Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.1.1.1 - carboxylesterase and Organism(s) Homo sapiens and UniProt Accession O00748

for references in articles please use BRENDA:EC3.1.1.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.1 carboxylesterase
IUBMB Comments
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: O00748
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
esterase, carboxylesterase, butyrate esterase, carboxyl esterase, carboxylesterase 1, egasyn, serine protease-like, hce-2, acyl coenzyme a:cholesterol acyltransferase, esterase a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylesterase 2
-
human carboxylesterase 2
-
ACAT
-
-
-
-
Acyl coenzyme A:cholesterol acyltransferase
-
-
-
-
ali-esterase
-
-
-
-
aliesterase
-
-
-
-
alpha-carboxylesterase
-
-
-
-
B-esterase
-
-
-
-
Brain carboxylesterase hBr1
-
-
-
-
butyrate esterase
-
-
-
-
butyryl esterase
-
-
-
-
CaE
-
-
-
-
carboxyesterase
-
-
-
-
Carboxyesterase ES-10
-
-
-
-
carboxyl ester hydrolase
-
-
-
-
carboxylate esterase
-
-
-
-
carboxylesterase 1
carboxylesterase 1A2
-
-
carboxylesterase 2
-
-
carboxylesterase-1
-
carboxylesterase-2
-
-
Carboxylesterase-5C
-
-
-
-
carboxylic acid esterase
-
-
-
-
carboxylic ester hydrolase
-
-
-
-
carboxylic esterase
-
-
-
-
Carboxylic-ester hydrolase
-
-
-
-
CE2
-
isozyme
CES-2
-
-
CES1-b
-
carboxylesterase 1 form b
CES1-c
-
carboxylesterase 1 form c
CES1A
CES1A1
precursor of CES1A
CES1A2
CES2A1
-
-
cholesteryl ester hydrolase
-
-
cocaine esterase
-
-
-
-
cocaine:benzoylecgonine esterase
-
-
CPT-CE
-
-
Egasyn
-
-
-
-
Es-22
-
-
-
-
ES-HTEL
-
-
-
-
ES-HVEL
-
-
-
-
ES-Male
-
-
-
-
ES-THET
-
-
-
-
EST-5A
-
-
-
-
EST-5B
-
-
-
-
EST-5C
-
-
-
-
esterase A
-
-
-
-
esterase B
-
-
-
-
esterase D
-
-
-
-
esterase, carboxyl
-
-
-
-
Esterase-22
-
-
-
-
Esterase-31
-
-
-
-
HCE2
-
isozyme
HMSE
-
-
-
-
hormone-sensitive lipase
-
-
human carboxylesterase 1
-
human liver carboxylesterase
-
Kidney microsomal carboxylesterase
-
-
-
-
Liver microsomal carboxylesterase
-
-
-
-
methylbutyrase
-
-
-
-
methylbutyrate esterase
-
-
-
-
Microsomal palmitoyl-CoA hydrolase
-
-
-
-
monobutyrase
-
-
-
-
Monocyte/macrophage serine esterase
-
-
-
-
Non-specific carboxylesterase
-
-
-
-
nonspecific carboxylesterase
-
-
-
-
PI 5.5 esterase
-
-
-
-
PI 6.1 esterase
-
-
-
-
polyisoprenylated methylated protein methyl esterase
-
-
procaine esterase
-
-
-
-
Proline-beta-naphthylamidase
-
-
-
-
propionyl esterase
-
-
-
-
triacetin esterase
-
-
-
-
triacylglycerol hydrolase
-
-
vitamin A esterase
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a carboxylic ester + H2O = an alcohol + a carboxylate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis
-
-
hydrolysis of carboxylic ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
carboxylic-ester hydrolase
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.
CAS REGISTRY NUMBER
COMMENTARY hide
9016-18-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-propranolyl 2-methyl-n-valerate + H2O
(R)-propranolol + 2-methylpentanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl 2-methylbutanoate + H2O
(R)-propranolol + 2-methylbutanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl 3-methylbutanoate + H2O
(R)-propranolol + 3-methylbutanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl 3-methylpentanoate + H2O
(R)-propranolol + 3-methylpentanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl hexanoate + H2O
(R)-propranolol + hexanoate
show the reaction diagram
-
-
-
?
(R)-propranolyl n-valerate + H2O
(R)-propranolol + pentanoate
show the reaction diagram
-
-
-
?
(S)-propranolol 3-methylpentanoate + H2O
(S)-propranolol + 3-methylpentanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl 2-methylbutanoate + H2O
(S)-propranolol + 2-methylbutanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl 2-methylpentanoate + H2O
(S)-propranolol + 2-methylpentanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl 3-methylbutanoate + H2O
(S)-propranolol + 3-methylbutanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl hexanoate + H2O
(S)-propranolol + hexanoate
show the reaction diagram
-
-
-
?
(S)-propranolyl n-valerate + H2O
(S)-propranolol + pentanoate
show the reaction diagram
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
show the reaction diagram
i.e anordrin
-
-
?
3-O-(4-ethylbenzoyl)-3-hydroxyflavone + H2O
3-hydroxylflavone + 4-ethylbenzoate
show the reaction diagram
-
-
-
?
butyl 4-aminobenzoate + H2O
4-aminobenzoate + butanol
show the reaction diagram
-
-
-
?
ethyl 4-aminobenzoate + H2O
4-aminobenzoate + ethanol
show the reaction diagram
-
-
-
?
fenofibrate + H2O
?
show the reaction diagram
-
-
-
?
fluorescein diacetate + H2O
?
show the reaction diagram
-
-
-
?
methyl 4-aminobenzoate + H2O
4-aminobenzoate + methanol
show the reaction diagram
-
-
-
?
phenacetin + H2O
?
show the reaction diagram
-
-
-
?
procaine + H2O
?
show the reaction diagram
-
-
-
?
propyl 4-aminobenzoate + H2O
4-aminobenzoate + propanol
show the reaction diagram
-
-
-
?
(-)-cocaine + H2O
O-benzoylecgonine + methanol
show the reaction diagram
CE-1 catalyzed hydrolysis of (-)-cocaine, reaction mechanism of cocaine hydrolysis catalyzed by CE-1, overview. Two reaction steps: a single-step acylation process and a single-step deacylation process. In the transition states of both single-step processes, the cocaine NH group joins the oxyanion hole to form an additional hydrogen bond with the negatively charged carbonyl oxygen atom of the cocaine. The transition states are stabilized by both intermolecular and intramolecular hydrogen bonds with the methyl ester of cocaine, specifically the carbonyl oxygen atom. The rate-limiting transition state is associated with the acylation process
-
-
?
(1R)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
(1R)-bioresmethrin + H2O
?
show the reaction diagram
-
substrate for isoform hCE1, not for hCE2
-
-
?
(1RS)-cis-permethrin + H2O
cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
show the reaction diagram
-
isoforms hCE1 and hCE2 hydrolyze trans-permethrin 8- and 28fold more efficiently than cis-permethrin, resp.
-
-
?
(1RS)-trans-permethrin + H2O
trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol
show the reaction diagram
-
isoforms hCE1 and hCE2 hydrolyze trans-permethrin 8- and 28fold more efficiently than cis-permethrin, resp.
-
-
?
(1S)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
(2R)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
(2S)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
show the reaction diagram
-
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
(2R)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid + H2O
(2S)-hydroxy(6-methoxy-2-naphthyl)acetonitrile + (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
show the reaction diagram
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
show the reaction diagram
-
-
-
-
?
1-naphthyl butyrate + H2O
1-naphthol + butyrate
show the reaction diagram
-
-
-
-
?
2'-ethylcarbonate-linked paclitaxel + H2O
paclitaxel + propanoate
show the reaction diagram
-
-
-
-
?
2,2-dimethylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
2-acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine + H2O
2-[2-oxo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone + ?
show the reaction diagram
-
also called prasugrel, the hydrolysis is at least 25times greater with CE2 than CE1
also called R-95913
-
?
2-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine + H2O
decitabine + ?
show the reaction diagram
-
-
-
-
?
2-methylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
2-nitrophenyl butyrate + H2O
2-nitrophenol + butyrate
show the reaction diagram
-
-
-
-
?
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
show the reaction diagram
i.e anordrin
-
-
?
4-aminobenzoic acid butyl ester + H2O
4-aminobenzoic acid + butanol
show the reaction diagram
-
-
-
-
?
4-aminobenzoic acid ethyl ester + H2O
4-aminobenzoic acid + ethanol
show the reaction diagram
-
-
-
-
?
4-aminobenzoic acid propyl ester + H2O
4-aminobenzoic acid + propanol
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferol + acetate
show the reaction diagram
-
-
-
?
4-methylumbelliferyl acetate + H2O
4-methylumbelliferone + acetate
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl butyrate + H2O
4-methylumbelliferone + butyrate
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl oleate + H2O
4-methylumbelliferol + oleate
show the reaction diagram
-
-
-
-
?
4-nitrobenzoic acid methyl ester + H2O
4-nitrobenzoic acid + methanol
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 5.5
-
-
?
4-nitrophenol acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
show the reaction diagram
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
show the reaction diagram
-
-
-
-
?
6-monoacetylmorphine + H2O
morphine + acetate
show the reaction diagram
hCE1 can metabolize the conversion of heroin to both 6-monoacetylmorphine and morphine. hCE1 is able to catalyze both reactions, but it is more efficient at the hydrolysis of heroin to 6-monoacetylmorphine, the first step of heroin metabolism
-
-
?
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 4-aminopiperidine-1-carboxylic acid
show the reaction diagram
-
i.e. NPC
-
-
?
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid
show the reaction diagram
-
i.e. irinotecan, CPT-11
-
-
?
7-ethyl-10-(4-N-(5-aminopentanoic acid)-1-piperidino)carbonyloxycampothecin + H2O
7-ethyl-10-hydroxycampothecin + 4-((4-carboxybutyl)amino)piperidine-1-carboxylic acid
show the reaction diagram
-
i.e. APC
-
-
?
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin + H2O
7-ethyl-10-hydroxycampothecin + ?
show the reaction diagram
-
i.e. irinotecan, CPT-11, prodrug
i.e. SN-38, topoisomerase inhibitor used in cancer therapy
-
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
show the reaction diagram
acetylsalicylic acid + H2O
acetate + salicylate
show the reaction diagram
CES2A1-specific substrate
-
-
?
acetylsalicylic acid + H2O
salicylic acid + acetate
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 0.94
-
-
?
aspirin + H2O
acetate + salicylate
show the reaction diagram
-
-
-
-
ir
betamethasone valerate + H2O
betamethasone + valerate
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 0.21
-
-
?
bioresmethrin + H2O
?
show the reaction diagram
-
-
-
-
?
butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
?
