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(1R,5S)-oxabicyclooctenone + H2O
?
-
hydrolysis: 0.83 micromol/min/mg
-
-
?
(1S,5R)-oxabicyclooctenone + H2O
?
-
hydrolysis: 1.67 micromol/min/mg
-
-
?
(S)-5-oxo-2-tetrahydrofurancarboxylic acid + H2O
L-alpha-hydroxyglutaric acid
-
-
-
-
?
6-phosphoglucono-1,5-lactone + H2O
?
-
-
-
-
?
alpha-angelica lactone + H2O
?
-
hydrolysis: 18.3 micromol/min/mg
-
-
?
beta-hydroxybutyrolactone + H2O
?
-
hydrolysis: 3.83 micromol/min/mg
-
-
?
D-cellobiono-1,5-lactone + H2O
?
-
-
-
-
?
D-galactonic acid + H2O
?
D-galactono-1,4-lactone + H2O
?
D-galactono-1,5-lactone + H2O
D-galactonate
-
-
-
-
?
D-glucono-1,4-lactone + H2O
D-gluconate
D-glucono-1,5-lactone + H2O
D-gluconate
D-gulono-1,4-lactone + H2O
D-galactonate
D-gulono-1,5-lactone + H2O
?
-
-
-
?
D-gulono-1,5-lactone + H2O
D-gulonate
-
-
-
-
?
D-xylono-1,5-lactone + H2O
D-xylonate
delta-decanolactone + H2O
?
-
hydrolysis: 25.1 micromol/min/mg
-
-
?
delta-dodecanolactone + H2O
?
-
hydrolysis: 9.65 micromol/min/mg
-
-
?
delta-hexalactone + H2O
?
-
hydrolysis: 7.2 micromol/min/mg
-
-
?
delta-nonalactone + H2O
5-hydroxynonanoate
-
hydrolysis: 15 micromol/min/mg
-
-
?
delta-undecatiolactone + H2O
?
-
hydrolysis: 28.7 micromol/min/mg
-
-
?
delta-valerolactone + H2O
?
-
hydrolysis: 67.1 micromol/min/mg
-
-
?
dihydrocoumarin + H2O
?
-
hydrolysis: 12.99 micromol/min/mg
-
-
?
epsilon-caprolactone + H2O
?
-
hydrolysis: 14.8 micromol/min/mg
-
-
?
gamma-butyrolactone + H2O
?
-
hydrolysis: 3.21 micromol/min/mg
-
-
?
gamma-decalactone + H2O
?
-
hydrolysis: 17.38 micromol/min/mg
-
-
?
gamma-heptalactone + H2O
?
-
hydrolysis: 5.72 micromol/min/mg
-
-
?
gamma-hexalactone + H2O
?
-
hydrolysis: 5.17 micromol/min/mg
-
-
?
gamma-nonalactone + H2O
4-hydroxynonanoate
-
hydrolysis: 14.47 micromol/min/mg
-
-
?
gamma-octalactone + H2O
?
-
hydrolysis: 6.92 micromol/min/mg
-
-
?
gamma-undecalactone + H2O
?
-
hydrolysis: 12.72 micromol/min/mg
-
-
?
gamma-valerolactone + H2O
?
-
hydrolysis: 4.5 micromol/min/mg
-
-
?
homogenestic acid lactone + H2O
?
-
hydrolysis: 32.95 micromol/min/mg
-
-
?
L-galactonic acid + H2O
?
-
-
-
?
L-galactono-1,4-lactone + H2O
?
wild type enzyme shows 0.37% specific activity, recombinant enzyme shows 62.8% specific activity compared to the reaction with D-glucono-1,5-lactone
-
-
r
L-galactono-1,5-lactone + H2O
L-galactonate
-
-
-
-
?
L-glucono-1,5-lactone + H2O
L-gluconate
L-gulonic acid + H2O
?
-
-
-
?
L-gulono-1,4-lactone + H2O
L-gulonate
wild type enzyme shows 1.24% specific activity, recombinant enzyme shows 105% specific activity compared to the reaction with D-glucono-1,5-lactone
-
-
r
L-gulono-1,5-lactone + H2O
L-gulonate
-
-
-
-
?
lactabionic-1,5-lactone + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
hydrolysis: 112 micromol/min/mg
-
-
?
valerolactone + H2O
?
-
-
-
-
?
additional information
?
