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Information on EC 3.1.1.1 - carboxylesterase and Organism(s) Homo sapiens and UniProt Accession O00748

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.1 carboxylesterase
IUBMB Comments
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: O00748
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
esterase, carboxylesterase, butyrate esterase, carboxyl esterase, egasyn, carboxylesterase 1, serine protease-like, hce-2, acyl coenzyme a:cholesterol acyltransferase, esterase a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ACAT
-
-
-
0
Acyl coenzyme A:cholesterol acyltransferase
-
-
-
0
ali-esterase
-
-
-
0
aliesterase
-
-
-
0
alpha-carboxylesterase
-
-
-
0
B-esterase
-
-
-
0
Brain carboxylesterase hBr1
-
-
-
0
butyrate esterase
-
-
-
0
butyryl esterase
-
-
-
0
CaE
-
-
-
0
carboxyesterase
-
-
-
0
Carboxyesterase ES-10
-
-
-
0
carboxyl ester hydrolase
-
-
-
0
carboxylate esterase
-
-
-
0
carboxylesterase 1
carboxylesterase 1A2
247
-
carboxylesterase 2
carboxylesterase-1
281853
-
carboxylesterase-2
247
-
Carboxylesterase-5C
-
-
-
0
carboxylic acid esterase
-
-
-
0
carboxylic ester hydrolase
-
-
-
0
carboxylic esterase
-
-
-
0
Carboxylic-ester hydrolase
-
-
-
0
CE-1
281853
-
CE2
247
isozyme
CEH
247
-
CES-2
247
-
CES1-b
247
carboxylesterase 1 form b
CES1-c
247
carboxylesterase 1 form c
CES1A
CES1A1
281853
precursor of CES1A
CES1A2
CES2A1
247
-
cholesteryl ester hydrolase
247
-
cocaine esterase
-
-
-
0
cocaine:benzoylecgonine esterase
247
-
CPT-CE
247
-
Egasyn
-
-
-
0
Es-22
-
-
-
0
ES-HTEL
-
-
-
0
ES-HVEL
-
-
-
0
ES-Male
-
-
-
0
ES-THET
-
-
-
0
EST-5A
-
-
-
0
EST-5B
-
-
-
0
EST-5C
-
-
-
0
esterase A
-
-
-
0
esterase B
-
-
-
0
esterase D
-
-
-
0
esterase, carboxyl
-
-
-
0
Esterase-22
-
-
-
0
Esterase-31
-
-
-
0
hCE-2
281852
-
hCES1
281853
-
HMSE
-
-
-
0
hormone-sensitive lipase
247
-
HSL
247
-
human carboxylesterase 1
281853
-
human carboxylesterase 2
281852
-
human liver carboxylesterase
281853
-
Kidney microsomal carboxylesterase
-
-
-
0
Liver microsomal carboxylesterase
-
-
-
0
methylbutyrase
-
-
-
0
methylbutyrate esterase
-
-
-
0
Microsomal palmitoyl-CoA hydrolase
-
-
-
0
monobutyrase
-
-
-
0
Monocyte/macrophage serine esterase
-
-
-
0
Non-specific carboxylesterase
-
-
-
0
nonspecific carboxylesterase
-
-
-
0
PI 5.5 esterase
-
-
-
0
PI 6.1 esterase
-
-
-
0
PMPMEase
247
-
polyisoprenylated methylated protein methyl esterase
247
-
procaine esterase
-
-
-
0
Proline-beta-naphthylamidase
-
-
-
0
propionyl esterase
-
-
-
0
TGH
247
-
triacetin esterase
-
-
-
0
triacylglycerol hydrolase
247
-
vitamin A esterase
-
-
-
0
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a carboxylic ester + H2O = an alcohol + a carboxylate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis
-
-
hydrolysis of carboxylic ester
-
-
-
0
SYSTEMATIC NAME
IUBMB Comments
carboxylic-ester hydrolase
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.