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyric acid + thiocholine
show the reaction diagram
-
activity of serum enzyme, no activity of liver enzyme
-
-
?
camptothecin-11 + H2O
?
show the reaction diagram
capecitabin + H2O
?
show the reaction diagram
-
-
-
?
cholesterol ester + H2O
?
show the reaction diagram
-
-
-
-
?
cholesterol oleate + H2O
cholesterol + oleate
show the reaction diagram
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
show the reaction diagram
-
-
-
-
?
cilazapril + H2O
?
show the reaction diagram
-
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
show the reaction diagram
cocaine + H2O
ecgonine methyl ester + benzoate
show the reaction diagram
cocaine + H2O
O-benzoylecgonine + methanol
show the reaction diagram
CPT-11 + H2O
SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2
show the reaction diagram
CPT-11 + H2O
SN-38 + ?
show the reaction diagram
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H2O
hydroxy(3-phenoxyphenyl)acetonitrile + 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate + H2O
hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2,3,3-tetramethylcyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid + H2O
hydroxy(6-methoxy-2-naphthyl)acetonitrile + 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid
show the reaction diagram
-
-
-
?
D-methyl phenidate + H2O
?
show the reaction diagram
-
-
-
?
D-methylphenidate + H2O
methanol + phenyl(piperidin-2-yl)acetate
show the reaction diagram
-
-
-
-
?
deltamethrin + H2O
3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
show the reaction diagram
-
-
-
-
?
derapril + H2O
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol
show the reaction diagram
-
-
-
?
DL-methylphenidate + H2O
methanol + phenyl(piperidin-2-yl)acetate
show the reaction diagram
-
-
-
-
?
enalapril + H2O
?
show the reaction diagram
-
-
-
-
?
fenofibrate + H2O
?
show the reaction diagram
-
-
-
?
fluorescein diacetate + H2O
?
show the reaction diagram
heroin + H2O
6-monoacetylmorphine + acetate
show the reaction diagram
hydroxyethylflurbiprofen + H2O
ethanol + flurbiprofen
show the reaction diagram
-
-
-
-
?
hydroxypropylflurbiprofen + H2O
propanol + flurbiprofen
show the reaction diagram
-
-
-
-
?
imidapril + H2O
?
show the reaction diagram
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
imidapril + H2O
imidaprilat + ?
show the reaction diagram
-
-
-
?
irinotecan + H2O
7-ethyl-10-hydroxycampothecin + 1,4'-bipiperidine-1'-carboxylic acid
show the reaction diagram
antitumor prodrug, poor substrate
-
-
?
isocarbophos + H2O
?
show the reaction diagram
-
-
-
-
?
ketoprofen ethyl ester + H2O
R-ketoprofen + ethanol
show the reaction diagram
-
-
R-isomer is main product of keratinocyte enzyme
-
?
L-methyl phenidate + H2O
?
show the reaction diagram
-
-
-
?
lidocaine + H2O
2,6-xylidine + N,N-diethylglycine
show the reaction diagram
the CES1A substrate lidocaine is metabolized to 2,6-xylidine via a MEGX intermediate
-
-
?
meperidine + H2O
?
show the reaction diagram
specific substrate for isozyme CES1
-
-
?
methyl 4-nitrobenzoate + H2O
4-nitrobenzoate + methanol
show the reaction diagram
-
specific substrate for isoform ES1
-
-
?
methyl butyrate + H2O
methanol + butyrate
show the reaction diagram
-
-
-
-
?
methyl salicylate + H2O
salicylic acid + methanol
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 15.3
-
-
?
methylphenidate + H2O
?
show the reaction diagram
specific substrate for isozyme CES1
-
-
?
methylprednisolone 21-hemisuccinate + H2O
?
show the reaction diagram
the substrate is more specific for isozyme CES2 than for CES1
-
-
?
monoethylglycylxylidine + H2O
2,6-xylidene + N-ethylglycine
show the reaction diagram
CES1A-specific substrate
-
-
?
mycophenolate mofetil + H2O
mycophenolic acid + mofetil
show the reaction diagram
-
prodrug, activation
-
-
?
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O
?
show the reaction diagram
-
specific enzyme substrate
-
-
?
N-acetyl-L-Ala-1-naphthyl ester + H2O
N-acetyl-L-Ala + 1-naphthol
show the reaction diagram
-
-
-
-
?
O-butyryl propranolol + H2O
butanoate + propranolol
show the reaction diagram
-
preferential hydrolysis of R-isomer by liver enzyme
-
-
?
oleoyl-CoA + H2O
oleic acid + CoA
show the reaction diagram
-
-
-
?
oseltamivir + H2O
?
show the reaction diagram
oxybutynin + H2O
2-cyclohexyl-2-phenylglycolic acid + ?
show the reaction diagram
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
show the reaction diagram
-
-
-
?
palmitoyl-CoA + H2O
palmitic acid + CoA
show the reaction diagram
weak
-
-
?
pentyl PABC-Doxazolidine + H2O
PABC-Doxazolidine + pentanol
show the reaction diagram
-
-
-
-
?
permethrin + H2O
?
show the reaction diagram
-
the cis-form of permethrin is favorably hydrolyzed by isozyme HCE2, whereas the trans-form is comparably hydrolyzed by HCE1 and HCE2
-
-
?
phenacetin + H2O
?
show the reaction diagram
-
-
-
?
polyisoprenylated methylated protein + H2O
?
show the reaction diagram
-
-
-
-
?
procaine + H2O
?
show the reaction diagram
-
-
-
?
quinapril + H2O
?
show the reaction diagram
-
-
-
?
ramipril + H2O
?
show the reaction diagram
-
-
-
-
?
S-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethanethioate + H2O
?
show the reaction diagram
-
-
-
?
sarin + H2O
?
show the reaction diagram
-
CE1 exhibits a 5fold preference for the PS isomer of a sarin analog
-
-
?
temocapril + H2O
(2S)-2-[[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino]-4-phenylbutanoic acid + ethanol
show the reaction diagram
-
ratio of the rates of hydrolysis in liver to intestine 734
-
-
?
temocapril + H2O
?
show the reaction diagram
trandolapril + H2O
?
show the reaction diagram
-
-
-
-
?
trandolapril + H2O
trandolaprilat + ?
show the reaction diagram
-
trandolapril is a CES1 selective substrate while CES2 exerts little to no catalytic activity towards this compound
-
-
?
trans-permethrin + H2O
?
show the reaction diagram
-
-
-
-
?
tributyrin + H2O
?
show the reaction diagram
-
-
-
-
?
tributyrylglycerol + H2O
butyrate + glycerol
show the reaction diagram
-
-
-
-
?
triolein + H2O
?
show the reaction diagram
-
-
-
-
?
tripropionin + H2O
?
show the reaction diagram
-
-
-
-
?
vinyl acetate + H2O
vinyl alcohol + acetate
show the reaction diagram
-
-
-
-
?
vinyl butanoate + H2O
vinyl alcohol + butanoate
show the reaction diagram
-
-
-
-
?
vinyl laurate + H2O
vinyl alcohol + laurate
show the reaction diagram
-
-
-
-
?
vinyl propionate + H2O
vinyl alcohol + propionate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
show the reaction diagram
i.e anordrin
-
-
?
(E)-2-(2-(6-((4-acetoxybenzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indolium + H2O
(E)-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium + 4-methylphenol + acetate
show the reaction diagram
-
-
-
-
?
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate + 2 H2O
anordiol + 2 propanoate
show the reaction diagram
i.e anordrin
-
-
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O
7-ethyl-10-hydroxy-camptothecin + ?
show the reaction diagram
acetylsalicylic acid + H2O
acetate + salicylate
show the reaction diagram
CES2A1-specific substrate
-
-
?
camptothecin-11 + H2O
?
show the reaction diagram
-
i.e. CPT-11, an anti-tumor agent
-
-
?
clopidogrel + H2O
(2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol
show the reaction diagram
-
an anti-thrombogenic agent
-
-
?
cocaine + H2O
O-benzoylecgonine + methanol
show the reaction diagram
monoethylglycylxylidine + H2O
2,6-xylidene + N-ethylglycine
show the reaction diagram
CES1A-specific substrate
-
-
?
mycophenolate mofetil + H2O
mycophenolic acid + mofetil
show the reaction diagram
-
prodrug, activation
-
-
?
oseltamivir + H2O
?
show the reaction diagram
-
an anti-viral drug
-
-
?
