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Information on EC - acetate CoA-transferase

for references in articles please use BRENDA:EC2.8.3.8
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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.3 CoA-transferases
       acetate CoA-transferase
IUBMB Comments
The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC, butyrate---acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA.
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Word Map
The enzyme appears in viruses and cellular organisms
butyryl-coa:acetate coa-transferase, butyryl-coa acetate coa-transferase, acetate:succinate coa-transferase, butyryl-coenzyme a coa transferase, acetate coa-transferase, acyl-coa:acetate coa-transferase, acetoacetate:acetate coa-transferase, succinyl-coa:acetate coa transferase, butyryl coa:acetate coa transferase, butyryl coenzyme a transferase, more
acyl-CoA + acetate = a fatty acid anion + acetyl-CoA
show the reaction diagram
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