-
D-galactonic acid + H2O
?
-
-
-
?
D-galactonic acid + H2O
?
-
-
-
?
D-galactono-1,4-lactone + H2O
?
wild type enzyme shows 4.33% specific activity, recombinant enzyme shows 70% specific activity compared to the reaction with D-glucono-1,5-lactone
-
-
r
D-galactono-1,4-lactone + H2O
?
wild type enzyme shows 4.33% specific activity, recombinant enzyme shows 70% specific activity compared to the reaction with D-glucono-1,5-lactone
-
-
r
D-galactono-1,4-lactone + H2O
?
-
-
-
-
?
D-glucono-1,4-lactone + H2O
D-gluconate
-
-
-
-
?
D-glucono-1,4-lactone + H2O
D-gluconate
-
15% of the activity with D-glucono-1,5-lactone
-
-
?
D-glucono-1,4-lactone + H2O
D-gluconate
-
no activity
-
-
?
D-glucono-1,4-lactone + H2O
D-gluconate
-
-
-
-
?
D-glucono-1,4-lactone + H2O
D-gluconate
-
25% of the activity with D-glucono-1,5-lactone
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
wild type and recombinant enzyme show 100% specific activity
-
-
r
D-glucono-1,5-lactone + H2O
D-gluconate
wild type and recombinant enzyme show 100% specific activity
-
-
r
D-glucono-1,5-lactone + H2O
D-gluconate
-
100% relative activity
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
100% relative activity
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
XC5397 exhibits lactonase activity only toward D-glucono-1,5-lactone
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
gluconolactone
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-glucono-1,5-lactone + H2O
D-gluconate
-
-
-
?
D-gulono-1,4-lactone + H2O
D-galactonate
wild type enzyme shows 12.0% specific activity, recombinant enzyme shows 20.1% specific activity compared to the reaction with D-glucono-1,5-lactone
-
-
r
D-gulono-1,4-lactone + H2O
D-galactonate
wild type enzyme shows 12.0% specific activity, recombinant enzyme shows 20.1% specific activity compared to the reaction with D-glucono-1,5-lactone
-
-
r
D-xylono-1,5-lactone + H2O
D-xylonate
-
90% relative activity compared to D-glucono-1,5-lactone
-
-
?
D-xylono-1,5-lactone + H2O
D-xylonate
-
90% relative activity compared to D-glucono-1,5-lactone
-
-
?
L-glucono-1,5-lactone + H2O
L-gluconate
wild type enzyme shows 2.49% specific activity, recombinant enzyme shows no activity compared to the reaction with D-glucono-1,5-lactone
-
-
r
L-glucono-1,5-lactone + H2O
L-gluconate
wild type enzyme shows 2.49% specific activity, recombinant enzyme shows no activity compared to the reaction with D-glucono-1,5-lactone
-
-
r
L-glucono-1,5-lactone + H2O
L-gluconate
-
-
-
-
?
xylitol + H2O
?
-
-
-
?
additional information
?
-
-
glucose and a high oxygen level are necessary for the induction of the enzyme in the wild-type strain. The goxB mutation results in constitutive expression of all three activities
-
-
?
additional information
?
-
-
neither beta-glucosidase nor lactonase alone can split cellobionic acid, but when the two enzymes are recombined the cellobionolytic activity is recovered
-
-
?
additional information
?
-
-
neither beta-glucosidase nor lactonase alone can splitt cellobionic acid, but when the two enzymes are recombined the cellobionolytic activity is revovered
-
-
?
additional information
?
-
-
relating lactones rate of hydrolysis reveal an inverse correlation with the docking energy of the ligands-PON1 complex, and a direct correlation with the lactone side chain length
-
-
?
additional information
?
-
-
GNL is a key enzyme involved in vitamin C biosynthesis
-
-
?
additional information
?
-
-
senescence marker protein 30 plays a role in ascorbic acid biosynthesis
-
-
?
additional information
?
-
XC5397 does not hydrolyze D-gulono-1,4-lactone, L-gulono-1,4-lactone, and D-ribono-1,4-lactone
-
-
?
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Zachariou, M.; Scopes, R.K.
Glucose-fructose oxidoreductase, a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production
J. Bacteriol.
167
863-869
1986
Zymomonas mobilis
brenda
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Simultaneous enzymatic synthesis of gluconic acid and sorbitol. Production, purification, and application of glucose-fructose oxidoreductase and gluconolactonase
Appl. Biochem. Biotechnol.