polyisoprenylated methylated protein + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biliary salts
-
activates
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,2-bis(4-fluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE1 and rabbit enzyme
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-Dglucopyranoside
-
18beta-11-deoxo-olean-12-en-30-oic acid
-
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3, 11-dioxo-olean-12-en-30-oic acid
-
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
-
18beta-glycyrrhetinic acid
-
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3',4',7-trihydroxyisoflavone
-
3',4'-dihydroxyflavone
-
3,6-dihydroxyflavone
-
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hiCE and rabbit enzyme
3-hydroxyflavone
-
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
-
4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
4beta,9alpha,20-trihydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
-
5,6,7-trimethoxybaicalein
-
5,6-dihydroxyflavone
a specific hCE2 inhibitor, exhibits reversible, noncompetitive inhibition, 5,6-dihydroxyflavone displays high specificity toward hCE2 over hCE1
5,7,8-trihydroxyflavone
-
5,7-dihydroxyflavone
-
5-hydroxy-6-methoxyflavone
-
5-hydroxyflavone
-
6,7-dihydroxyflavone
-
6-hydroxyflavone
-
6-methoxyflavone
-
7,8-dihydroxyflavone
-
7-hydroxyflavone
-
7-methoxybaicalein
-
8-nitrobaicalein
-
8beta-11-oxo-olean-12-en-30-amide
-
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
-
apigenin 7-O-methyl ether
-
baicalein
-
benzil
comparison with inhibition of human isoform hCE1 and rabbit enzyme
bis-4-nitrophenyl phosphate
bisdehydrophorbol
-
Calycosin
-
didehydrolangduin A-20-O-beta-D-glucopyranoside
-
diosmetin
-
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-glucopyranoside
-
ent-kaurane-16beta,17-diol-3,12-dione-19-O-beta-D-glucopyranoside
-
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
-
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-glucopyranoside
-
eupatilin
-
fischeroside A
-
fischeroside A-16-O-beta-D-glucopyranoside
-
genistein
-
glycitein
-
herbacetin
-
hispidulin
-
ingenol-19-O-beta-D-glucopyranoside
-
isorhamnetin
-
kaempferol
-
langduin F
-
loperamide
specifically inhibits CES2
nobiletin
-
oroxylin A
-
oroxyloside A
-
phorbol-13-acetate
-
quercetin
-
quercetin-3-rhamnoside
-
scutellarein
-
scutellarin
-
simvastatin
strongly inhibits hydrolytic process of anordrin in liver and intestine microsomes
tangeretin
-
yuexiandajisu D
-
yuexiandajisu E
-
(10Z)-hexadecenoic acid
-
-
(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
-
about 30% residual activity at 0.1 mM
(4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
-
-
(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate
-
-
(5Z,8Z,11Z,14Z)-eicosatetraenoic acid
-
-
(6Z,9Z,12Z)-octadecatrienoic acid
-
-
(9Z)-octadecenoic acid
-
-
(9Z)-tetradecenoic acid
-
-
(9Z,12Z)-octadecadienoic acid
-
-
(R)-cocaine
-
1,1'-ethane-1,2-diylbis(1H-indole-2,3-dione)
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
1,1,1-trifluoro-3-(hexylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
1,1,1-trifluoro-3-(octylsulfonyl)propane-2,2-diol
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfanyl]propan-2-one
-
-
1,1,1-trifluoro-3-[(2-phenylethyl)sulfonyl]propane-2,2-diol
-
-
1,1,1-trifluorododecan-2-one
-
-
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(2-chlorophenyl)ethane-1,2-dione
-
-
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione
-
-
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
1,2-bis(3-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(3-nitrophenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromo-2-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione
-
-
1,2-bis(4-bromothiophen-2-yl)ethane-1,2-dione
-
-
1,2-bis(4-chlorophenyl)ethane-1,2-dione
-
-
1,2-bis(4-fluorophenyl)ethane-1,2-dione
1,2-bis(4-methoxyphenyl)ethane-1,2-dione
-
-
1,2-bis(4-methylphenyl)ethane-1,2-dione
-
-
1,2-bis(5-bromothiophen-2-yl)ethane-1,2-dione
-
-
1,2-di(furan-2-yl)ethane-1,2-dione
-
-
1,2-di(naphthalen-2-yl)ethane-1,2-dione
-
-
1,2-di(pyridin-2-yl)ethane-1,2-dione
-
-
1,2-di(thiophen-2-yl)ethane-1,2-dione
-
-
1,2-di(thiophen-3-yl)ethane-1,2-dione
-
-
1,2-dicyclohexylethane-1,2-dione
-
-
1,2-difluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1,2-diphenylethane-1,2-dione
-
-
1,4-dibromo-1,4-diphenyl butane-2,3-dione
1-(2,4-dinitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(2-bromoethyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1,2-dione
-
-
1-(2-iodoethyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-(4[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl)benzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(4-chlorobenzyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione
-
-
1-(4-chlorophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methoxyphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(4-methylphenyl)-2-phenylethane-1,2-dione
-
-
1-(4-nitrophenyl)-2-phenylethane-1,2-dione
-
-
1-(pentachlorophenyl)-2-(pentafluorophenyl)ethane-1,2-dione
-
-
1-([(2-bromophenyl)amino]methyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-([(4-chlorophenyl)amino]methyl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-benzyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-dodecyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-hexadecyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
1-phenyl-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-[(2-naphthylamino)methyl]-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione
-
-
1-[4-[oxo(phenyl)acetyl]phenyl]-2-phenylethane-1,2-dione
-
-
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
-
11-piperazin-1-yl-dibenzo[b,f][1,4]thiazepine
-
-
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid
-
-
15-deoxy-DELTA12,14-prostaglandin J2
-
-
18beta-11-deoxo-olean-12-en-30-oic acid
-
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
-
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3, 11-dioxo-olean-12-en-30-oic acid
-
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
-
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
-
18beta-glycyrrhetinic acid
-
2,2-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
-
-
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
2,4-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
2,5-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
2,6,6-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2,7,7-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
-
-
2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-chloro-3,4-dimethoxybenzil
2-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-fluorophenanthrene-3,4-dione
-
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
comparison with inhibition of human isoform hCE2 and rabbit enzyme
2-methoxy-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
2-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
-
-
2-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl]ethanesulfonyl fluoride
-
-
22(R)-hydroxycholesterol
-
slight inhibition of CES1, not CES2
24(S),25-epoxycholesterol
-
inhibits only CES1, not CES2
24(S)-hydroxycholesterol
-
slight inhibition of CES1, not CES2
25-hydroxycholesterol
-
slight inhibition of CES1, not CES2
27-Hydroxycholesterol
-
partially noncompetitive inhibitor of recombinant CES1, impaires intracellular CES1 activity following treatment of intact THP1 cells. No inhibition of CES2
3,3-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
3,4-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
3,4-difluoro-N-(4-(phenylsulfonamido)phenyl)benzene sulfonamide
-
-
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
3-(butylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(decylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(decylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(decylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(dodecylsulfanyl)-1,1,1-trifluoropropan-2-one
-
-
3-(dodecylsulfinyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-(dodecylsulfonyl)-1,1,1-trifluoropropane-2,2-diol
-
-
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
comparison with inhibition of human isoform hCE1 and rabbit enzyme
3-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
-
4,6-dichloro-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
4,6-dimethyl-N1,N3-diphenylbenzene-1,3-disulfonamide
-
-
4,7-dichloro-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)-3-methylbenzoic acid
-
-
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)-N-methyl benzamide
-
-
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)benzoic acid
-
-
4-bromo-N-(4-ethoxyphenyl)benzene sulfonamide
-
-
4-chloro-N-(4-(4-fluorophenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-chloro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-chloro-N-(4-ethoxyphenyl)benzene sulfonamide
-
-
4-fluoro-N-(4-(4-methoxy phenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-fluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide
-
-
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-mercuribenzoate
-
-
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
-
-
4-[oxo(phenyl)acetyl]benzoic acid
-
-
5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
5-bromo-1-(2-methylprop-2-en-1-yl)-1H-indole-2,3-dione
comparison with inhibition of human acetyl- and butyrylcholinesterase and rabbit carboxyesterase rCE
6,6-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
7,7-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
-
7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin
-
i.e. irinotecan or CPT-11, an antitumor prodrug
7-oxocholesterol
-
slight inhibition of CES1, not CES2
8-methyl-1,4-dihydro-2H-naphtho[2,1-c]pyran-9,10-dione
-
8beta-11-oxo-olean-12-en-30-amide
-
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
-
amlodipine
-
about 40% residual activity at 0.1 mM
arachidonic acid
-
most potent fatty acid inhibitor of recombinant CES1 acting by a noncompetitive mechanism, overview. The inhibition is reversible by bovine serum albumin
aripiprazole
-
-
atomoxetine
-
-
atorvastatin
-
about 45% residual activity at 0.1 mM
bendroflumethiazide
-
about 70% residual activity at 0.1 mM
benzil
bioresmethrin
-
a pyrethroid insecticide
bis(4-nitrophenyl) phosphate
-
-
bis(4-nitrophenyl) phosphoric acid
-
97% inhibition at 1 mM
bis(4-nitrophenyl)phosphate
-
potent inhibitor
bis(p-nitrophenyl) phosphate
-
a specific inhibitor of carboxylesterases
bis-4-nitrophenyl phosphate
bis-4-nitrophenylphosphate
-
-
bisoprolol
-
about 90% residual activity at 0.1 mM
Carbaryl
-
78% inhibition
carvedilol
-
about 17% residual activity at 0.1 mM
chlorpyrifos
cholesterol
-
slight inhibition of CES1, not CES2
clopidogrel
-
about 15% residual activity at 0.1 mM
clozapine
-
-
cocaethylene
-
curcumin
-
reversible inhibition
cyclosarin
-
-
decane-5,6-dione
-
-
deltamethrin
-
48% inhibition
Digitonin
diisopropylfluorophosphate
-
-
diltiazem
-
about 23% residual activity at 0.1 mM
Dimethylsulfoxide
-
-
diphenyl carbonate
-
-
dodecane-6,7-dione
-
-
DTNB
-
weak
EGTA
-
minimal inhibition
eplerenone
-
about 80% residual activity at 0.1 mM
fluoxetine
-
-
Furosemide
-
about 78% residual activity at 0.1 mM
Galaxolide
-
synthetic fragrance Galaxolide induces human cancer cell degeneration with a EC50 value of 0.026 mM in neuroblastoma SH-SY5Y cells and 0.058 mM in lung cancer A549 cells
haloperidol
-
-
hexadecane-8,9-dione
-
-
hexadecanoic acid
-
-
Hg2+
-
HgCl2
imipramine
-
-
irbesartan
-
about 75% residual activity at 0.1 mM
isradipine
-
about 18% residual activity at 0.1 mM
lercanidipine
-
about 78% residual activity at 0.1 mM
loperamide
methyl paraoxon
-
-
miltirone
-
N,N'-(1,4-phenylene)bis(2,3-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,4,5-trichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,5-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2,6-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(2-fluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4,5-trifluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,4-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,5-dichlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3,5-difluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-bromobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-chlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(3-fluorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-fluoro-2-methylbenzene sulfonamide)
-
-
N,N'-(1,4-phenylene)bis(4-fluorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-fluoro-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetrafluoro-1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3,4-dichlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3,5-dichlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-bromobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-fluorobenzene sulfonamide)
