Any feedback?
Information on EC 2.8.2.9 - tyrosine-ester sulfotransferase
for references in articles please use BRENDA:EC2.8.2.9Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.8.2.9 tyrosine-ester sulfotransferaseIUBMB Comments
Phenols and organic hydroxylamines can act as acceptors (cf. EC 2.8.2.1 aryl sulfotransferase).
Specify your search results
Word Map
- 2.8.2.9
-
sults
- phenol
- pap
- steroid
- xenobiotics
- 3'-phosphoadenosine
- 5'-phosphosulfate
- dehydroepiandrosterone
-
glucuronidation
-
sulfatase
- 3'-phosphoadenosine-5'-phosphosulfate
- hydroxysteroids
- estradiol
-
udp-glucuronosyltransferase
- chondroitin
- heparan
- dheas
- estrone
-
drug-metabolizing
- p-nitrophenol
- pentachlorophenol
- sult1a3
-
sulfurylation
- n-hydroxy-2-acetylaminofluorene
-
sulfoconjugation
- minoxidil
-
arylamines
- 2-acetylaminofluorene
- l-selectin
- 2-naphthol
- 3'-phosphate
-
glucuronyltransferase
-
desulfated
- keratan
- pregnenolone
-
hepatocarcinogenicity
-
17beta-hydroxysteroid
-
monosulfate
-
2-amino-1-methyl-6-phenylimidazo4,5-bpyridine
-
n-hydroxy
-
35ssulfate
-
glucuronyl
-
32p-postlabeling
-
udp-glucuronosyl
- 4-sulfate
-
n-sulfation
- galactosylceramide
-
promutagens
-
3-o-sulfation
- tibolone
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
sulfotransferase, ast iv, aryl sulfotransferase iv, st1a1, sult1d1, tyrosine-ester sulfotransferase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
aryl sulfotransferase IV
beta-aryl sulfotransferase IV
-
-
-
-
beta-AST IV
-
-
-
-
L-tyrosine methyl ester sulfotransferase
-
-
-
-
ST1A1
-
-
-
-
sulfotransferase, tyrosine ester
-
-
-
-
tyrosine ester sulfotransferase
-
-
-
-
aryl sulfotransferase IV
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
mechanism
-
3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
random rapid equilibrium bi bi kinetic mechanism
-
3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
sulfate group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase
Phenols and organic hydroxylamines can act as acceptors (cf. EC 2.8.2.1 aryl sulfotransferase).
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9055-56-5
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1S)-2-methyl-1-phenylpropan-1-ol
adenosine 3',5'-bisphosphate + (1S)-2-methyl-1-phenylpropyl sulfate
-
stereochemical configuration is important, the other enantiomer acts as inhibitor
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + (R)-(-)-1,2,3,4-tetrahydro-1-naphthol
adenosine 3',5'-bisphosphate + (R)-(-)-1,2,3,4-tetrahydro-1-naphthyl sulfate
-
activity is abserved with wild-type enzyme and mutant enzymes F77A, F138A and Y236A
-
-
?
3'-phosphoadenylylsulfate + (S)-(+)-1,2,3,4-tetrahydro-1-naphthol
adenosine 3',5'-bisphosphate + (S)-(+)-1,2,3,4-tetrahydro-1-naphthyl sulfate
-
mutant enzyme F77A and F138A show activity, wild-type enzyme and mutant enzyme Y236A show no activity
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 2-chloro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2-chloro-4-nitrophenyl sulfate
3'-phosphoadenylylsulfate + 2-chlorophenol
adenosine 3',5'-bisphosphate + 2-chlorophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-cyanoethyl-N-hydroxythioacetamide
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-cyanoethyl-N-hydroxythioacetimidate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-fluoro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2-fluoro-4-nitrophenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-chlorophenol
adenosine 3',5'-bisphosphate + 3-chlorophenyl sulfate
3'-phosphoadenylylsulfate + 3-fluoro-4-nitrophenol
adenosine 3',5'-bisphosphate + 3-fluoro-4-nitrophenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-methoxy-4-hydroxyphenylglycol
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylylsulfate + 3-methylphenol
adenosine 3',5'-bisphosphate + 3-methylphenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-nitrophenol
adenosine 3',5'-bisphosphate + 3-nitrophenyl sulfate
3'-phosphoadenylylsulfate + 4-chlorophenol
adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
3'-phosphoadenylylsulfate + 4-methoxyphenol
adenosine 3',5'-bisphosphate + 4-methoxyphenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-methylphenol
adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferol
adenosine 3',5'-bisphosphate + 4-methylumbelliferyl sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
3'-phosphoadenylylsulfate + 5-hydroxytryptamine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptophol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + 9-hydroxy-N-2-fluorenylacetamide
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + Ala-Tyr
adenosine 3',5'-bisphosphate + Ala-(O-sulfo)Tyr
-
-
-
-
?
