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Information on EC 3.1.1.32 - phospholipase A1
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EC Tree
3.1.1.32 phospholipase A1IUBMB Comments
This enzyme has a much broader specificity than EC 3.1.1.4 phospholipase A2. Requires Ca2+.
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Word Map
- 3.1.1.32
- phospholipid
- platelet
- phospholipases
- lysosomal
- lysophospholipase
- phosphatidylethanolamine
- venom
- lysophospholipids
- thrombocytopenia
- lysophosphatidylcholine
- lipases
-
arachidonic
-
alloimmune
- wasp
-
alloantigens
- purpura
-
platelet-specific
- hymenoptera
-
deacylation
-
lysophosphatidic
-
gpiiia
- hornet
- hypotrichosis
-
2-acyl
- vespula
-
vespid
-
posttransfusion
-
component-resolved
- plasmalogens
-
degumming
-
alloantibody
- monoacylglycerol
-
3.1.1.4
-
phospholipidosis
- lysophosphatidylinositol
-
woolly
-
glanzmann
- thrombasthenia
- degradation
- synthesis
- medicine
- lysophosphatidylethanolamine
- pharmacology
- food industry
- nutrition
- analysis
- industry
The enzyme appears in viruses and cellular organisms
Synonyms
phospholipase a1, pla1, ompla, h-rev107, ddhd1, outer membrane phospholipase a, pla1a, lipase h, ves v 1, ipla-1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Allergen Dol m 1.01
-
-
-
-
Allergen Dol m 1.02
-
-
-
-
BveA
DAD1
endothelial lipase
H-Rev107
hepatic lipase
LIPI
mPA-PLA1alpha
mPA-PLA1beta
OM PLA
-
-
-
-
OMPLA
PA-PLA1
PA-PLA1/DDHD1
pancreatic lipase-related protein 2
phosphatidic acid-preferring phospholipase A1
phosphatidic acid-preferring phospholipase A1/DDHD1
Phosphatidylcholine 1-acylhydrolase
-
-
-
-
phospholipase A1
phospholipase A1/2
PLA A1
PLA1
PLA1/2
PLA1S
PLRP2
Yor022c
additional information
OMPLA
-
-
-
-
additional information
-
the isozymes belong to the pancreatic lipase gene family or to the phospholipase family
additional information
-
the enzyme belongs to the pancreatic lipase gene family
additional information
-
the enzyme belongs to the pancreatic lipase gene family
additional information
-
the enzyme belongs to the pancreatic lipase gene family
additional information
-
the enzyme belongs to the pancreatic lipase gene family
-
additional information
-
the isozymes belong to the pancreatic lipase gene family or to the phospholipase family
additional information
-
the isozymes belong to the pancreatic lipase gene family or to the phospholipase family
additional information
-
the isozymes belong to the pancreatic lipase gene family or to the phospholipase family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate
-
-
-
-
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate
structure-function relationship
-
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate
structure-function relationship
-
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate
structure-function relationship
-
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate
structure-function relationship
-
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate
structure-function relationship
-
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate
structure-function relationship
-
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate
structure-function relationship
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine 1-acylhydrolase
This enzyme has a much broader specificity than EC 3.1.1.4 phospholipase A2. Requires Ca2+.
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CAS REGISTRY NUMBER
COMMENTARY
9043-29-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2-didocosahexaenoyl-phosphatidylcholine + H2O
2-docosahexaenoyl-lysophosphatidylcholine + docosahexaenoic acid
-
19% of activity with 1-oleoyl-2-palmitoyl-phosphatidylcholine
-
?
1,2-dimyristoyl-sn-glycero-3-phosphocholine + H2O
2-myristoyl-sn-glycero-3-phosphocholine + myristic acid
-
-
?
1,2-dioctadecenoylthio-sn-glycero-3-phosphocholine + H2O
1-thio-2-octadecenoylthio-sn-glycero-3-phosphocholine + octadecenoate
-
-
-
?
1,2-dioctadecenoylthio-sn-glycero-3-phosphoethanolamine + H2O
1-thio-2-octadecenoylthio-sn-glycero-3-phosphoethanolamine + octadecenoate
-
-
-
?
1,2-dioctadecenoylthio-sn-glycero-3-phosphoglycerol + H2O
1-thio-2-octadecenoylthio-sn-glycero-3-phosphoglycerol + octadecenoate
-
-
-
?
1,2-dioleoylphosphatidylcholine + H2O
oleic acid + 2-oleoylglycerophosphocholine
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
2-palmitoyl-sn-glycerophosphocholine + palmitate
substrate from Glycine max
-
-
?
1- palmitoyl-2-oleoyl-phosphatidylcholine + H2O
2-oleoyl-lysophosphatidylcholine + palmitic acid
-
-
-
?
1-acyl-2-oleoyl-sn-glycerophosphocholine + H2O
acyl-glycerophosphocholine + oleic acid
-
labeled at the sn-2 position with [14C]oleic acid
-
-
?
1-acyl-lysophosphtidic acid + H2O
glycerol-3-phosphate + a carboxylate
-
7% of activity with phosphatidic acid
-
?
1-acyl-sn-glycero-3-phosphocholine + H2O
fatty acid + glycero-3-phosphocholine
-
-
-
-
?
1-myristoyl 2-oleyl phosphatidylcholine + H2O
2-oleylglycerophosphocholine + myristoate
-
-
-
?
1-oleoyl-2-palmitoyl-phosphatidylcholine + H2O
2-palmitoyl-lysophosphatidylcholine + oleic acid
-
-
-
?
1-palmitoyl-2-arachidonoyl-glycero-3-phosphoethanolamine + H2O
2-arachidonoyl-lysophosphatidylethanolamine + H2O
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
palmitic acid + 2-arachidonoylglycerophosphocholine
1-palmitoyl-2-docosahexaenoyl-phosphatidylcholine + H2O
2-docosahexaenoyl-lysophosphatidylcholine + palmitic acid
-
-
-
?
1-palmitoyl-2-linoleoyl phosphatidylcholine + H2O
?
-
the enzyme is responsible for about two-thirds of plasma 1-palmitoyl-2-linoleoyl phosphatidylcholine disappearance
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidyl choline + H2O
2-linoleoyl-lysophosphatidyl choline + palmitic acid
-
-
?
1-palmitoyl-2-linoleoyl-phosphorylcholine + H2O
palmitic acid + 2-linoleoyl-1-lysophosphoryl choline
-
-
-
?
1-palmitoyl-2-linoleoyl-sn-3-glycerophosphorylethanolamine + H2O
palmitic acid + 2-linoleoyl-sn-3-glycerophosphorylethanolamine
-
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O
2-oleoyl-lysophosphatidylcholine + palmitic acid
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
palmitic acid + 2-oleoylglycerophosphocholine
1-palmitoyl-2-oleyl-phosphatidylcholine + H2O
2-oleyl-lysophosphatidylcholine + palmitate
-
-
-
-
?
1-palmitoyl-2-oleyl-phosphatidylethanolamine + H2O
2-oleyl-lysophosphatidylethanolamine + palmitate
-
-
-
-
?
1-palmitoyl-2-palmitoylglycerophosphocholine + H2O
palmitic acid + 2-palmitoylglycerophosphocholine
-
-
-
-
?
1-palmitoyllysophosphatidylcholine + H2O
palmitic acid + lysophosphatidylcholine
-
weak activity
-
-
?
1-stearoyl-2-arachidonoylglycerophosphocholine + H2O
stearic acid + 2-arachidonoylglycerophosphocholine
1-stearoyl-2-arachidonoylglycerophosphoinositol + H2O
stearic acid + 2-arachidonoylglycerophosphoinositol
1-stearoyl-2-arachidonyl-sn-glycero-3-phosphoinositol + H2O
2-arachidonylglycero-3-phosphoinositol + ?
-
-
no release of free arachidonate
?
2-acyl-sn-glycero-3-phosphocholine + H2O
fatty acid + glycerophosphocholine
-
-
-
-
?