-
-
N,N'-(2,5-dibromo-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2,5-dibromo-1,4-phenylene)bisbenzene sulfonamide
-
-
N,N'-(2,5-dichloro-1,4-phenylene)bis(4-chlorobenzene sulfonamide)
-
-
N,N'-(2-chloro-1,4-phenylene)dibenzene sulfonamide
-
-
N,N'-(2-methyl-1,4-phenylene)benzene sulfonamide
-
-
N,N'-(2-methylbenzene-1,4-diyl)dibenzenesulfonamide
-
-
N,N'-(disulfanediyldibenzene-4,1-diyl)dimethanesulfonamide
-
-
N,N'-1,4-phenylenebis-2-naphthalene sulfonamide
-
-
N,N'-9H-fluorene-2,7-diylbis(3,4,5-trifluorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(3-bromobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(3-chlorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diylbis(4-chlorobenzenesulfonamide)
-
-
N,N'-9H-fluorene-2,7-diyldibenzenesulfonamide
-
-
N,N'-benzene-1,4-diyldibenzenesulfonamide
-
-
N-(4-(4-fluoromethylphenylsulfonamido)phenyl)-2,5-dimethylbenzene sulfonamide
-
-
n-butanol
-
1 M
n-desmethylclozapine
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]cyclohexanecarboxamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]hexanamide
-
-
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]pentanamide
-
-
neostigmine
-
serum enzyme is inhibited, liver enzyme is not affected
nimodipine
-
about 70% residual activity at 0.1 mM
octadecane-9,10-dione
-
-
octadecanoic acid
-
-
octane-4,5-dione
-
-
olanzapine
-
-
organophosphate compounds
-
-
-
organophosphate esters
-
-
-
p-trimethylammoniumanilinium dichloride
-
serum enzyme is inhibited, liver enzyme is not affected
paraoxon
PCMB
-
-
perphenazine
-
-
phenanthrene-3,4-dione
-
phenol
-
-
phenyl-1,2-butanedione
-
-
phenyl-1,2-heptanedione
-
-
phenyl-1,2-hexanedione
-
-
phenyl-1,2-octanedione
-
-
phenyl-1,2-pentanedione
-
-
phenyl-1,2-propanedione
-
-
Phenylmethyl sulfonylfluoride
-
-
Phenylmethylsulfonylfluoride
-
-
prasugrel
-
inhibits isozyme CE2 at high concentrations in vitro but not in vivo
prostaglandin E2
-
-
prostaglandin F2alpha
-
-
quetiapine
-
-
simvastatin
sirolimus
-
about 90% residual activity at 0.1 mM
soman
spironolactone
-
about 70% residual activity at 0.1 mM
tacrolimus
-
about 28% residual activity at 0.1 mM
telmisartan
4-nitrophenyl acetate hydrolysis in human iPS cell-derived enterocytes is significantly inhibited by the CES2A1-specific inhibitor telmisartan
tetradecane-7,8-dione
-
-
tetradecanoic acid
-
-
tetraisopropyl diphosphoramide
-
67% inhibition at 0.5 mM
thioridazine
-
-
Tonalide
-
synthetic fragrance Tonalide induces human cancer cell degeneration with a EC50 value of 0.098 mM in neuroblastoma SH-SY5Y cells and 0.014 mM in lung cancer A549 cells
trans-permethrin
-
a pyrethroid insecticide
triphenyl phosphate
-
-
valsartan
-
about 90% residual activity at 0.1 mM
ziprasidone
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ethanol
-
activates
ethylene glycol
-
little activating effect, except at high concentrations, 1 M
ethylene glycol monoethyl ether
-
little activating effect, except at high concentrations, 1 M
methanol
-
activates
n-butanol
-
0.1 M, increases activity
sarin
-
for enzyme inhibited by racemic mixtures of bona fide nerve agents, hCE1 spontaneously reactivates in the presence of sarin but not soman or cyclosarin. The addition of 2,3-butanedione monoxime increases the rate of reactivation of CE1 from sarin inhibition by more than 65fold
taurocholate
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0125
(R)-propranolyl 2-methylbutanoate
enzyme hCE2, pH and temperature not specified in the publication
0.0024
(R)-propranolyl 3-methylbutanoate
enzyme hCE2, pH and temperature not specified in the publication
0.012
(R)-propranolyl n-valerate
enzyme hCE2, pH and temperature not specified in the publication
0.0149
(S)-propranolyl 2-methylbutanoate
enzyme hCE2, pH and temperature not specified in the publication
0.004
(S)-propranolyl 3-methylbutanoate
enzyme hCE2, pH and temperature not specified in the publication
0.0178
(S)-propranolyl n-valerate
enzyme hCE2, pH and temperature not specified in the publication
0.00224 - 0.0169
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate
6.5
(1R)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
0.0086 - 0.0238
(1RS)-cis-permethrin
0.00757 - 0.0098
(1RS)-trans-permethrin
2.9
(1S)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
10.1
(2R)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
48.5
(2S)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
0.0003 - 0.0009
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0017 - 0.0025
(R)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0019
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0015 - 0.0017
(R)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0007 - 0.0009
(R)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
0.0003 - 0.0025
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0007 - 0.0028
(S)-cyano(6-methoxy-2-naphthyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0024 - 0.0038
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0014 - 0.004
(S)-cyano(6-methoxy-2-naphthyl)methyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0008 - 0.002
(S)-cyano(6-methoxynaphthalen-2-yl)methyl (2R)-2-(4-chlorophenyl)-3-methylbutanoic acid
0.16
1-naphthyl acetate
-
-
0.0076 - 0.33
1-naphthyl butyrate
4.6
2,2-dimethylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
0.00925
2-acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
isozyme CE1
13.7
2-methylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
0.1
2-Nitrophenyl butyrate
-
-
0.00224 - 0.0136
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate
0.11 - 0.13
4-aminobenzoic acid butyl ester
0.356 - 1.198
4-aminobenzoic acid ethyl ester
0.322 - 0.398
4-aminobenzoic acid propyl ester
0.1
4-Methylumbelliferyl butyrate
-
-
0.0229 - 1.5
4-nitrophenyl acetate
1
4-nitrophenyl butanoate
-
pH 7.5, 25°C
0.125
4-nitrophenyl pentanoate
-
-
0.022 - 2
4-yethylumbelliferyl acetate
0.0032 - 0.46
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin
0.001 - 0.137
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin
0.27
7-ethyl-10-(4-N-(5-aminopentanoic acid)-1-piperidino)carbonyloxycampothecin
-
pH 7.0, 37°C, isoform CES2
0.00034 - 0.0043
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin
0.00672
bioresmethrin
-
isoform hCE1, pH 7.4, 37°C
4.4
butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
pH and temperature not specified in the publication
1.3 - 2
cholesterol oleate
0.002 - 0.0091
cyano(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
0.0015 - 0.0054
cyano(6-methoxy-2-naphthyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate
0.0018 - 0.0021
cyano(6-methoxynaphthalen-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylic acid
0.6635
D-methyl phenidate
wild type enzyme
0.46 - 1.118
derapril
1.734
enalapril
-
in 100 mM phosphate buffer at 37°C, pH not specified in the publication
0.00194 - 0.00482
fluorescein diacetate
0.245 - 0.397
imidapril
0.00625 - 0.0828
irinotecan
0.7757
L-methyl phenidate
wild type enzyme
0.11
methyl butyrate
-
serum enzyme
1.03 - 1.2
mycophenolate mofetil
-
pH 7.4, 37°C
0.0236 - 0.0853
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester
0.211
N-acetyl-L-Ala-1-naphthyl ester
-
-
0.094 - 0.123
oxybutynin
0.0031 - 0.027
p-nitrophenyl acetate
0.901
ramipril
-
in 100 mM phosphate buffer at 37°C, pH not specified in the publication
2.1
S-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethanethioate
pH and temperature not specified in the publication
0.639 - 1.721
trandolapril
0.4
tributyrin
-
pH 7.5, 25°C
3.9 - 8.3
triolein
15
tripropionin
-
pH 7.5, 25°C
170
vinyl acetate
-
pH 7.5, 25°C
11
vinyl butanoate
-
pH 7.5, 25°C
3
vinyl laurate
-
pH 7.5, 25°C
70
vinyl propionate
-
pH 7.5, 25°C
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.028 - 0.056
(1RS)-cis-permethrin
0.0008 - 0.0028
(1RS)-trans-permethrin
48
1-naphthyl butyrate
-
-
7.6 - 20
4-nitrophenyl acetate
190
4-nitrophenyl butanoate
-
pH 7.5, 25°C
0.000003 - 0.004
7-ethyl-10-(4-(1-piperidino)-1-amino)carbonyloxycampothecin
0.000015 - 0.017
7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycampothecin
0.00041
7-ethyl-10-(4-N-(5-aminopentanoic acid)-1-piperidino)carbonyloxycampothecin
-
pH 7.0, 37°C, isoform CES2
0.034
bioresmethrin
-
isoform hCE1, pH 7.4, 37°C
651
N-acetyl-L-Ala-1-naphthyl ester
-
-
17 - 70
p-nitrophenyl acetate
18
tributyrin
-
pH 7.5, 25°C
7
tripropionin
-
pH 7.5, 25°C
140
vinyl acetate
-
pH 7.5, 25°C
210
vinyl butanoate
-
pH 7.5, 25°C
31
vinyl laurate
-
pH 7.5, 25°C
105
vinyl propionate
-
pH 7.5, 25°C
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000033
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
pH 7.4
0.0000007
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
pH 7.4
0.000001
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
pH 7.4
0.0000006
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
pH 7.4
0.0000136
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
-
0.0000319
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
-
0.00000498
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
-
0.0000552
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
-
0.00012
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
-
0.000071
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
-
0.0000306
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
-
0.0000259
1,2-bis(4-fluorophenyl)ethane-1,2-dione
-
0.0000257
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
-
0.0000995
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
-
0.0000143
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.0000005
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.0000003
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.0000004
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.0000004
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.00494
4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
pH and temperature not specified in the publication
0.00428
5,6-dihydroxyflavone
pH 7.4, 37°C
0.0000151
benzil
-
0.00154 - 0.00156
1,1'-ethane-1,2-diylbis(1H-indole-2,3-dione)
0.0000005
1,1,1,-trifluoro-3-(hexylsulfinyl)propane-2,2-diol
pH 7.4
0.0000037
1,1,1,-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
pH 7.4
0.0000011
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol
pH 7.4
0.0000005
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol
pH 7.4
0.0000913
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
-
0.00014
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
-
0.0000347
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
-
0.00023
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
-
0.00019
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
-
0.00017
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
-
0.0000972
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
-
0.0001
1,2-bis(4-fluorophenyl)ethane-1,2-dione
-
0.000005 - 0.000072
1,2-dicyclohexylethane-1,2-dione
0.000334 - 0.008
1,4-dibromo-1,4-diphenyl butane-2,3-dione
0.00029 - 0.00158
1-(2-bromoethyl)-1H-indole-2,3-dione
0.00013 - 0.00074
1-(2-iodoethyl)-1H-indole-2,3-dione
0.000031 - 0.000067
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione
0.000008 - 0.00001
1-(4-(4[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl)benzyl)-1H-indole-2,3-dione
0.000025 - 0.000032
1-(4-chlorobenzyl)-1H-indole-2,3-dione
0.000047 - 0.036
1-([(2-bromophenyl)amino]methyl)-1H-indole-2,3-dione
0.0002 - 0.00061
1-([(4-chlorophenyl)amino]methyl)-1H-indole-2,3-dione
0.00087 - 0.0017
1-benzyl-1H-indole-2,3-dione
0.000008 - 0.00001
1-dodecyl-1H-indole-2,3-dione
0.000011 - 0.00016
1-hexadecyl-1H-indole-2,3-dione
0.000023 - 0.00095
1-phenyl-1H-indole-2,3-dione
0.00011
1-[(2-naphthylamino)methyl]-1H-indole-2,3-dione
isoform hiCE
0.00000148 - 0.000279
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.00000323 - 0.1
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
0.000026
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
-
0.000665
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
-
0.00001
27-Hydroxycholesterol
-
pH 7.4, 37°C, recombinant CES1
0.00000273 - 0.001244
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.000002
3-butylsulfinyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.00000155 - 0.000756
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.0000005
3-decylsulfinyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.0000011
3-decylsulfonyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.0000004
3-dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.000001
3-dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol
pH 7.4
0.00062 - 0.00089
4,6-dichloro-1H-indole-2,3-dione
0.00059 - 0.00065
4,7-dichloro-1H-indole-2,3-dione
0.0000036 - 0.000381
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.00000467 - 0.1
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.00000286 - 0.001034
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
