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Information on EC 2.8.3.8 - acetate CoA-transferase

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.3 CoA-transferases
                2.8.3.8 acetate CoA-transferase
IUBMB Comments
The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC 2.8.3.9, butyrate---acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
AarC, acetate coenzyme A-transferase, acetate:succinate CoA-transferase, acetoacetate:acetate CoA-transferase, ActA, ASCT, But, butyryl CoA:acetate CoA transferase, butyryl coenzyme A transferase, butyryl coenzyme A:acetate transferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + acetate = a fatty acid anion + acetyl-CoA
show the reaction diagram
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