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Information on EC 2.8.3.25 - bile acid CoA-transferase

for references in articles please use BRENDA:EC2.8.3.25

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IUBMB Comments

The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bile acid 7α-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. Clostridium scindens possesses two forms of the enzyme, encoded by the baiF and baiK genes. While the enzymes have a broad acceptor specificity and can use allocholate, ursodeoxycholate, and β-muricholate, the donor specificity is more strict. BaiF acts on lithocholoyl-CoA and deoxycholoyl-CoA, and BaiK acts only on the latter.

The enzyme appears in viruses and cellular organisms

Synonyms
baiF, baiK, bile acid coenzyme A transferase, EC 3.1.2.26, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA
show the reaction diagram
(2)
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lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
MetaCyc
bile acid 7alpha-dehydroxylation, bile acid 7beta-dehydroxylation
Highest Expressing Human Cell Lines
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