3'-phosphoadenylylsulfate + Asp-Arg-Asp-Tyr-Met-Gly
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + caerulein
adenosine 3',5'-bisphosphate + ?
-
nonsulfated
-
-
?
3'-phosphoadenylylsulfate + cholecystokinin
adenosine 3',5'-bisphosphate + ?
-
nonsulfated
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + GlyTyr
adenosine 3',5'-bisphosphate + Gly-(O-sulfo)Tyr
-
-
-
-
?
3'-phosphoadenylylsulfate + hydrocortisone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + L-4-hydroxyphenylglycine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine
adenosine 3',5'-bisphosphate + tyrosine O4-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine allyl ester
adenosine 3',5'-bisphosphate + tyrosine allyl ester 4-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine amide
adenosine 3',5'-bisphosphate + O-sulfo-L-tyrosine amide
3'-phosphoadenylylsulfate + L-tyrosine benzyl ester
adenosine 3',5'-bisphosphate + tyrosine benzyl ester 4-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine ethyl ester
adenosine 3',5'-bisphosphate + tyrosine ethyl ester 4-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine methyl ester
adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
3'-phosphoadenylylsulfate + L-tyrosine tert-butyl ester
adenosine 3',5'-bisphosphate + tyrosine tert-butyl ester 4-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + methylphenol
adenosine 3',5'-bisphosphate + methylphenyl sulfate
-
3-methylphenol or 4-methylphenol
-
-
?
3'-phosphoadenylylsulfate + N-acetyl-L-tyrosine ethyl ester
adenosine 3',5'-bisphosphate + N-acetyl-L-tyrosine O4-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + N-acetylserotonin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-ethyl-N-hydroxyaniline
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-hydroxy-N-ethylaniline
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-hydroxy-N-methylaniline
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-hydroxy-N-n-propylaniline
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + nitrophenol
adenosine 3',5'-bisphosphate + nitrophenyl sulfate
3'-phosphoadenylylsulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + quercetin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + tert-butoxycarbonyl-Asp-Arg-Asp-Tyr-Met-Gly
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + tert-butoxycarbonyl-Asp-Tyr
adenosine 3',5'-bisphosphate + tert-butoxycarbonyl-Asp-Tyr-O4-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + tert-butoxycarbonyl-Asp-Tyr-Met
adenosine 3',5'-bisphosphate + tert-butoxycarbonyl-Asp-Tyr-(O4-sulfate)-Met
-
-
-
-
?
3'-phosphoadenylylsulfate + tert-butoxycarbonyl-Asp-Tyr-Met-Gly
adenosine 3',5'-bisphosphate + tert-butoxycarbonyl-Asp-Tyr-(O4-sulfate)-Met-Gly
-
-
-
-
?
3'-phosphoadenylylsulfate + tert-butoxycarbonyl-Asp-Tyr-Met-Gly-Trp
adenosine 3',5'-bisphosphate + tert-butoxycarbonyl-Asp-Tyr-(O4-sulfate)-Met-Gly-Trp
-
-
-
-
?
3'-phosphoadenylylsulfate + tert-butoxycarbonyl-Asp-Tyr-Met-Gly-Trp-Met
adenosine 3',5'-bisphosphate + tert-butoxycarbonyl-Asp-Tyr-(O4-sulfate)-Met-Gly-Trp-Met
-
-
-
-
?
3'-phosphoadenylylsulfate + tert-butoxycarbonyl-Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2
adenosine 3',5'-bisphosphate + tert-butoxycarbonyl-Asp-Tyr-(O4-sulfate)-Met-Gly-Trp-Met-Asp-Phe-NH2
-
i.e. Boc-CCK-8 ns
-
-
?
