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Information on EC 2.8.4.5 - tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase

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IUBMB Comments
The enzyme, which is a member of the S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes superfamily, binds two [4Fe-4S] clusters as well as the transferred sulfur. The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover. The identity of the electron donor is not known.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
+
sulfur-(sulfur carrier)
+
+
reduced electron acceptor
=
2-sulfanyl-N6-L-threonylcarbamoyladenine37 in tRNA
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(sulfur carrier)
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+
+
electron acceptor
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2-sulfanyl-N6-L-threonylcarbamoyladenine37 in tRNA
=
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2-(methylsulfanyl)-N6-L-threonylcarbamoyladenine37 in tRNA
Synonyms
CDKAL1, methylthio-threonylcarbamoyl-adenosine transferase B, MtaB, YqeV, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N6-L-threonylcarbamoyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced electron acceptor = 2-(methylsulfanyl)-N6-L-threonylcarbamoyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + electron acceptor
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N6-L-threonylcarbamoyladenine37 in tRNA + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced electron acceptor = 2-sulfanyl-N6-L-threonylcarbamoyladenine37 in tRNA + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + electron acceptor
show the reaction diagram
S-adenosyl-L-methionine + 2-sulfanyl-N6-L-threonylcarbamoyladenine37 in tRNA = S-adenosyl-L-homocysteine + 2-(methylsulfanyl)-N6-L-threonylcarbamoyladenine37 in tRNA
show the reaction diagram
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