0.000066 - 0.00028
5-bromo-1-(2-methylprop-2-en-1-yl)-1H-indole-2,3-dione
0.0018
arachidonic acid
-
pH 7.4, 37°C, recombinant CES1
0.000015 - 0.0000451
benzil
0.0003
curcumin
-
pH 7.4, 37°C
0.0000466 - 0.000189
decane-5,6-dione
0.000003 - 0.0000577
dodecane-6,7-dione
0.0000076 - 0.0000256
hexadecane-8,9-dione
0.00000465 - 0.1
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide
0.00000368 - 0.1
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide
0.00000117 - 0.000437
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide
0.00000084 - 0.0000057
octadecane-9,10-dione
0.00467 - 0.00806
octane-4,5-dione
0.00155 - 0.00242
phenyl-1,2-butanedione
0.00000665 - 0.0000455
phenyl-1,2-heptanedione
0.0000261 - 0.0000727
phenyl-1,2-hexanedione
0.00000219 - 0.0000287
phenyl-1,2-octanedione
0.000102 - 0.000401
phenyl-1,2-pentanedione
0.00184 - 0.00527
phenyl-1,2-propanedione
0.0000048 - 0.0000764
tetradecane-7,8-dione
additional information
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-D-(6'-galloyl)-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.1
13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-Dglucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.00695
18beta-11-deoxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.00399
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
Homo sapiens
pH 7.4, 37°C
0.0057
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
Homo sapiens
pH 7.4, 37°C
0.00561
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
Homo sapiens
pH 7.4, 37°C
0.00395
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
Homo sapiens
pH 7.4, 37°C
0.1
18beta-3, 11-dioxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.00002
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
Homo sapiens
pH 7.4, 37°C
0.00066
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
Homo sapiens
pH 7.4, 37°C
0.04051
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.00342
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
Homo sapiens
pH 7.4, 37°C
0.02075
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.06926
18beta-glycyrrhetinic acid
Homo sapiens
pH 7.4, 37°C
0.03706
3',4'-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.00506
3,6-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.1
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
Homo sapiens
pH 7.4, 37°C
0.00388
4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
Homo sapiens
pH and temperature not specified in the publication
0.00395
4beta,9alpha,20-trihydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione
Homo sapiens
pH and temperature not specified in the publication
0.0035
5,6-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.058
5,7,8-trihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.07549
5,7-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.03344
5-hydroxy-6-methoxyflavone
Homo sapiens
pH 7.4, 37°C
0.01457
6,7-dihydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.03067
6-hydroxyflavone
Homo sapiens
pH 7.4, 37°C
0.01569
7-methoxybaicalein
Homo sapiens
pH 7.4, 37°C
0.01421
8beta-11-oxo-olean-12-en-30-amide
Homo sapiens
pH 7.4, 37°C
0.00736
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
Homo sapiens
pH 7.4, 37°C
0.00473
apigenin 7-O-methyl ether
Homo sapiens
pH 7.4, 37°C
0.02112
baicalein
Homo sapiens
pH 7.4, 37°C
0.00431
bavachinin
Homo sapiens
pH 7.4, 37°C
0.00611
bis-4-nitrophenyl phosphate
Homo sapiens
pH 7.4, 37°C
0.00499
bisdehydrophorbol
Homo sapiens
pH and temperature not specified in the publication
0.01346
didehydrolangduin A-20-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.01786
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.1
ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.1
ent-kaurane-16beta,17-diol-3,12-dione-19-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.05327
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.1
ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.00685
eupatilin
Homo sapiens
pH 7.4, 37°C
0.02168
fischeroside A
Homo sapiens
pH and temperature not specified in the publication
0.0293
fischeroside A-16-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.01372
fisetin
Homo sapiens
pH 7.4, 37°C
0.01279
galangin
Homo sapiens
pH 7.4, 37°C
0.00764
hispidulin
Homo sapiens
pH 7.4, 37°C
0.03249
ingenol-19-O-beta-D-glucopyranoside
Homo sapiens
pH and temperature not specified in the publication
0.00363
isorhamnetin
Homo sapiens
pH 7.4, 37°C
0.02016
kaempferol
Homo sapiens
pH 7.4, 37°C
0.00521
langduin F
Homo sapiens
pH and temperature not specified in the publication
0.03473
luteolin
Homo sapiens
pH 7.4, 37°C
0.08049
nobiletin
Homo sapiens
pH 7.4, 37°C
0.02082
oroxylin A
Homo sapiens
pH 7.4, 37°C
0.00883
phorbol-13-acetate
Homo sapiens
pH and temperature not specified in the publication
0.01885
quercetin
Homo sapiens
pH 7.4, 37°C
0.02405
scutellarein
Homo sapiens
pH 7.4, 37°C
0.00694 - 0.0109
simvastatin
0.01216
wogonin
Homo sapiens
pH 7.4, 37°C
0.00479
yuexiandajisu D
Homo sapiens
pH and temperature not specified in the publication
0.00447
yuexiandajisu E
Homo sapiens
pH and temperature not specified in the publication
0.007
(10Z)-hexadecenoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.002
(5Z,8Z,11Z,14Z)-eicosatetraenoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.019
(6Z,9Z,12Z)-octadecatrienoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.007
(9Z)-octadecenoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.012
(9Z)-tetradecenoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.009
(9Z,12Z)-octadecadienoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.000102
1,2-difluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000259
1-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000144
1-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000251
1-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.027
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00402
11-piperazin-1-yl-dibenzo[b,f][1,4]thiazepine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.038
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.013
15-deoxy-DELTA12,14-prostaglandin J2
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.01053
18beta-11-deoxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.02509
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
Homo sapiens
pH 7.4, 37°C
0.02626
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
Homo sapiens
pH 7.4, 37°C
0.02236
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
Homo sapiens
pH 7.4, 37°C
0.00913
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
Homo sapiens
pH 7.4, 37°C
0.1
18beta-3, 11-dioxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.02041
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
Homo sapiens
pH 7.4, 37°C
0.1
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
Homo sapiens
pH 7.4, 37°C
0.04986
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.01231
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
Homo sapiens
pH 7.4, 37°C
0.02361
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
Homo sapiens
pH 7.4, 37°C
0.02097
18beta-glycyrrhetinic acid
Homo sapiens
pH 7.4, 37°C
0.0033
2,2-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000054
2,4-dichloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.002425
2,6,6-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.000495
2,7,7-trimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.000302
2-(4-methoxyphenyl)-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.001054
2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000122
2-fluoro-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.000042
2-fluoro-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000487
2-fluorophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000425
2-methoxy-6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.001223
2-methyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0025
2-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]propanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.0081
24(S),25-epoxycholesterol
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.000033
27-Hydroxycholesterol
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.0011
3,3-dimethyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000135
3,4-difluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.00025
3-chloro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.0023
3-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.1
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
Homo sapiens
pH 7.4, 37°C
0.000326
4-fluoro-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000213
4-methoxy-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000132
4-methyl-N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000131
5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.001871
6,6-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000319
6,6-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.004204
7,7-dimethyl-2-(propan-2-yl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.01
8-methyl-1,4-dihydro-2H-naphtho[2,1-c]pyran-9,10-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.00699
8beta-11-oxo-olean-12-en-30-amide
Homo sapiens
pH 7.4, 37°C
0.01097
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
Homo sapiens
pH 7.4, 37°C
0.00524 - 0.0617
aripiprazole
0.00407
atomoxetine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.00347
bavachinin
Homo sapiens
pH 7.4, 37°C
0.00016
benzil
Homo sapiens
-
-
0.0000104 - 0.000788
bis(4-nitrophenyl)phosphate
0.00014
bis-4-nitrophenyl phosphate
Homo sapiens
pH 7.4, 37°C
0.00000021
chlorpyrifos
Homo sapiens
-
-
0.00409
clozapine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.0124
curcumin
Homo sapiens
-
pH 7.4, 37°C
0.00521 - 0.0589
fluoxetine
0.00359
haloperidol
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.025
hexadecanoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00372
imipramine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.000287 - 0.1
loperamide
0.000049
methyl paraoxon
Homo sapiens
-
-
0.00253
miltirone
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0000079
N,N'-9H-fluorene-2,7-diylbis(3,4,5-trifluorobenzenesulfonamide)
Homo sapiens
-
-
0.00057
N,N'-9H-fluorene-2,7-diylbis(3-bromobenzenesulfonamide)
Homo sapiens
-
-
0.0001
N,N'-9H-fluorene-2,7-diylbis(3-chlorobenzenesulfonamide)
Homo sapiens
-
-
0.0000252
N,N'-9H-fluorene-2,7-diylbis(4-chlorobenzenesulfonamide)
Homo sapiens
-
-
0.0000984
N,N'-9H-fluorene-2,7-diyldibenzenesulfonamide
Homo sapiens
-
-
0.00399
n-desmethylclozapine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.000055
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-(thiophen-2-yl)acetamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000177
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-2-phenoxyacetamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000059
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]-4-(trifluoromethyl)benzamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.008
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]acetamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.0024
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]butanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000354
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]cyclohexanecarboxamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.00054
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]hexanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.000868
N-[3-[oxo(pyridin-2-yl)acetyl]phenyl]pentanamide
Homo sapiens
-
intestinal carboxylesterase, pH and temperature not specified in the publication
0.1
octadecanoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00338
olanzapine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.00000029
paraoxon
Homo sapiens
-
-
0.00486 - 0.065
perphenazine
0.000942
phenanthrene-3,4-dione
Homo sapiens
pH 7.4, temperature not specified in the publication
0.0765
prasugrel
Homo sapiens
-
isozyme CE2
0.1
prostaglandin E2
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.1
prostaglandin F2alpha
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00415
quetiapine
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
0.00694 - 0.0109
simvastatin
0.009
tetradecanoic acid
Homo sapiens
-
pH 7.4, 37°C, recombinant CES1
0.00515 - 0.0583
thioridazine
0.00413
ziprasidone
Homo sapiens
-
versus substrate 4-nitrophenyl acetate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000544
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate hydrolysis, intestinal microsomes, pH 7.4, 37°C
0.000137
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate hydrolysis, CES2, pH 7.4, 37°C
0.000476
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate hydrolysis, liver microsomes, pH 7.4, 37°C
0.00334
procaine hydrolysis, CES2 isozyme, pH 7.4, 37°C
0.004
procaine hydrolysis, liver microsomes, pH 7.4, 37°C
0.213
