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Information on EC 3.1.1.118 - phospholipid sn-1 acylhydrolase

for references in articles please use BRENDA:EC3.1.1.118
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.118 phospholipid sn-1 acylhydrolase
IUBMB Comments
The human enzyme shows broad specificity, and has a preference for phosphatidate over other phospholipids. Unlike EC 3.1.1.32, phospholipase A1, it is also active against phosphatidylinositol. It is not active towards acyl groups linked at the sn-2 position.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
a 1-phosphatidyl-1D-myo-inositol
+
=
a 2-acyl-sn-glycero-3-phospho-1D-myo-inositol
+
Synonyms
DDHD domain-containing protein 1, DDHD domaincontaining lipase 1, DDHD1, DDL1, iPLA1alpha, KIAA0725p, p125, PA-PLA1, PA-preferring phospholipase A1, phosphatidic acid-preferring phospholipase A1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 1,2-diacyl-sn-glycerol 3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid
show the reaction diagram
(2)
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a 1-phosphatidyl-1D-myo-inositol + H2O = a 2-acyl-sn-glycero-3-phospho-1D-myo-inositol + a fatty acid
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
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