CAS REGISTRY NUMBER
COMMENTARY hide
9016-18-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-propranolyl 2-methyl-n-valerate + H2O
(R)-propranolol + 2-methylpentanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl 2-methylbutanoate + H2O
(R)-propranolol + 2-methylbutanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl 3-methylbutanoate + H2O
(R)-propranolol + 3-methylbutanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl 3-methylpentanoate + H2O
(R)-propranolol + 3-methylpentanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl hexanoate + H2O
(R)-propranolol + hexanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl n-valerate + H2O
(R)-propranolol + pentanoate
show the reaction diagram
-
-
-
?
(S)-propranolol 3-methylpentanoate + H2O
(S)-propranolol + 3-methylpentanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl 2-methylbutanoate + H2O
(S)-propranolol + 2-methylbutanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl 2-methylpentanoate + H2O
(S)-propranolol + 2-methylpentanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl 3-methylbutanoate + H2O
(S)-propranolol + 3-methylbutanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl hexanoate + H2O
(S)-propranolol + hexanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl n-valerate + H2O
(S)-propranolol + pentanoate
show the reaction diagram
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
show the reaction diagram
i.e anordrin
-
-
?
3-O-(4-ethylbenzoyl)-3-hydroxyflavone + H2O
3-hydroxylflavone + 4-ethylbenzoate
show the reaction diagram
-
-
-
?
butyl 4-aminobenzoate + H2O
4-aminobenzoate + butanol
show the reaction diagram
-
-
-
?
ethyl 4-aminobenzoate + H2O
4-aminobenzoate + ethanol
show the reaction diagram
-
-
-
?
fenofibrate + H2O
?
show the reaction diagram
-
-
-
?
fluorescein diacetate + H2O
?
show the reaction diagram
-
-
-
?
methyl 4-aminobenzoate + H2O
4-aminobenzoate + methanol
show the reaction diagram
-
-
-
?
phenacetin + H2O
?
show the reaction diagram
-
-
-
?
procaine + H2O
?
show the reaction diagram
-
-
-
?
propyl 4-aminobenzoate + H2O
4-aminobenzoate + propanol
show the reaction diagram
-
-
-
?
(-)-cocaine + H2O
O-benzoylecgonine + methanol
show the reaction diagram
CE-1 catalyzed hydrolysis of (-)-cocaine, reaction mechanism of cocaine hydrolysis catalyzed by CE-1, overview. Two reaction steps: a single-step acylation process and a single-step deacylation process. In the transition states of both single-step processes, the cocaine NH group joins the oxyanion hole to form an additional hydrogen bond with the negatively charged carbonyl oxygen atom of the cocaine. The transition states are stabilized by both intermolecular and intramolecular hydrogen bonds with the methyl ester of cocaine, specifically the carbonyl oxygen atom. The rate-limiting transition state is associated with the acylation process
-
-
?
(1R)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
(1R)-bioresmethrin + H2O
?
show the reaction diagram
-
substrate for isoform hCE1, not for hCE2
-
-
?
(1RS)-cis-permethrin + H2O
cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
show the reaction diagram
-
isoforms hCE1 and hCE2 hydrolyze trans-permethrin 8- and 28fold more efficiently than cis-permethrin, resp.
-
-
?
(1RS)-trans-permethrin + H2O
trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
show the reaction diagram
-
isoforms hCE1 and hCE2 hydrolyze trans-permethrin 8- and 28fold more efficiently than cis-permethrin, resp.
-
-
?
(1S)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
(2R)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
(2S)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
show the reaction diagram
-
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2S)-2-(4-chlorophenyl)-3-methylbutanoic acid
show the reaction diagram
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
show the reaction diagram
-
-
-
-
?
1-naphthyl butyrate + H2O
1-naphthol + butyrate
show the reaction diagram
-
-
-
-
?
2'-ethylcarbonate-linked paclitaxel + H2O
paclitaxel + propanoate
show the reaction diagram
-
-
-
-
?
2,2-dimethylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
2-acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine + H2O
2-[2-oxo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone + ?
show the reaction diagram
-
also called prasugrel, the hydrolysis is at least 25times greater with CE2 than CE1
also called R-95913
-
?