fenofibrate hydrolysis, liver microsomes, pH 7.4, 37°C
102
phenacetin hydrolysis, intestinal microsomes, pH 7.4, 37°C
50.4
phenacetin hydrolysis, liver microsomes, pH 7.4, 37°C
0.000123
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate hydrolysis, CES1, pH 7.4, 37°C
0.000137
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate hydrolysis, CES2, pH 7.4, 37°C
0.000476
2alpha,17alpha-diethynyl-A-nor-5alpha-androstane-2beta,17beta-diol dipropionate hydrolysis, liver microsomes, pH 7.4, 37°C
0.00097
substrate cocaine, pH 7.4, temperature not specified in the publication
0.004
procaine hydrolysis, liver microsomes, pH 7.4, 37°C
0.0928
fenofibrate hydrolysis, CES1 isozyme, pH 7.4, 37°C
0.099
-
isoform CES2, using methyl 4-nitrobenzoate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.213
fenofibrate hydrolysis, liver microsomes, pH 7.4, 37°C
0.281
-
isoform CES1-c, fluorescein diacetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.357
-
isoform CES1-b, using fluorescein diacetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.68
-
isoform CES1-c, methyl 4-nitrobenzoate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.682
-
isoform CES2, using 4-nitrophenyl acetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
0.957
-
isoform CES1-b, using methyl 4-nitrobenzoate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
1.4
-
isoform CES1-c, using 4-nitrophenyl acetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
1.43
-
isoform CES1-b, using 4-nitrophenyl acetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
102
phenacetin hydrolysis, intestinal microsomes, pH 7.4, 37°C
109
purified recombinant refolded His-taggged mutant A270S, pH 7.5, 37°C, substrate 4-nitrophenyl acetate
113.2
-
isoform hCE1, substrate 4-nitrophenyl valerate, pH 7.4, 37°C
120
-
pH 7.0, 37°C, isoform CES2
128
purified recombinant refolded His-taggged mutant S76N, pH 7.5, 37°C, substrate 4-nitrophenyl acetate
13.8
-
isoform CES2, using fluorescein diacetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C
160.1
-
-
19.05
-
isoform hCE2, substrate 4-nitrophenyl acetate, pH 7.4, 37°C
193
purified recombinant refolded His-taggged mutant D204E, pH 7.5, 37°C, substrate 4-nitrophenyl acetate
293.1
-
isoform hCE1, substrate 4-nitrophenyl butanoate, pH 7.4, 37°C
315.2
-
isoform hCE2, substrate 4-nitrophenyl butanoate, pH 7.4, 37°C
36.14
-
isoform hCE1, substrate 4-nitrophenyl acetate, pH 7.4, 37°C
40 - 140
-
isozyme CE-2
5.8
-
pH 7.0, 37°C
50.4
phenacetin hydrolysis, liver microsomes, pH 7.4, 37°C
6.6
-
pH 7.0, 37°C, isoform CES1A1
610
-
isozyme CE-1
73
purified recombinant refolded His-taggged wild-type enzyme, pH 7.5, 37°C, substrate 4-nitrophenyl acetate
90.1
-
isoform hCE2, substrate 4-nitrophenyl valerate, pH 7.4, 37°C
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.3
-
hydrolysis of butyrylcholine, serum enzyme
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 10
-
pH 5.0: about 40% of maximal activity, pH 10: about 35% of maximal activity
6 - 12
-
less than 50% of maximal activity at pH less than 6 or more than 12
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.8
-
isoelectric focusing
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high expression of CES2 in human intestine epithelial cells
Manually annotated by BRENDA team
-
low expression
Manually annotated by BRENDA team
induced pluripotent stem cell-derived enterocytes
Manually annotated by BRENDA team
primary human intestinal epithelial cells
Manually annotated by BRENDA team
-
keratinocyte, high abundance of isoform hCE2, but not hCE1
Manually annotated by BRENDA team
-
low expression
Manually annotated by BRENDA team
-
low expression
Manually annotated by BRENDA team
-
hepatocyte, high abundance of isoforms hCE1 and hCE2
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
enzyme overexpression
Manually annotated by BRENDA team
induced pluripotent stem cell
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
the enzyme is secreted. Tunicamycin leads to decreased levels of secreted hCES2, but the enzyme is still active. Mutation of each and both N-glycosylation sites leads to decreased levels of secreted active hCES2
-
Manually annotated by BRENDA team
additional information
-
isozyme CES1 is not expressed in human intestinal microsomes
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
mutation of each and both N-glycosylation sites leads to decreased levels of secreted active hCES2. The thermostability of the glycosylation mutants is decreased
physiological function
malfunction
metabolism
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
EST2_HUMAN
559
0
61807
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
-
x * 100000, SDS-PAGE
170000
-
gel filtration
180000
-
liver enzyme, trimeric form, gel filtration in 50 mM Tris-HCl, pH 7.5, 200 mM KCl
181000 - 186000
-
gel filtration, disc electrophoresis, analytical ultracentrifugation
19500
-
gel filtration
20000
-
1 * 20000, SDS-PAGE
200000
-
gel filtration
340000
-
gel filtration
35000
-
2 * 35000, SDS-PAGE
59000
-
3 * 59000, SDS-PAGE
60000
61000
61500
-
3 * 61500, SDS-PAGE
62000
-
liver enzyme, monomeric enzyme form, gel filtration in 0.1 M acetate buffer
76000
-
gel filtration
85000
-
4 * 85000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 35000, SDS-PAGE
hexamer
trimer-hexamer equilibrium
monomer
tetramer
-
4 * 85000, SDS-PAGE
trimer
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
N-glycosylation of hCES2 is relevant for thermostability of the enzyme and also for its in vivo folding or secretion, but is not crucial for enzyme activity. Carboxylesterase 2 (hCES2) is a glycoprotein. Partial or non-glycosylated forms of a secreted form of hCES2 are obtained by three approaches: (i) enzymatic deglycosylation with peptide N-glycosidase F, (ii) incubation with the inhibitor tunicamycin, (iii) site-directed mutagenesis of each or both N-glycosylation sites. Deglycosylated protein does not show a detectable decrease in enzyme activity. The glycans are involved, to some extent, in protein folding in vivo, but removal of glycans does not abrogate the activity of secreted hCES2. Deglycosylation of purified recombinant His10-tagged hCES2 shows a decreased level of detection using the glycoprotein detection method with the deglycosylated bands only being faintly detected probably due to nonspecific binding or to O-glycosylation
glycoprotein
no modification
side-chain modification
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
carboxylesterase 1 in complex with cyclosarin, sitting drop vapor diffusion method, using 10% (w/v) polyethylene glycol 3350, 0.3 M Li2SO4, 0.1 M citrate, pH 5.5, 0.1 M NaCl, 0.1 M LiCl, and 5% (v/v) glycerol.
-
covalent acyl-enzyme intermediate complexes of isoform hCE1 with inhibitors soman and tabun. Enzyme binds stereoselectively, (S)-stereoisomer of soman is preferred 10000fold over the (R)-isomer. Comparison with similar complexes of acetylcholinesterase
crystal structure of hCE1 in complex with the cocaine analogue homatropine to 2.8 A resolution, and with the heroin analogue naloxone to 2.9 A resolution
-
crystallized in the presence of either 10 mM naloxone methiodide or 100 mM homatropine using sitting drop vapor diffusion at 22°C. Overview of hCE1 structures, crystal structures of the hCE1 glycoprotein in complex with the cocaine analog homatropine and the heroin analog naloxone provide details about narcotic metabolism in humans. The hCE1 active site contains both specific and promiscuous compartments, which enable the enzyme to act on structurally distinct chemicals. A selective surface ligand-binding site regulates the trimer-hexamer equilibrium of hCE1 and allows each hCE1 monomer to bind two narcotic molecules simultaneously
in complex with coenzyme A, palmitate, cholate and taurocholate. Enzyme contains two additional ligand binding sites, each exhibiting relatively non-specific ligand binding properties. Catalytic triad is formed by residues S221, H468 and E354
-
molecular modeling of istatin analogue inhibitors into crystal structure of isoform hCE1
using a mixture consisting of 45% protein solution, 45% of condition No. 83 (2 M ammonium sulfate, 0.1 M bis-Tris pH 6.5, adjusted from pH 5.5) and 10% of condition No. 21 (2 M sodium thiocyanate)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
N175Q
site-directed mutagenesis, the mutant lacks the first glycosylation site, the mutation reduces the catalytic activity (by 43%) and the thermostability of the enzyme compared to wild-type
N175Q/N340Q
site-directed mutagenesis, the mutant lacks both the glycosylation sites, the mutation reduces the catalytic activity (by 75%) and the thermostability of the enzyme compared to wild-type
N340Q
site-directed mutagenesis, the mutant lacks the second glycosylation site, the mutation reduces the catalytic activity (by 39%) and the thermostability of the enzyme compared to wild-type
A270S
site-directed mutagenesis, recombinant mutant shows increased activity compared to the recombinant wild-type
D204E
site-directed mutagenesis, recombinant mutant shows increased activity compared to the recombinant wild-type
DELTA458-473
-
inactive splice variant of isoform CES2, lacks activity against 4-methylumbelliferyl acetate and 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin and accounts for about 6% of total isoform transcripts in colon tissue
G143E
S76N
site-directed mutagenesis, the recombinant mutant shows increased activity compared to the recombinant wild-type
additional information
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 7.4
-
no degradation activity at pH 5.0, chemically stable at pH 6.0-7.4
691328
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
50% loss of activity upon lyophilization
-
dialysis using nitrocellulose membranes causes a significant loss of activity
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-80°C, 10% glycerol, stable for months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
esterase D-1 and esterase D-2
-
Fractogel EMD SO3 (M) cation-exchange column chromatography and Toyopearl GigaCap Q-650 anion-exchange column chromatography
gel filtration
-
isozymes CE-1 and CE-2
-
recombinant refolded His-taged enzyme from Escherichia coli strain BL21(DE3) by cobalt affinity chromatography using an elution buffer containing 20 mM sodium phosphate, pH 7.4, 300 mM NaCl, 8 M urea, 250 mM imidazole, and 2 mM 2-mercaptoethanol
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
CES2, recombinant expression of His10-tagged wild-type and mutant enzymes in HEK-293T cells, the enzyme is secreted to the cell medium
expression in Sf9 cell
expressed in baculovirus-infected High Five insect cells
-
expressed in baculovirus-infected Spodoptera frugiperda Sf21 cells
-
expressed in Flp-In-293 cells
expressed in HepG2 cells
-
expressed in Spodoptera frugiperda cells and in U373MG cells
-
expressed in Trichoplusia ni larvae
expression in MCF-7 cell and U-373MG glioblastoma cell
-
expression in sf21 cell
expression in Sf9 cell
gene CES2, genotyping of CES2 genetic polymorphisms in Japanese population, overview
-
overexpression of human liver enzyme in a human cell line
recombinant expression of wild-type and mutant His-tagged enzyme CES1 in Escherichia coli strain BL21(DE3) in inclusion bodies, the recombinant CES1 protein is expressed differently when grown at different temperatures, expression of CES1 grown at 25°C was much higher than in cells grown at 37°C
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
hepatitis C virus can induce CES1 expression to modulate the cellular environment to its advantage
-
RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
refolding of recombinant His-tagged CES1 expressed in Escherichia coli inclusion bodies is successful in Tris-HCl at pH 7.5 containing a combination of 1% glycerol and 2 mM 2-mercaptoethanol, whereas a mixture of other additives (trehalose, sorbitol and sucrose) and 2-mercaptoethanol fails to recover a functional protein. His-tagged recombinant CES1 retains its biological activity after refolding and can be used directly without removing the fusion tag
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
-
possible use of the enzyme as a protein biomarker and drug target for lung cancer
drug development
medicine
pharmacology
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hojring, N.; Svensmark, O.
Carboxylesterases of human brain extract. Purification and properties of a butyrylesterase
Biochim. Biophys. Acta
481
500-514
1977
Homo sapiens
Manually annotated by BRENDA team
Abouakil, N.; Rogalska, E.; Bonicel, J.; Lombardo, D.
Purification of pancreatic carboxylic-ester hydrolase by immunoaffinity and its application of the human bile-salt-stimulated lipase
Biochim. Biophys. Acta
961
299-308
1988
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Okada, Y.; Wakabayashi, K.
