Information on EC - L-seryl-tRNASec selenium transferase

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IUBMB Comments
A pyridoxal 5'-phosphate enzyme identified in Escherichia coli. Recognises specifically tRNASec-species. Binding of tRNASec also occurs in the absence of the seryl group. 2-Aminoacryloyl-tRNA, bound to the enzyme as an imine with the pyridoxal phosphate, is an intermediate in the reaction. Since the selenium atom replaces oxygen in serine, the product may also be referred to as L-selenoseryl-tRNASec. The symbol Sel has also been used for selenocysteine but Sec is preferred.
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  • autoantibodies
  • selenoproteins
  • antinuclear
  • anti-sla
  • antimitochondrial
  • sepsecs
  • selenocysteyl-trnasec
  • secis
  • trnasersec
  • anti-liver
  • selenocysteine-containing
  • trnaser
  • anti-lkm1
  • liver-pancreas
  • anti-smooth
  • ser-trnasec
  • non-organ
  • selenoproteome
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Cysteinyl-tRNA(Sec) selenium transferase, Cysteinyl-tRNASec-selenium transferase, CysteinyltRNASel-selenium transferase, GenBank Y14814-derived protein GI 2440135, L-Selenocysteine-tRNASec synthase selenocysteine synthase, L-Selenocysteine-tRNASel synthase, More, Sec synthase, SecS, SelA, more
L-seryl-tRNASec + selenophosphate = L-selenocysteinyl-tRNASec + phosphate
show the reaction diagram
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