63-65
173-188
1997
Delftia acidovorans, Pseudomonas aeruginosa, Pseudomonas chlororaphis, Pseudomonas fluorescens, Rhodotorula mucilaginosa, Zymomonas mobilis
brenda
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Gluconolactonase: a zinc containing metalloprotein
Experientia
38
1046-1047
1982
Bos taurus
brenda
Bailey, G.D.; Roberts, B.D.; Buess, C.M.; Carper, W.R.
Purification and partial characterization of beef liver gluconolactonase
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192
482-488
1979
Bos taurus
brenda
Roberts, B.D.; Bailey, G.D.; Buess, C.M.; Carper, W.R.
Purification and characterization of hepatic porcine gluconolactonase
Biochem. Biophys. Res. Commun.
84
322-327
1978
Sus scrofa
brenda
Moeller, P.
On the enzymatic hydrolysis of cellobionic acid. I. Synergistic effect of beta-glucosidase and lactonase fractions from Aspergillus cellulase
Hoppe-Seyler's Z. Physiol. Chem.
354
1271-1276
1973
Aspergillus sp.
brenda
Silveira, M.M.; Wisbeck, E.; Lemmel, C.; Erzinger, G.; Lopes da Costa, J.P.; Bertasso, M.; Jonas, R.
Bioconversion of glucose and fructose to sorbitol and gluconic acid by untreated cells of Zymomonas mobilis
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75
99-103
1999
Zymomonas mobilis
brenda
Hucho, F.; Wallenfels, K.
Glucono-lactonase from Escherichia coli
Biochim. Biophys. Acta
276
176-179
1972
Escherichia coli
brenda
Witteveen, C.F.B.; van de Vondervoort, P.J.I.; van den Broeck, H.C.; van Engelenburg, F.A.C.; de Graaff, L.H.; Hillebrand, M.H.B.C.; Schaap, P.J.; Visser, J.
Induction of glucose oxidase, catalase, and lactonase in Aspergillus niger
Curr. Genet.
24
408-416
1993
Aspergillus niger
brenda
Hanazato, Y.; Shiono, S.; Maeda, M.
Response characteristics of the glucose-sensitive field-effect transistor. Computer simulation of the effect of gluconolactonase coimmobilization in a glucose oxidase membrane
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231
213-220
1990
Aspergillus niger
-
brenda
Brodie, A.F.; Lipmann, F.
Identification of a gluconolactonase
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212
677-685
1955
Saccharomyces cerevisiae
brenda
Kanagasundaram, V.; Scopes, R.
Isolation and characterization of the gene encoding gluconolactonase from Zymomonas mobilis
Biochim. Biophys. Acta
1171
198-200
1992
Zymomonas mobilis
brenda
Constantinides, A.; Myles, S.J.; Vieth, W.R.
Glucono- -lactonase from Saccharomyces cerevisiae: extraction, purification and characterization
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43
121-128
1972
Saccharomyces cerevisiae
brenda
Wisbeck, E.; Silveira, M.M.; Ninow, J.; Jonas, R.
Evaluation of the flocculent strain Zymomonas mobilis Z1-81 for the production of sorbitol and gluconic acid
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37
445-449
1997
Zymomonas mobilis, Zymomonas mobilis Z1-81
-
brenda
Ogawa, K.; Nakajima-Kambe, T.; Nakahara, T.; Kokufuta, E.
Coimmobilization of gluconolactonase with glucose oxidase for improvement in kinetic property of enzymatically induced volume collapse in ionic gels
Biomacromolecules
3
625-631
2002
Aspergillus niger
brenda
Kondo, Y.; Inai, Y.; Sato, Y.; Handa, S.; Kubo, S.; Shimokado, K.; Goto, S.; Nishikimi, M.; Murayama, N.; Ishigami, A.
Senecence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy
Proc. Natl. Acad. Sci. USA
103
5723-2728
2006
Rattus norvegicus
brenda
Pedruzzi, I.; Malvessi, E.; Mata, V.G.; Silva, E.A.; Silveira, M.M.; Rodrigues, A.E.
