9 microg/g), indicating its lack of neurotoxic activity. It shows a moderate induction of local edema in vivo. Acidic PLA2-II does not play a key role in the pathophysiology of envenomings, its purpose may be restricted to digestive functions. Acidic and basic PLA2s form two different antigenic groups in venom
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PA2B3_BOTAS
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0
15751
Swiss-Prot
Secretory Pathway (Reliability: 2 )
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14210
electrospray ionization
15000
1 * 15000, SDS-PAGE, 1 * 16000, SDS-PAGE, both under reducing and non-reducing conditions
16000
1 * 15000, SDS-PAGE, 1 * 16000, SDS-PAGE, both under reducing and non-reducing conditions
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monomer
1 * 15000, SDS-PAGE, 1 * 16000, SDS-PAGE, both under reducing and non-reducing conditions
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cDNA cloned into the pGEM-T vector and transformed into Escherichia coli strain DH5alpha
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medicine
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C-terminal region of enzyme has bactericidal activity. Modulation of synthetic peptides based on the enzymic sequence, which have high bactericidal and endotoxin-neutralizing activity
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Santamaria, C.; Larios, S.; Angulo, Y.; Pizarro-Cerda, J.; Gorvel, J.P.; Moreno, E.; Lomonte, B.
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region
Toxicon
45
807-815
2005
Bothrops asper
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Quiros, S.; Alape-Giron, A.; Angulo, Y.; Lomonte, B.
Isolation, characterization and molecular cloning of AnMIP, a new alpha-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae)
Comp. Biochem. Physiol. B
146
60-68
2007
Bothrops asper, Oxyuranus scutellatus, Apis mellifera (P00630)
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Miyabara, E.H.; Baptista, I.L.; Lomonte, B.; Selistre-de-Araujo, H.S.; Gutierrez, J.M.; Moriscot, A.S.
Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro
Comp. Biochem. Physiol. C
143
284-294
2006
Bothrops asper (P20474), Bothrops asper
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Fernandez, J.; Gutierrez, J.M.; Angulo, Y.; Sanz, L.; Juarez, P.; Calvete, J.J.; Lomonte, B.
Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization
Biochimie
92
273-283
2010
Bothrops asper (P20474), Bothrops asper
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