2-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine + H2O
decitabine + ?
show the reaction diagram
-
-
-
-
?
2-methylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
show the reaction diagram
-
-
-
-
?
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
show the reaction diagram
i.e anordrin
-
-
?
4-aminobenzoic acid butyl ester + H2O
4-aminobenzoic acid + butanol
show the reaction diagram
-
-
-
-
?
4-aminobenzoic acid ethyl ester + H2O
4-aminobenzoic acid + ethanol
show the reaction diagram
-
-
-
-
?
4-aminobenzoic acid propyl ester + H2O
4-aminobenzoic acid + propanol
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
show the reaction diagram
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl oleate + H2O
4-methylumbelliferol + oleate
show the reaction diagram
-
-
-
-
?
4-nitrobenzoic acid methyl ester + H2O
4-nitrobenzoic acid + methanol
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 5.5
-
-
?
4-nitrophenol acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
show the reaction diagram
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
show the reaction diagram
-
-
-
-
?
6-monoacetylmorphine + H2O
morphine + acetate
show the reaction diagram
hCE1 can metabolize the conversion of heroin to both 6-monoacetylmorphine and morphine. hCE1 is able to catalyze both reactions, but it is more efficient at the hydrolysis of heroin to 6-monoacetylmorphine, the first step of heroin metabolism
-
-
?
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 4-aminopiperidine-1-carboxylic acid
show the reaction diagram
-
i.e. NPC
-
-
?
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid
show the reaction diagram
-
i.e. irinotecan, CPT-11
-
-
?
7-ethyl-10-(4-N-(5-aminopentanoic acid)-1-piperidino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 4-((4-carboxybutyl)amino)piperidine-1-carboxylic acid
show the reaction diagram
-
i.e. APC
-
-
?
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin + H2O
7-ethyl-10-hydroxycampothecin + ?
show the reaction diagram
-
i.e. irinotecan, CPT-11, prodrug
i.e. SN-38, topoisomerase inhibitor used in cancer therapy
-
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
show the reaction diagram
acetylsalicylic acid + H2O
acetate + salicylate
show the reaction diagram
CES2A1-specific substrate
-
-
?
acetylsalicylic acid + H2O
salicylic acid + acetate
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 0.94
-
-
?
aspirin + H2O
acetate + salicylate
show the reaction diagram
-
-
-
-
ir
betamethasone valerate + H2O
betamethasone + valerate
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 0.21
-
-
?
bioresmethrin + H2O
?
show the reaction diagram
-
-
-
-
?
butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyric acid + thiocholine
show the reaction diagram
-
activity of serum enzyme, no activity of liver enzyme
-
-
?
camptothecin-11 + H2O
?
show the reaction diagram
capecitabin + H2O
?
show the reaction diagram
-
-
-
?
cholesterol ester + H2O
?
show the reaction diagram
-
-
-
-
?
cholesterol oleate + H2O
cholesterol + oleate
show the reaction diagram
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
show the reaction diagram
-
-
-
-
?
cilazapril + H2O
?
show the reaction diagram
-
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
show the reaction diagram
cocaine + H2O
ecgonine methyl ester + benzoate
show the reaction diagram
cocaine + H2O
O-benzoylecgonine + methanol
show the reaction diagram
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
show the reaction diagram
CPT-11 + H2O
SN-38 + ?
show the reaction diagram
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
hydroxy(3-phenoxyphenyl)acetonitrile + 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate + H2O
hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2,3,3-tetramethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid + H2O
hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
D-methyl phenidate + H2O
?
show the reaction diagram
-
-
-
?
D-methylphenidate + H2O
methanol + phenyl(piperidin-2-yl)acetate
show the reaction diagram
-
-
-
-
?
deltamethrin + H2O
3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
show the reaction diagram
-
-
-
-
?
derapril + H2O
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol
show the reaction diagram
-
-
-
?