Quantification of lactobionic acid and sorbitol from enzymatic reaction of fructose and lactose by high-performance liquid chromatography
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1145
128-132
2007
Zymomonas mobilis
brenda
Kondo, Y.; Sasaki, T.; Sato, Y.; Amano, A.; Aizawa, S.; Iwama, M.; Handa, S.; Shimada, N.; Fukuda, M.; Akita, M.; Lee, J.; Jeong, K.S.; Maruyama, N.; Ishigami, A.
Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice
Biochem. Biophys. Res. Commun.
377
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2008
Mus musculus
brenda
Furusawa, H.; Sato, Y.; Tanaka, Y.; Inai, Y.; Amano, A.; Iwama, M.; Kondo, Y.; Handa, S.; Murata, A.; Nishikimi, M.; Goto, S.; Maruyama, N.; Takahashi, R.; Ishigami, A.
Vitamin C is not essential for carnitine biosynthesis in vivo: verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice
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31
1673-1679
2008
Mus musculus
brenda
Tavori, H.; Khatib, S.; Aviram, M.; Vaya, J.
Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity
Bioorg. Med. Chem.
16
7504-7509
2008
Homo sapiens
brenda
Shinagawa, E.; Ano, Y.; Yakushi, T.; Adachi, O.; Matsushita, K.
Solubilization, purification, and properties of membrane-bound D-glucono-delta-lactone hydrolase from Gluconobacter oxydans
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73
241-244
2009
Gluconobacter oxydans, Gluconobacter oxydans IFO 3244
brenda
Ishikawa, T.; Nishikawa, H.; Gao, Y.; Sawa, Y.; Shibata, H.; Yabuta, Y.; Maruta, T.; Shigeoka, S.
The pathway via D-galacturonate/L-galactonate is significant for ascorbate biosynthesis in Euglena gracilis: identification and functional characterization of aldonolactonase
J. Biol. Chem.
283
31133-31141
2008
Euglena gracilis (A9CPS8), Euglena gracilis, Euglena gracilis Z (A9CPS8)
brenda
Chen, C.N.; Chin, K.H.; Wang, A.H.; Chou, S.H.
The first crystal structure of gluconolactonase important in the glucose secondary metabolic pathways
J. Mol. Biol.
384
604-614
2008
Xanthomonas campestris (B0RN69)
brenda
Tarighi, S.; Wei, Q.; Camara, M.; Williams, P.; Fletcher, M.P.; Kajander, T.; Cornelis, P.
The PA4204 gene encodes a periplasmic gluconolactonase (PpgL) which is important for fitness of Pseudomonas aeruginosa
Microbiology
154
2979-2990
2008
Pseudomonas aeruginosa
brenda
Nguyen, S.D.; Hung, N.D.; Cheon-Ho, P.; Ree, K.M.; Dai-Eun, S.
Oxidative inactivation of lactonase activity of purified human paraoxonase 1 (PON1)
Biochim. Biophys. Acta
1790
155-160
2009
Homo sapiens
brenda
Tarighi, S.; Taheri, P.
The role of a periplasmic gluconolactonase (PpgL)-like protein in Pseudomonas syringae pv. syringae B728a
World J. Microbiol. Biotechnol.
27
1303-1311
2011
Pseudomonas syringae pv. syringae, Pseudomonas syringae pv. syringae B728a
brenda
Kagami, Y.; Kondo, Y.; Handa, S.; Maruyama, N.; Ishigami, A.
Senescence marker protein-30/gluconolactonase expression in the mouse ovary during gestation
Biol. Pharm. Bull.
36
2005-2008
2013
Mus musculus
brenda
Aizawa, S.; Senda, M.; Harada, A.; Maruyama, N.; Ishida, T.; Aigaki, T.; Ishigami, A.; Senda, T.
Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase
PLoS ONE
8
e53706
2013
Homo sapiens (Q15493), Mus musculus (Q64374), Mus musculus
brenda
Alvin, A.; Kim, J.; Jeong, G.T.; Tsang, Y.F.; Kwon, E.E.; Neilan, B.A.; Jeon, Y.J.
Industrial robustness linked to the gluconolactonase from Zymomonas mobilis
Appl. Microbiol. Biotechnol.
101
5089-5099
2017
Zymomonas mobilis subsp. mobilis (Q01578), Zymomonas mobilis subsp. mobilis ZM4 (Q01578), Zymomonas mobilis subsp. mobilis CP4 (Q01578), Zymomonas mobilis subsp. mobilis ATCC 31821 (Q01578)
brenda