Information on EC 2.8.3.11 - citramalate CoA-transferase

for references in articles please use BRENDA:EC2.8.3.11
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
2.8.3.11
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RECOMMENDED NAME
GeneOntology No.
citramalate CoA-transferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
coenzyme A transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
C5-Branched dibasic acid metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:citramalate CoA-transferase
The enzyme is a component of EC 4.1.3.22 citramalate lyase. Also catalyses the transfer of thioacyl carrier protein from its acetyl thioester to citramalate.
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CAS REGISTRY NUMBER
COMMENTARY hide
9033-60-7
indistinguishable from EC 2.8.3.7 in Chemical Abstracts
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
alpha-subunit of the citramalate enzyme complex
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + citramalate
acetate + (3S)-citramalyl-CoA
show the reaction diagram
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alpha-subunit of the citramalate enzyme complex
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r
acetyl-[acyl-carrier protein] + citramalate
citramalyl-[acyl-carrier protein] + acetate
show the reaction diagram
succinate + (3S)-citramalyl-CoA
succinyl-CoA + citramalate
show the reaction diagram
succinate + (S)-(+)-citramalyl-CoA
succinyl-CoA + citramalate
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-[acyl-carrier protein] + citramalate
citramalyl-[acyl-carrier protein] + acetate
show the reaction diagram
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biological significant reaction, alpha-subunit of citramalate lyase enzyme complex
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?
succinate + (S)-(+)-citramalyl-CoA
succinyl-CoA + citramalate
show the reaction diagram
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
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activity is enhanced in presence of CoA and succinate
CoA
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activity is enhanced in presence of ATP and succinate
succinate
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activity is enhanced in presence of CoA and ATP
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Renatured/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
reconstitution of the enzyme complex at pH 8.0, 25°C
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
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LINKS TO OTHER DATABASES (specific for EC-Number 2.8.3.11)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)