DL-methylphenidate + H2O
methanol + phenyl(piperidin-2-yl)acetate
show the reaction diagram
-
-
-
-
?
enalapril + H2O
?
show the reaction diagram
-
-
-
-
?
fenofibrate + H2O
?
show the reaction diagram
-
-
-
?
fluorescein diacetate + H2O
?
show the reaction diagram
heroin + H2O
6-monoacetylmorphine + acetate
show the reaction diagram
hydroxyethylflurbiprofen + H2O
ethanol + flurbiprofen
show the reaction diagram
-
-
-
-
?
hydroxypropylflurbiprofen + H2O
propanol + flurbiprofen
show the reaction diagram
-
-
-
-
?
imidapril + H2O
?
show the reaction diagram
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
imidapril + H2O
imidaprilat + ?
show the reaction diagram
-
-
-
?
irinotecan + H2O
7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid
show the reaction diagram
antitumor prodrug, poor substrate
-
-
?
isocarbophos + H2O
?
show the reaction diagram
-
-
-
-
?
ketoprofen ethyl ester + H2O
R-ketoprofen + ethanol
show the reaction diagram
-
-
R-isomer is main product of keratinocyte enzyme
-
?
L-methyl phenidate + H2O
?
show the reaction diagram
-
-
-
?
lidocaine + H2O
2,6-xylidine + N,N-diethylglycine
show the reaction diagram
the CES1A substrate lidocaine is metabolized to 2,6-xylidine via a MEGX intermediate
-
-
?
meperidine + H2O
?
show the reaction diagram
specific substrate for isozyme CES1
-
-
?
methyl 4-nitrobenzoate + H2O
4-nitrobenzoate + methanol
show the reaction diagram
-
specific substrate for isoform ES1
-
-
?
methyl butyrate + H2O
methanol + butyrate
show the reaction diagram
-
-
-
-
?
methyl salicylate + H2O
salicylic acid + methanol
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 15.3
-
-
?
methylphenidate + H2O
?
show the reaction diagram
specific substrate for isozyme CES1
-
-
?
methylprednisolone 21-hemisuccinate + H2O
?
show the reaction diagram
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
monoethylglycylxylidine + H2O
2,6-xylidene + N-ethylglycine
show the reaction diagram
CES1A-specific substrate
-
-
?
mycophenolate mofetil + H2O
mycophenolic acid + mofetil
show the reaction diagram
-
prodrug, activation
-
-
?
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O
?
show the reaction diagram
-
specific enzyme substrate
-
-
?
N-acetyl-L-Ala-1-naphthyl ester + H2O
N-acetyl-L-Ala + 1-naphthol
show the reaction diagram
-
-
-
-
?
O-butyryl propranolol + H2O
butanoate + propranolol
show the reaction diagram
-
preferential hydrolysis of R-isomer by liver enzyme
-
-
?
oleoyl-CoA + H2O
oleic acid + CoA
show the reaction diagram
-
-
-
?
oseltamivir + H2O
?
show the reaction diagram
oxybutynin + H2O
2-cyclohexyl-2-phenylglycolic acid + ?
show the reaction diagram
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
show the reaction diagram
-
-
-
?
palmitoyl-CoA + H2O
palmitic acid + CoA
show the reaction diagram
weak
-
-
?
pentyl PABC-Doxazolidine + H2O
PABC-Doxazolidine + pentanol
show the reaction diagram
-
-
-
-
?
permethrin + H2O
?
show the reaction diagram
-
the cis-form of permethrin is favorably hydrolyzed by isozyme HCE2, whereas the trans-form is comparably hydrolyzed by HCE1 and HCE2
-
-
?
phenacetin + H2O
?
show the reaction diagram
-
-
-
?
polyisoprenylated methylated protein + H2O
?
show the reaction diagram
-
-
-
-
?
procaine + H2O
?
show the reaction diagram
-
-
-
?
quinapril + H2O
?
show the reaction diagram
-
-
-
?
ramipril + H2O
?
show the reaction diagram
-
-
-
-
?
