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dipalmitoylphosphatidylcholine + H2O
palmitic acid + 1-lyso-2-palmitoylphosphatidylcholine
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
-
-
?
1,2-dioleoylphosphatidylcholine + H2O
oleic acid + 2-oleoylglycerophosphocholine
-
-
-
?
1-palmitoyl-2-linoleoyl phosphatidylcholine + H2O
?
-
the enzyme is responsible for about two-thirds of plasma 1-palmitoyl-2-linoleoyl phosphatidylcholine disappearance
-
-
?
1-palmitoyl-2-linoleoyl-sn-3-glycerophosphorylethanolamine + H2O
palmitic acid + 2-linoleoyl-sn-3-glycerophosphorylethanolamine
-
-
-
-
?
1-palmitoyl-2-linoleoylglycerophosphocholine + H2O
?
-
-
-
-
?
1-palmitoyllysophosphatidylcholine + H2O
palmitic acid + lysophosphatidylcholine
-
weak activity
-
-
?
1-stearoyl-2-arachidonyl-sn-glycero-3-phosphoinositol + H2O
2-arachidonylglycero-3-phosphoinositol + ?
-
-
no release of free arachidonate
?
2-oleoylphosphatidylcholine + H2O
oleic acid + glycerophosphocholine
-
-
-
-
?
diacyl-sn-glycero-3-phosphorylcholine + H2O
fatty acid + lysophosphatidylcholine
-
-
-
-
?
diacyl-sn-glycero-3-phosphorylethanolamine + H2O
fatty acid + lysophosphatidylethanolamine
-
-
-
-
?
dipalmitoylphosphatidylcholine + H2O
?
-
-
-
-
?
phosphatidic acid + H2O
?
-
phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
?
-
-
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
-
-
-
?
phosphatidylethanolamine + H2O
?
-
-
-
-
?
phosphatidylserine + H2O
?
-
phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A
-
-
?
additional information
?
-
additional information
?
-
His21 and Cys111 of H-Rev107 form a catalytic dyad. The N-terminal proline-rich and C-terminal hydrophobic domains are involved in the catalytic activity and/or proper folding
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
-
-
?
additional information
?
-
-
several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity
-
-
?
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Hostetler, K.Y.; Gardner, M.F.; Giordano, J.R.
Purification of lysosomal phospholipase A and demonstration of proteins that inhibit phospholipase A in a lysosomal fraction from rat kidney cortex
Biochemistry
25
6456-6461
1986
Rattus norvegicus
brenda
Nalbone, G.; Hostetler, K.Y.; Leonardi, J.; Trotz, M.; Lafont, H.
Partial characterization of rat heart cytosolic phospholipase A1 and demonstration of essential sulfhydryl groups
Biochim. Biophys. Acta
877
88-95
1986
Rattus norvegicus
brenda
Hostetler, K.Y.; Yazaki, P.J.; van den Bosch, H.
Purification of lysosomal phospholipase A. Evidence for multiple isoenzymes in rat liver
J. Biol. Chem.
257
13367-13373
1982
Rattus norvegicus
brenda
Ueda, H.; Kabayshi, T.; Kishimoto, M.; Tsutsumi, T.; Okuyama, H.
A possible pathway of phosphoinositide metabolism through EDTA-insensitive phospholipase A1 followed by lysophosphoinositide-specific phospholipase C in rat brain
J. Neurochem.
61
1874-1881
1993
Rattus norvegicus
brenda
Waite, M.; Rao, R.H.; Griffin, H.; Franson, R.; Miller, C.; Sisson, P.; Frye, J.
Phospholipases A1 from lysosomes and plasma membranes of rat liver
Methods Enzymol.
71
674-689
1981
Rattus norvegicus
brenda
Woelk, H.; Peiler-Ichikawa, K.; Binaglia, L.; Goracci, G.; Porcellati, G.
Distribution and properties of phospholipases A1 and A2 in synaptosomes and subsynaptosomal fractions of rat brain
Hoppe-Seyler's Z. Physiol. Chem.
355
1535-1542
1974
Rattus norvegicus
brenda
Woelk, H.; Porcellati, G.
Subcellular distribution and kinetic properties of rat brain phospholipases A1 and A2
Hoppe-Seyler's Z. Physiol. Chem.
354
90-100
1973
Rattus norvegicus
brenda
Hostetler, K.Y.; Gardner, M.F.
Purification of rat kidney lysosomal phospholipase A1
Methods Enzymol.
197
325-330
1991
Rattus norvegicus
brenda
Schmidt, M.; Lffler, B.M.; Kunze, H.
Protease inhibitors reduce lysosomal acid phospholipase A1 activity in cultured rat hepatocates
Biochem. Int.
20
337-342
1990
Rattus norvegicus
brenda
Scagnelli, G.P.; Cooper, P.S.; VandenBroek, J.M.; Berman, W.F.; Schwartz, C.C.
Plasma 1-palmitoyl-2-linoleoyl phosphatidylcholine. Evidence for extensive phospholipase A1 hydrolysis and hepatic metabolism of the product
J. Biol. Chem.
266
18002-18011
1991
Rattus norvegicus
brenda
Hostetler, K.Y.; Jellison, E.J.
Inhibition of kidney lysosomal phospholipase A1 by aminoglycosides is a novel variant of substrate depletion inhibition
J. Pharmacol. Exp. Ther.
254
188-191
1990
Rattus norvegicus
brenda
Uchiyama, S.I.; Miyazaki, Y.; Amakasu, Y.; Kuwata, H.; Nakatani, Y.; Atsumi, G.I.; Murakami, M.; Kudo, I.
Characterization of heparin low-affinity phospholipase A1 present in brain and testicular tissue
J. Biochem.
125
1001-1010
1999
Bos taurus, Mus musculus, Rattus norvegicus
brenda
Piret, J.; Schanck, A.; Delfosse, S.; Van Bambeke, F.; Kishore, B.K.; Tulkens, P.M.; Mingeot-Leclercq, M.P.
Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids
Chem. Phys. Lipids
133
1-15
2005
Rattus norvegicus
brenda
Nassogne, M.C.; Lizarraga, C.; N'Kuli, F.; Van Bambeke, F.; Van Binst, R.; Wallemacq, P.; Tulkens, P.M.; Mingeot-Leclercq, M.P.; Levade, T.; Courtoy, P.J.
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1
Toxicol. Appl. Pharmacol.
194
101-110
2004
Rattus norvegicus
brenda
Aoki, J.; Inoue, A.; Makide, K.; Saiki, N.; Arai, H.
Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family
Biochimie
89
197-204
2007
Bombyx mori, Cavia porcellus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Dolichovespula maculata
brenda
Uyama, T.; Morishita, J.; Jin, X.H.; Okamoto, Y.; Tsuboi, K.; Ueda, N.
The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type
J. Lipid Res.
50
685-693
2009
Homo sapiens, Mus musculus, Rattus norvegicus (P53817)
brenda