2-hexadecanoylthio-ethane-1-phosphocholine + H2O
thio-ethane-1-phosphocholine + hexadecanoate
-
-
-
?
2-oleoylphosphatidylcholine + H2O
oleic acid + glycerophosphocholine
-
-
-
-
?
diacyl-sn-glycero-3-phosphorylcholine + H2O
fatty acid + lysophosphatidylcholine
-
-
-
-
?
diacyl-sn-glycero-3-phosphorylethanolamine + H2O
fatty acid + lysophosphatidylethanolamine
-
-
-
-
?
dipalmitoylphosphatidylcholine + H2O
palmitic acid + 1-lyso-2-palmitoylphosphatidylcholine
hexadecanoylthioethane-1-phosphocholine + H2O
hexadecanoate + thioethane-1-phosphocholine
-
-
-
?
L-alpha-phosphatidyl-L-serine + H2O
2-acyl-1-glycerophosphoserine + a carboxylate
substrate from Glycine max
-
-
?
L-alpha-phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
PLA1 activity for egg yolk lecithin hydrolysis, substrate from egg yolk or Glycine max
-
-
?
L-alpha-phosphatidylinositol + H2O
2-acyl-sn-glycero-3-phosphoinositol + a carboxylate
-
-
-
?
monogalactosyldiacylglycerol + H2O
1-lyso-2-acyl-3-galactosyl-sn-glycerol + a fatty acid anion
-
-
-
?
phosphatidic acid + H2O
2-acylglycerol-3-phosphate + a carboxylate
-
-
-
?
phosphatidic acid + H2O
2-acyllysophosphatidic acid + a carboxylate
-
phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta
-
-
?
phosphatidylcholine + 2-acylglycerophosphocholine
2-acylglycerophosphocholine + phosphatidylcholine
-
regiospecific transacylation activity, PLA1 transfers a fatty acid at the sn-1 position of a donor phosphatidylcholine to the sn-1 position of an acceptor 2-acyl-lysophosphatidylcholine
-
?
phosphatidylcholine + H2O
1-acyl-2-oleoyl-sn-glycerophosphocholine + arachidonic acid
-
labeled at the sn-2 position with [14C]arachadonic acid
-
-
?
phosphatidylinositol + H2O
lysophosphatidylinositol + a carboxylate
-
1% of activity with phosphatidic acid, at 0.1% Triton X-100
-
?
phosphatidylserine + H2O
2-acylglycerophosphoserine + a carboxylate
-
low activity
-
?
1,2-dimyristoyl-sn-glycero-3-phosphate + H2O
?
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
?
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
?
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
?
-
-
-
?
1-palmitoyl-2-arachidonoyl-glycero-3-phosphoethanolamine + H2O
2-arachidonoyl-lysophosphatidylethanolamine + H2O
-
-
-
?
1-palmitoyl-2-arachidonoyl-glycero-3-phosphoethanolamine + H2O
2-arachidonoyl-lysophosphatidylethanolamine + H2O
-
-
-
-
?
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
palmitic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
palmitic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
palmitic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
palmitic acid + 2-oleoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
palmitic acid + 2-oleoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
palmitic acid + 2-oleoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
2-oleoylphosphatidylcholine + palmitate
-
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
2-oleoylphosphatidylcholine + palmitate
Trichoderma atroviride ZB-ZH292
-
-
-
-
?
1-palmitoyl-2-oleyl-phosphatidic acid + H2O
2-oleyl-lysophosphatidic acid + palmitate
-
-
-
-
?
1-palmitoyl-2-oleyl-phosphatidic acid + H2O
2-oleyl-lysophosphatidic acid + palmitate
-
-
-
-
?
1-stearoyl-2-arachidonoylglycerophosphocholine + H2O
stearic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-stearoyl-2-arachidonoylglycerophosphocholine + H2O
stearic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-stearoyl-2-arachidonoylglycerophosphoinositol + H2O
stearic acid + 2-arachidonoylglycerophosphoinositol
-
-
-
-
?
1-stearoyl-2-arachidonoylglycerophosphoinositol + H2O
stearic acid + 2-arachidonoylglycerophosphoinositol