S-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethanethioate + H2O
?
show the reaction diagram
-
-
-
?
sarin + H2O
?
show the reaction diagram
-
CE1 exhibits a 5fold preference for the PS isomer of a sarin analog
-
-
?
temocapril + H2O
(+)-[(2S,6R)-6-[[(S)-1-carboxyl-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid + propanol
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 734
-
-
?
temocapril + H2O
?
show the reaction diagram
trandolapril + H2O
?
show the reaction diagram
-
-
-
-
?
trandolapril + H2O
trandolaprilat + ?
show the reaction diagram
-
trandolapril is a CES1 selective substrate while CES2 exerts little to no catalytic activity towards this compound
-
-
?
trans-permethrin + H2O
?
show the reaction diagram
-
-
-
-
?
tributyrin + H2O
?
show the reaction diagram
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
show the reaction diagram
-
-
-
-
?
triolein + H2O
?
show the reaction diagram
-
-
-
-
?
tripropionin + H2O
?
show the reaction diagram
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
show the reaction diagram
-
-
-
-
?
vinyl butanoate + H2O
vinyl alcohol + butanoate
show the reaction diagram
-
-
-
-
?
vinyl laurate + H2O
vinyl alcohol + laurate
show the reaction diagram
-
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
show the reaction diagram
i.e anordrin
-
-
?
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
show the reaction diagram
-
-
-
-
?
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
show the reaction diagram
i.e anordrin
-
-
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
show the reaction diagram
acetylsalicylic acid + H2O
acetate + salicylate
show the reaction diagram
CES2A1-specific substrate
-
-
?
camptothecin-11 + H2O
?
show the reaction diagram
-
i.e. CPT-11, an anti-tumor agent
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
show the reaction diagram
-
an anti-thrombogenic agent
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
show the reaction diagram
monoethylglycylxylidine + H2O
2,6-xylidene + N-ethylglycine
show the reaction diagram
CES1A-specific substrate
-
-
?
mycophenolate mofetil + H2O
mycophenolic acid + mofetil
show the reaction diagram
-
prodrug, activation
-
-
?
oseltamivir + H2O
?
show the reaction diagram
-
an anti-viral drug
-
-
?
polyisoprenylated methylated protein + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biliary salts
-
activates
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(4-fluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-Dglucopyranoside
-
18beta-11-deoxo-olean-12-en-30-oic acid
-
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3, 11-dioxo-olean-12-en-30-oic acid
-
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
-
18beta-glycyrrhetinic acid
-
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3',4',7-trihydroxyisoflavone
-
3',4'-dihydroxyflavone
-
3,6-dihydroxyflavone
-
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-hydroxyflavone
-
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
-
4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
4beta,9alpha,20-trihydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
-
5,6,7-trimethoxybaicalein
-
5,6-dihydroxyflavone
a specific hCE2 inhibitor, exhibits reversible, noncompetitive inhibition, 5,6-dihydroxyflavone displays high specificity toward hCE2 over hCE1
5,7,8-trihydroxyflavone
-
5,7-dihydroxyflavone
-
5-hydroxy-6-methoxyflavone
-
5-hydroxyflavone
-
6,7-dihydroxyflavone
-
6-hydroxyflavone
-
6-methoxyflavone
-
7,8-dihydroxyflavone
-
7-hydroxyflavone
-
7-methoxybaicalein
-
8-nitrobaicalein
-
8beta-11-oxo-olean-12-en-30-amide
-
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
-
apigenin 7-O-methyl ether
-
baicalein
-
benzil
comparison with inhibition of human isoform hCE1 and rabbit enzyme
bis-4-nitrophenyl phosphate
bisdehydrophorbol
-
Calycosin
-
didehydrolangduin A-20-O-beta-D-glucopyranoside
-
diosmetin
-
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-glucopyranoside
-
ent-kaurane-16beta,17-diol-3,12-dione-19-O-beta-D-glucopyranoside
-
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-glucopyranoside
-
eupatilin
-
fischeroside A
-
fischeroside A-16-O-beta-D-glucopyranoside
-
genistein
-
glycitein
-
herbacetin
-
hispidulin
-
ingenol-19-O-beta-D-glucopyranoside
-
isorhamnetin
-
kaempferol
-
langduin F
-
loperamide
specifically inhibits CES2
nobiletin
-
oroxylin A
-
oroxyloside A
-
