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Information on EC 2.8.3.24 - (R)-2-hydroxy-4-methylpentanoate CoA-transferase

for references in articles please use BRENDA:EC2.8.3.24
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IUBMB Comments
The enzyme, characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway. The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate.
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The expected taxonomic range for this enzyme is: Clostridioides difficile
Synonyms
(R)-2-hydroxyisocaproate CoA transferase, HadA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA
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PATHWAY SOURCE
PATHWAYS
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