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Information on EC 2.8.3.13 - succinate-hydroxymethylglutarate CoA-transferase and Organism(s) Homo sapiens and UniProt Accession Q9HAC7

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IUBMB Comments
Malonyl-CoA can also act as donor, but more slowly.
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This record set is specific for:
Homo sapiens
UNIPROT: Q9HAC7
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
c7orf10, succinate-hydroxymethylglutarate coa-transferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C7orf10
hydroxymethylglutarate coenzyme A-transferase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
coenzyme A transfer
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-
-
-
PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase
Malonyl-CoA can also act as donor, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
80237-90-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-hydroxy-3-methylglutaryl-CoA + glutarate
3-hydroxy-3-methylglutarate + glutaryl-CoA
show the reaction diagram
highest activity
-
-
?
3-hydroxy-3-methylglutaryl-CoA + succinate
3-hydroxy-3-methylglutarate + succinyl-CoA
show the reaction diagram
-
-
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SUCHY_HUMAN
445
0
48462
Swiss-Prot
Mitochondrion (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50000
x * 50000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 50000, SDS-PAGE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
R336W
inactive
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells and HEK-293T cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Marlaire, S.; Van Schaftingen, E.; Veiga-da-Cunha, M.
C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA
J. Inherit. Metab. Dis.
37
13-19
2014
Homo sapiens (Q9HAC7), Homo sapiens
Manually annotated by BRENDA team