phorbol-13-acetate
-
quercetin
-
quercetin-3-rhamnoside
-
scutellarein
-
scutellarin
-
simvastatin
strongly inhibits hydrolytic process of anordrin in liver and intestine microsomes
tangeretin
-
yuexiandajisu D
-
yuexiandajisu E
-
(10Z)-hexadecenoic acid
-
-
(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
-
about 30% residual activity at 0.1 mM
(4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
-
-
(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate
-
-
(5Z,8Z,11Z,14Z)-eicosatetraenoic acid
-
-
(6Z,9Z,12Z)-octadecatrienoic acid
-
-
(9Z)-octadecenoic acid
-
-
(9Z)-tetradecenoic acid
-
-
(9Z,12Z)-octadecadienoic acid
-
-
(R)-cocaine
-
1,1'-ethane-1,2-diylbis(1H-indole-2,3-dione)
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,1,1-trifluoro-3-(hexylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
1,1,1-trifluoro-3-(octylsulfonyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfanyl]propan-2-one
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfonyl]propane-2,2-diol
-
-
1,1,1-trifluorododecan-2-one
-
-
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2-chlorophenyl)ethane-1,2-dione
-
-
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione
-
-
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
1,2-bis(3-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(3-nitrophenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromo-2-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromothiophen-2-yl)ethane-1,2-dione
-
-
1,2-bis(4-chlorophenyl)ethane-1,2-dione
-
-
1,2-bis(4-fluorophenyl)ethane-1,2-dione
1,2-bis(4-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(4-methylphenyl)ethane-1,2-dione
-
-
1,2-bis(5-bromothiophen-2-yl)ethane-1,2-dione
-
-
1,2-di(furan-2-yl)ethane-1,2-dione
-
-
1,2-di(naphthalen-2-yl)ethane-1,2-dione
-
-
1,2-di(pyridin-2-yl)ethane-1,2-dione
-
-
1,2-di(thiophen-2-yl)ethane-1,2-dione
-
-
1,2-di(thiophen-3-yl)ethane-1,2-dione
-
-
1,2-dicyclohexylethane-1,2-dione
-
-
1,2-difluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1,2-diphenylethane-1,2-dione
-
-
1,4-dibromo-1,4-diphenyl butane-2,3-dione
1-(2,4-dinitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(2-bromoethyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1,2-dione
-
-
1-(2-iodoethyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-(4[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl)benzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(4-chlorobenzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione
-
-
1-(4-chlorophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methoxyphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methylphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-nitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(pentachlorophenyl)-2-(pentafluorophenyl)ethane-1,2-dione
-
-
1-([(2-bromophenyl)amino]methyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-([(4-chlorophenyl)amino]methyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-benzyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-dodecyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-hexadecyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-phenyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-[(2-naphthylamino)methyl]-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione
-
-
1-[4-[oxo(phenyl)acetyl]phenyl]-2-phenylethane-1,2-dione
-
-
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
-
11-piperazin-1-yl-dibenzo[b,f][1,4]thiazepine
-
-
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid
-
-
15-deoxy-DELTA12,14-prostaglandin J2
-
-
18beta-11-deoxo-olean-12-en-30-oic acid
-
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3, 11-dioxo-olean-12-en-30-oic acid
-
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
-
18beta-glycyrrhetinic acid
-
2,2-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
-
-
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
2,4-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
2,5-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
2,6,6-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2,7,7-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
-
-
2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-chloro-3,4-dimethoxybenzil
2-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-fluorophenanthrene-3,4-dione
-
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
2-methoxy-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
