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Information on EC 3.1.1.4 - phospholipase A2 and Organism(s) Homo sapiens and UniProt Accession P14555

for references in articles please use BRENDA:EC3.1.1.4

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IUBMB Comments

Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.

The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms

Synonyms
phospholipase a2, cpla2, spla2, spla(2), prdx6, cytosolic phospholipase a2, crotoxin, pla2s, ipla2, spla2-iia, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GIIA sPLA2
-
Group IIA phospholipase A2
-
group IIA secretory phospholipase A2
-
human group IB PLA2
-
secreted phospholipase A2
-
secretory phospholipase A2
-
sPLA2-IIA
-
1-CysPrx
-
a dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities, also known as peroxiredoxin VI, non-selenium glutathione peroxidase, LTW4, antioxidant protein 2 (AOP2), Clara cell protein 26 (CC26) and p67phox binding protein
1-cysteine peroxiredoxin
-
a dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities
14 kDa phospholipase A2
-
-
-
-
acidic Ca2+-independent phospholipase A2
-
-
adiponutrin
-
-
Agkistrotoxin
-
-
-
-
aiPLA2
amdI1
-
-
-
-
Ammodytin I2
-
-
-
-
APLA
-
-
-
-
APP-D-49
-
-
-
-
ASPLA1
-
-
-
-
ASPLA10
-
-
-
-
ASPLA11
-
-
-
-
ASPLA12
-
-
-
-
ASPLA13
-
-
-
-
ASPLA14
-
-
-
-
ASPLA15
-
-
-
-
ASPLA16
-
-
-
-
ASPLA17
-
-
-
-
ASPLA2
-
-
-
-
ASPLA3
-
-
-
-
ASPLA4
-
-
-
-
ASPLA5
-
-
-
-
ASPLA6
-
-
-
-
ASPLA7
-
-
-
-
ASPLA8
-
-
-
-
ASPLA9
-
-
-
-
ATX
-
-
-
-
Basic protein I/II
-
-
-
-
BJ-PLA2
-
-
-
-
BJUPLA2
-
-
-
-
BPI/BPII
-
-
-
-
Ca2+ independent PLA2
-
group VIA PLA2
Ca2+-independent iPLA2
-
-
Ca2+-independent phospholipase A2
-
-
CaI-PLA2
-
-
-
-
calcium-independent group VIA iPLA2
-
Caudoxin
-
-
-
-
cPLA2
cPLA2-alpha
cPLA2-zeta2
-
cPLA2alpha
cPLA2beta
-
isoform
cPLA2delta
-
isoform
cPLA2epsilon
-
isoform
cPm09
-
-
-
-
cytosolic calcium-dependent PLA2
-
GIVA PLA2
cytosolic cPLA2
-
-
cytosolic gIVaPLA2
-
-
cytosolic group IVA cPLA2
-
cytosolic group IVa phospholipase A2
-
-
cytosolic phospholipase A2
-
-
cytosolic phospholipase A2-alpha
cytosolic phospholipase A2alpha
-
-
Enhancing factor
-
-
-
-
GIIA PLA2
-
-
GIIC sPLA2
-
-
-
-
GIID sPLA2
-
-
-
-
GIIE sPLA2
-
-
-
-
GIIF sPLA2
-
-
-
-
GIII sPLA2
-
-
-
-
GIVA cPLA2
-
-
GIVA phospholipase A2
-
GIVA PLA2
-
cytosolic calcium-dependent PLA2
GIVD cPLA2delta
-
Group IB phospholipase A2
-
-
-
-
Group IIA phospholipase A2
-
-
-
-
group IIA PLA2
-
-
group IIA secretory PLA2
-
-
group IID secretory phospholipase A2
-
group IV cPLA2
-
group IVA cPLA2
-
-
group IVA cytosolic phospholipase A2
group IVA phospholipase A2
group IVA PLA2
-
cytosolic calcium-dependent PLA2
group IVB phospholipase A2
-
-
Group V phospholipase A2
-
-
-
-
group V secreted phospholipase A2
-
-
Group VI phospholipase A2
-
-
-
-
Group VIA Ankyrin-1
-
syn: iPLA2-1, splice variant of iPLA2
Group VIA Ankyrin-2