Purification and characterization of esterases D-1 and D-2 from human erythrocytes
Arch. Biochem. Biophys.
263
130-136
1988
Homo sapiens
Manually annotated by BRENDA team
Saboori, A.M.; Newcombe, D.S.
Human monocyte carboxylesterase. Purification and kinetics
J. Biol. Chem.
265
19792-19799
1990
Homo sapiens
Manually annotated by BRENDA team
Hojring, N.; Svensmark, O.
Molecular and catalytic properties of a butyrylesterase from human red cells and brain
Arch. Biochem. Biophys.
260
351-358
1988
Homo sapiens
Manually annotated by BRENDA team
Wang, C.S.; Kloer, H.U.
Kinetic properties of human pancreatic carboxylesterase
Biochim. Biophys. Acta
754
142-149
1983
Homo sapiens
Manually annotated by BRENDA team
Tsujita, T.; Okuda, H.
Human liver carboxylesterase. Properties and comparison with human serum carboxylesterase
J. Biochem.
94
793-797
1983
Homo sapiens
Manually annotated by BRENDA team
Lombardo, D.; Guy, O.; Figarella, C.
Purification and characterization of a carboxyl ester hydrolase from human pancreatic juice
Biochim. Biophys. Acta
527
142-149
1978
Homo sapiens
Manually annotated by BRENDA team
Coates, P.M.; Edwards, Y.H.; Hopkinson, D.A.
Purification and properties of an esterase B4 from human liver
Eur. J. Biochem.
61
331-335
1976
Homo sapiens
Manually annotated by BRENDA team
Junge, W.; Heymann, E.; Krisch, K.; Hollandt, H.
Human liver carboxylesterase. Purification and molecular properties
Arch. Biochem. Biophys.
165
749-763
1974
Homo sapiens
Manually annotated by BRENDA team
Mori, M.; Hosokawa, M.; Ogasawara, Y.; Tsukada, E.; Chiba, K.
cDNA cloning, characterization and stable expression of a novel human brain carboxylesterase
FEBS Lett.
458
17-22
1999
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Scher, H.; Langmann, T.; Daig, R.; Becker, A.; Aslanidis, C.; Schmitz, G.
Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver
Biochem. Biophys. Res. Commun.
233
117-120
1997
Homo sapiens
Manually annotated by BRENDA team
Miller, A.D.; Scott, D.F.; Chacko, T.L.; Maywell, D.M.; Schlager, J.J.; Lanclos, K.D.
Expression and partial purification of a recombinant secretory form of human liver carboxylesterase
Protein Expr. Purif.
17
16-25
1999
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Hennebelle, I.; Terret, C.; Chatelut, E.; Bugat, R.; Canal, P.; Guichard, S.
Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: comparison with p-nitro-phenylacetate converting carboxylesterase activity
Anticancer Drugs
11
465-470
2000
Homo sapiens
Manually annotated by BRENDA team
Redinbo, M.R.; Bencharit, S.; Potter, P.M.
Human carboxylesterase 1: from drug metabolism to drug discovery
Biochem. Soc. Trans.
31
620-624
2003
Homo sapiens
Manually annotated by BRENDA team
Humerickhouse, R.; Lohrbach, K.; Li, L.; Bosron, W.F.; Dolan, M.E.
Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2
Cancer Res.
60
1189-1192
2000
Homo sapiens
Manually annotated by BRENDA team
Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.
Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases
Biochim. Biophys. Acta
1738
29-36
2005
Alicyclobacillus acidocaldarius, Archaeoglobus fulgidus, Homo sapiens
Manually annotated by BRENDA team
Nishi, K.; Huang, H.; Kamita, S.G.; Kim, I.H.; Morisseau, C.; Hammock, B.D.
Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2
Arch. Biochem. Biophys.
445
115-123
2006
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Sanghani, S.P.; Quinney, S.K.; Fredenburg, T.B.; Davis, W.I.; Murry, D.J.; Bosron, W.F.
Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3
Drug Metab. Dispos.
32
505-511
2004
Homo sapiens
Manually annotated by BRENDA team
Ross, M.K.; Borazjani, A.; Edwards, C.C.; Potter, P.M.
Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases
Biochem. Pharmacol.
71
657-669
2006
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Fleming, C.D.; Edwards, C.C.; Kirby, S.D.; Maxwell, D.M.; Potter, P.M.; Cerasoli, D.M.; Redinbo, M.R.
Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun
Biochemistry
46
5063-5071
2007
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Zhu, Q.G.; Hu, J.H.; Liu, J.Y.; Lu, S.W.; Liu, Y.X.; Wang, J.
Stereoselective characteristics and mechanisms of epidermal carboxylesterase metabolism observed in HaCaT keratinocytes
Biol. Pharm. Bull.
30
532-536
2007
Homo sapiens
Manually annotated by BRENDA team
Hicks, L.D.; Hyatt, J.L.; Moak, T.; Edwards, C.C.; Tsurkan, L.; Wierdl, M.; Ferreira, A.M.; Wadkins, R.M.; Potter, P.M.
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils
Bioorg. Med. Chem.
15
3801-3817
2007
Homo sapiens (O00748), Homo sapiens (P23141), Oryctolagus cuniculus (P12337)
Manually annotated by BRENDA team
Wierdl, M.; Tsurkan, L.; Hyatt, J.L.; Edwards, C.C.; Hatfield, M.J.; Morton, C.L.; Houghton, P.J.; Danks, M.K.; Redinbo, M.R.; Potter, P.M.
An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11
Cancer Gene Ther.
15
183-192
2008
Oryctolagus cuniculus (P12337), Oryctolagus cuniculus, Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Imai, T.; Taketani, M.; Shii, M.; Hosokawa, M.; Chiba, K.
Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine
Drug Metab. Dispos.
34
1734-1741
2006
Homo sapiens
Manually annotated by BRENDA team
Ross, M.K.; Crow, J.A.
Human carboxylesterases and their role in xenobiotic and endobiotic metabolism
J. Biochem. Mol. Toxicol.
21
187-196
2007
Homo sapiens
Manually annotated by BRENDA team
Hyatt, J.L.; Moak, T.; Hatfield, M.J.; Tsurkan, L.; Edwards, C.C.; Wierdl, M.; Danks, M.K.; Wadkins, R.M.; Potter, P.M.
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones
J. Med. Chem.
50
1876-1885
2007
Oryctolagus cuniculus, Homo sapiens (P23141)
Manually annotated by BRENDA team
Barthel, B.L.; Torres, R.C.; Hyatt, J.L.; Edwards, C.C.; Hatfield, M.J.; Potter, P.M.; Koch, T.H.
Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug
J. Med. Chem.
51
298-304
2008
Homo sapiens
Manually annotated by BRENDA team
Bencharit, S.; Edwards, C.C.; Morton, C.L.; Howard-Williams, E.L.; Kuhn, P.; Potter, P.M.; Redinbo, M.R.
Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J. Mol. Biol.
363
201-214
2006
Homo sapiens
Manually annotated by BRENDA team
Schiel, M.A.; Green, S.L.; Davis, W.I.; Sanghani, P.C.; Bosron, W.F.; Sanghani, S.P.
Expression and characterization of a human carboxylesterase 2 splice variant
J. Pharmacol. Exp. Ther.
323
94-101
2007
Homo sapiens
Manually annotated by BRENDA team
Taketani, M.; Shii, M.; Ohura, K.; Ninomiya, S.; Imai, T.
Carboxylesterase in the liver and small intestine of experimental animals and human
Life Sci.
81
924-932
2007
Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Wadkins, R.M.; Hyatt, J.L.; Edwards, C.C.; Tsurkan, L.; Redinbo, M.R.; Wheelock, C.E.; Jones, P.D.; Hammock, B.D.; Potter, P.M.
Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds
Mol. Pharmacol.
71
713-723
2007
Homo sapiens (O00748), Homo sapiens (P23141), Homo sapiens, Oryctolagus cuniculus (P12337)
Manually annotated by BRENDA team
Crow, J.A.; Borazjani, A.; Potter, P.M.; Ross, M.K.
Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases
Toxicol. Appl. Pharmacol.
221
1-12
2007
Homo sapiens, Rattus norvegicus (O70177)
Manually annotated by BRENDA team
Zhu, H.J.; Patrick, K.S.; Yuan, H.J.; Wang, J.S.; Donovan, J.L.; DeVane, C.L.; Malcolm, R.; Johnson, J.A.; Youngblood, G.L.; Sweet, D.H.; Langaee, T.Y.; Markowitz, J.S.
Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis
Am. J. Hum. Genet.
82
1241-1248
2008
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Yoshimura, M.; Kimura, T.; Ishii, M.; Ishii, K.; Matsuura, T.; Geshi, E.; Hosokawa, M.; Muramatsu, M.
Functional polymorphisms in carboxylesterase 1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites
Biochem. Biophys. Res. Commun.
369
939-942
2008
Homo sapiens
Manually annotated by BRENDA team
Zhu, H.J.; Appel, D.I.; Johnson, J.A.; Chavin, K.D.; Markowitz, J.S.
Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril
Biochem. Pharmacol.
77
1266-1272
2009
Homo sapiens
Manually annotated by BRENDA team
Yang, D.; Pearce, R.E.; Wang, X.; Gaedigk, R.; Wan, Y.J.; Yan, B.
Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin
Biochem. Pharmacol.
77
238-247
2009
Homo sapiens
Manually annotated by BRENDA team
Crow, J.A.; Middleton, B.L.; Borazjani, A.; Hatfield, M.J.; Potter, P.M.; Ross, M.K.
Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages
Biochim. Biophys. Acta
1781
643-654
2008
Homo sapiens
Manually annotated by BRENDA team
Tanino, T.; Nawa, A.; Miki, Y.; Iwaki, M.
Enzymatic stability of 2-ethylcarbonate-linked paclitaxel in serum and conversion to paclitaxel by rabbit liver carboxylesterase for use in prodrug/enzyme therapy
Biopharm. Drug Dispos.
29
259-269
2008
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Tang, X.; Wu, H.; Wu, Z.; Wang, G.; Wang, Z.; Zhu, D.
Carboxylesterase 2 is downregulated in colorectal cancer following progression of the disease
Cancer Invest.
26
178-181
2008
Homo sapiens
Manually annotated by BRENDA team
Byun, H.M.; Choi, S.H.; Laird, P.W.; Trinh, B.; Siddiqui, M.A.; Marquez, V.E.; Yang, A.S.
2-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1
Cancer Lett.
266
238-248
2008
Homo sapiens
Manually annotated by BRENDA team
Yano, H.; Kayukawa, S.; Iida, S.; Nakagawa, C.; Oguri, T.; Sanda, T.; Ding, J.; Mori, F.; Ito, A.; Ri, M.; Inagaki, A.; Kusumoto, S.; Ishida, T.; Komatsu, H.; Inagaki, H.; Suzuki, A.; Ueda, R.
Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma
Cancer Sci.