-
-
2-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl]ethanesulfonyl fluoride
-
-
22(R)-hydroxycholesterol
-
slight inhibition of CES1, not CES2
24(S),25-epoxycholesterol
-
inhibits only CES1, not CES2
24(S)-hydroxycholesterol
-
slight inhibition of CES1, not CES2
25-hydroxycholesterol
-
slight inhibition of CES1, not CES2
27-Hydroxycholesterol
-
partially noncompetitive inhibitor of recombinant CES1, impaires intracellular CES1 activity following treatment of intact THP1 cells. No inhibition of CES2
3,3-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
3,4-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
3,4-difluoro-N-(4-(phenylsulfonamido)phenyl)benzene sulfonamide
-
-
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
3-(butylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(decylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(decylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(decylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(dodecylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(dodecylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(dodecylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
-
4,6-dichloro-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
4,6-dimethyl-N1,N3-diphenylbenzene-1,3-disulfonamide
-
-
4,7-dichloro-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)-3-methylbenzoic acid
-
-
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)-N-methyl benzamide
-
-
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)benzoic acid
-
-
4-bromo-N-(4-ethoxyphenyl)benzene sulfonamide
-
-
4-chloro-N-(4-(4-fluorophenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-chloro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-chloro-N-(4-ethoxyphenyl)benzene sulfonamide
-
-
4-fluoro-N-(4-(4-methoxy phenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-fluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-mercuribenzoate
-
-
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-[oxo(phenyl)acetyl]benzoic acid
-
-
5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
5-bromo-1-(2-methylprop-2-en-1-yl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
6,6-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
7,7-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin
-
i.e. irinotecan or CPT-11, an antitumor prodrug
7-oxocholesterol
-
slight inhibition of CES1, not CES2
8-methyl-1,4-dihydro-2H-naphtho[2,1-c]pyran-9,10-dione
-
8beta-11-oxo-olean-12-en-30-amide
-
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
-
amlodipine
-
about 40% residual activity at 0.1 mM
arachidonic acid
-
most potent fatty acid inhibitor of recombinant CES1 acting by a noncompetitive mechanism, overview. The inhibition is reversible by bovine serum albumin
aripiprazole
-
-
atomoxetine
-
-
atorvastatin
-
about 45% residual activity at 0.1 mM
bendroflumethiazide
-
about 70% residual activity at 0.1 mM
benzil
bioresmethrin
-
a pyrethroid insecticide
bis(4-nitrophenyl) phosphate
-
-
bis(4-nitrophenyl) phosphoric acid
-
97% inhibition at 1 mM
bis(4-nitrophenyl)phosphate
-
potent inhibitor
bis(p-nitrophenyl) phosphate
-
a specific inhibitor of carboxylesterases
bis-4-nitrophenyl phosphate
bis-4-nitrophenylphosphate
-
-
bisoprolol
-
about 90% residual activity at 0.1 mM
Carbaryl
-
78% inhibition
carvedilol
-
about 17% residual activity at 0.1 mM
chlorpyrifos
cholesterol
-
slight inhibition of CES1, not CES2
clopidogrel
-
about 15% residual activity at 0.1 mM
clozapine
-
-
cocaethylene
-
curcumin
-
reversible inhibition
cyclosarin
-
-
decane-5,6-dione
-
-
deltamethrin
-
48% inhibition
Digitonin
diisopropylfluorophosphate
-
-
diltiazem
-
about 23% residual activity at 0.1 mM
Dimethylsulfoxide
-
-
diphenyl carbonate
-
-
dodecane-6,7-dione
-
-
DTNB
-
weak
EGTA
-
minimal inhibition
eplerenone
-
about 80% residual activity at 0.1 mM
fluoxetine
-
-
Furosemide
-
about 78% residual activity at 0.1 mM
Galaxolide
-
synthetic fragrance Galaxolide induces human cancer cell degeneration with a EC50 value of 0.026 mM in neuroblastoma SH-SY5Y cells and 0.058 mM in lung cancer A549 cells
haloperidol
-
-
hexadecane-8,9-dione
-
-
hexadecanoic acid
-
-
Hg2+
-
HgCl2
imipramine
-
-
irbesartan
-
about 75% residual activity at 0.1 mM
isradipine
-
about 18% residual activity at 0.1 mM
lercanidipine
-
about 78% residual activity at 0.1 mM
loperamide
methyl paraoxon
-
-
miltirone