-
syn: iPLA2-2, splice variant of iPLA2
group VIA calcium-independent phospholipase A
-
-
group VIA cPLA2
-
Group VIA PLA2
-
-
Group VIA-3
-
syn: iPLA2-2, splice variant of iPLA2
GVI PLA2
-
-
-
-
GVIA iPLA2
-
-
GVIA PLA2
-
-
GVIIA PLA2
-
PAF acetyl hydrolase/oxidized lipid LpPLA2
GX sPLA2
-
-
-
-
GXII sPLA2
-
-
-
-
GXIII sPLA2
-
-
-
-
hGX sPLA2
-
-
hIIAPLA2
-
-
human group IIA phospholipase A2
-
-
iPLA2
lecithinase A
-
-
-
-
lipoprotein-associated phospholipase A2
lipoprotein-associated PLA2
-
-
LLPL
-
-
Lp-PLA2
Lpla2
lysophospholipase
-
-
lysosomal phospholipase A2
-
lysosomal PLA2
-
-
MP-III 4R
-
-
-
-
Muscarinic inhibitor
-
-
-
-
Myotoxin
-
-
-
-
NAJPLA-2A
-
-
-
-
NAJPLA-2B
-
-
-
-
NAJPLA-2C
-
-
-
-
neuropathy target esterase
-
-
Nigexine
-
-
-
-
Non-pancreatic secretory phospholipase A2
Notechis 11'2
-
-
-
-
Notexin
-
-
-
-
NPLA
-
-
-
-
NPS-PLA2
-
-
-
-
OHV A-PLA2
-
-
-
-
OHV-APLA2
-
-
-
-
PAF acetyl hydrolase/oxidized lipid LpPLA2
-
-
PAF-AH
-
Lp-PLA2
peroxiredoxin 6
pgPLA 1a/pgPLA 2a
-
-
-
-
phosphatidase
-
-
-
-
phosphatide 2-acylhydrolase
-
-
-
-
phosphatidolipase
-
-
-
-
Phosphatidylcholine 2-acylhydrolase
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIIC
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIID
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIIE
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIIF
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIII
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GX
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GXII
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GXIII
-
-
-
-
phospholipase A
-
-
-
-
phospholipase A2
-
-
phospholipase A2 gamma
-
-
Phospholipase A2 inhibitor
-
-
-
-
phospholipase A2alpha
phospholipase A2s
-
-
pkP5
-
-
-
-
PLA2-10
-
-
-
-
PLA2-V
-
-
PLA2-VI
-
-
-
-
PLA2-VII
-
-
-
-
PLA2alpha
-
-
PLA2G4C
-
-
PLA2IID
-
-
-
-
PLA2s
-
-
platelet activating factor acetyl hydrolase
-
-
-
-
platelet activating factor acetyl hydrolase/oxidized lipid LpPLA2
-
GVIIA PLA2
platlet-activating factor acetylhydrolase
-
Lp-PLA2
Prdx6
Pt-PLA1
-
-
-
-
Pt-PLA2
-
-
-
-
secreted group IID phospholipase A2
-
-
secreted human phospholipase A2
-
-
secreted phospholipase A2
-
-
secreted phospholipases A2
secreted PLA2
-
sPLA2
secreted sPLA2
-
-
secretory Ca2+-dependent PLA2
-
-
secretory phospholipase
-
-
secretory phospholipase A2
-
-
secretory phospholipase A2 group IIA
-
-
Secretory-type PLA, stroma-associated homolog
-
-
-
-
sPLA(2)
-
-
sPLA(2)-IID
-
-
-
-
sPLA(2)-IIE
-
-
-
-
sPLA(2)-IIF
-
-
-
-
sPLA2
sPLA2 GIIA
-
-
sPLA2(IIA)
-
-
sPLA2-IIA
sPLA2-IID
-
-
sPLA2-V
-
-
sPLA2-X
-
-
sPLA2IB2
-
-
TMV-K49
-
-
-
-
Toxin VI
-
-
-
-
Toxin VI:5
-
-
-
-
TTS-2.2
-
-
type VIIA PLA2
-
Lp-PLA2
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
mechanism
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