99
2309-2314
2008
Homo sapiens
Manually annotated by BRENDA team
Williams, E.T.; Jones, K.O.; Ponsler, G.D.; Lowery, S.M.; Perkins, E.J.; Wrighton, S.A.; Ruterbories, K.J.; Kazui, M.; Farid, N.A.
The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2
Drug Metab. Dispos.
36
1227-1232
2008
Homo sapiens
Manually annotated by BRENDA team
Hosokawa, M.; Furihata, T.; Yaginuma, Y.; Yamamoto, N.; Watanabe, N.; Tsukada, E.; Ohhata, Y.; Kobayashi, K.; Satoh, T.; Chiba, K.
Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes
Drug Metab. Pharmacokinet.
23
73-84
2008
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Takahashi, S.; Katoh, M.; Saitoh, T.; Nakajima, M.; Yokoi, T.
Allosteric kinetics of human carboxylesterase 1: species differences and interindividual variability
J. Pharm. Sci.
97
5434-5445
2008
Rattus norvegicus, Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Hosokawa, M.
Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs
Molecules
13
412-431
2008
Canis lupus familiaris, Cavia porcellus, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Fukami, T.; Nakajima, M.; Maruichi, T.; Takahashi, S.; Takamiya, M.; Aoki, Y.; McLeod, H.L.; Yokoi, T.
Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes
Pharmacogenet. Genomics
18
911-920
2008
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Brzezinski, M.R.; Abraham, T.L.; Stone, C.L.; Dean. R.A.; Bosron, W.F.
Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine
Biochem. Pharmacol.
48
1747-1755
1994
Homo sapiens
Manually annotated by BRENDA team
Bencharit, S.; Morton, C.L.; Xue, Y.; Potter, P.M.; Redinbo, M.R.
Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme
Nat. Struct. Biol.
10
349-356
2003
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Crow, J.A.; Herring, K.L.; Xie, S.; Borazjani, A.; Potter, P.M.; Ross, M.K.
Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids
Biochim. Biophys. Acta
1801
31-41
2010
Homo sapiens
Manually annotated by BRENDA team
Harada, T.; Nakagawa, Y.; Wadkins, R.M.; Potter, P.M.; Wheelock, C.E.
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis
Bioorg. Med. Chem.
17
149-164
2009
Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Hicks, L.D.; Hyatt, J.L.; Stoddard, S.; Tsurkan, L.; Edwards, C.C.; Wadkins, R.M.; Potter, P.M.
Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan, CPT-11) toxicity
J. Med. Chem.
52
3742-3752
2009
Homo sapiens
Manually annotated by BRENDA team
Zhu, H.J.; Appel, D.I.; Peterson, Y.K.; Wang, Z.; Markowitz, J.S.
Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: potential sources of metabolic drug interactions
Toxicology
270
59-65
2010
Homo sapiens
Manually annotated by BRENDA team
Fujiyama, N.; Miura, M.; Satoh, S.; Inoue, K.; Kagaya, H.; Saito, M.; Habuchi, T.; Suzuki, T.
Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients
Xenobiotica
39
407-414
2009
Homo sapiens
Manually annotated by BRENDA team
Eng, H.; Niosi, M.; McDonald, T.S.; Wolford, A.; Chen, Y.; Simila, S.T.; Bauman, J.N.; Warmus, J.; Kalgutkar, A.S.
Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor
Xenobiotica
40
369-380
2010
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Lamego, J.; Coroadinha, A.S.; Simplicio, A.L.
Detection and quantification of carboxylesterase 2 activity by capillary electrophoresis
Anal. Chem.
83
881-887
2011
Bos taurus, Canis lupus familiaris, Equus caballus, Felis catus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Hatfield, M.J.; Tsurkan, L.; Garrett, M.; Shaver, T.M.; Hyatt, J.L.; Edwards, C.C.; Hicks, L.D.; Potter, P.M.
Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11
Biochem. Pharmacol.
81
24-31
2011
Homo sapiens
Manually annotated by BRENDA team
Parkinson, E.I.; Jason Hatfield, M.; Tsurkan, L.; Hyatt, J.L.; Edwards, C.C.; Hicks, L.D.; Yan, B.; Potter, P.M.
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones
Bioorg. Med. Chem.
19
4635-4643
2011
Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Wang, J.; Williams, E.T.; Bourgea, J.; Wong, Y.N.; Patten, C.J.
Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2
Drug Metab. Dispos.
39
1329-1333
2011
Homo sapiens
Manually annotated by BRENDA team
Blais, D.R.; Lyn, R.K.; Joyce, M.A.; Rouleau, Y.; Steenbergen, R.; Barsby, N.; Zhu, L.F.; Pegoraro, A.F.; Stolow, A.; Tyrrell, D.L.; Pezacki, J.P.
Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication
J. Biol. Chem.
285
25602-25612
2010
Homo sapiens
Manually annotated by BRENDA team
Young, B.M.; Hyatt, J.L.; Bouck, D.C.; Chen, T.; Hanumesh, P.; Price, J.; Boyd, V.A.; Potter, P.M.; Webb, T.R.
Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors
J. Med. Chem.
53
8709-8715
2010
Homo sapiens
Manually annotated by BRENDA team
Hemmert, A.C.; Otto, T.C.; Wierdl, M.; Edwards, C.C.; Fleming, C.D.; MacDonald, M.; Cashman, J.R.; Potter, P.M.; Cerasoli, D.M.; Redinbo, M.R.
Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin
Mol. Pharmacol.
77
508-516
2010
Homo sapiens
Manually annotated by BRENDA team
Greenblatt, H.M.; Otto, T.C.; Kirkpatrick, M.G.; Kovaleva, E.; Brown, S.; Buchman, G.; Cerasoli, D.M.; Sussman, J.L.
Structure of recombinant human carboxylesterase 1 isolated from whole cabbage looper larvae
Acta Crystallogr. Sect. F
68
269-272
2012
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Amissah, F.; Duverna, R.; Aguilar, B.J.; Poku, R.A.; Kiros, G.E.; Lamango, N.S.
Polyisoprenylated methylated protein methyl esterase overexpression and hyperactivity promotes lung cancer progression
Am. J. Cancer Res.
4
116-134
2014
Homo sapiens
Manually annotated by BRENDA team
Amissah, F.; Duverna, R.; Aguilar, B.J.; Poku, R.A.; Lamango, N.S.
Polyisoprenylated methylated protein methyl esterase is both sensitive to curcumin and overexpressed in colorectal cancer: implications for chemoprevention and treatment
BioMed Res. Int.
2013
416534
2013
Homo sapiens
Manually annotated by BRENDA team
Thomsen, R.; Rasmussen, H.B.; Linnet, K.; Linnet, K.
In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors
Drug Metab. Dispos.
42
126-133
2014
Homo sapiens
Manually annotated by BRENDA team
Ayuk-Takem, L.; Amissah, F.; Aguilar, B.J.; Lamango, N.S.
Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces cell degeneration
Environ. Toxicol.
29
466-477
2014
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Zhuang, X.M.; Wei, X.; Tan, Y.; Xiao, W.B.; Yang, H.Y.; Xie, J.W.; Lu, C.; Li, H.
Contribution of carboxylesterase and cytochrome P450 to the bioactivation and detoxification of isocarbophos and its enantiomers in human liver microsomes
Toxicol. Sci.
140
40-48
2014
Homo sapiens
Manually annotated by BRENDA team
Alves, M.; Lamego, J.; Bandeiras, T.; Castro, R.; Tomas, H.; Coroadinha, A.S.; Costa, J.; Simplicio, A.L.
Human carboxylesterase 2 studies on the role of glycosylation for enzymatic activity
Biochem. Biophys. Rep.
5
105-110
2016
Homo sapiens (O00748), Homo sapiens
Manually annotated by BRENDA team
Kabeya, T.; Matsumura, W.; Iwao, T.; Hosokawa, M.; Matsunaga, T.
Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes
Biochem. Biophys. Res. Commun.
486
143-148
2017
Homo sapiens, Homo sapiens (Q6LAP9)
Manually annotated by BRENDA team
Weng, Z.M.; Ge, G.B.; Dou, T.Y.; Wang, P.; Liu, P.K.; Tian, X.H.; Qiao, N.; Yu, Y.; Zou, L.W.; Zhou, Q.; Zhang, W.D.; Hou, J.
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2
Bioorg. Chem.
77
320-329
2018
Homo sapiens (O00748), Homo sapiens
Manually annotated by BRENDA team
Takahashi, M.; Ogawa, T.; Kashiwagi, H.; Fukushima, F.; Yoshitsugu, M.; Haba, M.; Hosokawa, M.
Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1
Bioorg. Med. Chem. Lett.
28
997-1000
2018
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Zou, L.W.; Li, Y.G.; Wang, P.; Zhou, K.; Hou, J.; Jin, Q.; Hao, D.C.; Ge, G.B.; Yang, L.
Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2
Eur. J. Med. Chem.
112
280-288
2016
Homo sapiens (O00748), Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Binder, R.J.; Hatfield, M.J.; Chi, L.; Potter, P.M.
Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors
Eur. J. Med. Chem.
149
79-89
2018
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Li, D.; Li, Z.; Chen, W.; Yang, X.
Imaging and detection of carboxylesterase in living cells and zebrafish pretreated with pesticides by a new near-infrared fluorescence off-on probe
J. Agric. Food Chem.
65
4209-4215
2017
Danio rerio, Homo sapiens
Manually annotated by BRENDA team
Igawa, Y.; Fujiwara, S.; Ohura, K.; Hirokawa, T.; Nishizawa, Y.; Uehara, S.; Uno, Y.; Imai, T.
Differences in intestinal hydrolytic activities between cynomolgus monkeys and humans evaluation of substrate specificities using recombinant carboxylesterase 2 isozymes
Mol. Pharm.
13
3176-3186
2016
Macaca fascicularis (A0A2K5V282), Macaca fascicularis, Homo sapiens (O00748), Homo sapiens
Manually annotated by BRENDA team
Yao, J.; Chen, X.; Zheng, F.; Zhan, C.G.
Catalytic reaction mechanism for drug metabolism in human carboxylesterase-1 cocaine hydrolysis pathway
Mol. Pharm.
15
3871-3880
2018
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Wang, A.H.; Tian, X.G.; Cui, Y.L.; Huo, X.K.; Zhang, B.J.; Deng, S.; Feng, L.; Ma, X.C.; Jia, J.M.; Wang, C.
Diterpenoids from the roots of Euphorbia ebracteolata and their inhibitory effects on human carboxylesterase 2
Phytochemistry
146
82-90
2018
Homo sapiens (O00748), Homo sapiens
Manually annotated by BRENDA team
Boonyuen, U.; Promnares, K.; Junkree, S.; Day, N.; Imwong, M.
Efficient in vitro refolding and functional characterization of recombinant human liver carboxylesterase (CES1) expressed in E. coli
Protein Expr. Purif.
107
68-75
2015
Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team
Jiang, J.; Chen, X.; Zhong, D.
Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans
Xenobiotica
48
533-540
2018
Homo sapiens (O00748), Homo sapiens (P23141), Homo sapiens
Manually annotated by BRENDA team