-
N,N'-(1,4-phenylene)bis(2,3-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,4,5-trichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,5-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,6-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2-fluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4,5-trifluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,5-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,5-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-bromobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-chlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-fluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-fluoro-2-methylbenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-fluorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-fluoro-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetrafluoro-1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3,4-dichlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3,5-dichlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-fluorobenzene sulfonamide)
-
-
N,N'-(2,5-dibromo-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,5-dibromo-1,4-phenylene)bisbenzene sulfonamide
-
-
N,N'-(2,5-dichloro-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2-chloro-1,4-phenylene)dibenzene sulfonamide
-
-
N,N'-(2-methyl-1,4-phenylene)benzene sulfonamide
-
-
N,N'-(2-methylbenzene-1,4-diyl)dibenzenesulfonamide
-
-
N,N'-(disulfanediyldibenzene-4,1-diyl)dimethanesulfonamide
-
-
N,N'-1,4-phenylenebis-2-naphthalene sulfonamide
-
-
N,N'-9H-fluorene-2,7-diylbis(3,4,5-trifluorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(3-bromobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(3-chlorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(4-chlorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diyldibenzenesulfonamide
-
-
N,N'-benzene-1,4-diyldibenzenesulfonamide
-
-
N-(4-(4-fluoromethylphenylsulfonamido)phenyl)-2,5-dimethylbenzene sulfonamide
-
-
n-butanol
-
1 M
n-desmethylclozapine
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]cyclohexanecarboxamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]hexanamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]pentanamide
-
-
neostigmine
-
serum enzyme is inhibited, liver enzyme is not affected
nimodipine
-
about 70% residual activity at 0.1 mM
octadecane-9,10-dione
-
-
octadecanoic acid
-
-
octane-4,5-dione
-
-
olanzapine
-
-
organophosphate compounds
-
-
-
organophosphate esters
-
-
-
p-trimethylammoniumanilinium dichloride
-
serum enzyme is inhibited, liver enzyme is not affected
paraoxon
PCMB
-
-
perphenazine
-
-
phenanthrene-3,4-dione
-
phenol
-
-
phenyl-1,2-butanedione
-
-
phenyl-1,2-heptanedione
-
-
phenyl-1,2-hexanedione
-
-
phenyl-1,2-octanedione
-
-
phenyl-1,2-pentanedione
-
-
phenyl-1,2-propanedione
-
-
Phenylmethyl sulfonylfluoride
-
-
Phenylmethylsulfonylfluoride
-
-
prasugrel
-
inhibits isozyme CE2 at high concentrations in vitro but not in vivo
prostaglandin E2
-
-
prostaglandin F2alpha
-
-
quetiapine
-
-
simvastatin
sirolimus
-
about 90% residual activity at 0.1 mM
soman
spironolactone
-
about 70% residual activity at 0.1 mM
tacrolimus
-
about 28% residual activity at 0.1 mM
telmisartan
4-nitrophenyl acetate hydrolysis in human iPS cell-derived enterocytes is significantly inhibited by the CES2A1-specific inhibitor telmisartan
tetradecane-7,8-dione
-
-
tetradecanoic acid
-
-
tetraisopropyl diphosphoramide
-
67% inhibition at 0.5 mM
thioridazine
-
-
Tonalide
-
synthetic fragrance Tonalide induces human cancer cell degeneration with a EC50 value of 0.098 mM in neuroblastoma SH-SY5Y cells and 0.014 mM in lung cancer A549 cells
trans-permethrin
-
a pyrethroid insecticide
triphenyl phosphate
-
-
valsartan
-
about 90% residual activity at 0.1 mM
ziprasidone
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ethanol
-
activates
ethylene glycol
-
little activating effect, except at high concentrations, 1 M
ethylene glycol monoethyl ether
-
little activating effect, except at high concentrations, 1 M
methanol
-
activates
n-butanol
-
0.1 M, increases activity
sarin
-
for enzyme inhibited by racemic mixtures of bona fide nerve agents, hCE1 spontaneously reactivates in the presence of sarin but not soman or cyclosarin. The addition of 2,3-butanedione monoxime increases the rate of reactivation of CE1 from sarin inhibition by more than 65fold
taurocholate