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Information on EC 2.9.1.3 - tRNA 2-selenouridine synthase

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EC Tree
     2 Transferases
         2.9 Transferring selenium-containing groups
             2.9.1 Selenotransferases
                2.9.1.3 tRNA 2-selenouridine synthase
IUBMB Comments
This bacterial enzyme converts 5-methylaminomethyl-2-uridine and 5-carboxymethylaminomethyl-2-uridine to the respective selenouridine forms in a two-step process that involves geranylation and subsequent phosphoselenation of the resulting geranylated intermediates. The resultant seleno-phosphorylated uridine intermediates further react with a water molecule to release a phosphate anion and 2-selenouridine tRNA. The enzyme contains a rhodanese domain.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
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+
+
5-methylaminomethyl-2-thiouridine34 in tRNA
+
=
5-methylaminomethyl-2-selenouridine34 in tRNA
+
(2E)-3,7-dimethylocta-2,6-diene-1-thiol
+
+
Synonyms
trna 2-selenouridine synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-methylaminomethyl-2-(Se-phospho)selenouridine34 in tRNA + H2O = 5-methylaminomethyl-2-selenouridine34 in tRNA + phosphate
show the reaction diagram
(1c)
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-
0
geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA = 5-methylaminomethyl-2-(S-geranyl)thiouridine34 in tRNA + diphosphate
show the reaction diagram
(1a)
-
-
0
selenophosphate + 5-methylaminomethyl-2-(S-geranyl)thiouridine34 in tRNA = 5-methylaminomethyl-2-(Se-phospho)selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol
show the reaction diagram
(1b)
-
-
0
selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O = 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
show the reaction diagram
overall reaction
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-
0
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