3'-phosphoadenylylsulfate + tert-butoxycarbonylcholecystokinin-octapeptide
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + TyrGly
adenosine 3',5'-bisphosphate + 4O-sulfo-Tyr-Gly
-
-
-
-
?
adenosine 3'-phosphate 5'-sulfophosphate + L-tyrosine methyl ester
?
-
-
-
-
?
R-(-)-1,2,3,4-tetrahydro-1-naphthol
adenosine 3',5'-bisphosphate + (R)-(-)-1,2,3,4-tetrahydro-1-naphthyl sulfate
-
stereochemical configuration is important, the other enantiomer acts as inhibitor
-
-
?
3'-phosphoadenylylsulfate + 2-chloro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2-chloro-4-nitrophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-chloro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2-chloro-4-nitrophenyl sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 3-chlorophenol
adenosine 3',5'-bisphosphate + 3-chlorophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-chlorophenol
adenosine 3',5'-bisphosphate + 3-chlorophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-methoxy-4-hydroxyphenylglycol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-methoxy-4-hydroxyphenylglycol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-nitrophenol
adenosine 3',5'-bisphosphate + 3-nitrophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-nitrophenol
adenosine 3',5'-bisphosphate + 3-nitrophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-chloro-N-hydroxyaniline
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-chloro-N-hydroxyaniline
adenosine 3',5'-bisphosphate + ?
-
oxidative degradation N-hydroxyaniline causes inhibition
-
-
?
3'-phosphoadenylylsulfate + 4-chloro-N-hydroxyaniline
adenosine 3',5'-bisphosphate + ?
-
oxidative degradation N-hydroxyaniline causes inhibition
-
-
?
3'-phosphoadenylylsulfate + 4-chlorophenol
adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-chlorophenol
adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine amide
adenosine 3',5'-bisphosphate + O-sulfo-L-tyrosine amide
-
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine amide
adenosine 3',5'-bisphosphate + O-sulfo-L-tyrosine amide
-
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine methyl ester
adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine methyl ester
adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + N-hydroxy-2-aminofluorene
adenosine 3',5'-bisphosphate + ?
-
causes inhibition under reaction conditions where oxidative degradation occurs
-
-
?
3'-phosphoadenylylsulfate + N-hydroxy-2-aminofluorene
adenosine 3',5'-bisphosphate + ?
-
causes inhibition under reaction conditions where oxidative degradation occurs
-
-
?
3'-phosphoadenylylsulfate + N-hydroxyaniline
adenosine 3',5'-bisphosphate + ?
-
oxidative degradation of N-hydroxyaniline causes inhibition
-
-
?
3'-phosphoadenylylsulfate + N-hydroxyaniline
adenosine 3',5'-bisphosphate + ?
-
oxidative degradation of N-hydroxyaniline causes inhibition
-
-
?
3'-phosphoadenylylsulfate + nitrophenol
adenosine 3',5'-bisphosphate + nitrophenyl sulfate
-
3-nitrophenol or 4-nitrophenol
-
-
?
3'-phosphoadenylylsulfate + nitrophenol
adenosine 3',5'-bisphosphate + nitrophenyl sulfate
-
3-nitrophenol or 4-nitrophenol
-
-
?
additional information
?
-
no substrate for isozymes HAST4 and HAST4v: dopamine
-
-
?
additional information
?
-
-
no substrate for isozymes HAST4 and HAST4v: dopamine
-
-
?
additional information
?
-
-
forms sulfuric acid esters from a wide range of phenols, tyrosine carboxyesters, catechols, benzylic alcohols, arylhydroxamic acids and N-hydroxy arylamines. Stereochemical configuration of chiral benzyclic alcohols is an important factor in substrate specificity. One enantiomer may act as substrate, the other as inhibitor
-
-
?
additional information
?
-
-
natural enzyme acts best with naphthylamine at an acidic pH and the recombinant enzyme best at high pH values
-
-
?
additional information
?
-
-
transfer of a sulfuryl group to an aryl hydroxyl group
-
-
?
additional information
?
-
-
involved in the sulfation of physiologically active amines
-
-
?
additional information
?
-
-
enzyme is specific for substrate molecules with a free and unprotonated amino group and an unionized hydroxyl group
-
-
?
additional information
?
-
-
catalyzes sulfate ester formation with simple phenols at an acidic pH and with several physiological metabolites at a more alkaline pH
-
-
?
additional information
?
-
-
active with phenols, hydroxylamines and esters of tyrosine
-
-
?
additional information
?