alpha-linolenate metabolites biosynthesis, anandamide biosynthesis I, anandamide biosynthesis II, arachidonate metabolites biosynthesis, aspirin triggered resolvin D biosynthesis, aspirin triggered resolvin E biosynthesis, di-homo-gamma-linolenate metabolites biosynthesis, docosahexaenoate metabolites biosynthesis, icosapentaenoate metabolites biosynthesis, linoleate metabolites biosynthesis, maresin biosynthesis, peptido-conjugates in tissue regeneration biosynthesis, phosphatidylcholine acyl editing, phospholipases, phospholipid remodeling (phosphatidate, yeast), phospholipid remodeling (phosphatidylcholine, yeast), phospholipid remodeling (phosphatidylethanolamine, yeast), plasmalogen degradation, protectin biosynthesis, resolvin D biosynthesis
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine 2-acylhydrolase
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-84-7
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
Reversibility
r=reversible
ir=irreversible
?=not specified
(2'R,2S)-2,3-dihydroxypropyl 2'-octadecanoyloxy-5'-hexadecyloxy-5'-oxopentan-1'-yl phosphate + H2O
?
show the reaction diagram
Substrates: -
Products: -
?
(2S,2'S,3R)-2,3-dihydroxypropyl 2',3'-octadecanoyloxy-nonadecyl phosphate + H2O
?
show the reaction diagram
Substrates: -
Products: -
?
(2S,2'S,3S)-2,3-dihydroxypropyl 2',3'-octadecanoyloxy-nonadecyl phosphate + H2O
?
show the reaction diagram
Substrates: -
Products: -
?
(R)-1,2-dipalmitoyl-glycero-3-phosphocholine + H2O
?
show the reaction diagram
Substrates: -
Products: -
?
(R)-1,2-dipalmitoyl-glycero-3-phosphoglycerol + H2O
?
show the reaction diagram
Substrates: -
Products: -
?
(R)-1-O-hexadecyl-2-palmitoyl-sn-glycero-3-phoshocholine + H2O
?
show the reaction diagram
Substrates: -
Products: -
?
1,2-bis-(10-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
1-(10-pyrenedecanoyl)-glycero-3-phosphocholine + 10-pyrenedecanoate
show the reaction diagram
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
show the reaction diagram
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-glycero-3-phosphoglycerol + palmitate
show the reaction diagram
Substrates: -
Products: -
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
Substrates: -
Products: -
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-sn-glycero-3-phosphorylglycerol + oleate
show the reaction diagram
Substrates: -
Products: -
?
1-palmitoyl-2-stearoyl-dibromo-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
Substrates: -
Products: -
?
(+/-)-3-O-(4-cyanomethylphenyl)-1,2-O-di-n-heptylglycerol + H2O
?
show the reaction diagram
-
Substrates: -
Products: -
?
(+/-)-3-O-(4-hydroxymethylphenyl)-1,2-O-di-n-heptylglycerol + H2O
?
show the reaction diagram
-
Substrates: -
Products: -
?
(R)-1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
Substrates: enzyme adsorbs to monolayers of L-alpha-1,2-dipalmitoyl-sn-glycero-3-phosphocholine, leading to hydrolysis of the monlayer
Products: -
?
1,2-bis(heptanoylthio)-glycerophosphocholine + H2O
?
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-bis-(10-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
1-(10-pyrenedecanoyl)-glycero-3-phosphocholine + 10-pyrenedecanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-di-O-hexadecyl-sn-glycerol-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-didodecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-diheptanoyl phosphatidylcholine + H2O
1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O
1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-diheptanoyl-sn-glycero-3-sulfate + H2O
1-heptanoyl-sn-glycero-3-sulfate + heptanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O
1-lauroyl-sn-glycero-3-phosphocholine + laureate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dimyristoyl-sn-glycero-3-phosphocholine + H2O
1-myristoyl-sn-glycero-3-phosphocholine + myristic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dimyristoyl-sn-phosphatidylcholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dinonanoyl-sn-glycero-3-phosphocholine + H2O
1-nonanoyl-sn-glycero-3-phosphocholine + nonanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dioctanoyl-sn-glycero-3-phosphoglycol + H2O
1-octanoyl-sn-glycero-3-phosphoglycol + octanoate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dioleoyl-L-alpha-phosphatidylcholine + H2O
?
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
1-oleoylglycerophosphocholine + oleic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dioleoyl-sn-glycerol + H2O
1-oleoyl-sn-glycerol + oleic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dioleoyl-sn-glycerol + H2O
?
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dioleoyl-sn-phosphatidylcholine + H2O
1-oleoyl-sn-phosphatidylcholine + oleate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O
1-oleoyl-sn-phosphatidylethanolamine + oleic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-phosphatidylethanolamine + H2O
1-palmitoyl-phosphatidylethanolamine + palmitic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + palmitic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoylglycerophosphocholine + palmitic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) + H2O
1-palmitoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) + palmitic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-glycero-3-phosphoglycerol + palmitate
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitic acid
show the reaction diagram
-
Substrates: in mixed micelles with Triton X-100
Products: -
?
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
?
show the reaction diagram
-
Substrates: -
Products: -
?
1,2-dipalmitoyl-sn-phosphatidylcholine + H2O
1-palmitoyl-sn-phosphatidylcholine + palmitate
show the reaction diagram
Substrates: the catalytic site for aiPLA2 activity is an S32-H26-D140 triad
Products: -
?
1,2-dithio-heptanoylphosphatidylcholine + H2O
?
show the reaction diagram
-
Substrates: detection of reaction product with 5,5'-dithio-bis-(2-nitrobenzoic acid)
Products: -
?
1-acyl-2-arachidonoyl-glycerophosphocholine + H2O
1-acyl-glycerophosphocholine + arachidonic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1-acyl-2-arachidonoyl-sn-glycerol phosphoethanolamine + H2O
1-acyl-sn-glycerol phosphoethanolamine + arachidonate
show the reaction diagram
Substrates: radiolabeled substrate
Products: -
?
1-acyl-2-arachidonoyl-sn-glycerophosphoethanolamine + H2O
1-acyl-sn-glycerophosphoethanolamine + arachidonic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O
1-acyl-3-phosphoethanolamine + linolic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1-acyl-2-linoleoyl-glycerophosphocholine + H2O
1-acyl-glycerophosphocholine + linolic acid
show the reaction diagram
-
Substrates: -
Products: -
?
1-decanoyl-2-(4-nitrophenylglutaryl)glycerol 3-phosphate + H2O
?
show the reaction diagram
-
Substrates: HSD-PLA2
Products: -
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphatidic acid + H2O
?
show the reaction diagram
-
Substrates: group V sPLA2
Products: -
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphocholine + H2O
1-hexadecanoyl-glycero-3-phosphocholine + 1-pyrenedecanoate
show the reaction diagram
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoethanolamine + H2O
1-hexadecanoyl-glycero-3-phosphoethanolamine + 1-pyrenedecanoate
show the reaction diagram
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoglycerol + H2O
1-hexadecanoyl-glycero-3-phosphoglycerol + 1-pyrenedecanoate
show the reaction diagram
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoserine + H2O
1-hexadecanoyl-glycero-3-phosphoserine + 1-pyrenedecanoate