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Information on EC 3.1.1.29 - aminoacyl-tRNA hydrolase
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3.1.1.29 aminoacyl-tRNA hydrolaseSpecify your search results
Word Map
- 3.1.1.29
- peptidyl-trnas
- aminoacyl-trnas
-
drop-off
- trnalys
-
infantile-onset
- drug development
The enzyme appears in viruses and cellular organisms
Synonyms
peptidyl-trna hydrolase, ankzf1, ptrhd1, spovc, mspth, bacterial peptidyl-trna hydrolase, peptidyl-trna hydrolase 2, yhr189w, abpth, aminoacyl-trna hydrolase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AbPth
aminoacyl-transfer ribonucleate hydrolase
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Cdc48 adaptor
hydrolase, aminoacyl-transfer ribonucleate
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MsPth
N-substituted aminoacyl transfer RNA hydrolase
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peptidyl-tRNA hydrolase
peptidyl-tRNA hydrolase 1
peptidyl-tRNA hydrolase 2
PH1539
PTH
Pth1
Pth2
SaPth
SSO0175
VcPth
VC_2184
Vms1
peptidyl-tRNA hydrolase
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peptidyl-tRNA hydrolase
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PTH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA
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N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA
reaction mechanism, active-site residues N10, H20 and D93 are crucial for catalysis
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N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA
residues K18, D86, and T90 are essential for catalytic activity, they are located in the N-part of alpha1 and in the beta3-beta4 loop. K18 and D86, which form a salt bridge, might play a role in the catalysis thanks to their acid and basic functions, whereas the OH group of T90 could act as a nucleophile
N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA
structure-function relationship, residues Asp95 and His115 are involved in catalysis, overview
N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA
structure-function relationship, residues Asp95 and His115 are involved in catalysis, overview
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
aminoacyl-tRNA aminoacylhydrolase
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CAS REGISTRY NUMBER
COMMENTARY
9054-98-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'(3')-O-L-(N,N-diacetyl-lysinyl)adenosine + H2O
?
minimalist substrate
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?
5'-dephosphorylated N,N-diacetyl-L-lysyl-tRNALys + H2O
N,N-diacetyl-L-lysine + 5'-dephosphorylated tRNALys
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?
5'-dephosphorylated N-formyl-L-methionyl-tRNA + H2O
N-formyl-L-methionine + 5'-dephosphorylated tRNA
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?
acetyl-histidine-tRNA + H2O
acetyl-histidine + tRNA
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?
acetyl-histidyl-tRNAHis + H2O
acetyl-histidine + tRNAHis
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?
dephosphorylated diacyl-lysine-tRNA + H2O
diacyl-lysine + dephosphorylated tRNA
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?
dephosphorylated formyl-Met-tRNAfMet + H2O
formyl-Met + dephosphorylated tRNAfMet
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?
dephosphorylated formyl-methioninyl-tRNA + H2O
formyl-methionine + dephosphorylated tRNA
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?
formyl-methionine-tRNA + H2O
formyl-methionine + tRNA
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?
formyl-methionyl-tRNAfMet + H2O
formyl-methionine + tRNAfMet
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Escherichia coli formyl-methionyltRNAfMet, phosphorylated and dephosphorylated substrate
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?
N-benzoyl-Gly-Gly-Phe-tRNA + H2O
N-benzoyl-Gly-Gly-Phe + tRNA
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?
N-benzoyl-Gly-GlyGly-Phe-tRNA + H2O
N-benzoyl-Gly-Gly-Gly-Phe + tRNA
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?
Oregon Green-methionine-tRNA + H2O
Oregon Green-methionine + tRNA
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?
diacetyl-Lys-tRNALys + H2O
diacetyl-Lys + tRNA
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diacetyl-Lys-tRNALys from E. coli
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?
diacetyl-lysine-tRNA + H2O
diacetyl-lysine + tRNA
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?
diacetyl-lysyl-tRNALys + H2O
diacetyl-lysine + tRNALys
diacetyl-lysyl-tRNALys is hydrolyzed by the wild type enzyme 360fold more efficiently than Lys-tRNALys
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?
diacetyl-lysyl-tRNALys + H2O
diacetyl-lysine + tRNALys
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?
diacetyl-lysyl-tRNALys + H2O
diacetyl-lysine + tRNALys
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Escherichia coli diacetyl-lysyl-tRNALys, phosphorylated and dephosphorylated substrate
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?
Flag-tagged CRPNSKn-tRNA + H2O
Flag-tagged CRPNSKn + tRNA
purified recombinant Ankzf1 catalyzes deacylation
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?
Flag-tagged CRPNSKn-tRNA + H2O
Flag-tagged CRPNSKn + tRNA
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?
Flag-tagged CRPNSKn-tRNA + H2O
Flag-tagged CRPNSKn + tRNA
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?
N-acetyl-Phe-tRNA + H2O
N-acetyl-Phe + tRNA
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enzyme from encysted embryos is specific for acetyl-Phe-tRNA
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?
N-acetyl-Phe-tRNA + H2O
N-acetyl-Phe + tRNA
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enzyme with broad specificity
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?
N-acetyl-Phe-tRNA + H2O
N-acetyl-Phe + tRNA
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enzyme with broad specificity
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?
N-acetyl-Phe-tRNA + H2O
N-acetyl-Phe + tRNA
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enzyme with broad specificity
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?
N-formyl-Val-tRNA + H2O
N-formyl-Val + tRNA
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reaction at a lower rate than with the N-acetyl derivative
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?
N-formyl-Val-tRNA + H2O
N-formyl-Val + tRNA
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reaction at a lower rate than with the N-acetyl derivative
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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the enzyme or an element directly controlled by the enzyme, is the target for the lethal effect by bacterophage lambda
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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Pth recycles N-acetyl-aminoacyl tRNAs and peptidyl-tRNAs by cleaving the ester bond between tRNA and peptide
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
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?
N-substituted aminoacyl-tRNA + H2O
N-substituted amino acid + tRNA
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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?