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Information on EC - bile acid CoA-transferase

for references in articles please use BRENDA:EC2.8.3.25
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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.3 CoA-transferases
       bile acid CoA-transferase
IUBMB Comments
The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bile acid 7alpha-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. Clostridium scindens possesses two forms of the enzyme, encoded by the baiF and baiK genes. While the enzymes have a broad acceptor specificity and can use allocholate, ursodeoxycholate, and beta-muricholate, the donor specificity is more strict. BaiF acts on lithocholoyl-CoA and deoxycholoyl-CoA, and BaiK acts only on the latter.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
baiF, baiK, bile acid coenzyme A transferase, more
deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA
show the reaction diagram
lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA
show the reaction diagram
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