-
-
it appears unlikely that the enzyme is involved in the biosynthesis of proteins containing L-tyrosine O-sulfate residues, it is probably important in sulfation of physiologically active amines
-
-
?
additional information
?
-
-
the enzyme is involved in detoxification and is susceptible to downregulation by hepatotoxic xenobiotics, overview
-
-
?
additional information
?
-
-
forms sulfuric acid esters from a wide range of phenols, tyrosine carboxyesters, catechols, benzylic alcohols, arylhydroxamic acids and N-hydroxy arylamines. Stereochemical configuration of chiral benzyclic alcohols is an important factor in substrate specificity. One enantiomer may act as substrate, the other as inhibitor
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
it appears unlikely that the enzyme is involved in the biosynthesis of proteins containing L-tyrosine O-sulfate residues, it is probably important in sulfation of physiologically active amines
-
-
?
additional information
?
-
-
the enzyme is involved in detoxification and is susceptible to downregulation by hepatotoxic xenobiotics, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-naphthylacetic acid
-
competitive with respect to 1-naphththalenemethanol
2'-O-[(R)-formyl(adenin-9-yl)methyl]-(S)-glyceraldehyde 3'-triphosphate
-
ATPDA, irreversible, inhibition prevented by either adenosine 3,5'-diphosphate or 3'-phosphoadenylylsulfate, binds to Lys65 and Cys66 at the PAPS binding site
2-acetylaminofluorene
-
increases and/or alters the inhibitory effect of metal ions, relationship between inhibition by heavy metal ions and dietary 2-acetylaminofluorene, overview
2-naphthylacetic acid
-
competitive with respect to 1-naphththalenemethanol
Cd2+
-
strong inhibition in vitro and in vivo, 50% inhibition of purified enzyme at about 0.0025 mM, 50% inhibition in liver cytosol at about 0.025 mM
Cu2+
-
elevated copper levels in the diet result in reduced enzyme levels in rat liver, strong inhibition in vitro and in vivo, 50% inhibition of purified enzyme at about 0.0025 mM, 50% inhibition in liver cytosol at about 0.025 mM
iodoacetamide
-
pH 7.5, 30°C, inhibition prevented by presence of 3'-phosphate 5'-sulfatophosphate but not by L-tyrosine methyl ester
N-Hydroxy-2-acetylaminofluorene
-
N-OH-2AAF, formation of AST IV:2AAF adducts leads to irreversible inactivation
N-hydroxy-2-aminofluorene
-
N-OH-2AF, causes inhibition under reaction conditions where oxidative degradation occurs
N-hydroxyaniline
-
causes inhibition under reaction conditions where oxidative degradation occurs, activity rapidly decreases to less than 10% of the initial activity
R-(+)-2-methyl-1-phenylpropanol
-
competitive, reversible inhibitor, stereochemical configuration is important, the other enantiomer acts as substrate
S-(+)-1,2,3,4-tetrahydro-1-naphthol
-
competitive, reversible inhibitor, stereochemical configuration is important, the other enantiomer acts as substrate
Zn2+
-
indirect inhibition mechanism, strong inhibition in vitro and in vivo, 50% inhibition of purified enzyme at about 0.0025 mM, 50% inhibition in liver cytosol at about 0.025 mM
2,6-Dichloro-4-nitrophenol
50% inhibition of HAST4 at 0.005 mM; 50% inhibition of HAST4v at 0.02 mM
4-chloro-N-hydroxyaniline
-
causes inhibition under reaction conditions where oxidative degradation occurs
adenosine 3',5'-bisphosphate
-
PAP, competitive to 3'-phosphoadenylylsulfate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-mercaptoethanol
-
activates, degree of activation is more marked with preparations previously stored at 0°C or -10°C
5,5'-dithiobis(2-nitrobenzoate)
-
low concentrations lead to increase of activity at a physiological pH, higher concentrations lead to complete inactivation
Diamide
-
low concentrations lead to increase of activity at a physiological pH, higher concentrations lead to complete inactivation
dithiothreitol
-
activates, degree of activation is more marked with preparations previously stored at 0°C or -10°C
glutathione
-
activates, degree of activation is more marked with preparations previously stored at 0°C or -10°C
glutathione disulfide
-
leads to the formation of internal disulfide bonds between Cys66 and Cys232, activates the enzyme and allows it to function at a pH optimum in the physiological range
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE