Information on EC 3.1.1.37 - steroid-lactonase

for references in articles please use BRENDA:EC3.1.1.37
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:


The expected taxonomic range for this enzyme is: Acremonium chrysogenum

EC NUMBER
COMMENTARY hide
3.1.1.37
-
RECOMMENDED NAME
GeneOntology No.
steroid-lactonase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
testololactone + H2O = testolate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
testololactone lactonohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37288-08-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
16alpha-hydroxytestololactone + H2O
16alpha-hydroxytestolate
show the reaction diagram
-
50% the rate of testololactone
-
?
testolate
testololactone + H2O
show the reaction diagram
-
lactone formation more rapidly than lactone hydrolysis, only at pH 6, presence of Mn2+
-
r
testololactone + H2O
?
show the reaction diagram
-
-
-
-
-
testololactone + H2O
testolate
show the reaction diagram
-
-
-
r
additional information
?
-
-
not: steroids containing gamma-lactones, digitoxigenin, spirolactone
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
testololactone + H2O
?
show the reaction diagram
-
-
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
optimum: 0.1 M, enhances
Mn2+
-
optimum: 0.1 M, enhances
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
p-Chloromercuriphenylsulfonate
-
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE