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Information on EC 2.9.1.3 - tRNA 2-selenouridine synthase and Organism(s) Salmonella typhimurium and UniProt Accession Q8ZR88

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EC Tree
     2 Transferases
         2.9 Transferring selenium-containing groups
             2.9.1 Selenotransferases
                2.9.1.3 tRNA 2-selenouridine synthase
IUBMB Comments
This bacterial enzyme converts 5-methylaminomethyl-2-uridine and 5-carboxymethylaminomethyl-2-uridine to the respective selenouridine forms in a two-step process that involves geranylation and subsequent phosphoselenation of the resulting geranylated intermediates. The resultant seleno-phosphorylated uridine intermediates further react with a water molecule to release a phosphate anion and 2-selenouridine tRNA. The enzyme contains a rhodanese domain.
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This record set is specific for:
Salmonella typhimurium
UNIPROT: Q8ZR88
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
+
5-methylaminomethyl-2-thiouridine34 in tRNA
+
=
5-methylaminomethyl-2-selenouridine34 in tRNA
+
(2E)-3,7-dimethylocta-2,6-diene-1-thiol
+
+
Synonyms
trna 2-selenouridine synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
mnmH
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selU
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-
-
-
sufY
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-
-
-
ybbB
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
geranyl diphosphate/selenophosphate:tRNA 5-methylaminomethyl-2-thiouridine34 geranyl/selenophosphatetransferase
This bacterial enzyme converts 5-methylaminomethyl-2-uridine and 5-carboxymethylaminomethyl-2-uridine to the respective selenouridine forms in a two-step process that involves geranylation and subsequent phosphoselenation of the resulting geranylated intermediates. The resultant seleno-phosphorylated uridine intermediates further react with a water molecule to release a phosphate anion and 2-selenouridine tRNA. The enzyme contains a rhodanese domain.