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Information on EC 3.1.1.105 - 3-O-acetylpapaveroxine carboxylesterase and Organism(s) Papaver somniferum and UniProt Accession A0A0A1EQ07

for references in articles please use BRENDA:EC3.1.1.105
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.105 3-O-acetylpapaveroxine carboxylesterase
IUBMB Comments
The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.
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This record set is specific for:
Papaver somniferum
UNIPROT: A0A0A1EQ07
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The taxonomic range for the selected organisms is: Papaver somniferum
The expected taxonomic range for this enzyme is: Papaver somniferum
Synonyms
CXE1, Cxe2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
3-O-acetylpapaveroxine acetatehydrolase
The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-O-acetylpapaveroxine + H2O
narcotine hemiacetal + acetate
show the reaction diagram
-
-
-
?
3-O-acetylpapaveroxine + H2O
narcotine hemiacetal + acetate
show the reaction diagram
4'-O-demethyl-3-O-acetylpapaveroxine + H2O
narcotoline hemiacetal + acetate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-O-acetylpapaveroxine + H2O
narcotine hemiacetal + acetate
show the reaction diagram
-
-
-
?
3-O-acetylpapaveroxine + H2O
narcotine hemiacetal + acetate
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0252
3-O-acetylpapaveroxine
pH not specified in the publication, temperature not specified in the publication
0.0471
3-O-acetylpapaveroxine
pH not specified in the publication, temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
enzyme is involved in biosynthesis of isoquinoline alkaloid noscapine
physiological function
enzyme is involved in biosynthesis of isoquinoline alkaloid noscapine
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CXE2_PAPSO
313
0
35154
Swiss-Prot
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dang, T.; Chen, X.; Facchini, P.
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy
Nat. Chem. Biol.
11
104-106
2015
Papaver somniferum (A0A0A1EQ07), Papaver somniferum (I3PLR2)
Manually annotated by BRENDA team
Park, M.; Chen, X.; Lang, D.; Ng, K.; Facchini, P.
Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy
Plant J.
95
252-267
2018
Papaver somniferum
Manually annotated by BRENDA team